Detailed information for compound 650503

Basic information

Technical information
  • TDR Targets ID: 650503
  • Name: 2-(4-methylphenyl)-3-phenyl-1,2-dihydroquinaz olin-4-one
  • MW: 314.38 | Formula: C21H18N2O
  • H donors: 1 H acceptors: 1 LogP: 4.69 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1Nc2ccccc2C(=O)N1c1ccccc1
  • InChi: 1S/C21H18N2O/c1-15-11-13-16(14-12-15)20-22-19-10-6-5-9-18(19)21(24)23(20)17-7-3-2-4-8-17/h2-14,20,22H,1H3
  • InChiKey: DOJJWBNXBPCRIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6145-05-7
  • CBMicro_005808
  • BIM-0005897.P001
  • STK168669
  • Oprea1_360435
  • EU-0007834

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SET domain containing protein 0.0016 0.0003 0.0033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0022 0.0311
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0058 0.055
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0034 0.003 0.1063
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0004 0.0041
Brugia malayi TAR-binding protein 0.0128 0.0168 0.159
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0043 0.0609
Trichomonas vaginalis helicase, putative 0.0019 0.0009 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.005 0.0282
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0085 0.115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0113 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0002 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Brugia malayi hypothetical protein 0.0015 0.0002 0.0022
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.02 0.1892
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0115 0.0149 0.7511
Echinococcus granulosus survival motor neuron protein 1 0.0734 0.1059 0.5971
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0022 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0022 0.0311
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0026 0.0308
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0033 0.1527
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0026 0.0308
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0033
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0115 0.0149 0.211
Toxoplasma gondii exonuclease III APE 0.004 0.004 0.1647
Brugia malayi MAP kinase sur-1 0.0053 0.0058 0.0545
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0003 0.002
Entamoeba histolytica hypothetical protein 0.0179 0.0243 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0067 0.0067
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0148 0.0198 0.1865
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.004 0.0223
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0011 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0085 0.1526
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0067 0.0378
Plasmodium vivax vivapain-2 0.0016 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0123 0.0161 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0058 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0004 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0022 0.0124
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0085 0.0925
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0077 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0022 0.0208
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0022
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0033 0.041
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0002 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0074 0.0074
Brugia malayi chromobox protein homolog 3 0.004 0.0039 0.0365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0003 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0004 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0201 0.1894
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0151 0.1425
Loa Loa (eye worm) hypothetical protein 0.0153 0.0206 0.1944
Mycobacterium ulcerans lipase LipD 0.0071 0.0085 0.1526
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0018 0.0747
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Echinococcus multilocularis musashi 0.0053 0.0058 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0113 0.0637
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0033 0.1207
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0168 0.0168
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0022 0.0208
Brugia malayi Pre-SET motif family protein 0.0064 0.0074 0.0702
Brugia malayi beta-lactamase family protein 0.0071 0.0085 0.0803
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0077 0.0727
Loa Loa (eye worm) Csnk2b protein 0.0115 0.0149 0.1409
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0115 0.0149 0.6064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.0326 0.3073
Schistosoma mansoni hypothetical protein 0.0172 0.0233 0.0233
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0085 0.0925
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.004 0.0192
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0004 0.0024
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0168 0.0168
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0022 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0022
Echinococcus multilocularis chromobox protein 1 0.0071 0.0084 0.0084
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.0644 0.0644
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0022 0.0208
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0058 0.2795
Onchocerca volvulus 0.0016 0.0004 0.006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0734 0.1059 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0067 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0113 0.0113
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.005 0.0472
Toxoplasma gondii ck2 beta subunit 0.0115 0.0149 0.6663
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0085 0.0085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0022 0.0124
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.1856
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0022 0.0124
Mycobacterium tuberculosis Conserved protein 0.0071 0.0085 0.0925
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.0644 0.3627
Brugia malayi beta-lactamase 0.0071 0.0085 0.0803
Onchocerca volvulus 0.0016 0.0004 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0033
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.004 1
Onchocerca volvulus 0.0086 0.0106 0.1503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0022 0.0208
Echinococcus granulosus tar DNA binding protein 0.0128 0.0168 0.0949
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0004 0.006
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0084 0.1139
Trichomonas vaginalis set domain proteins, putative 0.0495 0.0707 1
