Detailed information for compound 578102

Basic information

Technical information
  • TDR Targets ID: 578102
  • Name: 1-(1-adamantyl)imidazole
  • MW: 202.295 | Formula: C13H18N2
  • H donors: 0 H acceptors: 1 LogP: 2.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ncn(c1)C12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C13H18N2/c1-2-15(9-14-1)13-6-10-3-11(7-13)5-12(4-10)8-13/h1-2,9-12H,3-8H2
  • InChiKey: PJWXDQVZZXNUQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-adamantyl)imidazole
  • 69380-11-6
  • STOCK1S-63806
  • NSC283155
  • MLS000037904
  • SMR000039669
  • ZINC03957330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens solute carrier family 5 (sodium/choline cotransporter), member 7 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum High affinity choline transporter 1, putative Get druggable targets OG5_131601 All targets in OG5_131601
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni high-affinity choline transporter Get druggable targets OG5_131601 All targets in OG5_131601
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GH02984p Get druggable targets OG5_131601 All targets in OG5_131601
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum IPR001734,Na+/solute symporter,domain-containing Get druggable targets OG5_131601 All targets in OG5_131601
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SH2A 0.0101 0.0038 0.0002
Echinococcus granulosus suppressor of cytokine signaling 7 0.0101 0.0038 0.0037
Echinococcus multilocularis tensin 0.0101 0.0038 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.067 0.0484 0.8538
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0182 0.0102 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0743 0.054 0.9621
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0101 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Schistosoma mansoni growth factor receptor-bound protein 0.0199 0.0115 0.0079
Loa Loa (eye worm) hypothetical protein 0.0133 0.0063 0.0742
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0182 0.0102 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0101 0.0038 0.0037
Brugia malayi ephrin receptor 1 precursor 0.0109 0.0044 0.0157
Echinococcus multilocularis tyrosine protein kinase csk 0.0126 0.0058 0.042
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0133 0.0063 0.0522
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0101 0.0038 0.0037
Brugia malayi Tyrosine-protein kinase abl-1 0.0464 0.0322 0.5464
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0768 0.056 0.998
Loa Loa (eye worm) TK/CSK protein kinase 0.0126 0.0058 0.0642
Schistosoma mansoni suppressor of cytokine signaling 0.0101 0.0038 0.0002
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0182 0.0102 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Schistosoma mansoni high-affinity choline transporter 0.042 0.0288 0.0253
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Echinococcus granulosus signal transduction protein lnk realted 0.0101 0.0038 0.0037
Schistosoma mansoni tyrosine kinase 0.0133 0.0063 0.0027
Echinococcus multilocularis mitogen activated protein kinase 11 0.0372 0.0251 0.4093
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.067 0.0484 0.852
Echinococcus granulosus tensin 0.0101 0.0038 0.0037
Echinococcus granulosus ephrin type A receptor 4 A 0.0232 0.0141 0.1999
Schistosoma mansoni vav2 0.0101 0.0038 0.0002
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0768 0.056 0.998
Echinococcus multilocularis tyrosine protein kinase csk 0.0126 0.0058 0.042
Loa Loa (eye worm) TK/INSR protein kinase 0.0171 0.0093 0.1294
Echinococcus granulosus SH2 motif 0.0101 0.0038 0.0037
Onchocerca volvulus 0.0101 0.0038 0.0194
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0182 0.0102 1
Schistosoma mansoni suppressor of cytokine signaling 0.0101 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0768 0.056 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.056 0.998
Schistosoma mansoni nck2/grb4 0.0199 0.0115 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0182 0.0102 1
Brugia malayi Protein kinase domain containing protein 0.0133 0.0063 0.0522
Brugia malayi RNA, U transporter 1 0.0099 0.0037 0.0015
Brugia malayi SH2 domain containing protein 0.0227 0.0137 0.1919
