Detailed information for compound 577504

Basic information

Technical information
  • TDR Targets ID: 577504
  • Name: Oprea1_217660
  • MW: 265.263 | Formula: C16H11NO3
  • H donors: 0 H acceptors: 2 LogP: 3.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c3c1C(=O)c1ccccc1c3on2
  • InChi: 1S/C16H11NO3/c1-2-19-12-8-7-11-13-14(12)15(18)9-5-3-4-6-10(9)16(13)20-17-11/h3-8H,2H2,1H3
  • InChiKey: UAOUQDXIWHQNEH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • MLS000106837
  • SMR000111213
  • 5-Ethoxy-anthra[1,9-cd]isoxazol-6-one
  • BAS 01121564
  • ZINC00034247
  • Oprea1_427129
  • A1926/0081017
  • CBMicro_020481
  • EU-0033612
  • BIM-0020479.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apoptotic peptidase activating factor 1 Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens caspase 7, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Human herpesvirus 8 ORF 73 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans UDP-galactopyranose mutase Glf Get druggable targets OG5_139595 All targets in OG5_139595
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Brugia malayi Cell death protein 3 precursor caspase 7, apoptosis-related cysteine peptidase 303 aa 256 aa 37.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0068 0.1179
Loa Loa (eye worm) hypothetical protein 0.0056 0.0612 0.1153
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0068 0.1179
Loa Loa (eye worm) matrix metalloproteinase 0.0056 0.0612 0.1153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0022 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7121 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0435 0.7503
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0068 0.1179
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0435 0.1608
Leishmania major GTP-binding protein, putative 0.0026 0.0168 0.1915
Echinococcus multilocularis snurportin 1 0.0372 0.5306 0.7452
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0022 0.0022
Brugia malayi Muscleblind-like protein 0.018 0.2465 0.9103
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0053 0.058 0.1094
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.007 0.1215
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0871 0.1642
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0068 0.0096
Loa Loa (eye worm) matrixin family protein 0.0134 0.1781 0.3357
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0168 0.1915
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.5027 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0941 0.1322
Onchocerca volvulus Matrilysin homolog 0.0123 0.1616 0.8608
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0068 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Brugia malayi hypothetical protein 0.0036 0.0328 0.1211
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.058 0.6626
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2708 0.3803
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.045 0.0632
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0876 0.0876
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0202 0.2785 0.3912
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0876 0.123
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0206 0.3301
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.045 0.0632
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1334 0.1334
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0068 0.0096
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0132 0.2269
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0022 0.0383
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0304 0.5242
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0068 0.0781
Brugia malayi Isocitrate dehydrogenase 0.0019 0.007 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Schistosoma mansoni tyrosine kinase 0.0047 0.0481 0.0675
Trichomonas vaginalis ran, putative 0.0026 0.0168 0.0291
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0168 0.0236
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.007 0.0864
Schistosoma mansoni alpha-glucosidase 0.0169 0.2302 0.3232
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1278 0.1795
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0328 0.0461
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.045 0.1662
Leishmania major importin beta-1 subunit, putative 0.0028 0.0206 0.2357
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2708 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0206 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0287 0.0541
Schistosoma mansoni cpg binding protein 0.0037 0.0331 0.0466
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2708 0.5104
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1334 0.1334
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0022 0.0082
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Onchocerca volvulus 0.0114 0.1477 0.7851
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.007 0.0099
Schistosoma mansoni caspase-7 (C14 family) 0.014 0.1873 0.263
Plasmodium falciparum importin beta, putative 0.0035 0.0304 0.5052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Loa Loa (eye worm) hypothetical protein 0.014 0.1873 0.353
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Loa Loa (eye worm) hypothetical protein 0.018 0.2465 0.4646
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0304 0.3473
Schistosoma mansoni caspase-3 (C14 family) 0.0141 0.1884 0.2646
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0132 0.2269
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0031
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0435 0.4971
Echinococcus granulosus importin subunit beta 1 0.0035 0.0304 0.0427
Echinococcus granulosus caspase 8 0.0053 0.058 0.0815
Onchocerca volvulus 0.0035 0.0302 0.1483
Trypanosoma brucei trypanothione reductase 0.0046 0.0465 0.802
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.045 0.7758
Leishmania major hypothetical protein, conserved 0.0019 0.0068 0.0781
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1334 0.1334
Brugia malayi jmjC domain containing protein 0.0019 0.0068 0.0253
Loa Loa (eye worm) hypothetical protein 0.0045 0.045 0.0849
Trypanosoma cruzi metacaspase, putative 0.0053 0.058 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0022 0.0254
Schistosoma mansoni hypothetical protein 0.0087 0.108 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2347 0.2347
Plasmodium vivax JmjC domain containing protein 0.0019 0.0068 0.0827
Echinococcus granulosus caspase 2 0.014 0.1873 0.263
Mycobacterium ulcerans hydrolase 0.0068 0.0792 0.0792
Brugia malayi Cytochrome P450 family protein 0.0034 0.0287 0.1059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0206 0.0368