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0115 0.0149 0.7511
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0018 0.0747
Brugia malayi intermediate filament protein 0.0053 0.0058 0.055
Trypanosoma brucei protein kinase, putative 0.0053 0.0058 0.2795
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0076 0.0429
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0058 0.0545
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0034 0.003 0.0362
Schistosoma mansoni intermediate filament proteins 0.0053 0.0058 0.0058
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0085 0.048
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0058 0.2795
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0023 0.0128
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0079 0.0743
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0058 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0022 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0058 0.076
Brugia malayi ecdysteroid receptor 0.0028 0.0022 0.0208
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0148 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0121 0.1143
Mycobacterium tuberculosis Conserved protein 0.0071 0.0085 0.0925
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0003 0.0003
Echinococcus granulosus cpg binding protein 0.0091 0.0113 0.064
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Echinococcus granulosus dnaJ subfamily B 0.122 0.1774 1
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.3504
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0033 0.1527
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0004 0.0041
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0004 0.004
Entamoeba histolytica casein kinase, putative 0.0148 0.0198 0.8085
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0085 0.0925
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0085 0.4205
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0022 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0085 0.115
Trypanosoma cruzi casein kinase II, putative 0.0148 0.0198 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.0161 0.2278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Echinococcus granulosus phd:f box containing protein 0.0016 0.0003 0.002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Brugia malayi nuclear receptor NHR-88 0.0028 0.0022 0.0208
Onchocerca volvulus 0.0071 0.0085 0.1203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0033 0.041
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0004 0.004
Echinococcus granulosus cathepsin l1 0.0016 0.0004 0.0024
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0058 0.2795
Brugia malayi steroid hormone receptor 0.0028 0.0022 0.0208
Echinococcus multilocularis cpg binding protein 0.0091 0.0113 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Brugia malayi Csnk2b protein 0.0115 0.0149 0.1409
Giardia lamblia Casein kinase II beta chain 0.0115 0.0149 0.7122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0106 0.1003
Loa Loa (eye worm) hypothetical protein 0.0047 0.005 0.0472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0113 0.1068
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Toxoplasma gondii histone lysine methyltransferase SET1 0.0165 0.0222 1
Plasmodium falciparum casein kinase 2, alpha subunit 0.0148 0.0198 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0085 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.3504
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0003 0.0003
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0022 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0076 0.1263
Schistosoma mansoni hypothetical protein 0.015 0.02 0.02
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0076 0.3744
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0022 0.0022
Echinococcus multilocularis muscleblind protein 0.015 0.0201 0.0201
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.004 0.1474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.004
Schistosoma mansoni hypothetical protein 0.122 0.1774 0.1774
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0043 0.0552
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0018 0.0662
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0022 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Echinococcus multilocularis muscleblind protein 1 0.015 0.0201 0.0201
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0085 0.0803
Entamoeba histolytica hypothetical protein 0.0179 0.0243 1
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0022 0.0208
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0041
Mycobacterium ulcerans glutaminase 0.0268 0.0374 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.0148 0.0198 0.0198
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0022 0.0022
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.015 0.0201 0.1895
Brugia malayi hypothetical protein 0.0096 0.0121 0.1143
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0201 0.1894
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0015 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0022 0.0208
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0002 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Plasmodium vivax casein kinase II beta chain, putative 0.0115 0.0149 0.7511
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0015 0.0015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0004 0.004
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0043 0.0552
Echinococcus granulosus muscleblind protein 0.015 0.0201 0.1132
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0085 0.4205
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0085 0.115
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.3504
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0004 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.0619 0.5847
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0747
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.004 0.0188
Schistosoma mansoni eyes absent homolog 0.0096 0.0121 0.0121
Loa Loa (eye worm) RNA binding protein 0.0128 0.0168 0.159
Echinococcus granulosus casein kinase ii subunit alpha 0.0148 0.0198 0.1114
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0079 0.0079
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0131 0.1236
Brugia malayi beta-lactamase family protein 0.0071 0.0085 0.0803
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0085 0.0925
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0179 0.0243 0.1372
Brugia malayi hypothetical protein 0.0179 0.0243 0.2297
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0085 0.0925
Trypanosoma brucei Casein kinase II 0.0148 0.0198 1
Leishmania major hypothetical protein, conserved 0.0026 0.0018 0.0747