Plasmodium falciparum beta-hydroxyacyl-ACP dehydratase 0.0497 0.0348 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Loa Loa (eye worm) TK/ABL protein kinase 0.0743 0.054 0.963
Echinococcus granulosus tyrosine protein kinase Src42A 0.0638 0.0458 0.8036
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.056 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Toxoplasma gondii cytochrome p450 superfamily protein 0.0942 0.0696 0.0439
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0182 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0182 0.0102 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Onchocerca volvulus 0.0133 0.0063 0.2721
Schistosoma mansoni tyrosine kinase 0.0234 0.0143 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0061 0.0026
Schistosoma mansoni hypothetical protein 0.0372 0.025 0.0215
Echinococcus granulosus tyrosine protein kinase shark 0.0133 0.0063 0.0521
Wolbachia endosymbiont of Brugia malayi (3R)-hydroxymyristoyl-ACP dehydratase 0.0497 0.0348 0.5
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0101 0.0038 0.0268
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0231 0.014 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0098 0.0036 0.0232
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0638 0.0458 0.8053
Loa Loa (eye worm) STAT protein 0.0101 0.0038 0.0268
Echinococcus multilocularis tyrosine kinase 0.0133 0.0063 0.0522
Onchocerca volvulus 0.0133 0.0063 0.2721
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Schistosoma mansoni tyrosine kinase 0.0234 0.0143 0.0107
Echinococcus granulosus SHC transforming protein 3 0.0101 0.0038 0.0037
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0199 0.0115 0.0079
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Echinococcus granulosus tyrosine protein kinase csk 0.0126 0.0058 0.0419
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0102 0.0039 0.0082
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0133 0.0063 0.0521
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0182 0.0102 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0133 0.0063 0.0522
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0101 0.0038 0.0037
Onchocerca volvulus 0.0101 0.0038 0.0194
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0182 0.0102 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0182 0.0102 1
Echinococcus multilocularis epidermal growth factor receptor 0.0267 0.0168 0.252
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0768 0.056 1
Mycobacterium leprae putative cytochrome p450 0.0182 0.0102 0.5
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0098 0.0036 0.0232
Echinococcus granulosus tyrosine protein kinase Srms 0.0133 0.0063 0.0521
Schistosoma mansoni tensin 0.0101 0.0038 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0101 0.0038 0.0037
Echinococcus multilocularis 0.0137 0.0066 0.0574
Loa Loa (eye worm) cytochrome P450 family protein 0.0099 0.0037 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0768 0.056 0.998
Echinococcus multilocularis epidermal growth factor receptor 0.0471 0.0328 0.5564
Schistosoma mansoni ephrin receptor 0.0194 0.0111 0.0075
Echinococcus multilocularis tyrosine protein kinase HCK 0.057 0.0405 0.7038
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0182 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Echinococcus multilocularis tensin 0.0101 0.0038 0.0037
Echinococcus granulosus tyrosine protein kinase ABL1 0.0743 0.054 0.9602
Schistosoma mansoni tyrosine kinase 0.0768 0.056 0.0526
Schistosoma mansoni tyrosine kinase 0.0234 0.0143 0.0107
Schistosoma mansoni hypothetical protein 0.0101 0.0038 0.0002
Brugia malayi P38 map kinase family protein 2 0.0372 0.0251 0.4093
Loa Loa (eye worm) TK/EPH protein kinase 0.0238 0.0146 0.2273
Loa Loa (eye worm) hypothetical protein 0.0161 0.0086 0.1155
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0182 0.0102 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.067 0.0484 0.8538
Onchocerca volvulus 0.0101 0.0038 0.0194
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0098 0.0036 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0199 0.0115 0.1497
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Echinococcus granulosus tyrosine protein kinase Lyn 0.077 0.0561 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0038 0.0002
