Detailed information for compound 631244

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.303 | Formula: C18H13F3N2O3
  • H donors: 2 H acceptors: 3 LogP: 3.36 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(O)c2ccccc2n(c1=O)C)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C18H13F3N2O3/c1-23-13-8-3-2-7-12(13)15(24)14(17(23)26)16(25)22-11-6-4-5-10(9-11)18(19,20)21/h2-9,24H,1H3,(H,22,25)
  • InChiKey: KISFQVBUPVDCOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0032 0.0191 0.1852
Schistosoma mansoni bromodomain containing protein 0.0071 0.0823 0.0823
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0681 0.0675
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1191 0.1191
Schistosoma mansoni ap endonuclease 0.0042 0.0368 0.0348
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0681 0.0675
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.008 0.0047
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0226 0.0175
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0289 0.0567
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0032 0.0191 0.0138
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0368 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.033 0.0308
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0615 0.962 1
Brugia malayi PHD-finger family protein 0.0028 0.0131 0.0052
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0681 0.0675
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.1562 0.1554
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0179 0.0151
Brugia malayi Pre-SET motif family protein 0.0223 0.3286 0.3232
Brugia malayi Inositol-1 0.0038 0.0289 0.0212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0191 0.0751
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.1562 1
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.3575 0.3694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1191 0.1206
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0638 1 1
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0681 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.3286 0.3286
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.1562 0.1576
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0189 0.0297
Loa Loa (eye worm) hypothetical protein 0.0241 0.3575 0.3575
Schistosoma mansoni hypothetical protein 0.0035 0.0242 0.0217
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1562 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0198 0.012
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0189 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0681 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0506 0.0492
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0191 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0191 0.0118
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0647 0.0639
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.1562 0.1594
Brugia malayi phosphofructokinase 0.0116 0.1562 0.1495
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0368 0.1945
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0198 0.0171
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0529 0.0942
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0189 0.1826
Toxoplasma gondii exonuclease III APE 0.0042 0.0368 0.4794
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0189 0.3809
Brugia malayi 6-phosphofructokinase 0.0116 0.1562 0.1495
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0502 0.0426
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0368 0.1301
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0368 0.018
Entamoeba histolytica acyl-coA synthetase, putative 0.0032 0.0191 0.0751
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0189 0.1826
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.008 0.0047
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0189 0.1826
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0647 0.0572
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0681 0.0675
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0368 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Trichomonas vaginalis set domain proteins, putative 0.0254 0.3784 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.033 0.0308
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0368 0.0291
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0054 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0607 0.949 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0502 0.0426
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.008 0.0047
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0032 0.0191 0.0751
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0368 0.0368
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0242 0.0164
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0638 1 1
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0607 0.949 1
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0615 0.962 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0759 0.0755
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Brugia malayi mbt repeat family protein 0.0052 0.0529 0.0453
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1562 0.4003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.3162 0.3263
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0615 0.962 1
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.1562 0.1594
Brugia malayi Bromodomain containing protein 0.0084 0.1035 0.0963
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0191 0.0117
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0529 0.0516
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.1562 0.1475
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0032 0.0191 0.0112
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0032 0.0191 0.0751
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0759 0.0755
Loa Loa (eye worm) hypothetical protein 0.0051 0.0502 0.0502
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Echinococcus granulosus long chain fatty acid transport protein 4 0.0615 0.962 1
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.1562 0.1594
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1562 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0529 0.0516
Loa Loa (eye worm) T-complex protein 1 0.0025 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Brugia malayi hypothetical protein 0.0241 0.3575 0.3524
Plasmodium vivax acetyl-CoA synthetase, putative 0.0032 0.0191 0.3863
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.0223
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.1562 0.1398
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Leishmania major fatty acid transporter protein-like protein 0.0607 0.949 1
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0368 0.0779
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.1562 0.1594
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0647 0.0639
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.3575 0.3694
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0529 0.0516
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0191 0.0118
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0368 1
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0191 0.0118
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0368 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0191 0.0138
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0189 0.3809
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0191 0.0751
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0529 0.0516
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0088 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0191 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0191 0.0112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0198 0.1973
