Detailed information for compound 574732

Basic information

Technical information
  • TDR Targets ID: 574732
  • Name: triamcinolone acetonide 21-palmitate
  • MW: 672.907 | Formula: C40H61FO7
  • H donors: 1 H acceptors: 4 LogP: 9.54 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCC(=O)OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)C=C[C@]21C)F)(C)C
  • InChi: 1S/C40H61FO7/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-35(45)46-27-33(44)40-34(47-36(2,3)48-40)25-31-30-21-20-28-24-29(42)22-23-37(28,4)39(30,41)32(43)26-38(31,40)5/h22-24,30-32,34,43H,6-21,25-27H2,1-5H3/t30-,31-,32-,34+,37-,38-,39-,40+/m0/s1
  • InChiKey: DZQIYNZZUKIZNS-RCFDOMGHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 92626-27-2
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-21-((1-oxohexadecyl)oxy)-, (11beta,16alpha)-
  • Tca 21-P

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0051 0.0069
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0236 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.1424 0.1852
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Echinococcus granulosus Smad4 0.0024 0.0101 0.0067
Echinococcus multilocularis tumor protein p63 0.0332 0.3526 0.3785
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0245 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0193 0.0135
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0245 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0886 0.091
Brugia malayi MH1 domain containing protein 0.0024 0.0101 0.0267
Leishmania major hypothetical protein, conserved 0.0143 0.1424 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0176 0.0168
Brugia malayi steroid hormone receptor 0.002 0.0051 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0536 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0051 0.0136
Onchocerca volvulus 0.0233 0.2421 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0173
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0129 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0051 0.0069
Brugia malayi MH1 domain containing protein 0.0024 0.0101 0.0267
Loa Loa (eye worm) hypothetical protein 0.0686 0.7463 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0051 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0079
Echinococcus granulosus tumor protein p63 0.0332 0.3526 0.4688
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0129 0.0299
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0176 0.0118
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0129 0.0518
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.035 0.0927
Schistosoma mansoni DNA polymerase eta 0.002 0.0059 0.001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0236 0.0239
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0403
Brugia malayi nuclear receptor NHR-88 0.002 0.0051 0.0136
Echinococcus multilocularis musashi 0.0028 0.0145 0.0103
Loa Loa (eye worm) hypothetical protein 0.0147 0.1468 0.1966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0886 0.1127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0051 0.0136
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0027 0.0129 0.0185
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0129 0.0106
Schistosoma mansoni hypothetical protein 0.0331 0.3511 0.4668
Brugia malayi Ceramide kinase 0.0027 0.0129 0.0343
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0176 0.0235
Brugia malayi hypothetical protein 0.0027 0.0129 0.0343
Echinococcus granulosus lamin dm0 0.0028 0.0145 0.0127
Echinococcus multilocularis dna polymerase eta 0.002 0.0059 0.0008
Brugia malayi TAR-binding protein 0.0062 0.0525 0.139
Brugia malayi Pre-SET motif family protein 0.0029 0.0159 0.042
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.034
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Onchocerca volvulus 0.0028 0.0145 0.0398
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0051 0.0136
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0245 0.0252
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0129 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0159 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0159 0.0145
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.1291 0.1351
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1424 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0101 0.0135
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0176 0.0856
Echinococcus granulosus Diacylglycerol kinase zeta 0.0027 0.0129 0.0106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0536 0.048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0051 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0051 0.0069
Mycobacterium ulcerans hypothetical protein 0.0686 0.7463 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0236 0.0239
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0129 0.0096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0245 0.1368
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0143 0.1424 0.1852
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0129 0.0518
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0176 0.0535
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Mycobacterium tuberculosis Conserved protein 0.0686 0.7463 0.7448
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0129 0.0096
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0027 0.0129 0.0106
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0245 0.079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.035 0.0403
Brugia malayi MH2 domain containing protein 0.0354 0.3774 1
Trypanosoma brucei Sphingosine kinase 0.0027 0.0129 0.0518
Onchocerca volvulus 0.0143 0.1424 0.5791
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0101 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0245 0.1368