Loa Loa (eye worm) SH2 domain-containing protein 0.0101 0.0038 0.0268
Echinococcus granulosus hypothetical protein 0.0101 0.0038 0.0037
Echinococcus granulosus epidermal growth factor receptor 0.0471 0.0328 0.5553
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Loa Loa (eye worm) guanylate kinase 0.0098 0.0036 0.0232
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0101 0.0038 0.0268
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0182 0.0102 1
Plasmodium vivax beta-hydroxyacyl-ACP dehydratase precursor, putative 0.0497 0.0348 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Echinococcus multilocularis NCK adaptor protein 0.0199 0.0115 0.15
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0038 0.0002
Schistosoma mansoni adapter molecule crk 0.0199 0.0115 0.0079
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0372 0.0251 0.423
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Schistosoma mansoni signal transduction protein lnk-related 0.0101 0.0038 0.0002
Loa Loa (eye worm) thyroid receptor interactor 0.0098 0.0036 0.0232
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Entamoeba histolytica protein kinase, putative 0.0102 0.0039 0.0082
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0101 0.0038 0.0037
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0101 0.0038 0.0037
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0038 0.0037
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0182 0.0102 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0182 0.0102 1
Schistosoma mansoni tyrosine kinase 0.0325 0.0213 0.0178
Onchocerca volvulus 0.0101 0.0038 0.0194
Echinococcus granulosus NCK adaptor protein 0.0199 0.0115 0.1497
Echinococcus multilocularis N chimaerin 0.0101 0.0038 0.0037
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.025 0.422
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0038 0.0037
Brugia malayi Cytochrome P450 family protein 0.0099 0.0037 0.0012
Brugia malayi tRNA modification GTPase TrmE family protein 0.0101 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Echinococcus multilocularis tyrosine protein kinase Blk 0.067 0.0484 0.8538
Brugia malayi Protein kinase domain containing protein 0.0133 0.0063 0.0522
Schistosoma mansoni tensin 0.0101 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0231 0.014 0.1985
Schistosoma mansoni tensin-related 0.0101 0.0038 0.0002
Echinococcus multilocularis tyrosine protein kinase Abl 0.0464 0.0322 0.5464
Echinococcus granulosus tyrosine protein kinase csk 0.0126 0.0058 0.0419
Loa Loa (eye worm) TK protein kinase 0.057 0.0405 0.7107
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Entamoeba histolytica protein kinase, putative 0.057 0.0405 1
Brugia malayi Variant SH3 domain containing protein 0.0199 0.0115 0.15
Chlamydia trachomatis 3-hydroxyacyl-ACP dehydratase 0.0497 0.0348 0.5
Echinococcus multilocularis mitogen activated protein kinase 14 0.0372 0.0251 0.4093
Schistosoma mansoni growth factor receptor-bound protein 0.0199 0.0115 0.0079
Echinococcus granulosus snurportin 1 0.0372 0.025 0.4074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Echinococcus granulosus mitogen activated protein kinase 14 0.0372 0.0251 0.4084
Echinococcus multilocularis SH2 motif 0.0101 0.0038 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0231 0.014 0.1981
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0101 0.0038 0.0268
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0101 0.0038 0.0037
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Echinococcus granulosus SH2 motif 0.0101 0.0038 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0182 0.0102 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0182 0.0102 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0101 0.0038 0.0037
Schistosoma mansoni tyrosine kinase 0.0133 0.0063 0.0027
Echinococcus granulosus tyrosine protein kinase HCK 0.057 0.0405 0.7024
Loa Loa (eye worm) SH2 domain-containing protein 0.0194 0.0111 0.1633
Entamoeba histolytica SH2 domain containing protein 0.0101 0.0038 0.0053
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0101 0.0038 0.0002
Echinococcus granulosus mitogen activated protein kinase 11 0.0372 0.0251 0.4084
Loa Loa (eye worm) hypothetical protein 0.0199 0.0115 0.1697
