Detailed information for compound 649634

Basic information

Technical information
  • TDR Targets ID: 649634
  • Name: 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2- fluorophenyl)piperazine-1-carbothioamide
  • MW: 407.889 | Formula: C19H19ClFN3O2S
  • H donors: 1 H acceptors: 0 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)F)NC(=S)N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C19H19ClFN3O2S/c20-14-2-3-16(15(21)10-14)22-19(27)24-7-5-23(6-8-24)11-13-1-4-17-18(9-13)26-12-25-17/h1-4,9-10H,5-8,11-12H2,(H,22,27)
  • InChiKey: BRFIJKZVZUEUJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2-fluoro-phenyl)piperazine-1-carbothioamide
  • 4-(1,3-benzodioxol-5-ylmethyl)-N-(4-chloro-2-fluorophenyl)-1-piperazinecarbothioamide
  • STOCK2S-99257
  • Oprea1_754192

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis esterase, putative 0.0034 0.009 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0142 0.0771
Onchocerca volvulus 0.0034 0.009 0.019
Echinococcus granulosus tumor protein p63 0.033 0.1531 0.1531
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0142 0.0142
Mycobacterium leprae Probable lipase LipE 0.0034 0.009 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.0488 0.2691
Echinococcus granulosus lamin dm0 0.0055 0.0194 0.0194
Brugia malayi CXXC zinc finger family protein 0.0026 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Echinococcus granulosus dnaJ subfamily B 0.0373 0.1737 0.1737
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0034 0.0089 0.1349
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.026
Trichomonas vaginalis chromobox protein, putative 0.0207 0.093 0.4253
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.009 0.0005
Onchocerca volvulus Huntingtin homolog 0.0248 0.1131 0.5356
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Onchocerca volvulus 0.0091 0.0366 0.1562
Brugia malayi Associated with TFs and helicases family protein 0.0034 0.0089 0.0266
Onchocerca volvulus 0.0055 0.0194 0.0707
Trichomonas vaginalis set domain proteins, putative 0.044 0.2066 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0102 0.0068
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0114 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0089 0.0035
Schistosoma mansoni lamin 0.0055 0.0194 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0135 0.0525
Echinococcus granulosus intermediate filament protein 0.0055 0.0194 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Brugia malayi RNA binding protein 0.0058 0.0205 0.0924
Loa Loa (eye worm) hypothetical protein 0.0055 0.0194 0.1061
Leishmania major hypothetical protein, conserved 0.0034 0.009 0.4248
Brugia malayi intermediate filament protein 0.0055 0.0194 0.0862
Mycobacterium leprae conserved hypothetical protein 0.0034 0.009 0.5
Echinococcus granulosus cpg binding protein 0.0029 0.0067 0.0067
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0037 0.0105 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.016 0.0869
Loa Loa (eye worm) hypothetical protein 0.0248 0.1131 0.6253
Echinococcus granulosus chromobox protein 2 0.0034 0.0089 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0488 0.2018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0054 0.0189 0.1034
Onchocerca volvulus 0.0055 0.0194 0.0707
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1023 0.4899 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.009 0.0037
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0373 0.1737 0.1737
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1023 0.4899 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0361 0.0361
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Onchocerca volvulus 0.0102 0.0419 0.1823
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.009 0.0037
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0114 0.0127
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.3366
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0531 0.2235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0509
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.0779 0.4305
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0034 0.0089 0.0035
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0034 0.0089 0.0266
Onchocerca volvulus 0.0034 0.0089 0.0185
Onchocerca volvulus 0.0034 0.0089 0.0185
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.009 0.0272
Onchocerca volvulus Huntingtin homolog 0.0248 0.1131 0.5356
Brugia malayi Bromodomain containing protein 0.007 0.0264 0.1258
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0072 0.0385
Loa Loa (eye worm) hypothetical protein 0.0141 0.0612 0.3375
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0194 0.1061
Echinococcus multilocularis Chromo domain 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0091 0.0366 0.2016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0116 0.0488 0.2166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0089 0.1349
Schistosoma mansoni hypothetical protein 0.0154 0.0675 0.0675
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1023 0.4899 1
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.009 0.009
Echinococcus multilocularis chromobox protein 2 0.0034 0.0089 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0142 0.0565
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.009 0.0037
Echinococcus multilocularis chromobox protein 1 0.0207 0.093 0.093
Echinococcus multilocularis geminin 0.0154 0.0675 0.0675
Brugia malayi hypothetical protein 0.0034 0.0089 0.0266
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Schistosoma mansoni chromobox protein 0.0207 0.093 0.093
Schistosoma mansoni lamin 0.0055 0.0194 0.0194
