Detailed information for compound 607506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.537 | Formula: C30H23N5
  • H donors: 1 H acceptors: 1 LogP: 7.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Nc1ccc2c(c1N=Nc1nc3c(n1Cc1ccccc1)cccc3)cccc2
  • InChi: 1S/C30H23N5/c1-3-11-22(12-4-1)21-35-28-18-10-9-17-26(28)32-30(35)34-33-29-25-16-8-7-13-23(25)19-20-27(29)31-24-14-5-2-6-15-24/h1-20,31H,21H2/b34-33+
  • InChiKey: DAEPSCKFIWDJAQ-JEIPZWNWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Leishmania major hypothetical protein, conserved 0.0042 0.0473 0.7596
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0218 0.0272
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0009 0.0011
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0397 0.039
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.2516 0.3743
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0218 0.0599
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0078 0.0101
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2532
Schistosoma mansoni glucose transporter 0.0018 0.0163 0.0273
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0507 0.0501
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0015 0.0128 0.0155
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Schistosoma mansoni hypothetical protein 0.0024 0.0244 0.0415
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0017 0.0022
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0128 0.0165
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0218 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0133 0.1914
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.1362 0.4031
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0163 0.3187
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0373 0.0366
Onchocerca volvulus 0.0018 0.0163 0.0542
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0211 0.0301
Brugia malayi Sugar transporter family protein 0.0126 0.1534 0.1976
Schistosoma mansoni importin-beta 2 0.0006 0.0009 0.0003
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0163 0.0231
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0497 0.7952
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.0538
Brugia malayi follicle stimulating hormone receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0427 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Brugia malayi Muscleblind-like protein 0.0619 0.7762 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0133 0.5534
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.2039
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0241 0.0669
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.1362 0.4031
Brugia malayi Dopamine receptor protein 2 0.0005 0.0007 0.0009
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Brugia malayi G-protein alpha subunit 0.0006 0.0017 0.0022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Brugia malayi G protein-coupled receptor 0.0005 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.2039
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Onchocerca volvulus 0.0042 0.0473 0.1617
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0163 0.0156
Plasmodium vivax sugar transporter, putative 0.0018 0.0163 0.0231
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0053 0.0059
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0238 0.0689
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.131 0.1687
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0244 0.0237
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0017 0.001
Brugia malayi ORL1-like opioid receptor 0.0005 0.0007 0.0009
Mycobacterium ulcerans lipase LipD 0.0042 0.0473 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus 0.003 0.0318 0.108
Loa Loa (eye worm) hypothetical protein 0.0619 0.7762 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0457 0.5715 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0017 0.0022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0133 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0039 0.0427 0.055
Brugia malayi Thioredoxin reductase 0.0044 0.05 0.0644
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0318 0.0545
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0128 0.0165
Trichomonas vaginalis ran, putative 0.0022 0.0211 0.0609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0218 0.3319
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0427 0.0625
Onchocerca volvulus 0.0015 0.0128 0.0419
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0475
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2039
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0473 0.7596
Leishmania major glucose transporter, lmgt1 0.0039 0.0433 0.695
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0473 0.0816
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.176 0.1754
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0078 0.0091
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Brugia malayi Serotonin receptor 0.0005 0.0007 0.0009
Mycobacterium ulcerans beta-lactamase 0.0042 0.0473 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0295 0.0645
Echinococcus granulosus translational activator gcn1 0.0006 0.0009 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0433 0.1254
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.05 0.8008
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0473 0.1365
Onchocerca volvulus 0.0015 0.0128 0.0419
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0473 0.0816
Plasmodium falciparum threonine--tRNA ligase 0.0007 0.0029 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0373 0.0471
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0211 0.0455
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Brugia malayi Serotonin receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0133 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0163 0.0472
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0876 0.1129
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0427 0.055
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0017 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0015 0.0128 0.0155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.1219 0.3603
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0318 0.0311
Brugia malayi beta-lactamase family protein 0.0042 0.0473 0.0609
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0133 0.0281
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.0029 0.0028
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0017 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.1362 0.4031
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0006 0.0017 0.005
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0017 0.0022