Echinococcus granulosus tyrosine protein kinase Blk 0.067 0.0484 0.852
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0768 0.056 1
Loa Loa (eye worm) hypothetical protein 0.042 0.0288 0.492
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0101 0.0038 0.0268
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.2334 0.1785 0.1755
Echinococcus granulosus c src tyrosine kinase 0.0325 0.0213 0.3375
Toxoplasma gondii 1,3-beta-glucan synthase component protein 1.0656 0.8294 1
Loa Loa (eye worm) hypothetical protein 0.0266 0.0167 0.2675
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Brugia malayi hypothetical protein 0.0133 0.0063 0.0522
Brugia malayi Protein kinase domain containing protein 0.0133 0.0063 0.0522
Echinococcus multilocularis SH2 domain containing protein 7 0.0101 0.0038 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Echinococcus granulosus insulin receptor 0.0171 0.0093 0.1085
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0101 0.0038 0.0037
Brugia malayi cytokine inducible SH2-containing protein 5 0.0101 0.0038 0.0037
Echinococcus granulosus SH2 domain containing protein 7 0.0101 0.0038 0.0037
Echinococcus multilocularis insulin receptor 0.0171 0.0093 0.1088
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0182 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0182 0.0102 1
Brugia malayi SRC-1 0.0768 0.056 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0126 0.0058 0.042
Schistosoma mansoni tyrosine kinase 0.0171 0.0093 0.0057
Brugia malayi Protein kinase domain containing protein 0.0171 0.0093 0.1088
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0182 0.0102 1
Schistosoma mansoni tensin 0.0101 0.0038 0.0002
Echinococcus granulosus tyrosine kinase 0.067 0.0484 0.852
Trichomonas vaginalis p67phox protein, putative 0.0098 0.0036 0.5
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Echinococcus multilocularis high affinity choline transporter 1 0.042 0.0288 0.4799
Schistosoma mansoni tyrosine kinase 0.0267 0.0168 0.0133
Echinococcus granulosus expressed conserved protein 0.0101 0.0038 0.0037
Schistosoma mansoni hypothetical protein 0.0101 0.0038 0.0002
Echinococcus granulosus epidermal growth factor receptor 0.0267 0.0168 0.2515
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.056 0.998
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.056 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0232 0.0141 0.2003
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Brugia malayi Furin-like cysteine rich region family protein 0.0471 0.0328 0.5564
Echinococcus granulosus suppressor of cytokine signaling 6 0.0101 0.0038 0.0037
Brugia malayi Protein kinase domain containing protein 0.0133 0.0063 0.0522
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0372 0.0251 1
Echinococcus multilocularis SHC transforming protein 3 0.0101 0.0038 0.0037
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0101 0.0038 0.0037
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0182 0.0102 1
Brugia malayi Variant SH3 domain containing protein 0.0199 0.0115 0.15
Brugia malayi STAT protein, DNA binding domain containing protein 0.0101 0.0038 0.0037
Onchocerca volvulus 0.0099 0.0037 0.0106
Loa Loa (eye worm) p53BP2 0.0098 0.0036 0.0232
Echinococcus multilocularis growth factor receptor bound protein 2 0.0199 0.0115 0.15
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0133 0.0063 0.0742
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0101 0.0038 0.0194
Echinococcus multilocularis mitogen activated protein kinase 11 0.0372 0.0251 0.4093
Schistosoma mansoni tensin-related 0.0101 0.0038 0.0002
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0182 0.0102 1
Echinococcus multilocularis snurportin 1 0.0372 0.025 0.4083
Onchocerca volvulus 0.0133 0.0063 0.2721
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0768 0.056 1
Onchocerca volvulus 0.0133 0.0063 0.2721
Schistosoma mansoni GTPase activating protein 0.0101 0.0038 0.0002
Schistosoma mansoni shc transforming protein 0.0101 0.0038 0.0002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0182 0.0102 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0199 0.0115 0.1697
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0101 0.0038 0.0037
Schistosoma mansoni tyrosine kinase 0.0471 0.0328 0.0293
