Detailed information for compound 573293

Basic information

Technical information
  • TDR Targets ID: 573293
  • Name: chloroplatinum; 6-(6-piperidin-1-id-2-ylpiper idin-1-id-2-yl)-2H-pyridin-1-ide
  • MW: 474.886 | Formula: C15H22ClN3Pt---
  • H donors: 1 H acceptors: 0 LogP: 2.75 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1C[N-]C(CC1)C1CCCC([N-]1)C1=CC=CC[N-]1.Cl[Pt]
  • InChi: 1S/C15H22N3.ClH.Pt/c1-3-10-16-12(6-1)14-8-5-9-15(18-14)13-7-2-4-11-17-13;;/h1,3,6,13-15H,2,4-5,7-11H2;1H;/q-3;;+1/p-1
  • InChiKey: LQTJWZORRHJDAH-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • chloroplatinum; 6-[6-(2-piperidin-1-idyl)-2-piperidin-1-idyl]-2H-pyridin-1-ide
  • chloroterpyridineplatinum(II)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0297 0.0339
Brugia malayi Thioredoxin reductase 0.0037 0.0325 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0297 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0547 0.0632
Trypanosoma brucei glucosidase, putative 0.0035 0.0297 0.0343
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.1022 0.1181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0147 0.0121
Onchocerca volvulus 0.0091 0.1138 0.1497
Echinococcus multilocularis cpg binding protein 0.0031 0.0241 0.0216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.4451 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0075 0.0895 0.1118
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2543 0.3263
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0121 0.014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0352 0.031
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2132 0.2112
Schistosoma mansoni microtubule-associated protein tau 0.0682 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.0862 0.0996
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0325 0.0376
Brugia malayi TAR-binding protein 0.0123 0.1615 0.1965
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0895 0.1034
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0659 0.4958
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0659 0.1223
Brugia malayi ecdysteroid receptor 0.0025 0.0147 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0895 0.1034
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.028 0.3977 0.4595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0147 0.0146
Trichomonas vaginalis glutaminase, putative 0.053 0.7719 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0185 0.2543 0.3187
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1172 0.2411
Leishmania major trypanothione reductase 0.0037 0.0325 0.0376
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Onchocerca volvulus 0.0028 0.0189 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0183 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0147 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0147 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0297 0.0339
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0627 0.0769
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1032 0.2086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0147 0.0121
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0627 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0342 0.0399
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0131 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0147 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0297 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0297 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0352 0.0411
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0895 0.1018
Loa Loa (eye worm) hypothetical protein 0.0093 0.116 0.1464
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0147 0.0147
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0365 0.5237 0.5225
Trypanosoma cruzi DNA polymerase eta, putative 0.0124 0.1636 0.189
Echinococcus multilocularis chromobox protein 1 0.0069 0.0806 0.0782
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0121 0.014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0352 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0659 0.0708
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0297 0.0339
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2543 0.3263
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Schistosoma mansoni tar DNA-binding protein 0.0123 0.1615 0.1615
Schistosoma mansoni tar DNA-binding protein 0.0123 0.1615 0.1615
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0297 0.0271
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.1022 0.1181
Brugia malayi Pre-SET motif family protein 0.006 0.0676 0.073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0306 0.0281
Echinococcus granulosus chromobox protein 1 0.0069 0.0806 0.0782
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0297 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0121 0.0112
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0682 0.0657
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0185 0.2543 0.3187
Schistosoma mansoni hypothetical protein 0.0395 0.5696 0.5696
Mycobacterium tuberculosis Probable reductase 0.0084 0.1032 0.2086
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0026
Echinococcus multilocularis zinc finger protein 0.0021 0.0087 0.0061
Trypanosoma brucei unspecified product 0.0075 0.0895 0.1034
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0676 0.0652
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0659 0.0708
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0297 0.0339
Brugia malayi nuclear hormone receptor 0.0025 0.0147 0.0034
Onchocerca volvulus 0.0185 0.2543 0.3621
Brugia malayi chromobox protein homolog 3 0.0039 0.0352 0.0303
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0147 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0147 0.0121
