Detailed information for compound 620759

Basic information

Technical information
  • TDR Targets ID: 620759
  • Name: methyl 2-[3-(4-methoxyphenyl)-2-oxochromen-7- yl]oxyacetate
  • MW: 340.327 | Formula: C19H16O6
  • H donors: 0 H acceptors: 2 LogP: 3.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)COc1ccc2c(c1)oc(=O)c(c2)c1ccc(cc1)OC
  • InChi: 1S/C19H16O6/c1-22-14-6-3-12(4-7-14)16-9-13-5-8-15(24-11-18(20)23-2)10-17(13)25-19(16)21/h3-10H,11H2,1-2H3
  • InChiKey: FDAHEHBUYSOXNF-UHFFFAOYSA-N  


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Synonyms

  • methyl 2-[3-(4-methoxyphenyl)-2-oxo-chromen-7-yl]oxyacetate
  • 2-[[3-(4-methoxyphenyl)-2-oxo-7-chromenyl]oxy]acetic acid methyl ester
  • 2-[2-keto-3-(4-methoxyphenyl)chromen-7-yl]oxyacetic acid methyl ester
  • methyl 2-[3-(4-methoxyphenyl)-2-oxo-chromen-7-yl]oxyethanoate
  • ZINC01317623

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0284 0.0455
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0241 0.0242
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0789 0.1757
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0377 0.0553
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0376 0.8412
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0153 0.3424
Leishmania major glucose transporter, lmgt1 0.0034 0.0383 0.8555
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Leishmania major protein kinase, putative 0.0034 0.0376 0.8412
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) TAR-binding protein 0.014 0.1937 0.3104
Brugia malayi Sugar transporter family protein 0.0111 0.151 0.2419
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Onchocerca volvulus 0.0016 0.0106 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1621 0.2597
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0298 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0241 0.0242
Loa Loa (eye worm) sugar transporter 0.0111 0.151 0.2419
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0366 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Onchocerca volvulus 0.0016 0.0106 0.0149
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0292 0.0468
Schistosoma mansoni hypothetical protein 0.0017 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0111
Schistosoma mansoni hypothetical protein 0.0017 0.0119 0.012
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0366 0.0587
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0376 0.0603
Loa Loa (eye worm) hypothetical protein 0.0021 0.0191 0.0306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0174 0.5844
Brugia malayi MH2 domain containing protein 0.0119 0.1621 0.2597
Loa Loa (eye worm) hypothetical protein 0.0021 0.0191 0.0306
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0106 0.017
Onchocerca volvulus 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0376 0.0529
Onchocerca volvulus 0.0016 0.0106 0.0149
Schistosoma mansoni hypothetical protein 0.0017 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0274 0.044
Plasmodium falciparum mitogen-activated protein kinase 2 0.0179 0.2516 0.3695
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0119 0.0191
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0298 0.8121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.0477
Brugia malayi RNA recognition motif domain containing protein 0.014 0.1937 0.3104
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0191 0.6421
Schistosoma mansoni sugar transporter 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0241 0.5383
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0106 0.0106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0298 0.8121
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.151 0.151
Plasmodium vivax hexose transporter 0.0111 0.151 0.2217
Schistosoma mansoni hypothetical protein 0.0036 0.0401 0.0403
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0106 0.3563
Onchocerca volvulus 0.0029 0.0298 0.0418
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0241 0.0338
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0377 0.0839
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.8555
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.0477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0789 0.0792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0789 0.0792
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.8555
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0241 0.8097
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0106 0.3563
Leishmania major glucose transporter, lmgt3 0.0034 0.0383 0.8555
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0106 0.0106
Schistosoma mansoni sugar transporter 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0111
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0174 0.5844
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0366 0.0366
Echinococcus multilocularis tar DNA binding protein 0.014 0.1937 0.1937
Loa Loa (eye worm) hypothetical protein 0.0021 0.0191 0.0306
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0298 1
Onchocerca volvulus 0.0028 0.0292 0.041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0119 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0401 0.0643
Echinococcus multilocularis solute carrier family 22 0.0016 0.0106 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.0538
Entamoeba histolytica protein kinase, putative 0.0034 0.0376 1
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0106 0.0149
Onchocerca volvulus 0.0016 0.0106 0.0149
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Onchocerca volvulus 0.0016 0.0106 0.0149
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0241 0.5383
Schistosoma mansoni protein kinase 0.0034 0.0376 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0191 0.0306
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0377 0.0553
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0077 0.0077
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0077 0.0124
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0346 0.0346
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0448 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.8555
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0106 0.3563
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0377 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.0477
Entamoeba histolytica hypothetical protein 0.0025 0.0241 0.6399
Schistosoma mansoni hypothetical protein 0.0111 0.151 0.1516
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0448 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Brugia malayi hypothetical protein 0.0016 0.0106 0.017
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0377 0.0553
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0106 0.0149
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0191 0.6421
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.4464 0.7154
Onchocerca volvulus 0.0101 0.1358 0.1907
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Plasmodium vivax sugar transporter, putative 0.0016 0.0106 0.0156
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0077 0.0077
Echinococcus granulosus lamin 0.0028 0.0292 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0376 0.0378
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Echinococcus granulosus General substrate transporter 0.0095 0.128 0.128