Schistosoma mansoni tyrosine kinase 0.0231 0.014 0.0104
Loa Loa (eye worm) SH2 domain-containing protein 0.0101 0.0038 0.0268
Brugia malayi SH2 domain containing protein 0.0101 0.0038 0.0037
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0372 0.0251 1
Brugia malayi SH2 domain containing protein 0.0133 0.0063 0.0522
Schistosoma mansoni tyrosine kinase 0.0267 0.0168 0.0133
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0768 0.056 1
Schistosoma mansoni tyrosine kinase 0.0642 0.0462 0.0427
Loa Loa (eye worm) hypothetical protein 0.0101 0.0038 0.0268
Loa Loa (eye worm) TK protein kinase 0.067 0.0484 0.8571
Brugia malayi RhoGAP domain containing protein 0.0101 0.0038 0.0037
Brugia malayi Protein kinase domain containing protein 0.0133 0.0063 0.0522
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0768 0.056 1
Onchocerca volvulus 0.0161 0.0086 0.4923
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0182 0.0102 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0377 0.0254 0.4157
Loa Loa (eye worm) SRC-1 0.0768 0.056 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0372 0.0251 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0177 0.0098 0.1178
Echinococcus multilocularis 0.0101 0.0038 0.0037
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0182 0.0102 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0101 0.0038 0.0037
Brugia malayi Tensin 0.0101 0.0038 0.0037
Onchocerca volvulus 0.0101 0.0038 0.0194
Echinococcus granulosus tyrosine kinase 0.0133 0.0063 0.0521
Echinococcus granulosus tyrosine protein kinase csk 0.0126 0.0058 0.0419
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0101 0.0038 0.0194
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Schistosoma mansoni tyrosine kinase 0.0768 0.056 0.0526
Echinococcus granulosus high affinity choline transporter 1 0.042 0.0288 0.4789
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0101 0.0038 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Onchocerca volvulus 0.0133 0.0063 0.2721
Echinococcus granulosus N chimaerin 0.0101 0.0038 0.0037
Brugia malayi Sex muscle abnormal protein 5 0.0199 0.0115 0.15
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0182 0.0102 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0768 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Loa Loa (eye worm) TK/EGFR protein kinase 0.0471 0.0328 0.5667
Loa Loa (eye worm) TK/FER protein kinase 0.0133 0.0063 0.0742
Echinococcus multilocularis mitogen activated protein kinase 14 0.0372 0.0251 0.4093
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0038 0.0037
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0267 0.0168 0.2515
Echinococcus multilocularis tyrosine protein kinase csk 0.0126 0.0058 0.042
Onchocerca volvulus 0.0101 0.0038 0.0194
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0101 0.0038 0.0037
Echinococcus granulosus tyrosine protein kinase Src42A 0.0768 0.056 0.998
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0372 0.0251 1
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0036 0.5
Echinococcus multilocularis SH2 motif 0.0101 0.0038 0.0037
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0177 0.0098 0.1176
Brugia malayi hypothetical protein 0.0101 0.0038 0.0037
Loa Loa (eye worm) protein-tyrosine kinase 0.0098 0.0036 0.0232
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0199 0.0115 0.1697
Echinococcus multilocularis c src tyrosine kinase 0.0325 0.0213 0.3382
Echinococcus multilocularis SH2 motif 0.0101 0.0038 0.0037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0768 0.056 0.998
Brugia malayi GH02984p 0.042 0.0288 0.4799
Loa Loa (eye worm) hypothetical protein 0.0098 0.0036 0.0232
Onchocerca volvulus 0.0227 0.0137 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0101 0.0038 0.0037
Brugia malayi protein-tyrosine kinase 0.067 0.0484 0.8538
Schistosoma mansoni tyrosine kinase 0.0171 0.0093 0.0057

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 3.571674683 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 10 point CRC. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.430796028 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222] ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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