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0536 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0051 0.0136
Brugia malayi Eye-specific diacylglycerol kinase 0.0027 0.0129 0.0343
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0236 0.0749
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Brugia malayi MH2 domain containing protein 0.0024 0.0101 0.0267
Echinococcus granulosus dna polymerase eta 0.002 0.0059 0.001
Echinococcus multilocularis Smad4 0.0024 0.0101 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Mycobacterium ulcerans diacylglycerol kinase 0.0027 0.0129 0.0096
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0027 0.0129 0.0106
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.1424 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.034
Brugia malayi beta-lactamase family protein 0.0143 0.1424 0.3773
Brugia malayi hypothetical protein 0.0025 0.0105 0.0278
Brugia malayi intermediate filament protein 0.0028 0.0145 0.0385
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0525 0.0703
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0639
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0143 0.1424 0.1373
Echinococcus multilocularis ceramide kinase 0.0027 0.0129 0.0085
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0536 0.0654
Mycobacterium tuberculosis Probable esterase LipL 0.0143 0.1424 0.1373
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0129 0.0518
Leishmania major hypothetical protein, conserved 0.0025 0.0105 0.034
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0245 0.0188
Brugia malayi Smad1 0.0024 0.0101 0.0267
Schistosoma mansoni hypothetical protein 0.0331 0.3511 0.4668
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0236 0.0249
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0245 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0051 0.0136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0176 0.0136
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0027 0.0129 0.0173
Echinococcus multilocularis sphingosine kinase 1 0.0686 0.7463 0.8075
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0245 0.1368
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0245 0.1368
Plasmodium vivax hypothetical protein, conserved 0.0143 0.1424 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0525 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0236 0.099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0236 0.0749
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.1468 0.3889
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0536 0.3267
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1424 0.5777
Schistosoma mansoni smad 0.0024 0.0101 0.0067
Echinococcus granulosus beta LACTamase domain containing family member 0.0143 0.1424 0.1852
Brugia malayi nuclear hormone receptor 0.002 0.0051 0.0136
Schistosoma mansoni intermediate filament proteins 0.0028 0.0145 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0886 0.1127
Toxoplasma gondii exonuclease III APE 0.0037 0.0245 0.1065
Brugia malayi Pre-SET motif family protein 0.0205 0.2107 0.5583
Echinococcus multilocularis dna polymerase kappa 0.002 0.0059 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0639
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0027 0.0129 0.0085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.035 0.0325
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0027 0.0129 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0159 0.0145
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0129 0.0185
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0176 0.0856
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0059 0.0079
Echinococcus granulosus geminin 0.0331 0.3511 0.4668
Trypanosoma brucei diacylglycerol kinase, putative 0.0027 0.0129 0.0518
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0101 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.1468 0.1966
Echinococcus multilocularis lamin dm0 0.0028 0.0145 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0886 0.1188
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0525 0.139
Mycobacterium ulcerans lipase LipD 0.0143 0.1424 0.1843
Schistosoma mansoni lamin 0.0028 0.0145 0.0127
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0143 0.1424 0.1908
Brugia malayi diacylglycerol kinase 0.0027 0.0129 0.0343
Brugia malayi RNA binding protein 0.0062 0.0525 0.139
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0536 0.0654
Echinococcus granulosus GPCR family 2 0.0047 0.035 0.0403
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0176 0.0465
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.1424 0.5777
Onchocerca volvulus 0.0027 0.0129 0.033
Schistosoma mansoni smad1 5 8 and 0.0024 0.0101 0.0067
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0059 0.001
Echinococcus granulosus tar DNA binding protein 0.0062 0.0525 0.0639
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0536 0.3496
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0143 0.1424 0.1373
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0536 0.0644
Brugia malayi Inositol-1 0.0036 0.0236 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0069
Trichomonas vaginalis bmru protein, putative 0.0027 0.0129 0.0299
Brugia malayi ecdysteroid receptor 0.002 0.0051 0.0136
Mycobacterium tuberculosis Conserved protein 0.0143 0.1424 0.1373
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0027 0.0129 0.0299
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0129 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0129 0.0518
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.1296
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0403
Echinococcus granulosus lamin 0.0028 0.0145 0.0127
