Detailed information for compound 607494

Basic information

Technical information
  • TDR Targets ID: 607494
  • Name: N-(4-diethylaminophenyl)thiophene-2-carboxami de
  • MW: 274.381 | Formula: C15H18N2OS
  • H donors: 1 H acceptors: 1 LogP: 3.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)NC(=O)c1cccs1)CC
  • InChi: 1S/C15H18N2OS/c1-3-17(4-2)13-9-7-12(8-10-13)16-15(18)14-6-5-11-19-14/h5-11H,3-4H2,1-2H3,(H,16,18)
  • InChiKey: RFTGCCNSOIXDRC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-diethylaminophenyl)-2-thiophenecarboxamide
  • Oprea1_018838
  • Oprea1_347023
  • BAS 01261994
  • Thiophene-2-carboxylic acid (4-diethylamino-phenyl)-amide
  • ZINC00146493
  • EU-0035967
  • CBMicro_026561
  • BIM-0026555.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0845
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0414 0.6932
Toxoplasma gondii sugar transporter ST2 0.0018 0.0217 0.0327
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0733 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Plasmodium falciparum protein kinase 7 0.0357 0.6617 0.6612
Entamoeba histolytica protein kinase, putative 0.0039 0.0611 1
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0217 0.0956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0161 0.2246
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0597 0.1335
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0845
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0213
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 0.5587
Echinococcus multilocularis raf serine:threonine protein kinase 0.0034 0.0522 0.2125
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0845
Echinococcus multilocularis G protein signaling modulator 2 0.0009 0.006 0.0188
Schistosoma mansoni glucose transport protein 0.0126 0.2266 0.945
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0414 0.1672
Mycobacterium ulcerans sugar transporter 0.0018 0.0217 0.2957
Toxoplasma gondii exonuclease III APE 0.0015 0.0161 0.0243
Leishmania major glucose transporter, lmgt1 0.0039 0.0621 0.8471
Schistosoma mansoni glucose transport protein 0.0126 0.2266 0.945
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0103
Brugia malayi hypothetical protein 0.0237 0.4367 1
Schistosoma mansoni protein kinase 0.0039 0.0611 0.2503
Schistosoma mansoni hypothetical protein 0.0133 0.2397 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.2266 0.945
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.303
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0333 0.4549
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0597 0.2441
Loa Loa (eye worm) raf kinase 0.0034 0.0522 0.1163
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0733 1
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0414 0.0399
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0134 0.8173
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0612 0.0597
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0733 0.3013
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Schistosoma mansoni ap endonuclease 0.0015 0.0161 0.0609
Echinococcus granulosus General substrate transporter 0.0108 0.193 0.8042
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0611 0.1369
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0462
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0414 0.1672
Loa Loa (eye worm) sugar transporter 0.0018 0.0217 0.0462
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0676 0.1517
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0045 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.4367 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0414 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.2266 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0161 0.0333
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0161 0.0609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0161 0.2191
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0462
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0217 0.2957
Schistosoma mansoni glucose transporter 0.0018 0.0217 0.0845
Trypanosoma brucei sugar transporter, putative 0.0018 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Onchocerca volvulus 0.0237 0.4367 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0414 0.5783
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0016 0.0213
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0161 0.2433
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0611 0.855
Schistosoma mansoni hypothetical protein 0.0126 0.2266 0.945
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0217 0.0845
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0845
Echinococcus granulosus geminin 0.0133 0.2397 1
Brugia malayi hypothetical protein 0.0018 0.0217 0.0462
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0161 0.2495
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 1 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0621 0.274
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.2266 0.3424
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0217 0.0462
Echinococcus multilocularis geminin 0.0133 0.2397 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0175 0.0366
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0217 0.0956
Echinococcus granulosus raf serine:threonine protein kinase 0.0034 0.0522 0.2125
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0039 0.0611 0.1369
Brugia malayi GoLoco motif family protein 0.0009 0.006 0.0103
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0715 0.0701
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0217 0.0845
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0217 0.2957
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0161 0.2246
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0217 0.0201
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0612 0.0925
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0414 0.0915
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0217 0.303
Toxoplasma gondii sugar transporter ST1 0.0018 0.0217 0.0327
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0597 0.9752
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0414 0.5643
Brugia malayi GoLoco motif family protein 0.0009 0.006 0.0103
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0597 0.2634
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0621 0.274
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0566 0.2313
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0217 0.2957
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.868
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0845
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Brugia malayi Cam kinase protein 1 0.0039 0.0611 0.1369
Schistosoma mansoni hypothetical protein 0.0009 0.006 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0161 0.0145
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0845
Trypanosoma brucei glucose transporter 1E 0.0039 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0217 0.0845
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.868
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0161 0.2191
Plasmodium vivax hexose transporter 0.0126 0.2266 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Entamoeba histolytica hypothetical protein 0.0028 0.0414 0.6679
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Loa Loa (eye worm) hypothetical protein 0.0038 0.0597 0.1335
Giardia lamblia Sugar-proton symporter 0.0018 0.0217 0.346
Brugia malayi major facilitator superfamily protein 0.0018 0.0217 0.0462
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0286 0.3994
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0333 0.4549
Entamoeba histolytica protein kinase, putative 0.0039 0.0611 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0134 0.183
Schistosoma mansoni glucose transport protein 0.0126 0.2266 0.945
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Schistosoma mansoni protein kinase 0.0039 0.0611 0.2503
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0612 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0621 0.274
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0845
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0845
Loa Loa (eye worm) hypothetical protein 0.0031 0.0463 0.1027
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0414 0.5643
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0161 0.2246
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0217 0.303
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0733 0.1648
Loa Loa (eye worm) hypothetical protein 0.0028 0.0414 0.0915
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Schistosoma mansoni sugar transporter 0.0018 0.0217 0.0845
Schistosoma mansoni hypothetical protein 0.0133 0.2397 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.868