Trichomonas vaginalis chromobox protein, putative 0.0125 0.0531 0.2235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0141 0.0612 0.3375
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Loa Loa (eye worm) CHromoDomain protein family member 0.0037 0.0105 0.0566
Loa Loa (eye worm) hypothetical protein 0.0072 0.0272 0.1495
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.009 0.0037
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0069 0.0152
Loa Loa (eye worm) RNA binding protein 0.0058 0.0205 0.1122
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0218 0.0982 0.1886
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Echinococcus granulosus zinc finger protein 0.0019 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.009 0.4248
Echinococcus granulosus chromobox protein 1 0.0207 0.093 0.093
Chlamydia trachomatis oxoacyl-ACP synthase III 0.1023 0.4899 0.5
Brugia malayi hypothetical protein 0.0248 0.1131 0.617
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.009 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0197 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0032 0.0032
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.009 0.009
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0055 0.0055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Brugia malayi beta-lactamase 0.0034 0.009 0.0272
Loa Loa (eye worm) helicase 0.0034 0.0089 0.0478
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1023 0.4899 1
Loa Loa (eye worm) heterochromatin protein 1 0.0207 0.093 0.514
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.009 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0135 0.0135
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0205 0.0205
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Brugia malayi Heterochromatin protein 1 0.0207 0.093 0.5032
Brugia malayi Pre-SET motif family protein 0.0387 0.1807 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0248 0.1131 0.6253
Echinococcus multilocularis Chromobox protein 3 0.0034 0.0089 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.2072 1 1
Brugia malayi TAR-binding protein 0.0058 0.0205 0.0924
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0204 0.0204
Onchocerca volvulus 0.009 0.0361 0.1537
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0324 0.1186
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0089 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0194 0.1061
Brugia malayi Isocitrate dehydrogenase 0.003 0.0072 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0114 0.0114
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0205 0.0924
Echinococcus multilocularis lamin dm0 0.0055 0.0194 0.0194
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0387 0.1807 1
Brugia malayi SET domain containing protein 0.0036 0.0102 0.0338
Echinococcus granulosus GPCR family 2 0.0045 0.0142 0.0142
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0056 0.0197 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1023 0.4899 1
Brugia malayi chromobox protein homolog 3 0.0116 0.0488 0.2528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0045 0.0142 0.0771
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0089 0.0035
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Schistosoma mansoni cpg binding protein 0.0026 0.0052 0.0052
Schistosoma mansoni alpha-glucosidase 0.0151 0.066 0.066
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0034 0.0089 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.009 0.4248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0272 0.0272
Brugia malayi N-terminal motif family protein 0.0165 0.0724 0.3867
Echinococcus multilocularis dnaJ subfamily B 0.0373 0.1737 0.1737
Schistosoma mansoni chromobox protein 0.0034 0.0089 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0207 0.093 0.4253
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0052 0.0272
Loa Loa (eye worm) hypothetical protein 0.0064 0.0238 0.1303
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0522
Brugia malayi Protein cec-1. 0.0034 0.0089 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0135 0.0135
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0205 0.0205
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0205 0.1122
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.016 0.016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0205 0.1122
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.026
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Echinococcus granulosus tar DNA binding protein 0.0058 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0135 0.0135
Loa Loa (eye worm) beta-lactamase 0.0034 0.009 0.0484
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0288
Schistosoma mansoni chromobox protein 0.0034 0.0089 0.0089
Plasmodium falciparum heterochromatin protein 1 0.0034 0.0089 0.0035
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0056 0.0196 0.0196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0104 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0141 0.0612 0.3228
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0186 0.913
Echinococcus multilocularis chromobox protein 1 0.0207 0.093 0.093
Schistosoma mansoni bromodomain containing protein 0.0059 0.0212 0.0212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0034 0.0089 0.0089
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0055 0.0055
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0165 0.0724 0.3339
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.009 0.0005
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0037 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0324 0.1186
Loa Loa (eye worm) hypothetical protein 0.004 0.0121 0.0654
