Detailed information for compound 619480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.218 | Formula: C14H11BrN2O2S
  • H donors: 0 H acceptors: 1 LogP: 4.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(=NC(=O)c2ccco2)sc2c1ccc(c2)Br
  • InChi: 1S/C14H11BrN2O2S/c1-2-17-10-6-5-9(15)8-12(10)20-14(17)16-13(18)11-4-3-7-19-11/h3-8H,2H2,1H3/b16-14+
  • InChiKey: HMVOLCRMTFBSTD-JQIJEIRASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0059 0.0604
Brugia malayi CXXC zinc finger family protein 0.0062 0.0114 0.011
Trichomonas vaginalis porcupine, putative 0.0416 0.0848 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0041 0.007 1
Loa Loa (eye worm) MBOAT family protein 0.0416 0.0848 0.0841
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.007 0.0924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0023 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0059 0.0604
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0416 0.0848 0.0844
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.003 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Echinococcus multilocularis muscleblind protein 1 0.0147 0.029 0.0285
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0023 0.0015
Echinococcus granulosus sterol O acyltransferase 1 0.0416 0.0848 0.0844
Entamoeba histolytica hypothetical protein 0.0416 0.0848 1
Plasmodium vivax vivapain-2 0.0018 0.0023 0.0218
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0004
Brugia malayi follicle stimulating hormone receptor 0.0504 0.1032 0.1028
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0416 0.0848 0.0848
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Loa Loa (eye worm) hypothetical protein 0.0416 0.0848 0.0841
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.0058 0.0678
Leishmania major hypothetical protein, conserved 0.0416 0.0848 1
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0416 0.0848 1
Echinococcus multilocularis geminin 0.0199 0.0398 0.0394
Schistosoma mansoni hypothetical protein 0.0439 0.0897 0.0897
Trichomonas vaginalis esterase, putative 0.0041 0.007 0.0819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus granulosus o acyltransferase membrane bound domain 0.0416 0.0848 0.0844
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.007 0.0924
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0023 0.0267
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0058 0.0053
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Trypanosoma cruzi glycerol uptake protein, putative 0.0416 0.0848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.001 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0078 0.0078
Echinococcus multilocularis cysteine protease 0.0018 0.0023 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0025 0.002
Leishmania major cathepsin L-like protease 0.0018 0.0023 0.0177
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0129 0.1478
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.007 0.0066
Brugia malayi hypothetical protein 0.0022 0.003 0.0026
Brugia malayi Doublecortin family protein 0.0022 0.003 0.0026
Leishmania major glycerol uptake protein, putative 0.0416 0.0848 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0416 0.0848 0.0844
Onchocerca volvulus 0.0041 0.007 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0004 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0003
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0416 0.0848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0023 0.0262
Trypanosoma cruzi glycerol uptake protein, putative 0.0416 0.0848 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0059 0.0643
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0416 0.0848 1
Onchocerca volvulus 0.0018 0.0023 0.0182
Schistosoma mansoni hypothetical protein 0.0416 0.0848 0.0848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0003
Schistosoma mansoni lipoxygenase 0.0022 0.003 0.003
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0004 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0003
Leishmania major glycerol uptake protein, putative 0.0416 0.0848 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0129 0.1478
Onchocerca volvulus 0.0018 0.0023 0.0182
Echinococcus granulosus zinc finger protein 0.4407 0.9137 0.9137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0416 0.0848 0.0848
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0023 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0004 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0023 0.0018
Echinococcus granulosus muscleblind protein 0.0147 0.029 0.0285
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0023
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0003
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0416 0.0848 0.0844
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.007 0.0819
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0944 0.1944 0.1941
Schistosoma mansoni rab6-interacting 0.0022 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.007 0.0777
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0078 0.0078
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0416 0.0848 0.0848
Brugia malayi Hhat protein 0.0416 0.0848 0.0844
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0007
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0416 0.0848 0.0848
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.007 1
Echinococcus multilocularis cysteine protease 0.0018 0.0023 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0023 0.0019
Leishmania major cathepsin L-like protease 0.0018 0.0023 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.003 0.0353
Onchocerca volvulus 0.0041 0.007 0.0744
Toxoplasma gondii ABC1 family protein 0.0041 0.007 0.0739
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0023 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0003
Brugia malayi hypothetical protein 0.0022 0.003 0.0026
Mycobacterium tuberculosis Conserved protein 0.0041 0.007 0.0924
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.0897 0.0893
Trypanosoma brucei glycerol uptake protein, putative 0.0416 0.0848 1
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0023 0.0182
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.007 0.0777
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0023 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0003
Brugia malayi Muscleblind-like protein 0.0147 0.029 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0078 0.0074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0504 0.1032 0.1025
Echinococcus granulosus cathepsin l1 0.0018 0.0023 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.007 0.0924
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Schistosoma mansoni hypothetical protein 0.0199 0.0398 0.0398
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0017 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0014 0.016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.0224
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.003 0.0026
Schistosoma mansoni loxhd1 0.0022 0.003 0.003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0023 0.0016
