Detailed information for compound 606081

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.532 | Formula: C25H30N4O
  • H donors: 2 H acceptors: 2 LogP: 3.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)[C@@H]1C[C@H](CN1Cc1ccc2c(c1)cccc2)NCc1cccnc1)C
  • InChi: 1S/C25H30N4O/c1-18(2)28-25(30)24-13-23(27-15-20-6-5-11-26-14-20)17-29(24)16-19-9-10-21-7-3-4-8-22(21)12-19/h3-12,14,18,23-24,27H,13,15-17H2,1-2H3,(H,28,30)/t23-,24+/m1/s1
  • InChiKey: JWMYDAYZOBYZFN-RPWUZVMVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0451 0.0481
Schistosoma mansoni Smad4 0.0017 0.0091 0.0097
Toxoplasma gondii ABC1 family protein 0.0078 0.1178 0.2168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0106 0.0901
Onchocerca volvulus Putative transporter 0.0015 0.0056 0.0477
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0363
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0215 0.1419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0026 0.0245 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.4269 0.4269
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0105 0.0094
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0341 0.0364
Echinococcus granulosus smad 0.0017 0.0091 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0363 0.0388
Loa Loa (eye worm) hypothetical protein 0.0438 0.7591 0.7591
Loa Loa (eye worm) hypothetical protein 0.0059 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Trypanosoma brucei glucose transporter 1E 0.0034 0.0383 0.2913
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0432
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0106 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0056 0.006
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0026 0.0245 0.0203
Schistosoma mansoni integrin alpha-ps 0.0135 0.2194 0.234
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1178 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Onchocerca volvulus 0.0015 0.0056 0.0477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Toxoplasma gondii microneme protein MIC2 0.0026 0.0245 0.0366
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0376 0.0404
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0707 0.0707
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0106 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0106 0.062
Echinococcus multilocularis Smad4 0.0017 0.0091 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0328
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0175 0.2899 0.3595
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0375 0.0375
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0593 0.0632
Schistosoma mansoni tar DNA-binding protein 0.0538 0.9376 1
Schistosoma mansoni hypothetical protein 0.0108 0.1712 0.1826
Echinococcus granulosus integrin alpha ps 0.026 0.4412 0.4705
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0375 0.2845
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0091 0.0097
Schistosoma mansoni lamin 0.0058 0.0823 0.0878
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Plasmodium falciparum protein kinase 7 0.0306 0.523 0.6542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0593 0.0632
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Echinococcus multilocularis lamin dm0 0.0058 0.0823 0.0823
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0023 0.0023
Echinococcus granulosus solute carrier family 22 0.0015 0.0056 0.006
Mycobacterium tuberculosis Conserved protein 0.0078 0.1178 0.13
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0105 0.0432
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0902 0.7539
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.5818 0.6183
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0215 0.023
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.2913
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1178 0.1256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1178 0.1256
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0105 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0286 0.0305
Echinococcus multilocularis cysteine protease 0.0018 0.0106 0.0054
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0459 0.3593
Onchocerca volvulus 0.0015 0.0056 0.0477
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0105 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0106 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1178 1
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0097
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1888 0.881
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0363 1
Onchocerca volvulus 0.0015 0.0056 0.0477
Loa Loa (eye worm) hypothetical protein 0.0028 0.0286 0.0286
Echinococcus granulosus integrin alpha 3 0.0124 0.2003 0.2136
Onchocerca volvulus 0.0018 0.0106 0.0901
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0215 0.023
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0026 0.0245 0.0366
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0459 0.3593
Leishmania major hypothetical protein, conserved 0.0078 0.1178 1
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0026 0.0245 0.0239
Toxoplasma gondii protein kinase, putative 0.0306 0.523 1
Schistosoma mansoni sugar transporter 0.0015 0.0056 0.006
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0363 0.9682
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0459 0.3593
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.0445
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1178 0.6878
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.2236
Schistosoma mansoni integrin alpha-ps 0.026 0.4412 0.4705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0056 0.006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0105 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0105 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1178 0.1256
Brugia malayi beta-lactamase family protein 0.0078 0.1178 0.1256
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1178 0.6878
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1888 0.2123
Schistosoma mansoni sugar transporter 0.0015 0.0056 0.006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0112
Entamoeba histolytica protein kinase, putative 0.0033 0.0375 1
Entamoeba histolytica hypothetical protein 0.0024 0.0215 0.5738
Echinococcus granulosus intermediate filament protein 0.0058 0.0823 0.0878
Treponema pallidum hypothetical protein 0.0026 0.0245 1
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0245 0.6539
Onchocerca volvulus 0.0015 0.0056 0.0477
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Schistosoma mansoni intermediate filament proteins 0.0058 0.0823 0.0878