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1278 0.1795
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0068 0.0781
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1278 0.1795
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0168 0.289
Brugia malayi jmjC domain containing protein 0.0071 0.0842 0.3108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0435 0.0814
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2347 0.2347
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0879 0.1235
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1278 0.4718
Echinococcus granulosus caspase 3 0.0088 0.1091 0.1532
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0763 0.8708
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0202 0.2785 0.3912
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0435 0.0825
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0206 0.0368
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0168 0.0316
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0168 0.0619
Onchocerca volvulus 0.0087 0.108 0.57
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.1958 0.2749
Echinococcus multilocularis apoptotic protease activating factor 1 0.0087 0.108 0.1517
Toxoplasma gondii thioredoxin reductase 0.0046 0.0465 0.5314
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0068 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0029 0.0013
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0098 0.0137
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0029 0.0106
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0842 0.1182
Entamoeba histolytica Ran family GTPase 0.0026 0.0168 0.0278
Onchocerca volvulus Cell death protein 3 homolog 0.014 0.1873 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0842 0.1182
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0328 0.0461
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0068 0.0827
Trypanosoma cruzi metacaspase, putative 0.0053 0.058 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0331 0.0466
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Echinococcus granulosus apoptotic protease activating factor 1 0.0087 0.108 0.1517
Schistosoma mansoni ran 0.0026 0.0168 0.0236
Brugia malayi Protein kinase domain containing protein 0.0047 0.0481 0.1775
Schistosoma mansoni tyrosine kinase 0.0047 0.0481 0.0675
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.058 0.6626
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0168 0.2606
Echinococcus granulosus phd:f box containing protein 0.0019 0.0068 0.0096
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0435 0.0611
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0435 0.4971
Onchocerca volvulus 0.0056 0.0612 0.3162
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0132 0.0248
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0304 0.5242
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0876 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0098 0.0137
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0022 0.0383
Entamoeba histolytica hypothetical protein 0.0036 0.0328 0.0599
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.007 0.0864
Plasmodium vivax hypothetical protein, conserved 0.0053 0.058 1
Echinococcus multilocularis caspase 3 0.0088 0.1091 0.1532
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0465 0.802
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0876 0.0876
Plasmodium vivax glutathione reductase, putative 0.0046 0.0465 0.7941
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.007 0.0805
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0304 0.0427
Trypanosoma brucei metacaspase 0.0053 0.058 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0435 0.0611
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.058 0.2143
Trypanosoma brucei metacaspase MCA2 0.0053 0.058 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0029 0.0493
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0435 0.0825
Echinococcus granulosus muscleblind protein 0.018 0.2465 0.3462
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.007 0.0099
Schistosoma mansoni importin beta-1 0.0035 0.0304 0.0427
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0022 0.0022
Brugia malayi Importin beta-1 subunit 0.0035 0.0304 0.1123
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0842 0.1182
Plasmodium falciparum metacaspase 1 0.0053 0.058 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.007 0.0099
Brugia malayi RNA, U transporter 1 0.0099 0.1257 0.4643
Brugia malayi jmjC domain containing protein 0.0019 0.0068 0.0253
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7121 1
Brugia malayi Thioredoxin reductase 0.0046 0.0465 0.1719
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0435 0.0825
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.045 0.0855
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0068 0.0096
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0168 0.289
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.5027 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.007 0.0805
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0132 0.0248
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0029 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0029 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Trypanosoma brucei metacaspase MCA3 0.0053 0.058 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0941 0.1322
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1507 0.1507
Echinococcus multilocularis caspase 2 0.014 0.1873 0.263
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0129
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.058 0.0815
Loa Loa (eye worm) hypothetical protein 0.0068 0.0792 0.1492
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0022 0.0254
Leishmania major cytochrome p450-like protein 0.0023 0.0132 0.1504
Schistosoma mansoni tyrosine kinase 0.0079 0.0953 0.1339
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0465 0.0465
Echinococcus multilocularis muscleblind protein 1 0.018 0.2465 0.3462
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0022 0.0254
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0068 0.0129
Echinococcus multilocularis caspase 8 0.0053 0.058 0.0815
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Entamoeba histolytica hypothetical protein 0.0028 0.0206 0.0356
Plasmodium falciparum metacaspase-like protein 0.0053 0.058 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.058 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0068 0.0792 0.0792
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0029 0.0493
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0474 0.0666