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0659 0.0659
Echinococcus multilocularis histone acetyltransferase MYST2 0.0105 0.1352 0.1329
Schistosoma mansoni chromobox protein 0.0069 0.0806 0.0806
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0682 0.0657
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1172 0.2411
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0619 0.0594
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.116 0.116
Toxoplasma gondii hypothetical protein 0.0096 0.1206 1
Brugia malayi Pre-SET motif family protein 0.041 0.5919 0.763
Schistosoma mansoni glutaminase 0.053 0.7719 0.7719
Trypanosoma brucei trypanothione reductase 0.0037 0.0325 0.0376
Plasmodium vivax SET domain protein, putative 0.006 0.0676 1
Leishmania major DNA damage repair protein, putative 0.0023 0.0121 0.014
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0806 0.1001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0147 0.0034
Plasmodium vivax glutathione reductase, putative 0.0037 0.0325 0.3671
Trichomonas vaginalis set domain proteins, putative 0.0466 0.6764 0.8757
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0147 0.0034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0332 0.0307
Schistosoma mansoni sex comb on midleg homolog 0.0093 0.116 0.116
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0131 0.0012
Schistosoma mansoni hypothetical protein 0.0562 0.8202 0.8202
Brugia malayi steroid hormone receptor 0.0025 0.0147 0.0034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.2132 0.2112
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0121 0.014
Echinococcus multilocularis microtubule associated protein 2 0.0682 1 1
Schistosoma mansoni tar DNA-binding protein 0.0123 0.1615 0.1615
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0659 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0547 0.0632
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0147 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0123 0.1615 0.1615
Schistosoma mansoni SET domain protein 0.0034 0.0289 0.0289
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0147 0.0034
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0131 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0121 0.014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0147 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0806 0.1001
Loa Loa (eye worm) hypothetical protein 0.0124 0.1636 0.2083
Echinococcus multilocularis polycomb protein SCMH1 0.0093 0.116 0.1137
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2543 0.3263
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0289 0.0264
Echinococcus granulosus SAM and MBT domain containing protein 0.0093 0.116 0.1137
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0147 0.0147
Onchocerca volvulus 0.0466 0.6764 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0895 0.2664
Schistosoma mansoni zinc finger protein 0.0021 0.0087 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0189 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0124 0.1636 0.1993
Schistosoma mansoni alpha-glucosidase 0.0135 0.1804 0.1804
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0659 0.0635
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0929 0.0905
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.5696 0.5685
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1032 0.2086
Leishmania major DNA polymerase eta, putative 0.0124 0.1636 0.189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0147 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0147 0.0034
Leishmania major DNA polymerase kappa, putative 0.0023 0.0121 0.014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.8655 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0547 0.0632
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0131 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2877 0.3324
Brugia malayi glutathione reductase 0.0037 0.0325 0.0268
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0147 0.0146
Brugia malayi PHD-finger family protein 0.0026 0.0166 0.0059
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0185 0.2543 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0147 0.0121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.2132 0.2647
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0325 0.045
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0093 0.116 0.1531
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0147 0.0034
Plasmodium falciparum thioredoxin reductase 0.0037 0.0325 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0131 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Trypanosoma brucei unspecified product 0.0052 0.0547 0.0632
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0093 0.116 0.116
Schistosoma mansoni tar DNA-binding protein 0.0123 0.1615 0.1615
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0147 0.0121
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0079 0.0057
Onchocerca volvulus 0.0093 0.116 0.1531
Trypanosoma brucei unspecified product 0.0052 0.0547 0.0632
Loa Loa (eye worm) glutaminase 2 0.053 0.7719 1
Leishmania major hypothetical protein, conserved 0.0207 0.2877 0.3324
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2543 0.3263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0147 0.0146
Echinococcus multilocularis tar DNA binding protein 0.0123 0.1615 0.1593
Brugia malayi Bromodomain containing protein 0.0038 0.0341 0.0289
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0075 0.0895 0.1769
Echinococcus granulosus polycomb protein SCMH1 0.0093 0.116 0.1137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Loa Loa (eye worm) mbt repeat family protein 0.0093 0.116 0.1464
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.1022 0.1181