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0114 0.0408
Echinococcus granulosus Chromo domain 0.0034 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0142 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0135 0.0135
Brugia malayi beta-lactamase family protein 0.0034 0.009 0.0272
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0105 0.0105
Brugia malayi Pre-SET motif family protein 0.0056 0.0197 0.0877
Brugia malayi CHD4 protein 0.0037 0.0105 0.0355
Echinococcus multilocularis musashi 0.0055 0.0194 0.0194
Entamoeba histolytica fatty acid elongase, putative 0.0133 0.057 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0034 0.0089 0.0089
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.009 0.0037
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0531 0.2379
Brugia malayi isocitrate dehydrogenase 0.003 0.0072 0.0171
Echinococcus granulosus chromobox protein 1 0.0207 0.093 0.093
Onchocerca volvulus 0.0034 0.009 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0488 0.2018
Echinococcus multilocularis tumor protein p63 0.033 0.1531 0.1531
Echinococcus multilocularis lamin 0.0055 0.0194 0.0194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0045 0.0142 0.0142
Onchocerca volvulus 0.0048 0.016 0.0535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Echinococcus granulosus geminin 0.0154 0.0675 0.0675
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0114 1
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0045 0.0142 0.0142
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0034 0.0089 0.1349
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.009 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0272 0.0272
Echinococcus multilocularis microtubule associated protein 2 0.2072 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0016 0.0073
Schistosoma mansoni hypothetical protein 0.0097 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Schistosoma mansoni chromobox protein 0.0207 0.093 0.093
Echinococcus multilocularis cpg binding protein 0.0029 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0567
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0072 0.0072
Schistosoma mansoni alpha-glucosidase 0.0151 0.066 0.066
Brugia malayi Valyl-tRNA synthetase 0.0034 0.0089 0.0266
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.009 0.009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0056 0.0196 0.0196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0118 0.0146
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0272 0.0272
Plasmodium vivax hypothetical protein, conserved 0.0034 0.009 0.0037
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0104 0.0078
Onchocerca volvulus 0.044 0.2066 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0084 0.0084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0084 0.0084
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0194 0.0862
Echinococcus multilocularis zinc finger protein 0.0019 0.0018 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0118 0.0146
Schistosoma mansoni intermediate filament proteins 0.0055 0.0194 0.0194
Echinococcus multilocularis GPCR, family 2 0.0045 0.0142 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0184 0.0184
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0118 0.0146
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0114 0.0618
Mycobacterium tuberculosis Conserved protein 0.0034 0.009 0.0037
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0478
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0034 0.0089 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0154 0.0675 0.0675
Plasmodium vivax SET domain protein, putative 0.0056 0.0197 0.0258
Plasmodium vivax heterochromatin protein 1, putative 0.0034 0.0089 0.0035
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.0779 0.0779
Echinococcus granulosus Chromobox protein 3 0.0034 0.0089 0.0089
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0069 0.0367
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0045 0.0142 0.0142
Trypanosoma brucei glucosidase, putative 0.0039 0.0114 1
Brugia malayi beta-lactamase family protein 0.0034 0.009 0.0272
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0114 0.0522
Brugia malayi M-phase phosphoprotein, mpp8 0.0034 0.0089 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0097 0.0394 0.1995
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.009 0.4248
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0142 0.0565
Schistosoma mansoni alpha glucosidase 0.0039 0.0114 0.0114
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.0779 0.4178
Loa Loa (eye worm) hypothetical protein 0.0165 0.0724 0.4001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0135 0.0732
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0114 0.0127
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0032 0.0032
Brugia malayi Bromodomain containing protein 0.0035 0.0094 0.0295
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0127
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0056 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0097 0.0394 0.217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0135 0.0135
Onchocerca volvulus 0.0034 0.009 0.019
Toxoplasma gondii ABC1 family protein 0.0034 0.009 0.143
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1023 0.4899 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1023 0.4899 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0114 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0141 0.0612 0.3228
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.009 0.0037
Echinococcus granulosus lamin 0.0055 0.0194 0.0194

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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