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0025 0.0241 0.0386
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0241 0.0536
Trypanosoma cruzi hexose transporter 0.0034 0.0383 0.8555
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Brugia malayi major facilitator superfamily protein 0.0016 0.0106 0.017
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0119 0.0191
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0179 0.2516 0.3695
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0298 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0174 0.5844
Onchocerca volvulus 0.0016 0.0106 0.0149
Brugia malayi Pre-SET motif family protein 0.0433 0.6241 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Schistosoma mansoni tar DNA-binding protein 0.014 0.1937 0.1945
Onchocerca volvulus 0.0016 0.0106 0.0149
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.151 0.3361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0298 1
Onchocerca volvulus 0.0016 0.0106 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0298 1
Loa Loa (eye worm) RNA binding protein 0.014 0.1937 0.3104
Onchocerca volvulus 0.0016 0.0106 0.0149
Schistosoma mansoni glucose transport protein 0.0111 0.151 0.1516
Schistosoma mansoni tar DNA-binding protein 0.014 0.1937 0.1945
Echinococcus granulosus microtubule associated protein 2 0.0685 0.996 0.996
Plasmodium vivax CDK-related protein kinase 6, putative 0.0471 0.6809 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0186 0.625
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.4464 0.7154
Plasmodium falciparum hexose transporter 0.0111 0.151 0.2217
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0298 0.0477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0119 0.0119
Brugia malayi hypothetical protein 0.0016 0.0106 0.017
Echinococcus granulosus solute carrier family 22 0.0016 0.0106 0.0106
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0241 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.2887 0.4054
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0377 0.0839
Brugia malayi intermediate filament protein 0.0028 0.0292 0.0468
Echinococcus multilocularis geminin 0.0205 0.2887 0.2887
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0149
Mycobacterium ulcerans hypothetical protein 0.0029 0.0298 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0241 0.0241
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0377 0.0839
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0106 0.0149
Schistosoma mansoni hypothetical protein 0.0205 0.2887 0.2898
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0106 0.2368
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Echinococcus multilocularis solute carrier family 22 0.0016 0.0106 0.0106
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0106 0.2368
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0049 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0644 0.1032
Brugia malayi Pre-SET motif family protein 0.0062 0.0789 0.1265
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0106 0.017
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0448 0.0657
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0448 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.151 0.212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0789 0.0789
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0448 1
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0383 0.0538
Onchocerca volvulus 0.0016 0.0106 0.0149
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0186 0.5076
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0366 0.9731
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0049 0.1661
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0106 0.0106
Trypanosoma brucei sugar transporter, putative 0.0016 0.0106 0.2368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0401 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Schistosoma mansoni tar DNA-binding protein 0.014 0.1937 0.1945
Plasmodium falciparum protein kinase 6 0.0471 0.6809 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0174 0.5844
Echinococcus granulosus solute carrier family 22 0.0016 0.0106 0.0106
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.3049 0.4282
Schistosoma mansoni glucose transporter 0.0016 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0106 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0383 0.0538
Schistosoma mansoni protein kinase 0.0034 0.0376 0.0378
Brugia malayi TAR-binding protein 0.014 0.1937 0.3104
Onchocerca volvulus Putative transporter 0.0016 0.0106 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0383 0.0538
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0241 0.0354
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0298 0.7903
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0119 0.0119
Loa Loa (eye worm) sugar transporter 0.0016 0.0106 0.017
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0241 0.6576
Onchocerca volvulus 0.0016 0.0106 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0346 0.0346
Toxoplasma gondii sugar transporter ST2 0.0016 0.0106 0.0236
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0106 0.2368
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0099 0.0158
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0191 0.0281
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0789 0.0789
Toxoplasma gondii sugar transporter ST3 0.0016 0.0106 0.0236
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0448 0.0657
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0062 0.0789 0.1265
Onchocerca volvulus 0.0016 0.0106 0.0149
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0377 0.0553
Onchocerca volvulus 0.0492 0.712 1
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0241 0.0386
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0106 0.5
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0298 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.8555
Onchocerca volvulus 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0149
Echinococcus granulosus lamin dm0 0.0028 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0241 0.5383
Trypanosoma brucei glucose transporter 2A 0.0034 0.0383 0.8555
Trypanosoma brucei glucose transporter 1E 0.0034 0.0383 0.8555
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0149
Echinococcus multilocularis lamin 0.0028 0.0292 0.0292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0119 0.0119
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0191 0.7396
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0191 0.0306
Toxoplasma gondii protein kinase, putative 0.0314 0.4491 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Schistosoma mansoni glucose transport protein 0.0111 0.151 0.1516
Echinococcus granulosus geminin 0.0205 0.2887 0.2887
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0298 0.7903
Echinococcus multilocularis tumor protein p63 0.0688 1 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0366 0.0515
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0292 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0292 0.0468
Brugia malayi Sugar transporter family protein 0.0016 0.0106 0.017
Plasmodium falciparum protein kinase 7 0.0314 0.4491 0.6596
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0241 0.0241