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3303
Loa Loa (eye worm) hypothetical protein 0.0034 0.0373 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0473 0.7559
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0295 0.0371
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Schistosoma mansoni hypothetical protein 0.0312 0.388 0.6784
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Echinococcus multilocularis low density lipoprotein receptor protein 0.0015 0.0128 0.0121
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0017 0.0017
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Brugia malayi sulfakinin receptor protein 0.0005 0.0007 0.0009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0218 0.4868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0473 0.0609
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0295 0.0504
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0163 0.3187
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Onchocerca volvulus Putative transporter 0.0018 0.0163 0.0542
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0473 0.0609
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0238 0.0689
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0417 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0078 0.0071
Toxoplasma gondii exonuclease III APE 0.0022 0.0218 0.0471
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0433 0.695
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Treponema pallidum NADH oxidase 0.0015 0.0133 0.5534
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.0007 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.05 0.0644
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi CXXC zinc finger family protein 0.0032 0.0344 0.0444
Plasmodium falciparum protein kinase 7 0.0357 0.4444 0.6622
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Onchocerca volvulus 0.0018 0.0163 0.0542
Echinococcus granulosus muscleblind protein 0.0619 0.7762 1
Leishmania major hypothetical protein, conserved 0.0018 0.0163 0.2527
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0473 0.1365
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.3457 0.4454
Echinococcus granulosus low density lipoprotein receptor protein 0.0015 0.0128 0.0155
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0427 0.055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0126
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0218 0.063
Onchocerca volvulus 0.0018 0.0163 0.0542
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.1219 0.8937
Leishmania major GTP-binding protein, putative 0.0022 0.0211 0.3303
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0133 0.5534
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0163 0.0201
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0473 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0427 0.0625
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0241 0.166
Echinococcus multilocularis GPCR, family 2 0.0034 0.0373 0.0366
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) RNA binding protein 0.0069 0.0815 0.105
Loa Loa (eye worm) hypothetical protein 0.0108 0.131 0.1687
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0029 0.0031
Onchocerca volvulus 0.0015 0.0128 0.0419
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0128 0.0121
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0417 0.041
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0815 0.105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0007 0.0009
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Echinococcus multilocularis cpg binding protein 0.0034 0.0368 0.0361
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.0007 0.0009
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi beta-lactamase 0.0042 0.0473 0.0609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0218 0.0312
Leishmania major importin beta-1 subunit, putative 0.0024 0.0238 0.3756
Schistosoma mansoni ran 0.0022 0.0211 0.0356
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0082 0.0105
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0721 0.1606
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0017 0.0013
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0507 0.0645
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0373 0.048
Onchocerca volvulus 0.0018 0.0163 0.0542
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0218 0.063
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0128 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.388 0.4998
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.05 0.1446
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Plasmodium falciparum glutathione reductase 0.0015 0.0133 0.0186
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.062 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Schistosoma mansoni cpg binding protein 0.0032 0.0344 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0133 0.2532
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4598
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Echinococcus multilocularis snurportin 1 0.0312 0.388 0.3875
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0427 0.0944
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0007 0.0009
Brugia malayi AKH receptor 0.0005 0.0007 0.0009
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.3457 0.4454
Echinococcus granulosus dnaJ subfamily B 0.0457 0.5715 0.736
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0308 0.0675
Schistosoma mansoni hypothetical protein 0.0183 0.2256 0.3939
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0308 0.0301
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0241 0.0669
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0218 0.3422
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2372 0.686
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Brugia malayi CUB domain containing protein 0.0015 0.0128 0.0165
Schistosoma mansoni cpg binding protein 0.0034 0.0368 0.0631
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0017 0.0017
Toxoplasma gondii sugar transporter ST2 0.0018 0.0163 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0473 0.0466
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0039 0.0499
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0417 0.0538
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0211 0.0204
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0009 0.0011
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0133 0.2532
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Toxoplasma gondii protein kinase, putative 0.0357 0.4444 1
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0163 0.0472
