Detailed information for compound 649634

Basic information

Technical information
  • TDR Targets ID: 649634
  • Name: 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2- fluorophenyl)piperazine-1-carbothioamide
  • MW: 407.889 | Formula: C19H19ClFN3O2S
  • H donors: 1 H acceptors: 0 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)F)NC(=S)N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C19H19ClFN3O2S/c20-14-2-3-16(15(21)10-14)22-19(27)24-7-5-23(6-8-24)11-13-1-4-17-18(9-13)26-12-25-17/h1-4,9-10H,5-8,11-12H2,(H,22,27)
  • InChiKey: BRFIJKZVZUEUJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2-fluoro-phenyl)piperazine-1-carbothioamide
  • 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2-fluorophenyl)-1-piperazinecarbothioamide
  • STOCK2S-99257
  • Oprea1_754192

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1023 0.4899 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0045 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Mycobacterium leprae conserved hypothetical protein 0.0034 0.009 0.5
Toxoplasma gondii ABC1 family protein 0.0034 0.009 0.143
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Loa Loa (eye worm) helicase 0.0034 0.0089 0.0478
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0069 0.0367
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0089 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0165 0.0724 0.4001
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0205 0.1122
Echinococcus multilocularis zinc finger protein 0.0019 0.0018 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Echinococcus multilocularis lamin 0.0055 0.0194 0.0194
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.009 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.009 0.4248
Echinococcus granulosus Chromo domain 0.0034 0.0089 0.0089
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Brugia malayi Bromodomain containing protein 0.007 0.0264 0.1258
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 1
Trichomonas vaginalis chromobox protein, putative 0.0207 0.093 0.4253
Echinococcus multilocularis dnaJ subfamily B 0.0373 0.1737 0.1737
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0089 0.0035
Echinococcus multilocularis chromobox protein 1 0.0207 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1023 0.4899 1
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0205 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0488 0.2018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0056 0.0197 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0324 0.1186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0037 0.0105 0.0105
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1023 0.4899 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0366 0.2016
Brugia malayi CHD4 protein 0.0037 0.0105 0.0355
Onchocerca volvulus Huntingtin homolog 0.0248 0.1131 0.5356
Onchocerca volvulus 0.009 0.0361 0.1537
Loa Loa (eye worm) heterochromatin protein 1 0.0207 0.093 0.514
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0522
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0056 0.0196 0.0196
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0072 0.0072
Echinococcus granulosus geminin 0.0154 0.0675 0.0675
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.009 0.009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0032 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0142 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.009 0.4248
Echinococcus granulosus chromobox protein 1 0.0207 0.093 0.093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.004 0.0121 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0488 0.2018
Plasmodium vivax hypothetical protein, conserved 0.0034 0.009 0.0037
Brugia malayi Isocitrate dehydrogenase 0.003 0.0072 0.0171
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0205 0.1122
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0037 0.0105 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0084 0.0084
Plasmodium vivax SET domain protein, putative 0.0056 0.0197 0.0258
Echinococcus granulosus Chromobox protein 3 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0116 0.0488 0.2691
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0056 0.0196 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0135 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0194 0.0862
Brugia malayi Calcitonin receptor-like protein seb-1 0.0141 0.0612 0.3228
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0089 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.009 0.0037
Echinococcus granulosus zinc finger protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0387 0.1807 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Onchocerca volvulus 0.0055 0.0194 0.0707
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Echinococcus multilocularis microtubule associated protein 2 0.2072 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.009 0.0037
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0052 0.0272
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.0779 0.4178
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0072 0.0072
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0069 0.0152
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.009 0.0037
Brugia malayi Bromodomain containing protein 0.0035 0.0094 0.0295
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0114 0.0618
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Echinococcus granulosus GPCR family 2 0.0045 0.0142 0.0142
Echinococcus multilocularis Chromo domain 0.0034 0.0089 0.0089
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0089 0.1349
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0135 0.0135
Brugia malayi hypothetical protein 0.0248 0.1131 0.617
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.009 0.0037
Trypanosoma brucei glucosidase, putative 0.0039 0.0114 1
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Brugia malayi beta-lactamase 0.0034 0.009 0.0272
Brugia malayi N-terminal motif family protein 0.0165 0.0724 0.3867
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0135 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0104 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.009 0.0272
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0016 0.0073
Echinococcus granulosus intermediate filament protein 0.0055 0.0194 0.0194
Trichomonas vaginalis chromobox protein, putative 0.0207 0.093 0.4253
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0531 0.2379
Brugia malayi hypothetical protein 0.0034 0.0089 0.0266
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0089 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0135 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Echinococcus granulosus chromobox protein 2 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0248 0.1131 0.6253
Brugia malayi Pre-SET motif family protein 0.0056 0.0197 0.0877
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.3366
Onchocerca volvulus 0.0034 0.0089 0.0185
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0114 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0324 0.1186
Schistosoma mansoni alpha glucosidase 0.0039 0.0114 0.0114
Echinococcus multilocularis tumor protein p63 0.033 0.1531 0.1531
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.009 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0272 0.1495
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0097 0.0394 0.1995
Echinococcus multilocularis chromobox protein 1 0.0207 0.093 0.093
Onchocerca volvulus 0.0102 0.0419 0.1823
Schistosoma mansoni hypothetical protein 0.0154 0.0675 0.0675
Schistosoma mansoni chromobox protein 0.0034 0.0089 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0288
Schistosoma mansoni cpg binding protein 0.0026 0.0052 0.0052
Trichomonas vaginalis esterase, putative 0.0034 0.009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.009 0.4248
Brugia malayi Pre-SET motif family protein 0.0387 0.1807 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0141 0.0612 0.3375
Onchocerca volvulus 0.0034 0.009 0.019