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0451 0.0481
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.0445
Schistosoma mansoni hypothetical protein 0.0026 0.0245 0.0262
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0105 0.0611
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0091 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0538 0.9376 1
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.2236
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0376 0.0404
Schistosoma mansoni sodium/solute symporter 0.0037 0.0451 0.0481
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0215 0.1258
Loa Loa (eye worm) TAR-binding protein 0.0538 0.9376 0.9376
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1178 0.1418
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0105 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Schistosoma mansoni sugar transporter 0.0015 0.0056 0.006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0105 0.0432
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0106 0.0113
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0451 0.0762
Schistosoma mansoni integrin alpha 0.026 0.4412 0.4705
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0383 0.2236
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0105 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.2236
Entamoeba histolytica cysteine protease, putative 0.0018 0.0106 0.2827
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1888 0.2123
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0105 0.0611
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0026 0.0245 0.0262
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1777
Schistosoma mansoni high-affinity choline transporter 0.0339 0.5818 0.6205
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0328
Mycobacterium ulcerans hypothetical protein 0.0078 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Echinococcus multilocularis integrin alpha ps 0.026 0.4412 0.4673
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1008 0.8485
Onchocerca volvulus 0.0018 0.0106 0.0901
Onchocerca volvulus 0.0026 0.0245 0.2084
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.1712 0.3201
Brugia malayi Integrin alpha pat-2 precursor 0.026 0.4412 0.4705
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0026 0.0245 0.0239
Brugia malayi beta-lactamase family protein 0.0078 0.1178 0.1256
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0215 0.023
Echinococcus granulosus solute carrier family 22 0.0015 0.0056 0.006
Mycobacterium leprae Probable lipase LipE 0.0078 0.1178 0.521
Brugia malayi RNA binding protein 0.0538 0.9376 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.2122 0.2395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0026 0.0245 0.0245
Brugia malayi hypothetical protein 0.0026 0.0245 0.0262
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.04
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0376 0.0404
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0707 0.0754
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0383 0.2913
Treponema pallidum 76K protein 0.0026 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0027 0.0267 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0328
Schistosoma mansoni glucose transporter 0.0015 0.0056 0.006
Onchocerca volvulus 0.0026 0.0245 0.2084
Echinococcus multilocularis musashi 0.0058 0.0823 0.0823
Schistosoma mansoni hypothetical protein 0.0124 0.2003 0.2136
Onchocerca volvulus 0.0078 0.1178 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0432
Onchocerca volvulus 0.0058 0.0823 0.699
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0056 0.0328
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0052
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0091 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Onchocerca volvulus 0.0018 0.0106 0.0901
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0383 0.2236
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0459 0.051
Brugia malayi Sugar transporter family protein 0.0108 0.1712 0.1826
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1826
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0097
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0451 0.0481
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0091 0.0091
Onchocerca volvulus 0.0058 0.0823 0.699
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0383 0.2236
Schistosoma mansoni glucose transport protein 0.0108 0.1712 0.1826
Loa Loa (eye worm) ctsf protein 0.0018 0.0106 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0106 0.0445
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0056 0.0328
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0451 0.0423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0538 0.9376 1
Schistosoma mansoni tar DNA-binding protein 0.0538 0.9376 1
Echinococcus granulosus integrin alpha ps 0.0124 0.2003 0.2136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1888 0.2123
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.2122 0.2395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Brugia malayi Cam kinase protein 1 0.0033 0.0375 0.04
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0175 0.2899 0.5495
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0459 0.3593
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0376 0.0404
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0105 0.1576
Onchocerca volvulus 0.0015 0.0056 0.0477
Onchocerca volvulus 0.0026 0.0245 0.2084
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1008 0.8485
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1826
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.1178 0.13
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus granulosus lamin 0.0058 0.0823 0.0878
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1178 1
Onchocerca volvulus 0.0018 0.0106 0.0901
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0438 0.7591 0.8096
Plasmodium vivax vivapain-2 0.0018 0.0106 0.0063
Brugia malayi Zona pellucida-like domain containing protein 0.0026 0.0245 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0106 0.0054
Schistosoma mansoni inositol transporter 0.0037 0.0451 0.0481
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Schistosoma mansoni smad 0.0017 0.0091 0.0097
Onchocerca volvulus 0.0015 0.0056 0.0477
Trypanosoma brucei glucose transporter 2A 0.0034 0.0383 0.2913
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0459 0.3593
Mycobacterium leprae conserved hypothetical protein 0.0078 0.1178 0.521