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0427 0.055
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0017 0.0022
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0128 0.0211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0011 0.0006
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0017 0.001
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0163 0.0273
Trypanosoma brucei glucose transporter 2A 0.0039 0.0433 0.695
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.1219 0.3603
Onchocerca volvulus 0.0018 0.0163 0.0542
Onchocerca volvulus 0.0018 0.0163 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0473 0.7559
Mycobacterium leprae Probable lipase LipE 0.0042 0.0473 0.3385
Loa Loa (eye worm) beta-lactamase 0.0042 0.0473 0.0609
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Brugia malayi G-protein coupled receptor 0.0005 0.0007 0.0009
Plasmodium vivax SET domain protein, putative 0.003 0.0318 0.0462
Brugia malayi RNA binding protein 0.0069 0.0815 0.105
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0163 0.7108
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0017 0.0017
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0163 0.3187
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0133 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0015 0.0128 0.0419
Echinococcus multilocularis geminin 0.0183 0.2256 0.225
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0028 0.0295 0.6837
Brugia malayi neuropeptide F receptor 0.0005 0.0007 0.0009
Brugia malayi kap beta 3 protein 0.0006 0.0009 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0813 0.1411
Trypanosoma brucei trypanothione reductase 0.0044 0.05 0.8039
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Leishmania major trypanothione reductase 0.0044 0.05 0.8039
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0497 0.11
Onchocerca volvulus 0.0018 0.0163 0.0542
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0295 0.0427
Loa Loa (eye worm) sugar transporter 0.0018 0.0163 0.021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0128 0.0155
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0209 0.3176
Brugia malayi TAR-binding protein 0.0069 0.0815 0.105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0163 0.0435
Echinococcus multilocularis translational activator gcn1 0.0006 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.062 0.0799
Plasmodium falciparum thioredoxin reductase 0.0044 0.05 0.0733
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0473 0.1365
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0006 0.0017 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.176 0.2268
Loa Loa (eye worm) hypothetical protein 0.0029 0.0308 0.0397
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.062 0.0912
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.2247 0.778
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0015 0.0128 0.0165
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Entamoeba histolytica G protein alpha subunit, putative 0.0006 0.0017 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0163 0.2409
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0497 0.0728
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0473 0.1365
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0427 0.6848
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0417 0.1207
Loa Loa (eye worm) glutathione reductase 0.0044 0.05 0.0644
Leishmania major glucose transporter, lmgt2 0.0039 0.0433 0.695
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0163 0.0348
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0344 0.0444
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0318 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0427 0.0736
Onchocerca volvulus 0.0015 0.0128 0.0419
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0155
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0029 0.023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0133 0.2039
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0417 0.2971
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0133 0.0281
Echinococcus granulosus cpg binding protein 0.0034 0.0368 0.0465
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0318 0.0311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0053 0.0081
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.0007 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0218 0.0281
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0433 0.1254
Brugia malayi G-protein coupled receptor 0.0005 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Toxoplasma gondii sugar transporter ST1 0.0018 0.0163 0.0348
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0017 0.001
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Onchocerca volvulus 0.0015 0.0128 0.0419
Mycobacterium ulcerans sugar transporter 0.0018 0.0163 0.3187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0427 0.0944
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.062 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0128 0.0121
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.0007 0.0009
Entamoeba histolytica protein kinase, putative 0.0039 0.0427 1
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0007 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0133 0.0186
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.0007 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0373 0.048
Schistosoma mansoni hypothetical protein 0.0074 0.0876 0.1522
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Onchocerca volvulus 0.0006 0.0017 0.0035
Schistosoma mansoni hypothetical protein 0.0015 0.0128 0.0211
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0296 0.0372
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0211 0.3198
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax glutathione reductase, putative 0.0044 0.05 0.0733
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Onchocerca volvulus 0.0006 0.0017 0.0035
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0473 0.1365
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0373 0.0366
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0133 0.1914
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0108 0.1973
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Trypanosoma brucei sugar transporter, putative 0.0018 0.0163 0.2527
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0082 0.0105
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0251 0.0726
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0015 0.0128 0.0419
Brugia malayi basement membrane proteoglycan precursor 0.0015 0.0128 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.1219 0.3603