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0481 0.0675
Brugia malayi Matrixin family protein 0.0056 0.0612 0.2259
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0054
Onchocerca volvulus 0.01 0.1278 0.6773
Trypanosoma brucei Metacaspase-4 0.0053 0.058 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.045 0.0632
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 1 1
Echinococcus multilocularis caspase 0.0141 0.1884 0.2646
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0022 0.0383
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.045 0.7758
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0022 0.0254
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0141 0.1884 0.2646
Brugia malayi jmjC domain containing protein 0.0019 0.0068 0.0253
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2708 0.3803
Onchocerca volvulus Matrilysin homolog 0.0056 0.0612 0.3162
Schistosoma mansoni cpg binding protein 0.0035 0.0302 0.0424
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0876 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0206 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0871 0.1223
Schistosoma mansoni hypothetical protein 0.0036 0.0328 0.0461
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.045 0.0632
Brugia malayi Cytochrome P450 family protein 0.0023 0.0132 0.0486
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0031
Brugia malayi Matrixin family protein 0.0056 0.0612 0.2259
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0435 0.0821
Entamoeba histolytica hypothetical protein 0.0036 0.0328 0.0599
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0435 0.0825
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0383
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.045 0.0632
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0068 0.0129
Loa Loa (eye worm) hypothetical protein 0.0056 0.0612 0.1153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0474 0.0666
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0206 0.0368
Brugia malayi jmjC domain containing protein 0.0073 0.0871 0.3216
Trypanosoma brucei glucosidase, putative 0.0044 0.0435 0.7503
Brugia malayi glutathione reductase 0.0046 0.0465 0.1719
Brugia malayi Cytochrome P450 family protein 0.0023 0.0132 0.0486
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0206 0.0368
Brugia malayi CXXC zinc finger family protein 0.0035 0.0302 0.1116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0302 0.0569
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.007 0.0099
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.045 0.0632
Brugia malayi hypothetical protein 0.0087 0.108 0.3987
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.1958 0.2749
Echinococcus granulosus snurportin 1 0.0372 0.5306 0.7452
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0132 0.2269
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0056 0.0612 0.0859
Schistosoma mansoni ran 0.0026 0.0168 0.0236
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2708 0.3803
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.058 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.007 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0435 0.0825
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.058 0.6626
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0435 0.0825
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0029 0.0327
Echinococcus granulosus insulin receptor 0.0047 0.0481 0.0675
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0876 0.123
Echinococcus granulosus cpg binding protein 0.0037 0.0331 0.0466
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1334 0.1334
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Schistosoma mansoni tyrosine kinase 0.0146 0.1958 0.2749
Mycobacterium tuberculosis Probable reductase 0.0104 0.1334 0.1334
Entamoeba histolytica hypothetical protein 0.0036 0.0328 0.0599
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0465 0.7941
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.045 0.0855
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.007 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.058 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1507 0.1507
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0168 0.289
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0953 0.1339
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.058 0.1115
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0068 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0435 0.0825
Schistosoma mansoni cpg binding protein 0.0037 0.0331 0.0466
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.045 0.0843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5306 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.108 0.2035
Schistosoma mansoni tyrosine kinase 0.0079 0.0953 0.1339
Plasmodium falciparum thioredoxin reductase 0.0046 0.0465 0.7941
Trypanosoma brucei metacaspase 5, putative 0.0053 0.058 1
Schistosoma mansoni tyrosine kinase 0.0078 0.0941 0.1322
Trypanosoma cruzi metacaspase, putative 0.0053 0.058 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0029 0.0013
Loa Loa (eye worm) hypothetical protein 0.01 0.1278 0.2408
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0029 0.0013
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0206 0.2357
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0481 0.0906
Brugia malayi isocitrate dehydrogenase 0.0019 0.007 0.026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0168 0.0236
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0435 0.0825
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.1958 0.7229
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.045 0.0855
Leishmania major trypanothione reductase 0.0046 0.0465 0.5314
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0481 0.0675
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0068 0.0792 0.0792
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0068 0.0096
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0254
Brugia malayi Matrixin family protein 0.0056 0.0612 0.2259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0068 0.0129
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0022 0.0383
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5027 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0876 0.123
Schistosoma mansoni alpha-glucosidase 0.0169 0.2302 0.3232
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0328 0.0461
Entamoeba histolytica hypothetical protein 0.0028 0.0206 0.0356
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1334 0.1334
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0206 0.2357
Plasmodium falciparum glutathione reductase 0.0046 0.0465 0.7941