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0085 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0011 0.009
Brugia malayi RNA binding protein 0.0128 0.0168 0.159
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0071 0.3504
Echinococcus multilocularis lamin 0.0053 0.0058 0.0058
Brugia malayi Casein kinase II, alpha chain 0.0148 0.0198 0.1865
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0004 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.1008 0.1008
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0002 0.0002
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0003 0.002
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0022 0.0209
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0074 0.0419
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0058 0.2479
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0022 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0074 0.0074
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0085 0.1526
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Echinococcus multilocularis cysteine protease 0.0016 0.0004 0.0004
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0034 0.003 0.1063
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0079 0.0079
Schistosoma mansoni inositol monophosphatase 0.0036 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0085 0.0925
Brugia malayi Heterochromatin protein 1 0.0071 0.0084 0.0796
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0074 0.0701
Schistosoma mansoni hypothetical protein 0.0179 0.0243 0.0243
Schistosoma mansoni cpg binding protein 0.0086 0.0106 0.0106
Schistosoma mansoni glutaminase 0.0268 0.0374 0.0374
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0033
Brugia malayi nuclear hormone receptor 0.0028 0.0022 0.0208
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0033 0.1355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0113 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0022 0.0247
Loa Loa (eye worm) hypothetical protein 0.0102 0.0131 0.1236
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0022 0.0208
Onchocerca volvulus 0.0076 0.0091 0.1292
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0005 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0022 0.0208
Loa Loa (eye worm) hypothetical protein 0.0052 0.0057 0.0536
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0168 0.0168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.004 0.0373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0022 0.0208
Schistosoma mansoni inositol monophosphatase 0.0036 0.0033 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0074 0.3239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0022
Brugia malayi nuclear receptor RXR 0.0015 0.0002 0.0022
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0058 0.167
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Onchocerca volvulus 0.0016 0.0004 0.006
Echinococcus granulosus lamin 0.0053 0.0058 0.0328
Trichomonas vaginalis glutaminase, putative 0.0268 0.0374 0.5256
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Echinococcus granulosus chromobox protein 1 0.0071 0.0084 0.0475
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0022 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0022 0.0208
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0058 0.0058
Schistosoma mansoni chromobox protein 0.0071 0.0084 0.0084
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0076 0.3321
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0005 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Mycobacterium tuberculosis Conserved protein 0.0071 0.0085 0.0925
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.0198 0.8085
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0115 0.0149 0.211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0002 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.005 0.0282
Schistosoma mansoni lamin 0.0053 0.0058 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0168 0.159
Loa Loa (eye worm) glutaminase 2 0.0268 0.0374 0.3529
Echinococcus multilocularis geminin 0.0172 0.0233 0.0233
Onchocerca volvulus Huntingtin homolog 0.0123 0.0161 0.2278
Plasmodium vivax unspecified product 0.0148 0.0198 1
Schistosoma mansoni cpg binding protein 0.0091 0.0113 0.0113
Schistosoma mansoni ap endonuclease 0.004 0.004 0.004
Brugia malayi Pre-SET motif family protein 0.0435 0.0619 0.5847
Onchocerca volvulus 0.0071 0.0085 0.1203
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0501
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0079 0.3874
Loa Loa (eye worm) hypothetical protein 0.0096 0.0121 0.1143
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0003 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0022 0.0124
Echinococcus granulosus neuropeptide s receptor 0.0451 0.0644 0.3627
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0015 0.0084
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0022 0.0022
Plasmodium falciparum casein kinase II beta chain 0.0115 0.0149 0.7511
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Mycobacterium ulcerans beta-lactamase 0.0071 0.0085 0.1526
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0058 0.0325
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0113 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0747
Brugia malayi jmjC domain containing protein 0.0059 0.0067 0.0634
Leishmania major cathepsin L-like protease 0.0062 0.0071 0.3504
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0033 0.1527
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0058 0.2795
Echinococcus granulosus intermediate filament protein 0.0053 0.0058 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0039 0.0489
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0022 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0076 0.1263
Brugia malayi MH2 domain containing protein 0.0116 0.0151 0.1425
Leishmania major casein kinase II, putative 0.0148 0.0198 1
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0201 0.1894
Onchocerca volvulus 0.0016 0.0004 0.006
Giardia lamblia Kinase, CMGC CK2 0.0148 0.0198 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.1856
Echinococcus multilocularis dnaJ subfamily B 0.122 0.1774 0.1774
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0003 0.002
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0058 0.0058
Loa Loa (eye worm) inositol-1 0.0036 0.0033 0.0313
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0068 0.0385
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0085 0.0925
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0022 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0156
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0058 0.0325
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0033 0.041