Schistosoma mansoni intermediate filament proteins 0.0055 0.0194 0.0194
Schistosoma mansoni lamin 0.0055 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0142 0.0565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0272 0.0272
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni chromobox protein 0.0207 0.093 0.093
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0531 0.2235
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0127
Echinococcus multilocularis cpg binding protein 0.0029 0.0067 0.0067
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Leishmania major hypothetical protein, conserved 0.0034 0.009 0.4248
Brugia malayi TAR-binding protein 0.0058 0.0205 0.0924
Brugia malayi intermediate filament protein 0.0055 0.0194 0.0862
Schistosoma mansoni lamin 0.0055 0.0194 0.0194
Echinococcus multilocularis GPCR, family 2 0.0045 0.0142 0.0142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.009 0.009
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0154 0.0675 0.0675
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0105 0.0105
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.009 0.0037
Brugia malayi beta-lactamase family protein 0.0034 0.009 0.0272
Brugia malayi RNA binding protein 0.0058 0.0205 0.0924
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0056 0.0197 0.0197
Echinococcus granulosus tumor protein p63 0.033 0.1531 0.1531
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0509
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0135 0.0525
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.009 0.009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0194 0.1061
Onchocerca volvulus 0.0091 0.0366 0.1562
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0186 0.913
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Schistosoma mansoni chromobox protein 0.0207 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0141 0.0612 0.3375
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0771
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Echinococcus granulosus chromobox protein 1 0.0207 0.093 0.093
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0361 0.0361
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1023 0.4899 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0089 0.0035
Brugia malayi SET domain containing protein 0.0036 0.0102 0.0338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Loa Loa (eye worm) CHromoDomain protein family member 0.0037 0.0105 0.0566
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.0779 0.4305
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0869
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0135 0.0135
Onchocerca volvulus 0.044 0.2066 1
Onchocerca volvulus 0.0034 0.009 0.019
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Brugia malayi chromobox protein homolog 3 0.0116 0.0488 0.2528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Schistosoma mansoni alpha-glucosidase 0.0151 0.066 0.066
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0089 0.0266
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0084 0.0084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0097 0.0394 0.217
Loa Loa (eye worm) hypothetical protein 0.0064 0.0238 0.1303
Loa Loa (eye worm) hypothetical protein 0.0054 0.0189 0.1034
Schistosoma mansoni alpha-glucosidase 0.0151 0.066 0.066
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0165 0.0724 0.3339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0197 0.0197
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0184 0.0184
Onchocerca volvulus Huntingtin homolog 0.0248 0.1131 0.5356
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0141 0.0612 0.3228
Echinococcus granulosus cpg binding protein 0.0029 0.0067 0.0067
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0089 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0142 0.0771
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0089 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Loa Loa (eye worm) RNA binding protein 0.0058 0.0205 0.1122
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 1
Onchocerca volvulus 0.0048 0.016 0.0535
Loa Loa (eye worm) hypothetical protein 0.0055 0.0194 0.1061
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1023 0.4899 1
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Brugia malayi Protein cec-1. 0.0034 0.0089 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0373 0.1737 0.1737
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1023 0.4899 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0045 0.0142 0.0142
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0116 0.0488 0.2166
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Brugia malayi CXXC zinc finger family protein 0.0026 0.0052 0.0055
Echinococcus granulosus lamin dm0 0.0055 0.0194 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Brugia malayi beta-lactamase family protein 0.0034 0.009 0.0272
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.009 0.0484
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0089 0.1349
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0089 0.0266
Trichomonas vaginalis set domain proteins, putative 0.044 0.2066 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0218 0.0982 0.1886
Schistosoma mansoni microtubule-associated protein tau 0.2072 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0204 0.0204
Echinococcus granulosus lamin 0.0055 0.0194 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0248 0.1131 0.6253
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0522
Mycobacterium leprae Probable lipase LipE 0.0034 0.009 0.5
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0142 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Onchocerca volvulus 0.0034 0.0089 0.0185
Onchocerca volvulus 0.0034 0.009 0.019
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0205 0.0205
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0118 0.0146
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0072 0.0385
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0531 0.2235
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0194 0.1061
Echinococcus multilocularis musashi 0.0055 0.0194 0.0194
Echinococcus multilocularis lamin dm0 0.0055 0.0194 0.0194
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.016 0.016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0104 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0089 0.0266
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0089 0.0089
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1023 0.4899 1
Echinococcus granulosus dnaJ subfamily B 0.0373 0.1737 0.1737
Schistosoma mansoni hypothetical protein 0.0097 0.0394 0.0394
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0089 0.1349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0102 0.0068
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1023 0.4899 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0114 0.0408
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Onchocerca volvulus 0.0055 0.0194 0.0707
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0114 1
Schistosoma mansoni bromodomain containing protein 0.0059 0.0212 0.0212
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.009 0.009
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0032 0.0032
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0089 0.0266
Schistosoma mansoni chromobox protein 0.0034 0.0089 0.0089
Echinococcus multilocularis geminin 0.0154 0.0675 0.0675
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0567
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0118 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.0089 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Brugia malayi Heterochromatin protein 1 0.0207 0.093 0.5032
Echinococcus granulosus tar DNA binding protein 0.0058 0.0205 0.0205
Loa Loa (eye worm) beta-lactamase 0.0034 0.009 0.0484
Echinococcus multilocularis chromobox protein 2 0.0034 0.0089 0.0089
Brugia malayi isocitrate dehydrogenase 0.003 0.0072 0.0171

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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