Schistosoma mansoni cpg binding protein 0.0062 0.0114 0.0114
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0098 0.1112
Onchocerca volvulus 0.0022 0.003 0.0269
Mycobacterium leprae conserved hypothetical protein 0.0041 0.007 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0007
Echinococcus granulosus o acyltransferase membrane bound domain 0.0416 0.0848 0.0844
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.001 0.0119
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0129 0.1478
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0058 0.0678
Loa Loa (eye worm) cysteine protease 0.0018 0.0023 0.0015
Echinococcus granulosus o acyltransferase membrane bound domain 0.0416 0.0848 0.0844
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0129 0.1478
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0416 0.0848 0.0844
Brugia malayi MBOAT family protein 0.0416 0.0848 0.0844
Loa Loa (eye worm) hhat protein 0.0416 0.0848 0.0841
Echinococcus multilocularis RUN 0.0022 0.003 0.0026
Brugia malayi cathepsin L-like precursor 0.0012 0.001 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0008 0.0041
Echinococcus granulosus cpg binding protein 0.0066 0.0121 0.0117
Leishmania major cathepsin L-like protease 0.0018 0.0023 0.0177
Schistosoma mansoni cpg binding protein 0.0066 0.0121 0.0121
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0003
Echinococcus granulosus RUN 0.0022 0.003 0.0026
Trypanosoma cruzi GUP1, putative 0.0416 0.0848 1
Trichomonas vaginalis helicase, putative 0.0014 0.0014 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0258 0.0258
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0024 0.002
Leishmania major glycerol uptake protein, putative 0.0416 0.0848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Leishmania major cathepsin L-like protease 0.0018 0.0023 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0023 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0023 0.0019
Leishmania major hypothetical protein, conserved 0.0041 0.007 0.0739
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0416 0.0848 0.0844
Onchocerca volvulus 0.0022 0.003 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0014 0.016
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0023 0.0018
Schistosoma mansoni hypothetical protein 0.0199 0.0398 0.0398
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0059 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.0848 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0023 0.0267
Onchocerca volvulus 0.0041 0.007 0.0744
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0416 0.0848 0.0848
Entamoeba histolytica hypothetical protein, conserved 0.0416 0.0848 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0416 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.0282
Onchocerca volvulus 0.0416 0.0848 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Leishmania major glycerol uptake protein, putative 0.0416 0.0848 1
Loa Loa (eye worm) fibroinase 0.0018 0.0023 0.0015
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0416 0.0848 0.0848
Entamoeba histolytica hypothetical protein 0.0035 0.0058 0.0678
Loa Loa (eye worm) hypothetical protein 0.0416 0.0848 0.0841
Trichomonas vaginalis rotamase, putative 0.0036 0.006 0.0706
Brugia malayi beta-lactamase 0.0041 0.007 0.0066
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.007 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0114 0.0107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0017 0.0013
Trichomonas vaginalis rotamase, putative 0.0035 0.0059 0.0685
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0416 0.0848 0.0844
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0023 0.0273
Loa Loa (eye worm) doublecortin family protein 0.0022 0.003 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0416 0.0848 0.0841
Trypanosoma cruzi glycerol uptake protein, putative 0.0416 0.0848 1
Onchocerca volvulus 0.0018 0.0023 0.0182
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0023 1
Schistosoma mansoni zinc finger protein 0.4823 1 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0003
Trypanosoma cruzi GUP1, putative 0.0416 0.0848 1
Loa Loa (eye worm) MBOAT family protein 0.4823 1 1
Onchocerca volvulus Huntingtin homolog 0.0275 0.0555 0.6516
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0025 0.0017
Mycobacterium ulcerans hypothetical protein 0.0041 0.007 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.007 0.0819
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0023 0.0018
Mycobacterium ulcerans lipase LipD 0.0041 0.007 1
Schistosoma mansoni lipoxygenase 0.0061 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0078 0.0071
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0017 0.0013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.007 0.0063
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0008 0.0041
Leishmania major cathepsin L-like protease 0.0018 0.0023 0.0177
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0416 0.0848 0.0841
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0023 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Onchocerca volvulus 0.0012 0.001 0.0033
Leishmania major cathepsin L-like protease 0.0069 0.0129 0.1443
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0416 0.0848 0.0844
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0416 0.0848 1
Plasmodium vivax vivapain-2 0.0018 0.0023 0.0218
Onchocerca volvulus 0.0062 0.0114 0.1266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus multilocularis sterol O acyltransferase 1 0.0416 0.0848 0.0844
Echinococcus granulosus dnaJ subfamily B 0.0439 0.0897 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.001 0.0114
Loa Loa (eye worm) hypothetical protein 0.0275 0.0555 0.0548
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.005
Trichomonas vaginalis transmembrane protein nessy, putative 0.0416 0.0848 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0058 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0012 0.001 0.0006
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0275 0.0555 0.0548
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.007 0.0819
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0078 0.0074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.007 0.0066
Schistosoma mansoni rotamase 0.0036 0.006 0.006
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0004 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.007 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.007 0.0777
Onchocerca volvulus 0.0018 0.0023 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.007 0.0819
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.007 0.0924
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.0026
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0111 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0416 0.0848 0.0844
Toxoplasma gondii hypothetical protein 0.0416 0.0848 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0078 0.0074
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0023 0.0182
