Detailed information for compound 604328

Basic information

Technical information
  • TDR Targets ID: 604328
  • Name: (4-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6- methoxyquinolin-4-yl)methanol hydrochloride
  • MW: 360.878 | Formula: C20H25ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC12CCN(CC1)C(C2)C(c1ccnc2c1cc(OC)cc2)O.Cl
  • InChi: 1S/C20H24N2O2.ClH/c1-3-20-7-10-22(11-8-20)18(13-20)19(23)15-6-9-21-17-5-4-14(24-2)12-16(15)17;/h3-6,9,12,18-19,23H,1,7-8,10-11,13H2,2H3;1H
  • InChiKey: PKLFKSABAIAQBR-UHFFFAOYSA-N  


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Synonyms

  • (6-methoxy-4-quinolyl)-(4-vinylquinuclidin-2-yl)methanol hydrochloride
  • (6-methoxy-4-quinolyl)-(4-vinyl-2-quinuclidinyl)methanol hydrochloride
  • 11034-23-4
  • 130-89-2
  • 70181-37-2
  • 70181-38-3
  • CCRIS 2002
  • Chinimetten
  • Cinchonan-9-ol, 6'-methoxy-, monohydrochloride, (8-alpha,9R)- (9CI)
  • Cinchonan-9-ol, 6'-methoxy-, monohydrochloride, (8alpha,9R)-
  • Cinchonan-9-ol, 6'-methoxy-, monohydrochloride, dihydrate, (8alpha,9R)-
  • EINECS 205-001-1
  • FEMA No. 2976
  • QUININE, MONOHYDROCHLORIDE
  • Quinine chloride
  • Quinine monohydrochloride
  • Quinine muriate
  • (8alpha,9R)-6'-Methoxycinchonan-9-ol monohydrochloride
  • 6'-Methoxycinchonan-9-ol monohydrochloride, (8alpha,9R)-
  • AI3-62121