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0241 0.8097
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0298 0.0477
Loa Loa (eye worm) hypothetical protein 0.0033 0.0366 0.0587
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0241 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.0538
Trypanosoma brucei glucose transporter, putative 0.0034 0.0383 0.8555
Loa Loa (eye worm) hypothetical protein 0.0052 0.0644 0.1032
Echinococcus granulosus solute carrier family 22 0.0016 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Brugia malayi Cam kinase protein 1 0.0034 0.0376 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0149
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0241 0.5182
Brugia malayi Sugar transporter family protein 0.0016 0.0106 0.017
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0383 0.0538
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0298 0.7903
Toxoplasma gondii sugar transporter ST1 0.0016 0.0106 0.0236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0298 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0106 0.3563
Leishmania major glucose transporter, lmgt2 0.0034 0.0383 0.8555
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.151 0.151
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0298 0.6648
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1621 0.2597
Mycobacterium ulcerans sugar transporter 0.0016 0.0106 0.3563
Loa Loa (eye worm) hypothetical protein 0.0033 0.0366 0.0587
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.1937 0.3104
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0376 0.0603
Schistosoma mansoni hypothetical protein 0.0205 0.2887 0.2898
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0298 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0644 0.1032
Brugia malayi major facilitator superfamily protein 0.0016 0.0106 0.017
Echinococcus multilocularis solute carrier family 22 0.0016 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0292 0.0468
Schistosoma mansoni hypothetical protein 0.0017 0.0119 0.012
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0196 0.0275
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0366 0.0366
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0298 0.0477
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0123
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0106 0.017
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0366 0.0587
Plasmodium vivax SET domain protein, putative 0.0062 0.0789 0.1159
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0756 0.0756
Schistosoma mansoni protein kinase 0.0034 0.0376 0.0378
Echinococcus granulosus intermediate filament protein 0.0028 0.0292 0.0292
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0448 0.0997
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0119 0.0191
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0366 0.0368
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0106 0.2368
Echinococcus multilocularis General substrate transporter 0.0095 0.128 0.128
Onchocerca volvulus 0.0016 0.0106 0.0149
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0106 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0789 0.0792
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.996 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Brugia malayi RNA binding protein 0.014 0.1937 0.3104
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0298 0.6648
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0377 0.0553
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0186 0.625
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0377 0.0553
Echinococcus granulosus solute carrier family 22 0.0016 0.0106 0.0106
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0377 0.0553
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0298 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.6241 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0448 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Trichomonas vaginalis set domain proteins, putative 0.0492 0.712 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.1358 0.1364
Echinococcus granulosus GPCR family 2 0.0017 0.0119 0.0119
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0298 0.6648
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.3049 0.4282
Schistosoma mansoni intermediate filament proteins 0.0028 0.0292 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0383 0.8555
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0099 0.0158
Schistosoma mansoni lamin 0.0028 0.0292 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0106 0.3563
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0377 0.0553
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0376 0.0376
Brugia malayi hypothetical protein 0.0016 0.0106 0.017
Schistosoma mansoni lamin 0.0028 0.0292 0.0293
Loa Loa (eye worm) hypothetical protein 0.0034 0.0376 0.0603
Schistosoma mansoni sugar transporter 0.0016 0.0106 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0644 0.1032
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Echinococcus multilocularis solute carrier family 22 0.0016 0.0106 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2887 0.4054
Echinococcus multilocularis GPCR, family 2 0.0017 0.0119 0.0119
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0366 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Echinococcus multilocularis musashi 0.0028 0.0292 0.0292
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0383 0.8555
Schistosoma mansoni glucose transport protein 0.0111 0.151 0.1516
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0179 0.2516 0.5601
Schistosoma mansoni tar DNA-binding protein 0.014 0.1937 0.1945
Entamoeba histolytica protein kinase, putative 0.0034 0.0376 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0383 0.0538
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0376 0.0376
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Onchocerca volvulus 0.0016 0.0106 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0106 0.0236
Schistosoma mansoni sugar transporter 0.0016 0.0106 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0789 0.0792
Onchocerca volvulus 0.0028 0.0292 0.041
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.4464 0.627
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0106 0.2368
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0106 0.0149
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0383 0.8555
Leishmania major hypothetical protein, conserved 0.0016 0.0106 0.2368
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.996 0.996
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0106 0.017
Echinococcus multilocularis lamin dm0 0.0028 0.0292 0.0292
Schistosoma mansoni tar DNA-binding protein 0.014 0.1937 0.1945
Echinococcus granulosus tar DNA binding protein 0.014 0.1937 0.1937
Onchocerca volvulus 0.0062 0.0789 0.1108
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0191 0.0281
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0376 0.0603
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0366 0.0368
Loa Loa (eye worm) hypothetical protein 0.0101 0.1358 0.2176
Loa Loa (eye worm) hypothetical protein 0.0016 0.0106 0.017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5101 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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