Loa Loa (eye worm) glutathione reductase 0.0046 0.0465 0.0877
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1334 0.1334
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0129
Echinococcus granulosus caspase 0.0141 0.1884 0.2646
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0068 0.0096
Schistosoma mansoni hypothetical protein 0.0372 0.5306 0.7452
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0254
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0029 0.0013
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0953 0.1339
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0435 0.0814
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0168 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0435 0.7503
Plasmodium vivax metacaspase 1, putative 0.0053 0.058 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0206 0.3557
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.007 0.0805
Echinococcus multilocularis insulin receptor 0.0047 0.0481 0.0675
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.045 0.0855
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0876 0.0876
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5027 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0871 0.1223
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0465 0.0877
Brugia malayi Cell death protein 3 precursor 0.014 0.1873 0.6916
Brugia malayi Matrixin family protein 0.0134 0.1781 0.6576
Plasmodium vivax importin-beta 2, putative 0.0035 0.0304 0.5052
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.007 0.1215
Loa Loa (eye worm) hypothetical protein 0.0056 0.0612 0.1153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0132 0.0248
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0871 0.1223
Entamoeba histolytica hypothetical protein 0.0036 0.0328 0.0599
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0141 0.1884 0.2646
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0842 0.1182
Brugia malayi Matrixin family protein 0.0056 0.0612 0.2259
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0876 0.123
Onchocerca volvulus Matrix metalloproteinase homolog 0.0123 0.1616 0.8608
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0068 0.0096
Leishmania major metacaspase, putative 0.0053 0.058 0.6626
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0206 0.0206
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.007 0.0133
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.007 0.1215
Onchocerca volvulus 0.0079 0.0956 0.5031
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.045 0.514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0132 0.0132
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.007 0.007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.045 0.7758
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0206 0.2357
Brugia malayi Hemopexin family protein 0.0079 0.0956 0.3532
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0031
Schistosoma mansoni alpha glucosidase 0.0044 0.0435 0.0611
Schistosoma mansoni caspase-7 (C14 family) 0.0141 0.1884 0.2646
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0206 0.0206
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0383
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2347 0.2347
Loa Loa (eye worm) hypothetical protein 0.0035 0.0304 0.0573
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0022 0.0383
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0168 0.2606
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0435 0.0825
Echinococcus multilocularis muscleblind protein 0.018 0.2465 0.3462
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0068 0.0096
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.045 0.0632
Schistosoma mansoni hypothetical protein 0.0494 0.7121 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0206 0.0206
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.007 0.1215
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0029 0.0013
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0206 0.3301
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0206 0.3558
Loa Loa (eye worm) matrixin family protein 0.0123 0.1616 0.3046
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.0953 0.1339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0876 0.0876
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0992 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.058 0.1115
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0068 0.0792 0.2923
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.045 0.0632
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1507 0.1507
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0068 0.0096
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0068 0.0096
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.1958 0.369
Loa Loa (eye worm) hypothetical protein 0.018 0.2465 0.4646
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5027 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0029 0.0493
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0022 0.0383
Echinococcus multilocularis 0.0045 0.0459 0.0645
Schistosoma mansoni hypothetical protein 0.0079 0.0956 0.1343
Brugia malayi jmjC domain containing protein 0.0019 0.0068 0.0253
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0029 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.007 0.0099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1507 0.1507

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.356 uM PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] ChEMBL. No reference
AC50 (binding) = 0.572 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
EC50 (functional) = 4.946 uM PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescent artifacts and/or optically active compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
EC50 (functional) = 13.7 uM PUBCHEM_BIOASSAY: Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489031, AID492946] ChEMBL. No reference
EC50 (binding) > 54.662 uM PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588439, AID588440, AID588442] ChEMBL. No reference
EC50 (functional) > 54.662 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
IC50 (functional) = 87.4 uM PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945] ChEMBL. No reference
IC50 (functional) > 89.137 uM PUBCHEM_BIOASSAY: Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
Max_Activity_Concent (functional) 6 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0708 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2239 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (binding) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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