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Loa Loa (eye worm) hypothetical protein 0.0031 0.0462 0.1987
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Giardia lamblia Hexose transporter 0.0018 0.0217 0.109
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0016 0.0468
Entamoeba histolytica protein kinase, putative 0.0039 0.0617 0.3264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0039 0.062 0.274
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0175 0.0709
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0217 0.5239
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0618 0.0603
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0617 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0039 0.062 0.274
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0217 1
Brugia malayi hypothetical protein 0.0018 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0596 0.315
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.062 0.3337
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0618 0.0603
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0618 0.0603
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0413 0.2157
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0618 0.0603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0894
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.04
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 0.3844
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0413 0.1826
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0884 0.3903
Leishmania major glucose transporter, lmgt3 0.0039 0.062 0.3337
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0596 0.315
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0217 0.1165
Brugia malayi hypothetical protein 0.0018 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0126 0.2264 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0217 0.04
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0715 0.07
Schistosoma mansoni glucose transport protein 0.0126 0.2264 1
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0894
Echinococcus multilocularis General substrate transporter 0.0108 0.1929 0.381
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0217 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 1 1
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0217 0.0327
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0894
Plasmodium vivax hexose transporter 0.0126 0.2264 0.2252
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.04
Mycobacterium ulcerans sugar transporter 0.0018 0.0217 0.5239
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2264 1
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0016 0.0084
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0618 0.0603
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0715 0.108
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0217 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0617 0.2676
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0413 0.1769
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 0.5038 1
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0333 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Toxoplasma gondii sugar transporter ST1 0.0018 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0016 0.0024
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0134 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0039 0.0617 0.2676
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0084
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0413 0.2223
Echinococcus granulosus tm gpcr rhodopsin 0.0273132 0.5 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Schistosoma mansoni kinase 0.0054 0.0909 0.3974
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0617 0.2727
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0028 0.0413 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0039 0.062 0.274
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Entamoeba histolytica protein kinase, putative 0.0039 0.0617 0.3264
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Giardia lamblia Kinase, PLK 0.0105 0.1859 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0069
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.04
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0285 0.1535
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1859 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.3844
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0596 0.1156
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0596 0.2634
Leishmania major glucose transporter, lmgt2 0.0039 0.062 0.3337
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0413 0.1769
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Schistosoma mansoni hypothetical protein 0.0126 0.2264 1
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.04
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3738 0.3728
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273132 0.5 0.5
Echinococcus granulosus General substrate transporter 0.0108 0.1929 0.381
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0217 0.6499
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0413 0.0792
Plasmodium falciparum hexose transporter 0.0126 0.2264 0.2252
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0596 0.2583
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0413 0.0624
Plasmodium vivax sugar transporter, putative 0.0018 0.0217 0.0201
Loa Loa (eye worm) hypothetical protein 0.0038 0.0596 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.062 0.274
Plasmodium falciparum protein kinase 7 0.0357 0.6619 0.6614
Trichomonas vaginalis glucose transporter, putative 0.0039 0.062 0.274
Trypanosoma brucei polo-like protein kinase 0.0105 0.1859 1
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0413 0.2223
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0596 0.2583
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0596 1
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0566 0.1096
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0617 0.2676
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0894
Trypanosoma cruzi hexose transporter 0.0039 0.062 0.3337
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0413 0.2223
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0217 0.5239
Leishmania major glucose transporter, lmgt1 0.0039 0.062 0.3337
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0617 0.3321
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0618 0.0933
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0217 0.0201
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0413 0.0398
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0413 0.1769
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Toxoplasma gondii sugar transporter ST3 0.0018 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Trypanosoma brucei glucose transporter 2A 0.0039 0.062 0.3337
Schistosoma mansoni glucose transport protein 0.0126 0.2264 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0413 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.1165
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Giardia lamblia Sugar-proton symporter 0.0018 0.0217 0.109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Leishmania major protein kinase, putative 0.0039 0.0617 0.3321
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0596 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0596 0.1156
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0039 0.062 0.3337
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0217 0.5239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.04
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0084
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0618 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0617 0.2676
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.1165
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0217 0.04
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0894
Trypanosoma brucei sugar transporter, putative 0.0018 0.0217 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0566 0.1096
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0413 1
Schistosoma mansoni glucose transporter 0.0018 0.0217 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1859 0.3671
Brugia malayi Sugar transporter family protein 0.0126 0.2264 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0217 0.6499
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0884 0.3903
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0618 0.0933
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.3844
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 0.3844
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0894
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0134 0.3243
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.04
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0596 0.2583
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0715 0.07
Leishmania major hypothetical protein, conserved 0.0018 0.0217 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0217 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0016 0.0377
Echinococcus granulosus tm gpcr rhodopsin 0.0273 0.5038 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1859 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.062 0.3337
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0016 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1859 0.8212
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 0.5587
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0618 0.0603
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Trypanosoma cruzi hexose transporter, putative 0.0039 0.062 0.3337
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0016 0.0262
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1859 0.3671
Brugia malayi hypothetical protein 0.0018 0.0217 0.0894
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0413 0.0792
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0894
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.04
Schistosoma mansoni protein kinase 0.0039 0.0617 0.2676
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.2264 0.4477
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0617 0.1198
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.062 0.3337
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0618 0.0603
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.062 0.3337
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0618 0.0603
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0617 0.2676
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0618 0.0933
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1859 0.82
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0039 0.0617 0.2676
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1859 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3738 0.5647
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1859 0.82
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0018 0.0217 0.0894
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.04
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3738 0.3728
Toxoplasma gondii protein kinase, putative 0.0357 0.6619 1
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1859 0.82
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.3844
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1859 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Brugia malayi Cam kinase protein 1 0.0039 0.0617 0.2676
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.2264 0.342
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0217 0.04
Entamoeba histolytica hypothetical protein 0.0028 0.0413 0.2157
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1859 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0217 0.0894
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0016 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2264 0.4477
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0596 0.2583
Schistosoma mansoni protein kinase 0.0039 0.0617 0.2676
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0894
Toxoplasma gondii sugar transporter ST2 0.0018 0.0217 0.0327
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.062 0.3337
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0348 0.1536
Trypanosoma brucei glucose transporter 1E 0.0039 0.062 0.3337
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.062 0.274
Schistosoma mansoni glucose transport protein 0.0126 0.2264 1
Trichomonas vaginalis sugar transporter, putative 0.0039 0.062 0.274
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0413 1
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0894
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0413 0.6932
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0217 0.04
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.0039 0.062 0.3337

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) = 77.68 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 = 77.68 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 28.1 nM MMV: Inhibition of Plasmodium falciparum K1 (EC50). ChEMBL. No reference
EC50 (functional) = 42.3 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) = 0.00682 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.00682 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.02933 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.02933 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
Growth Inhibition (functional) = 15.913 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 418 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 0.009 uM MMV: Modified 3H-Hyoxanthine uptake assay; 1% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) = 0.019 uM MMV: 3H-Hyoxanthine uptake assay; 5% O2, 5% CO2 in N2. ChEMBL. No reference
IC50 (functional) = 0.021 uM MMV: 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#11875-093) with Sodium Bicarbonate (NaHCO3) 2000 mg/mL. ChEMBL. No reference
IC50 (functional) = 0.04 uM MMV: Modified 3H-Hyoxanthine uptake assay; RPMI 1640 (Invitrogen cat#23400-013) without Sodium Bicarbonate (NaHCO3). ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 16 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Inhibition (functional) = -31.3333966283965 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -29.0831898932241 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -25.1501358118998 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -25.150135811899798 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 1.2461129852075277 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 1.24611298520753 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 18.8 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 20 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 27.2 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 84 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 96 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
IZ = 0 mm MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin. ChEMBL. No reference
Ratio (functional) = 0.693333333333333 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.0044 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.1178 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.1593 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783
Trypanosoma brucei gambiense

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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