Entamoeba histolytica hypothetical protein 0.0024 0.0238 0.5485
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0017 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0218 0.4391
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0295 0.6084
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.0029 0.0021
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0108 0.2978
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0017 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0108 0.4189
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0029 0.023
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0163 0.2409
Onchocerca volvulus 0.0006 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Mycobacterium ulcerans hypothetical protein 0.0042 0.0473 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Brugia malayi enteropeptidase precursor 0.0015 0.0128 0.0165
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0029 0.0038
Echinococcus multilocularis muscleblind protein 1 0.0619 0.7762 0.7761
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0373 0.0471
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.253 0.3259
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1968
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0017 0.0022
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0029 0.0078
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0473 0.1365
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0015 0.0128 0.0165
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0163 0.2527
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0295 0.2059
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0473 0.1368
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.3351 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0133 0.2039
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0133 0.1914
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0076 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Toxoplasma gondii thioredoxin reductase 0.0044 0.05 0.1108
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.0007 0.0009
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0053 0.0046
Schistosoma mansoni ran 0.0022 0.0211 0.0356
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0433 0.6902
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0473 1
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0018 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0318 0.0401
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.062 0.0912
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0007 0.0029 0.0037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.1219 0.3603
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Brugia malayi glutathione reductase 0.0044 0.05 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis hypothetical protein 0.0006 0.0009 0.0025
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0133 0.3933
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0433 0.1254
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Brugia malayi glycyl-tRNA synthetase 0.0007 0.0029 0.0037
Brugia malayi Pre-SET motif family protein 0.003 0.0318 0.041
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Melatonin receptor type 1A 0.0005 0.0007 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.176 0.226
Loa Loa (eye worm) sugar transporter 0.0126 0.1534 0.1976
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0133 0.0172
Onchocerca volvulus 0.0032 0.0344 0.1171
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0017 0.0022
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.0029 0.0028
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0238 0.0689
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0427 0.0625
Leishmania major hypothetical protein, conserved 0.0054 0.062 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.0007 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0053 0.0046
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0218 0.3422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0218 0.3319
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0163 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.131 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0433 0.1254
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0373 0.048
Onchocerca volvulus 0.0233 0.2887 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0133 0.2039
Brugia malayi RNA, U transporter 1 0.0083 0.0989 0.1274
Schistosoma mansoni protein kinase 0.0039 0.0427 0.0736
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0006 0.0018 0.0021
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2887 0.835
Echinococcus granulosus importin 5 0.0006 0.0009 0.0002
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0497 0.7952
Plasmodium vivax glycine--tRNA ligase, putative 0.0007 0.0029 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Giardia lamblia Sugar-proton symporter 0.0018 0.0163 0.346
Onchocerca volvulus 0.0015 0.0128 0.0419
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.062 1
Mycobacterium tuberculosis Probable reductase 0.0101 0.1219 0.3603
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0133 0.2039
Onchocerca volvulus 0.0018 0.0163 0.0542
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0083
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0473 0.3385
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax importin-beta 2, putative 0.0029 0.0308 0.0447
Plasmodium falciparum importin beta, putative 0.0029 0.0308 0.0447
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus General substrate transporter 0.0108 0.1309 0.1679
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0074 0.0876 0.1129
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1534 0.3438
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0133 0.0386
Leishmania major protein kinase, putative 0.0039 0.0427 0.6848
Schistosoma mansoni ap endonuclease 0.0022 0.0218 0.0369
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0295 0.0288
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0022
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0015 0.0128 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Echinococcus granulosus expressed protein 0.0006 0.0017 0.0013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0218 0.4997
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0244 0.0306
Trichomonas vaginalis esterase, putative 0.0042 0.0473 0.1368
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0427 0.0625
Entamoeba histolytica Ran family GTPase 0.0022 0.0211 0.4824
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0163 0.0472
Echinococcus multilocularis muscleblind protein 0.0619 0.7762 0.7761