Schistosoma mansoni DNA polymerase eta 0.0124 0.1636 0.1636
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0077 0.0929 0.1163
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0147 0.0121
Echinococcus multilocularis dna polymerase kappa 0.0075 0.0895 0.0871
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0147 0.0034
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.2877 0.3324
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0147 0.0121
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0332 0.0307
Schistosoma mansoni SET domain protein 0.0016 0.002 0.002
Mycobacterium ulcerans hypothetical protein 0.0024 0.0131 0.0012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0593 0.8655 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.8655 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0325 0.0377
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0895 0.0895
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0895 0.1034
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0147 0.0147
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0131 0.0012
Loa Loa (eye worm) glutaminase 0.053 0.7719 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2543 0.3263
Mycobacterium ulcerans hypothetical protein 0.0024 0.0131 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0147 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0147 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0676 0.0676
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0895 0.1018
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0131 0.0123
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0289 0.0264
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0121 0.014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0147 0.0147
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0131 0.0151
Loa Loa (eye worm) TAR-binding protein 0.0123 0.1615 0.2056
Loa Loa (eye worm) hypothetical protein 0.0044 0.0429 0.0513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0147 0.0146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1032 0.2086
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0365 0.5237 0.5225
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1032 0.2086
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0396 0.0468
Brugia malayi hypothetical protein 0.0294 0.4182 0.5344
Schistosoma mansoni bromodomain containing protein 0.0064 0.0735 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0297 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0121 0.014
Trypanosoma brucei DNA polymerase eta, putative 0.0124 0.1636 0.189
Echinococcus granulosus dnaJ subfamily B 0.0395 0.5696 0.5685
Brugia malayi mbt repeat family protein 0.0093 0.116 0.1367
Brugia malayi nuclear receptor NHR-88 0.0025 0.0147 0.0034
Loa Loa (eye worm) RNA binding protein 0.0123 0.1615 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Leishmania major DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Echinococcus granulosus tar DNA binding protein 0.0123 0.1615 0.1593
Onchocerca volvulus 0.0294 0.4182 0.6098
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0147 0.0121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0297 0.0231
Loa Loa (eye worm) hypothetical protein 0.0294 0.4182 0.5397
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0147 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0147 0.0147
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0297 0.0339
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0396 0.0468
Echinococcus granulosus dna polymerase kappa 0.0075 0.0895 0.0871
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.5919 0.7657
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0105 0.1352 0.1329
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0895 0.0871
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1172 0.2411
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0026
Onchocerca volvulus 0.0072 0.0845 0.1055
Loa Loa (eye worm) hypothetical protein 0.004 0.0377 0.0445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0121 0.014
Brugia malayi RNA binding protein 0.0123 0.1615 0.1965
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0352 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0627 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0183 0.0191
Loa Loa (eye worm) hypothetical protein 0.003 0.0227 0.025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0895 0.1769
Plasmodium falciparum glutathione reductase 0.0037 0.0325 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0147 0.0147
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2543 0.3263
Schistosoma mansoni cpg binding protein 0.0031 0.0241 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.028 0.3977 0.4595
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.2132 0.2729
Brugia malayi CXXC zinc finger family protein 0.0028 0.0189 0.0089
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0895 0.1018
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0128 0.1689 0.3607
Echinococcus granulosus zinc finger protein 0.0021 0.0087 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.1295 0.1497
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0297 0.0343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0704 0.0704
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0297 0.0339
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0929 0.0929
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.2132 0.2112
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0147 0.0147
Brugia malayi Bromodomain containing protein 0.0076 0.0908 0.1036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0147 0.0121
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0121 0.014
Leishmania major hypothetical protein, conserved 0.0057 0.0627 0.0725