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0376 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.04
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1777
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0026 0.0245 0.0262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0823 0.0823
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.0342
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0707 0.0754
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Onchocerca volvulus 0.0026 0.0245 0.2084
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0056 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0105 0.0432
Entamoeba histolytica hypothetical protein 0.0026 0.0245 0.6539
Entamoeba histolytica protein kinase, putative 0.0033 0.0375 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0215 1
Onchocerca volvulus 0.0015 0.0056 0.0477
Brugia malayi Sugar transporter family protein 0.0015 0.0056 0.006
Plasmodium falciparum glutathione reductase 0.0052 0.0707 0.0823
Brugia malayi MH1 domain containing protein 0.0017 0.0091 0.0097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0341 0.0341
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.1178 0.13
Loa Loa (eye worm) fibroinase 0.0018 0.0106 0.0106
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0106 0.0445
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0106 0.0901
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0026 0.0245 0.0239
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.5818 0.6205
Loa Loa (eye worm) hypothetical protein 0.0124 0.2003 0.2003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Schistosoma mansoni lamin 0.0058 0.0823 0.0878
Loa Loa (eye worm) hypothetical protein 0.0057 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Leishmania major protein kinase, putative 0.0033 0.0375 0.2845
Mycobacterium ulcerans lipase LipD 0.0078 0.1178 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus multilocularis smad 0.0017 0.0091 0.0037
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Brugia malayi glutathione reductase 0.0052 0.0707 0.0754
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0376 0.0404
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1888 0.2123
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.0342
Brugia malayi Thioredoxin reductase 0.0052 0.0707 0.0754
Leishmania major glucose transporter, lmgt3 0.0034 0.0383 0.2913
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1888 0.2123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0375 0.04
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0432
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.4269 0.4269
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0026 0.0245 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Echinococcus granulosus Smad4 0.0017 0.0091 0.0097
Onchocerca volvulus 0.0078 0.1178 1
Plasmodium vivax thrombospondin-related anonymous protein 0.0026 0.0245 0.0239
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.1178 0.13
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.1178 0.13
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1826
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.04
Loa Loa (eye worm) hypothetical protein 0.0135 0.2194 0.2194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0593 0.0576
Leishmania major glucose transporter, lmgt2 0.0034 0.0383 0.2913
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0746 0.6152
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0215 0.1419
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0823 0.0823
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.002 0.0021
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0026 0.0245 0.0239
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0056 0.006
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0376 0.0404
Echinococcus multilocularis integrin alpha ps 0.026 0.4412 0.4673
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.1178 0.13
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1826
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Plasmodium falciparum mitogen-activated protein kinase 2 0.0175 0.2899 0.3595
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0056 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Brugia malayi von Willebrand Factor 0.0026 0.0245 0.0262
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0363 0.0388
Onchocerca volvulus 0.0018 0.0106 0.0901
Echinococcus granulosus cathepsin l1 0.0018 0.0106 0.0113
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0376 0.0617
Loa Loa (eye worm) sugar transporter 0.0108 0.1712 0.1712
Brugia malayi hypothetical protein 0.0015 0.0056 0.006
Leishmania major cathepsin L-like protease 0.0069 0.1008 0.8485
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.0342
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Plasmodium falciparum hexose transporter 0.0108 0.1712 0.2094
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0215 0.0201
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0105 0.0061
Toxoplasma gondii thioredoxin reductase 0.0052 0.0707 0.1258
Brugia malayi TAR-binding protein 0.0538 0.9376 1
Echinococcus multilocularis integrin alpha 3 0.0124 0.2003 0.2089
Echinococcus multilocularis solute carrier family 5 0.0037 0.0451 0.0423
Onchocerca volvulus 0.0015 0.0056 0.0477
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Onchocerca volvulus 0.0015 0.0056 0.0477
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0151 0.0109
Plasmodium vivax hexose transporter 0.0108 0.1712 0.2094
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0106 0.0901
Loa Loa (eye worm) CUTiclin family member 0.0026 0.0245 0.0245
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Leishmania major cathepsin L-like protease 0.0069 0.1008 0.8485
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) Smad1 0.0017 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1178 0.6878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Brugia malayi RNA recognition motif domain containing protein 0.0538 0.9376 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0267 0.0267
Trichomonas vaginalis esterase, putative 0.0078 0.1178 0.6878
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0593 0.0632
Brugia malayi major facilitator superfamily protein 0.0015 0.0056 0.006
Echinococcus multilocularis lamin 0.0058 0.0823 0.0823
Echinococcus granulosus tar DNA binding protein 0.0538 0.9376 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0245 0.6539
Onchocerca volvulus 0.0037 0.0451 0.3826
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0215 0.1419
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0091 0.0037