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0612 0.0597
Brugia malayi hypothetical protein 0.0018 0.0217 0.0462
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0621 0.274
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 1
Toxoplasma gondii protein kinase, putative 0.0357 0.6617 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.3734 0.5643
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Toxoplasma gondii sugar transporter ST3 0.0018 0.0217 0.0327
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0045 0.0733 0.3013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0126 0.2266 0.5171
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.3734 0.3724
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0045 0.0733 1
Schistosoma mansoni protein kinase 0.0039 0.0611 0.2503
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0016 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0069
Brugia malayi Sugar transporter family protein 0.0126 0.2266 0.5171
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0621 0.8471
Trypanosoma brucei glucose transporter 2A 0.0039 0.0621 0.868
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0597 0.2441
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.868
Leishmania major glucose transporter, lmgt2 0.0039 0.0621 0.8471
Trypanosoma cruzi hexose transporter 0.0039 0.0621 0.868
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0612 0.0597
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0611 0.2503
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Giardia lamblia Hexose transporter 0.0018 0.0217 0.346
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0414 0.6849
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0462
Echinococcus multilocularis General substrate transporter 0.0108 0.193 0.8042
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0161 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0161 0.0333
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0597 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0621 0.868
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0597 0.2441
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.9759
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0161 0.0709
Echinococcus granulosus G protein signaling modulator 2 0.0009 0.006 0.0188
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0612 0.0925
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0715 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.3734 0.3724
Schistosoma mansoni ap endonuclease 0.0015 0.0161 0.0609
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0217 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0611 0.2503
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0161 0.0609
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0522 0.2125
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0217 0.2957
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0161 0.0145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0016 0.0213
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0161 0.7211
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0845
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0611 0.1369
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0016 0.0024
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0597 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0611 0.1369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Plasmodium falciparum hexose transporter 0.0126 0.2266 0.2253
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0715 0.1081
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0621 0.868
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0217 1
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0414 0.0625
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Brugia malayi hypothetical protein 0.0018 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Plasmodium vivax sugar transporter, putative 0.0018 0.0217 0.0201
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0217 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0611 0.2699
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0611 0.2503
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0597 0.2441
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0161 1
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0217 0.303
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0217 0.0845
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0217 0.2957
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0597 0.1335
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 0.9759
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0733 0.3013
Echinococcus granulosus solute carrier family 22 0.0018 0.0217 0.0845
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0566 0.2313
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0009 0.006 0.0103
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0161 0.2191
Brugia malayi Raf kinase 0.0034 0.0522 0.1163
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Brugia malayi Sugar transporter family protein 0.0018 0.0217 0.0462
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0612 0.0597
Echinococcus multilocularis solute carrier family 22 0.0018 0.0217 0.0845
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0348 0.1536
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0217 0.0956
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0016 0.0262
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0621 0.274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.2266 0.945
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Leishmania major hypothetical protein, conserved 0.0018 0.0217 0.2957
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0217 0.2957
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0414 0.1672
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0217 0.0845
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0414 0.1672
Loa Loa (eye worm) hypothetical protein 0.0018 0.0217 0.0462
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0612 0.0597
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0016 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0612 0.0925
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0134 0.2978
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Leishmania major glucose transporter, lmgt3 0.0039 0.0621 0.8471
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0414 0.1826
Leishmania major protein kinase, putative 0.0039 0.0611 0.8343
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0039 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0217 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0016 0.0213
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0414 0.5643
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0597 0.1335

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
CC50 > 100 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) = 0.414 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.414 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.77 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.77 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
Growth Inhibition (functional) = 3.9542 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 513.9 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 0.396 uM NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration ChEMBL. 22096101
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IFI promiscuity index = 0.07092 IFI promiscuity index Novartis-GNF Malaria Box. No reference
Inhibition (functional) = -55.7323676283062 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -5.41584762639717 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -1 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 1 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 4.01 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 13.1 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 23.385262793427167 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 23.3852627934272 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 44.6691402467533 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 88 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Ratio (functional) = 1 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.4168 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.1938 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.0445 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Schizont size (functional) = 54.07 um NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration ChEMBL. 22096101
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783
Plasmodium yoelii ChEMBL23 22096101

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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