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0115 0.0149 0.6663
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Brugia malayi CXXC zinc finger family protein 0.0086 0.0106 0.1003
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0077 0.3791
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0076 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Brugia malayi Muscleblind-like protein 0.015 0.0201 0.1895
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0079 0.3874
Loa Loa (eye worm) casein kinase II 0.0034 0.003 0.028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0079 0.3112
Loa Loa (eye worm) cysteine protease 0.0016 0.0004 0.004
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0003 0.0003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0079 0.0743
Echinococcus granulosus geminin 0.0172 0.0233 0.1315
Onchocerca volvulus 0.0071 0.0085 0.1203
Echinococcus multilocularis casein kinase ii subunit beta 0.0115 0.0149 0.0149
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0018 0.0747
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.1856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.005 0.005
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0168 0.0168
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0037 0.021
Entamoeba histolytica hypothetical protein 0.0179 0.0243 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0026 0.0308
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0076 0.1263
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0022 0.0208
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Onchocerca volvulus 0.0053 0.0058 0.0823
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0077 0.0077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.065 1
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0115 0.0149 0.6064
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0168 0.159
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.017
Brugia malayi follicle stimulating hormone receptor 0.0235 0.0326 0.3073
Onchocerca volvulus 0.0031 0.0026 0.0368
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0074 0.0074
Plasmodium vivax SET domain protein, putative 0.0064 0.0074 0.3651
Onchocerca volvulus 0.0016 0.0004 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0085 0.4205
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0022 0.0208
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0169
Brugia malayi Inositol-1 0.0036 0.0033 0.0313
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0058 0.076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.1856
Echinococcus granulosus chromobox protein 1 0.0071 0.0084 0.0475
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.005 0.0472
Onchocerca volvulus 0.0495 0.0707 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0022 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0022 0.0208
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0022 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0022 0.0208
Brugia malayi jmjC domain containing protein 0.0064 0.0074 0.0701
Schistosoma mansoni coup transcription factor 0.0028 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0123 0.0161 0.1521
Brugia malayi Latrophilin receptor protein 2 0.0047 0.005 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0198 0.275
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0002 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0022 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0058 0.2795
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0076 0.0781
Onchocerca volvulus 0.0016 0.0004 0.006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0058 0.2795
Onchocerca volvulus 0.0153 0.0206 0.2912
Entamoeba histolytica hypothetical protein 0.0179 0.0243 1
Brugia malayi hypothetical protein 0.0017 0.0005 0.0044
Loa Loa (eye worm) hypothetical protein 0.015 0.0201 0.1894
Plasmodium falciparum casein kinase II beta chain 0.0115 0.0149 0.7511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0022 0.0208
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0115 0.0149 0.7511
Toxoplasma gondii CMGC kinase, CK2 family 0.0148 0.0198 0.8871
Toxoplasma gondii cathepsin CPL 0.0016 0.0004 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.1008 0.1008
Brugia malayi hypothetical protein 0.0123 0.0161 0.1521
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0026 0.0246
Brugia malayi jmjC domain containing protein 0.0016 0.0003 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0052 0.2499
Schistosoma mansoni ap endonuclease 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0074 0.0702
Loa Loa (eye worm) hypothetical protein 0.015 0.0201 0.1895
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0022 0.0022
Onchocerca volvulus 0.0028 0.0022 0.0311
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0115 0.0149 0.7511
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0034 0.003 0.0362
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0022 0.0022
Onchocerca volvulus 0.0053 0.0058 0.0823
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.0365
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0041
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Brugia malayi hypothetical protein 0.0734 0.1059 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0085 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0039 0.0489
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0022
Toxoplasma gondii ABC1 family protein 0.0071 0.0085 0.373
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0064 0.3097
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0022 0.0022
Brugia malayi hypothetical protein 0.0015 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Schistosoma mansoni lamin 0.0053 0.0058 0.0058
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.1139 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0022 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Schistosoma mansoni chromobox protein 0.0071 0.0084 0.0084
Echinococcus granulosus casein kinase ii subunit beta 0.0115 0.0149 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0071 0.3504
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Schistosoma mansoni survival motor neuron protein 0.015 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0022 0.0208
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.004 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0074 0.0419
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Loa Loa (eye worm) glutaminase 0.0268 0.0374 0.3529
Brugia malayi hypothetical protein 0.0026 0.0018 0.017
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Schistosoma mansoni hypothetical protein 0.0102 0.0131 0.0131
Echinococcus multilocularis survival motor neuron protein 1 0.0734 0.1059 0.1059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0022 0.0208