Schistosoma mansoni hypothetical protein 0.0131 0.1291 0.1673
Brugia malayi diacylglycerol kinase 0.0027 0.0129 0.0343
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0143 0.1424 0.3773
Loa Loa (eye worm) ceramide kinase 0.0027 0.0129 0.0173
Echinococcus multilocularis beta LACTamase domain containing family member 0.0143 0.1424 0.1495
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0176 0.0136
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.095 0.2518
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0051 0.0069
Entamoeba histolytica hypothetical protein, conserved 0.0686 0.7463 1
Mycobacterium tuberculosis Probable lipase LipD 0.0143 0.1424 0.1373
Brugia malayi Diacylglycerol kinase protein 2 0.0027 0.0129 0.0343
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0536 0.0644
Schistosoma mansoni Smad4 0.0024 0.0101 0.0067
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0176 0.0535
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0129 0.0096
Brugia malayi isocitrate dehydrogenase 0.0031 0.0176 0.0465
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0143 0.1424 0.1843
Mycobacterium ulcerans esterase/lipase LipP 0.0143 0.1424 0.1843
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0159 0.0145
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0129 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.1468 0.3889
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.1296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0176 0.0136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0141
Schistosoma mansoni ap endonuclease 0.0037 0.0245 0.0262
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0051 0.0069
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0245 0.065
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0525 0.0703
Leishmania major hypothetical protein, conserved 0.0027 0.0129 0.0518
Schistosoma mansoni lamin 0.0028 0.0145 0.0127
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0159 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0639
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0129 0.1737
Brugia malayi MH2 domain containing protein 0.0024 0.0101 0.0267
Echinococcus multilocularis Diacylglycerol kinase theta 0.0027 0.0129 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.3774 0.5057
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1424 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0027 0.0129 0.0185
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0176 0.0856
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0176 0.0856
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0639
Mycobacterium tuberculosis Conserved protein 0.0143 0.1424 0.1373
Onchocerca volvulus 0.0143 0.1424 0.5791
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0101 0.0067
Echinococcus granulosus ceramide kinase 0.0027 0.0129 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0886 0.091
Onchocerca volvulus 0.0029 0.0159 0.0453
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.3774 0.5057
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0051 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0051 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0051 0.0136
Loa Loa (eye worm) diacylglycerol kinase 2 0.0027 0.0129 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0159 0.0145
Mycobacterium ulcerans beta-lactamase 0.0143 0.1424 0.1843
Trichomonas vaginalis esterase, putative 0.0143 0.1424 0.5777
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0145 0.0195
Echinococcus granulosus intermediate filament protein 0.0028 0.0145 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0051 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0886 0.1127
Onchocerca volvulus 0.0028 0.0145 0.0398
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0403
Mycobacterium tuberculosis Diacylglycerol kinase 0.0027 0.0129 0.0071
Brugia malayi Latrophilin receptor protein 2 0.0047 0.035 0.0927
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.1291 0.1673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0051 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0051 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0639
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0245 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0886 0.1127
Mycobacterium tuberculosis Probable lipase LipE 0.0143 0.1424 0.1373
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0101 0.0067
Onchocerca volvulus 0.0143 0.1424 0.5791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0886 0.2349
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0059 0.0156
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0176 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0143 0.1424 0.1373
Schistosoma mansoni thyroid hormone receptor 0.0151 0.151 0.1968
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0176 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0101 0.0135
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0145 0.0385
Mycobacterium leprae conserved hypothetical protein 0.0143 0.1424 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0176 0.0856
Echinococcus granulosus smad 0.0024 0.0101 0.0067
Brugia malayi hypothetical protein 0.0016 0.0008 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0536 0.0654
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1424 0.5777
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0059 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0173
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0051 0.0136
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0373 0.0434
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0129 0.0518
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.1296
Loa Loa (eye worm) Smad1 0.0024 0.0101 0.0135