Echinococcus multilocularis transportin 1 0.0006 0.0009 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.4682
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0089
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.5715 0.5712
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0427 0.0625
Brugia malayi hypothetical protein 0.0035 0.0379 0.0488
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0029 0.0045
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0017 0.001
Onchocerca volvulus Arrow homolog 0.0015 0.0128 0.0419
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Brugia malayi Sugar transporter family protein 0.0018 0.0163 0.021
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi neuropeptide F receptor 0.0005 0.0007 0.0009
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0163 0.2409
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0017 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Echinococcus granulosus transportin 1 0.0006 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Brugia malayi hypothetical protein 0.0018 0.0163 0.021
Leishmania major glucose transporter, lmgt3 0.0039 0.0433 0.695
Plasmodium vivax threonine--tRNA ligase, putative 0.0007 0.0029 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Pre-SET motif family protein 0.0205 0.253 0.3259
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0433 0.1254
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0174
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0017 0.0017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1534 0.1527
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.1219 0.3603
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0128 0.0155
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0238 0.3658
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4682
Plasmodium vivax hexose transporter 0.0126 0.1534 0.2276
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Schistosoma mansoni ap endonuclease 0.0022 0.0218 0.0369
Trypanosoma cruzi hexose transporter 0.0039 0.0433 0.6902
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.2516 0.3743
Schistosoma mansoni importin beta-1 0.0029 0.0308 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Plasmodium falciparum thioredoxin reductase 0.0015 0.0133 0.0186
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi hypothetical protein 0.0054 0.062 0.0799
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.2516 0.5652
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1534 0.4436
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi Dopamine receptor 0.0005 0.0007 0.0009
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0007 0.0029 0.0037
Echinococcus granulosus tar DNA binding protein 0.0069 0.0815 0.1041
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0133 0.0386
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0007 0.0029 0.0475
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0815 0.1415
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0218 0.0312
Brugia malayi hypothetical protein 0.0006 0.0017 0.0022
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0017 0.001
Echinococcus granulosus geminin 0.0183 0.2256 0.2899
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0007 0.0029 0.0037
Plasmodium falciparum protein kinase 6 0.0536 0.6707 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0007 0.0029 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0211 0.0262
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Brugia malayi major facilitator superfamily protein 0.0018 0.0163 0.021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0211 0.0271
Brugia malayi hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0007 0.0029 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0133 0.1914
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0473 0.0693
Echinococcus granulosus GPCR family 2 0.0034 0.0373 0.0471
Brugia malayi Cam kinase protein 1 0.0039 0.0427 0.055
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0295 0.6084
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.062 0.0912
Onchocerca volvulus 0.0042 0.0473 0.1617
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.176 0.2268
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0295 0.6849
Echinococcus granulosus basement membrane specific heparan sulfate 0.0015 0.0128 0.0155
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Loa Loa (eye worm) hypothetical protein 0.003 0.0318 0.041
Echinococcus granulosus importin subunit beta 1 0.0029 0.0308 0.0388
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.0007 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0163 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0427 0.1236
Plasmodium falciparum hexose transporter 0.0126 0.1534 0.2276
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.042
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0497 0.7983
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0015 0.0128 0.0165
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Schistosoma mansoni sugar transporter 0.0018 0.0163 0.0273
Echinococcus multilocularis solute carrier family 22 0.0018 0.0163 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0473 0.1368
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0017 0.0017
Brugia malayi major facilitator superfamily protein 0.0018 0.0163 0.021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.1362 1
Giardia lamblia Hexose transporter 0.0018 0.0163 0.346
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.0007 0.0009
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0427 0.0944
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0163 0.021
Onchocerca volvulus 0.0018 0.0163 0.0542
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Schistosoma mansoni hypothetical protein 0.0183 0.2256 0.3939
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0619 0.7762 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.6707 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0295 0.0853
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0427 0.0625
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0427 0.0625
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0417 0.0538
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0017 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0218 1
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0417 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0006 0.0017 0.005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.0007 0.0009
Plasmodium falciparum glutathione reductase 0.0044 0.05 0.0733
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0295 0.4682
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1534 0.1527