Plasmodium vivax hypothetical protein, conserved 0.0041 0.007 0.0777
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0003
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0059 0.069
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0268
Onchocerca volvulus 0.0018 0.0023 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0003
Treponema pallidum alginate O-acetylation protein (algI) 0.0416 0.0848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0416 0.0848 0.0844
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0078 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Entamoeba histolytica cysteine protease, putative 0.0018 0.0023 0.0267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0003
Brugia malayi hypothetical protein 0.0035 0.0058 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Trypanosoma brucei glycerol uptake protein, putative 0.0416 0.0848 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0023 0.0267
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0023 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.006 0.0706
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0004
Brugia malayi MBOAT family protein 0.0416 0.0848 0.0844
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0023 0.0218
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0229 0.2635
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0017 0.0013
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Mycobacterium tuberculosis Conserved protein 0.0041 0.007 0.0924
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0268
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.001 0.0006
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4823 1 1
Echinococcus granulosus expressed protein 0.0036 0.006 0.0056
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.006 0.0056
Echinococcus granulosus cathepsin l1 0.0012 0.001 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.007 0.0924
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.0848 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0416 0.0848 1
Echinococcus multilocularis expressed protein 0.0036 0.006 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Onchocerca volvulus 0.0018 0.0023 0.0182
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Schistosoma mansoni sterol O-acyltransferase 1 0.0416 0.0848 0.0848
Schistosoma mansoni polycystin 1-related 0.0022 0.003 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.007 0.007
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0023 0.0177
Leishmania major glycerol uptake protein, putative 0.0416 0.0848 1
Brugia malayi MBOAT family protein 0.0416 0.0848 0.0844
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0023 0.0023
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0004 0.005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0528 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0025 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0003
Loa Loa (eye worm) ctsf protein 0.0018 0.0023 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0003
Brugia malayi diacylglycerol acyltransferase 0.0416 0.0848 0.0844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0116 0.133
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0416 0.0848 0.0844
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0023 0.0267
Entamoeba histolytica hypothetical protein 0.0035 0.0058 0.0678
Brugia malayi Cathepsin L-like precursor 0.0012 0.001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0008 0.0041
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0023 0.0018
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.0282
Mycobacterium tuberculosis Conserved protein 0.0041 0.007 0.0924
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0111 0.0107
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0059 0.0643
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.0273
Schistosoma mansoni cpg binding protein 0.0066 0.0121 0.0121
Brugia malayi Cathepsin L-like precursor 0.0018 0.0023 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.007 0.0924
Onchocerca volvulus Huntingtin homolog 0.0275 0.0555 0.6516
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.0848 1
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.007 0.0924
Mycobacterium leprae Probable lipase LipE 0.0041 0.007 0.5
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0416 0.0848 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Echinococcus granulosus geminin 0.0199 0.0398 0.0394
Toxoplasma gondii exonuclease III APE 0.0018 0.0023 0.0184
Brugia malayi beta-lactamase family protein 0.0041 0.007 0.0066
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0023 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0014 0.016
Loa Loa (eye worm) hypothetical protein 0.0416 0.0848 0.0841
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Brugia malayi beta-lactamase family protein 0.0041 0.007 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.007 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0023 0.0262
Brugia malayi hypothetical protein 0.0275 0.0555 0.0551
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.005
Onchocerca volvulus 0.0018 0.0023 0.0182
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.005
Leishmania major cathepsin L-like protease 0.0069 0.0129 0.1443
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0058 0.0053
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0416 0.0848 0.0844
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.007 0.0819
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.006 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0023 0.0262
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0014 0.016
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Echinococcus multilocularis cpg binding protein 0.0066 0.0121 0.0117
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.003 0.0026
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0416 0.0848 0.0841
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0224
Loa Loa (eye worm) MBOAT family protein 0.0416 0.0848 0.0841
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0129 0.1478
Loa Loa (eye worm) beta-lactamase 0.0041 0.007 0.0063
Leishmania major cathepsin L-like protease 0.0069 0.0129 0.1443
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0023 0.0019
Entamoeba histolytica vacuolar protein sorting 26 0.0416 0.0848 1
Toxoplasma gondii cathepsin CPL 0.0018 0.0023 0.0177
Echinococcus multilocularis muscleblind protein 0.0147 0.029 0.0285
Brugia malayi MBOAT family protein 0.0416 0.0848 0.0844
Loa Loa (eye worm) hhat protein 0.0416 0.0848 0.0841
Echinococcus multilocularis zinc finger protein 0.4407 0.9137 0.9137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0023 0.0267
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4823 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0023 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0078 0.0078
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0003
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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