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0105 0.1352 0.1619
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0185 0.2543 0.3264
Schistosoma mansoni myelin transcription factor 1 myt1 0.0105 0.1352 0.1352
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0147 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0297 0.0339
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0147 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0147 0.0121
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0075 0.0895 0.1118
Mycobacterium ulcerans hypothetical protein 0.0312 0.4451 0.5699
Loa Loa (eye worm) hypothetical protein 0.0105 0.1352 0.1713
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.1615 0.1965
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1172 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.2543 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0929 0.0905
Loa Loa (eye worm) glutathione reductase 0.0037 0.0325 0.0377
Loa Loa (eye worm) hypothetical protein 0.0025 0.0147 0.0146
Echinococcus granulosus histone acetyltransferase MYST2 0.0105 0.1352 0.1329
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0131 0.0105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.1615 0.2056
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0147 0.0034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0895 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0147 0.0034
Schistosoma mansoni alpha-glucosidase 0.0135 0.1804 0.1804
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0131 0.0105
Mycobacterium ulcerans glutaminase 0.053 0.7719 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.2543 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0845 0.0845
Onchocerca volvulus 0.003 0.0227 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0627 0.0725
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0147 0.0121
Schistosoma mansoni alpha glucosidase 0.0035 0.0297 0.0297
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1032 0.2086
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0659 0.0635
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0105 0.1352 0.1329
Schistosoma mansoni chromobox protein 0.0069 0.0806 0.0806
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0131 0.0105
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0297 0.1616
Schistosoma mansoni cpg binding protein 0.0031 0.0241 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.1022 0.1181
Schistosoma mansoni coup transcription factor 0.0025 0.0147 0.0147
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0147 0.0121
Giardia lamblia DINP protein human, muc B family 0.0075 0.0895 0.3195
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0325 0.3671
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0121 0.014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0306 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0147 0.0034
Leishmania major DNA polymerase eta, putative 0.0073 0.0862 0.0996
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0659 0.0761
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0659 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0147 0.0034
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0895 0.1119
Brugia malayi glutaminase DH11.1 0.053 0.7719 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0147 0.0146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0147 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0396 0.0376
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0297 0.0341
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0644 0.4823
Leishmania major mitochondrial DNA polymerase beta 0.0593 0.8655 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0147 0.0147
Loa Loa (eye worm) MBCTL1 0.0105 0.1352 0.1713
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0131 0.0105
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0676 0.5115
Echinococcus granulosus cpg binding protein 0.0031 0.0241 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0929 0.0929
Schistosoma mansoni cpg binding protein 0.0028 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.002 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2877 0.3324
Toxoplasma gondii thioredoxin reductase 0.0037 0.0325 0.1878
Loa Loa (eye worm) hypothetical protein 0.007 0.0821 0.1023
Brugia malayi Heterochromatin protein 1 0.0069 0.0806 0.0901
Echinococcus multilocularis chromobox protein 1 0.0069 0.0806 0.0782
Echinococcus granulosus chromobox protein 1 0.0069 0.0806 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0147 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0895 0.1034
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0121 0.014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.028 0.3977 0.4595
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0627 0.0769
Brugia malayi mbt repeat family protein 0.0093 0.116 0.1367
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0147 0.0121
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0075 0.0895 0.1034
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0073 0.0862 0.6829
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0147 0.0147
Echinococcus multilocularis dna polymerase eta 0.0124 0.1636 0.1614
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0895 0.0871
Echinococcus granulosus dna polymerase eta 0.0124 0.1636 0.1614
Echinococcus multilocularis SAM and MBT domain containing protein 0.0093 0.116 0.1137
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0806 0.1003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0147 0.0146
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0121 0.014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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