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1191 0.1206
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0032 0.0191 0.0138
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.3162 0.3263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0191 0.0191
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.1562 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0502 0.0502
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0032 0.0191 0.0163
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0189 0.3809
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0191 0.0138
Echinococcus granulosus geminin 0.0351 0.5347 0.5542
Schistosoma mansoni ap endonuclease 0.0042 0.0368 0.0348
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0368 0.0325
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0529 0.0529
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0032 0.0191 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1191 0.1206
Brugia malayi mbt repeat family protein 0.0052 0.0529 0.0453
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0289 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1562 0.4003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0032 0.0191 0.0117
Loa Loa (eye worm) MBCTL1 0.006 0.0647 0.0647
Loa Loa (eye worm) hypothetical protein 0.0035 0.0242 0.0242
Schistosoma mansoni inositol monophosphatase 0.0038 0.0289 0.0266
Brugia malayi 6-phosphofructokinase 0.0116 0.1562 0.1495
Loa Loa (eye worm) hypothetical protein 0.0045 0.0416 0.0416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0368 0.0302
Schistosoma mansoni survival motor neuron protein 0.0049 0.0475 0.046
Schistosoma mansoni hypothetical protein 0.0351 0.5347 0.5542
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0368 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0368 0.0348
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0226 0.0037
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0088 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0368 0.0779
Toxoplasma gondii propionate-CoA ligase 0.0032 0.0191 0.1852
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0032 0.0191 0.0138
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.1416
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0191 0.0138
Schistosoma mansoni acetyl-CoA synthetase 0.0032 0.0191 0.0163
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0032 0.0191 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1191 0.1206
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0647 0.0639
Onchocerca volvulus 0.0032 0.0198 0.002
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0088 0.0056
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0289 0.1416
Brugia malayi Bromodomain containing protein 0.0043 0.0372 0.0295
Plasmodium vivax SET domain protein, putative 0.0032 0.0198 0.4115
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0191 0.0751
Loa Loa (eye worm) hypothetical protein 0.0079 0.0958 0.0958
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Loa Loa (eye worm) hypothetical protein 0.006 0.0647 0.0647
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0032 0.0191 0.3863
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0529 0.0516
Schistosoma mansoni hypothetical protein 0.0351 0.5347 0.5542
Schistosoma mansoni hypothetical protein 0.0023 0.0054 0.002
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0529 0.0516
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.1562 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0506 0.0492
Echinococcus multilocularis geminin 0.0351 0.5347 0.5542
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0368 0.0306
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0506 0.0492
Loa Loa (eye worm) hypothetical protein 0.0043 0.0374 0.0374
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.1562 0.1562
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0191 0.0301
Loa Loa (eye worm) hypothetical protein 0.0048 0.0451 0.0451
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0032 0.0191 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0191 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1562 0.4003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0198 0.0171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0289 0.0567
Schistosoma mansoni hypothetical protein 0.0328 0.4976 0.5155
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0368 0.1945
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1191 0.112
Leishmania major 4-coumarate:coa ligase-like protein 0.0032 0.0191 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0681 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1191 0.1206
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0189 0.0297
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0475 0.0399
Leishmania major acetyl-CoA synthetase, putative 0.0032 0.0191 0.0118
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0289 0.0567
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0647 0.0639
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0681 0.0639
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0368 0.0302
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0289 0.0266
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0032 0.0191 0.0138
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0191 0.0117
Loa Loa (eye worm) phosphofructokinase 0.0116 0.1562 0.1562
Loa Loa (eye worm) hypothetical protein 0.0052 0.0529 0.0529
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0647 0.0639
Schistosoma mansoni hypothetical protein 0.0049 0.0475 0.046
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.022
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0529 0.0516
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0032 0.0191 0.0117
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0289 0.01
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0032 0.0191 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0681 0.05
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.1562 0.1592
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.1562 0.4003
Loa Loa (eye worm) oxidoreductase 0.0032 0.0191 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1191 0.1206
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0681 0.05
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.008 0.0047
Trichomonas vaginalis antibiotic synthetase, putative 0.0032 0.0191 0.0301
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0189 0.3809
Onchocerca volvulus 0.0052 0.0529 0.0942
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0032 0.0191 0.1852
Schistosoma mansoni inositol monophosphatase 0.0038 0.0289 0.0266
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.008 0.0047
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.1562 0.1562
Onchocerca volvulus 0.0049 0.0475 0.0792
Loa Loa (eye worm) inositol-1 0.0038 0.0289 0.0289
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0189 0.3809
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0289 0.3489
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0189 0.0741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1191 0.1206
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0032 0.0191 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0506 0.0492
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0198 0.0171
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0189 0.5
Onchocerca volvulus 0.0254 0.3784 1
Schistosoma mansoni FFA transport protein 0.0615 0.962 1
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0191 0.0112
Loa Loa (eye worm) hypothetical protein 0.0051 0.0506 0.0506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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