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0815 0.105
Brugia malayi Sugar transporter family protein 0.0018 0.0163 0.021
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0017 0.0022
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0015 0.0128 0.0211
Trichomonas vaginalis helicase, putative 0.0007 0.0031 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0318 0.0545
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Echinococcus multilocularis expressed protein 0.0006 0.0017 0.001
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0133 0.2039
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Echinococcus granulosus snurportin 1 0.0312 0.388 0.4993
Echinococcus granulosus solute carrier family 22 0.0018 0.0163 0.0201
Echinococcus multilocularis General substrate transporter 0.0108 0.1309 0.1303
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Entamoeba histolytica protein kinase, putative 0.0039 0.0427 1
Toxoplasma gondii sugar transporter ST3 0.0018 0.0163 0.0348
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0006 0.0017 0.005
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0163 0.0435
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0815 0.0808
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0397 0.0503
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0015 0.0128 0.0121
Trypanosoma brucei glucose transporter 1E 0.0039 0.0433 0.695
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0163 0.0472
Echinococcus granulosus low density lipoprotein receptor ldl 0.0015 0.0128 0.0155
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0427 0.0625
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0417 0.0529
Loa Loa (eye worm) hypothetical protein 0.0042 0.0473 0.0609
Schistosoma mansoni glucose transport protein 0.0126 0.1534 0.2674
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0417 0.9764
Mycobacterium tuberculosis Conserved protein 0.0042 0.0473 0.1365
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0295 0.0504
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0433 0.695
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0017 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0017 0.0017
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0007 0.0009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0221
Brugia malayi Importin beta-1 subunit 0.0029 0.0308 0.0397
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Schistosoma mansoni hypothetical protein 0.0015 0.0128 0.0211
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0308 0.4898
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0128 0.0165
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0133 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0155
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0029 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0815 0.105
Loa Loa (eye worm) hypothetical protein 0.0031 0.0328 0.0422
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0133 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0473 0.0601
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0163 0.2527
Onchocerca volvulus 0.0018 0.0163 0.0542
Brugia malayi Dopamine receptor protein 1 0.0005 0.0007 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0053 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.176 0.1754
Brugia malayi larval opioid receptor 0.0005 0.0007 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.3457 1
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0218 0.0281
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0029 0.0174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.0538
Onchocerca volvulus 0.0042 0.0473 0.1617
Brugia malayi beta-lactamase family protein 0.0042 0.0473 0.0609
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0295 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.131 0.1687
Brugia malayi putative neuropeptide receptor 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0017 0.0017
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0417 0.0719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.176 0.226
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0006 0.0017 0.005
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0135 0.0174
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0015 0.0128 0.0165
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.0029 0.0021
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0163 0.0201
Schistosoma mansoni cpg binding protein 0.0034 0.0368 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0473 0.1368
Schistosoma mansoni hypothetical protein 0.0034 0.0373 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0089
Brugia malayi GnHR receptor homolog 0.0005 0.0007 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0053
Toxoplasma gondii ABC1 family protein 0.0042 0.0473 0.1047
Trypanosoma brucei glucose transporter, putative 0.0039 0.0433 0.695
Loa Loa (eye worm) hypothetical protein 0.0018 0.0163 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.176 0.3071
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0133 0.2694
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.2372 0.686
Brugia malayi RE15519p 0.0005 0.0007 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.05 0.0733
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0295 0.0427
Echinococcus multilocularis importin 5 0.0006 0.0009 0.0002
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0017 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0163 0.0472
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0308 0.4898
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0163 0.021
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0497 0.0728
Schistosoma mansoni hypothetical protein 0.0126 0.1534 0.2674
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.0007 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.062 0.1378
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0427 0.0542
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0427 0.0542
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0295 0.038
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0473 0.1365
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.2247 0.6501

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 88.01 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box. No reference
EC50 (functional) = 0.669 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box. No reference
EC50 (functional) = 2.734 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box. No reference
IFI promiscuity index = 0.15079 IFI promiscuity index Novartis-GNF Malaria Box. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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