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0215 0.1419
Echinococcus granulosus solute carrier family 22 0.0015 0.0056 0.006
Schistosoma mansoni inositol transporter 0.0037 0.0451 0.0481
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0215 0.0201
Plasmodium falciparum thrombospondin-related anonymous protein 0.0026 0.0245 0.0239
Onchocerca volvulus 0.0015 0.0056 0.0477
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0105 0.0432
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Onchocerca volvulus 0.0018 0.0106 0.0901
Loa Loa (eye worm) glutathione reductase 0.0052 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Schistosoma mansoni glucose transport protein 0.0108 0.1712 0.1826
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0215 0.0308
Loa Loa (eye worm) sugar transporter 0.0015 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0593 0.0632
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0839 0.0895
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0459 0.051
Plasmodium vivax glutathione reductase, putative 0.0052 0.0707 0.0823
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.002 0.0021
Echinococcus multilocularis integrin alpha ps 0.0124 0.2003 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0106 0.0106
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0112 0.0497
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.2913
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0383 0.2236
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0593 0.0593
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0707 0.0823
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0376 0.0404
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0105 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0105 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Leishmania major trypanothione reductase 0.0052 0.0707 0.5802
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0286 0.0247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1178 0.1178
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0363 0.1079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Echinococcus multilocularis General substrate transporter 0.0093 0.1441 0.1486
Onchocerca volvulus 0.0015 0.0056 0.0477
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0091 0.0097
Trypanosoma cruzi hexose transporter 0.0034 0.0383 0.2913
Trypanosoma brucei trypanothione reductase 0.0052 0.0707 0.5802
Plasmodium vivax CDK-related protein kinase 6, putative 0.0459 0.7965 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0026 0.0245 0.0239
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Loa Loa (eye worm) hypothetical protein 0.0058 0.0823 0.0823
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0105 0.0061
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.2913
Loa Loa (eye worm) hypothetical protein 0.0026 0.0255 0.0255
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.1008 0.8485
Echinococcus multilocularis cysteine protease 0.0018 0.0106 0.0054
Brugia malayi hypothetical protein 0.0015 0.0056 0.006
Echinococcus granulosus collagen alpha 1VII chain 0.0026 0.0245 0.0262
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0375 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0375 0.04
Loa Loa (eye worm) hypothetical protein 0.0033 0.0375 0.0375
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0245 0.0239
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1008 0.8485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Brugia malayi hypothetical protein 0.0015 0.0056 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0106 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0707 0.5802
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0106 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0538 0.9376 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0363 0.0388
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.2913
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0105 1
Echinococcus multilocularis tar DNA binding protein 0.0538 0.9376 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0451 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0328
Loa Loa (eye worm) hypothetical protein 0.0339 0.5818 0.5818
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0215 0.0171
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.0445
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0162 0.0948
Onchocerca volvulus 0.0015 0.0056 0.0477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0363 0.033
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0451 0.0423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Plasmodium falciparum glutathione reductase 0.0018 0.0105 0.0061
Plasmodium falciparum thioredoxin reductase 0.0052 0.0707 0.0823
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1178 0.6878
Echinococcus granulosus General substrate transporter 0.0093 0.1441 0.1537
Brugia malayi MH2 domain containing protein 0.0017 0.0091 0.0097
Mycobacterium tuberculosis Conserved protein 0.0078 0.1178 0.13
Onchocerca volvulus 0.0015 0.0056 0.0477
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0056 0.0056
Onchocerca volvulus 0.0015 0.0056 0.0477
Brugia malayi beta-lactamase 0.0078 0.1178 0.1256
Schistosoma mansoni protein kinase 0.0033 0.0375 0.04
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0106 0.0113
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0707 0.0698
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0363 0.0388
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Mycobacterium tuberculosis Conserved protein 0.0078 0.1178 0.13
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.1178 0.13
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0215 0.5182
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0215 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0245 0.0245
Echinococcus multilocularis tumor protein p63 0.0404 0.6987 0.7437
Brugia malayi GH02984p 0.0339 0.5818 0.6205
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0363 0.2122
Schistosoma mansoni glucose transport protein 0.0108 0.1712 0.1826
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0215 0.023
Onchocerca volvulus 0.0015 0.0056 0.0477
Loa Loa (eye worm) beta-lactamase 0.0078 0.1178 0.1178
Schistosoma mansoni sugar transporter 0.0015 0.0056 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0375 0.2192
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0106 0.2827
Brugia malayi Cathepsin L-like precursor 0.0018 0.0106 0.0113
Plasmodium falciparum protein kinase 6 0.0459 0.7965 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0339 0.0361