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0022 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0074 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0085 0.0803
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0033 0.0187
Schistosoma mansoni cpg binding protein 0.0091 0.0113 0.0113
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0058 0.055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0005 0.0043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0084 0.0796
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0077 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0113 0.0113
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0003 0.0003
Plasmodium vivax vivapain-2 0.0016 0.0004 0.0041
Echinococcus granulosus lamin dm0 0.0053 0.0058 0.0328
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0113 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.3504
Trichomonas vaginalis casein kinase II beta chain, putative 0.0034 0.003 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0074 0.0074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0077 0.129
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0003 0.0033
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0077 0.0434
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0013 0.012
Schistosoma mansoni notum 0.6816 1 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0085 0.1526
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0058 0.076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0022 0.0022
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0039 0.0546
Loa Loa (eye worm) hypothetical protein 0.0053 0.0058 0.055
Schistosoma mansoni casein kinase II beta subunit 0.0115 0.0149 0.0149
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.004 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0066
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.0644 0.0644
Loa Loa (eye worm) fibroinase 0.0016 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Schistosoma mansoni transcription factor LCR-F1 0.0179 0.0243 0.0243
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0058 0.076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0022 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0018 0.0747
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0085 0.4205
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0074 0.0074
Brugia malayi glutaminase DH11.1 0.0268 0.0374 0.3529
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0085 0.115
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0084 0.1139
Plasmodium vivax casein kinase II beta chain, putative 0.0115 0.0149 0.7511
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0041
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0004 0.006
Loa Loa (eye worm) ctsf protein 0.0016 0.0004 0.004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0022 0.0022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0018 0.0101
Mycobacterium leprae Probable lipase LipE 0.0071 0.0085 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0022 0.0124
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0004 0.0004
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0037 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.004 0.1856
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0033 0.1527
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0168 0.159
Trichomonas vaginalis esterase, putative 0.0071 0.0085 0.115
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0022 0.0208
Leishmania major hypothetical protein, conserved 0.0071 0.0085 0.4205
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.004 0.0585
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0079 0.3874
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0501
Echinococcus granulosus GPCR family 2 0.0047 0.005 0.0282
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0011 0.006
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0004 0.006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0077 0.129
Trichomonas vaginalis casein kinase II beta chain, putative 0.0115 0.0149 0.2063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0022 0.0124
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0115 0.0149 0.6064
Echinococcus granulosus microtubule associated protein 2 0.0699 0.1008 0.5684
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.004 0.0373
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0179 0.0243 0.0243
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0015 0.0015
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0004 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0022 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.005 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0015 0.0015
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.006 0.0567
Echinococcus multilocularis chromobox protein 1 0.0071 0.0084 0.0084
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0208
Echinococcus multilocularis cysteine protease 0.0016 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0047 0.005 0.005
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0067 0.0067
Brugia malayi CHD4 protein 0.0016 0.0005 0.0043
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0079 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0022 0.0247
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0071 0.3504
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0002 0.0002
Schistosoma mansoni protein kinase 0.0148 0.0198 0.0198
Brugia malayi casein kinase II, putaitve 0.0034 0.003 0.028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.004 0.1856
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0079 0.3874
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0004 0.0041
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0113 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0168 0.0168
Onchocerca volvulus 0.015 0.02 0.2833
Onchocerca volvulus 0.0016 0.0004 0.006
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0058 0.2795
Loa Loa (eye worm) beta-lactamase 0.0071 0.0085 0.0803
Echinococcus multilocularis lamin dm0 0.0053 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0085 0.115
Schistosoma mansoni hypothetical protein 0.0172 0.0233 0.0233
Brugia malayi hypothetical protein 0.0153 0.0206 0.1944
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0022 0.0124
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0033 0.0033
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0023 0.0214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0151 0.1425
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.0251 0.0251

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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