Leishmania major diacylglycerol kinase, putative 0.0027 0.0129 0.0518
Schistosoma mansoni inositol monophosphatase 0.0036 0.0236 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0051 0.0069
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0027 0.0129 0.0106
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0105 0.034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0173
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0245 0.1065
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0159 0.0145
Mycobacterium tuberculosis Conserved protein 0.0143 0.1424 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0129 0.0299
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0059 0.0156
Schistosoma mansoni smad1 5 8 and 0.0024 0.0101 0.0067
Mycobacterium ulcerans hypothetical protein 0.0143 0.1424 0.1843
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0147 0.0129
Schistosoma mansoni ap endonuclease 0.0037 0.0245 0.0262
Loa Loa (eye worm) inositol-1 0.0036 0.0236 0.0316
Onchocerca volvulus Ceramide kinase 1 homolog 0.0027 0.0129 0.033
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0129 0.0299
Schistosoma mansoni sphingoid long chain base kinase 0.0686 0.7463 1
Loa Loa (eye worm) beta-lactamase 0.0143 0.1424 0.1908
Echinococcus multilocularis GPCR, family 2 0.0047 0.035 0.0325
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0129 0.1737
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0059 0.0008
Schistosoma mansoni sphingosine kinase A B 0.0686 0.7463 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0129 0.0518
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0129 0.0299
Echinococcus granulosus dna polymerase kappa 0.002 0.0059 0.001
Leishmania major sphingosine kinase A, B, putative 0.0027 0.0129 0.0518
Loa Loa (eye worm) hypothetical protein 0.0049 0.0373 0.05
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0129 0.0518
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0245 1
Brugia malayi beta-lactamase family protein 0.0143 0.1424 0.3773
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.151 0.159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0051 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.035 0.0469
Echinococcus granulosus sphingosine kinase 1 0.0686 0.7463 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0236 0.0749
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0245 0.0262
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0176 0.0535
Mycobacterium tuberculosis Probable hydrolase 0.0143 0.1424 0.1373
Schistosoma mansoni inositol monophosphatase 0.0036 0.0236 0.0249
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.035 0.0403
Mycobacterium leprae Probable lipase LipE 0.0143 0.1424 1
Trichomonas vaginalis D-aminoacylase, putative 0.0143 0.1424 0.5777
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0129 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0159 0.0117
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0129 0.0096
Schistosoma mansoni hypothetical protein 0.01 0.095 0.1213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0886 0.1127
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0176 0.5021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2107 0.2823
Loa Loa (eye worm) hypothetical protein 0.01 0.095 0.1273
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0176 0.0168
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0245 0.079
Loa Loa (eye worm) RNA binding protein 0.0062 0.0525 0.0703
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0027 0.0129 0.0185
Trichomonas vaginalis bmru protein, putative 0.0027 0.0129 0.0299
Plasmodium vivax SET domain protein, putative 0.0029 0.0159 0.0405
Schistosoma mansoni smad1 5 8 and 0.0024 0.0101 0.0067
Schistosoma mansoni hypothetical protein 0.0027 0.0129 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0212
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0051 0.0069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0059 0.001
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2421 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0245 0.0252
Echinococcus granulosus Diacylglycerol kinase theta 0.0027 0.0129 0.0106
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0129 0.0299
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0101 0.0054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.923 1
Echinococcus multilocularis lamin 0.0028 0.0145 0.0103
Leishmania major hypothetical protein, conserved 0.0027 0.0129 0.0518
Onchocerca volvulus 0.0049 0.0373 0.1357
Echinococcus multilocularis smad 0.0024 0.0101 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.035 0.0325
Schistosoma mansoni hypothetical protein 0.0047 0.035 0.0403
Echinococcus multilocularis geminin 0.0331 0.3511 0.377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0051 0.0136
Loa Loa (eye worm) hypothetical protein 0.0028 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0051 0.0136
Brugia malayi beta-lactamase 0.0143 0.1424 0.3773
Trichomonas vaginalis penicillin-binding protein, putative 0.0143 0.1424 0.5777
Schistosoma mansoni thyroid hormone receptor 0.0151 0.151 0.1968
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0236 0.1296
Toxoplasma gondii ABC1 family protein 0.0143 0.1424 1
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0129 0.0299
Loa Loa (eye worm) hypothetical protein 0.0047 0.035 0.0469
Loa Loa (eye worm) hypothetical protein 0.0143 0.1424 0.1908
Leishmania major diacylglycerol kinase-like protein 0.0027 0.0129 0.0518
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0245 0.0212
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0129 0.0518

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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