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0823 0.0878
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.0445
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0056 0.0056
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.2913
Onchocerca volvulus 0.0078 0.1178 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.1712 0.1777
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0499 0.8682 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0245 0.0262
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0451 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0106 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0106 0.0054
Brugia malayi von Willebrand factor type A domain containing protein 0.0026 0.0245 0.0262
Schistosoma mansoni hypothetical protein 0.0026 0.0245 0.0262
Entamoeba histolytica elongation factor-2 kinase, putative 0.0026 0.0245 0.6539
Loa Loa (eye worm) hypothetical protein 0.0135 0.2194 0.2194
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1712 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0538 0.9376 0.9376
Echinococcus granulosus tumor protein p63 0.0404 0.6987 0.7452
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0026 0.0245 0.1433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0105 0.0056
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0376 0.0617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0593 0.0632
Plasmodium vivax vivapain-2 0.0018 0.0106 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0215 0.1419
Brugia malayi MH2 domain containing protein 0.0252 0.4269 0.4553
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.2913
Schistosoma mansoni protein kinase 0.0033 0.0375 0.04
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0106 0.0113
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0375 0.0375
Brugia malayi Zona pellucida-like domain containing protein 0.0026 0.0245 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) RNA binding protein 0.0538 0.9376 0.9376
Leishmania major glucose transporter, lmgt1 0.0034 0.0383 0.2913
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0091 0.0037
Mycobacterium ulcerans beta-lactamase 0.0078 0.1178 1
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0056 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Onchocerca volvulus 0.0026 0.0245 0.2084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0593 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0105 0.0432
Brugia malayi intermediate filament protein 0.0058 0.0823 0.0878
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Onchocerca volvulus 0.0059 0.0839 0.7126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0106 0.2827
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0105 1
Onchocerca volvulus 0.0018 0.0106 0.0901
Onchocerca volvulus 0.0015 0.0056 0.0477
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0105 0.0432
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0105 0.0432
Echinococcus granulosus voltage dependent calcium channel subunit 0.0026 0.0245 0.0262
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.2122 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1178 0.1256
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0106 0.0106
Echinococcus granulosus solute carrier family 22 0.0015 0.0056 0.006
Onchocerca volvulus 0.0026 0.0245 0.2084
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0106 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.1178 0.13
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0106 0.0054
Loa Loa (eye worm) hypothetical protein 0.0078 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0056 0.0056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0106 0.0054
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0151 0.0109
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0056 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1178 1
Leishmania major cathepsin L-like protease 0.0069 0.1008 0.8485
Schistosoma mansoni smad1 5 8 and 0.0017 0.0091 0.0097
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.2122 0.2395
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0593 0.0576
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1178 0.1203
Loa Loa (eye worm) CUTiclin-Like family member 0.0026 0.0245 0.0245
Mycobacterium tuberculosis Probable reductase 0.0118 0.1888 0.2123
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0451 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Echinococcus granulosus lamin dm0 0.0058 0.0823 0.0878
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0376 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1008 0.8485
Leishmania major cathepsin L-like protease 0.0018 0.0106 0.0445
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0375 0.0342
Brugia malayi Smad1 0.0017 0.0091 0.0097
Brugia malayi major facilitator superfamily protein 0.0015 0.0056 0.006
Brugia malayi Sugar transporter family protein 0.0015 0.0056 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Toxoplasma gondii cathepsin CPL 0.0018 0.0106 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0451 0.0451
Onchocerca volvulus 0.0026 0.0245 0.2084
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0363 0.0388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0106 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0328
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0376 0.0617
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.2913
Loa Loa (eye worm) hypothetical protein 0.0024 0.0215 0.0215
Schistosoma mansoni protein kinase 0.0033 0.0375 0.04
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0339 0.0303
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.1712 0.1777
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0459 0.0779
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1178 0.6878
Echinococcus granulosus solute carrier family 5 0.0037 0.0451 0.0481
Plasmodium falciparum thioredoxin reductase 0.0018 0.0105 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0363 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0106 0.062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0056 0.0328
Loa Loa (eye worm) cysteine protease 0.0018 0.0106 0.0106

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 (functional) > 100 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 100 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 3.31 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 3.31 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) > 10.93 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) > 10.93 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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