Detailed information for compound 659835

Basic information

Technical information
  • TDR Targets ID: 659835
  • Name: 2-butyl-1,3-dioxo-N-pyridin-3-ylisoindole-5-c arboxamide
  • MW: 323.346 | Formula: C18H17N3O3
  • H donors: 1 H acceptors: 4 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1C(=O)c2c(C1=O)cc(cc2)C(=O)Nc1cccnc1
  • InChi: 1S/C18H17N3O3/c1-2-3-9-21-17(23)14-7-6-12(10-15(14)18(21)24)16(22)20-13-5-4-8-19-11-13/h4-8,10-11H,2-3,9H2,1H3,(H,20,22)
  • InChiKey: DMBZAAVTSWKZRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-butyl-1,3-dioxo-N-(3-pyridyl)isoindoline-5-carboxamide
  • 2-butyl-1,3-dioxo-N-(3-pyridyl)-5-isoindolinecarboxamide
  • 2-butyl-1,3-diketo-N-(3-pyridyl)isoindoline-5-carboxamide
  • 2-butyl-1,3-dioxo-N-pyridin-3-yl-isoindole-5-carboxamide
  • MLS000062521
  • SMR000073345
  • STK224410
  • ZINC02836902
  • 2-butyl-1,3-dioxo-N-3-pyridinyl-5-isoindolinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0164 0.018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0155 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Brugia malayi Heterochromatin protein 1 0.0076 0.2699 0.2966
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.023 0.0252
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0155 0.0171
Echinococcus granulosus Chromobox protein 3 0.0012 0.0164 0.018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0283 0.0311
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0796 0.2597
Loa Loa (eye worm) hypothetical protein 0.01 0.3679 0.4042
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.9101 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1874 0.2059
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.071 0.078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0155 0.0171
Schistosoma mansoni hypothetical protein 0.0171 0.648 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.2126 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0184 0.7001 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.2597 0.2853
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.3679 0.5677
Loa Loa (eye worm) hypothetical protein 0.0049 0.1612 0.1771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1874 0.2893
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.9101 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2126 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2164 0.334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0155 0.0171
Onchocerca volvulus 0.0024 0.0619 0.0471
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0796 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0155 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.1367 0.1223
Loa Loa (eye worm) hypothetical protein 0.018 0.6874 0.7553
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0073 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Onchocerca volvulus 0.0033 0.1 0.0858
Entamoeba histolytica hypothetical protein 0.0043 0.1403 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1612 0.1771
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0155 0.0171
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0619 0.72
Schistosoma mansoni hypothetical protein 0.0043 0.1403 0.2166
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.2126 0.5
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 0.7001 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0155 0.0171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0073 0.008
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0796 0.7632
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2126 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0304 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0992 0.1531
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2597 0.2999
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.071 0.2246
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2597 0.2999
Schistosoma mansoni hypothetical protein 0.0015 0.0283 0.0436
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.2126 0.8064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.8749 0.9613
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0304 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0871 0.0719
Schistosoma mansoni hypothetical protein 0.0015 0.0283 0.0436
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0155 0.024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0155 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0155 0.0171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0425 0.0266
Echinococcus multilocularis chromobox protein 1 0.0076 0.2699 0.2966
Schistosoma mansoni lipoxygenase 0.01 0.3645 0.5626
Onchocerca volvulus 0.0012 0.0164 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1874 0.2059
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.4546 0.4995
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0164 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0992 0.109
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.2597 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.2126 0.2336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0155 0.0171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1874 0.2059
Schistosoma mansoni hypothetical protein 0.0024 0.0619 0.0955
Brugia malayi Protein cec-1. 0.0012 0.0164 0.018
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.071 0.078
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0155 0.0171
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.5357 0.5887
Onchocerca volvulus 0.0046 0.1488 0.1354
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.4546 0.4995
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 0.7001 1
Brugia malayi nuclear hormone receptor 0.0012 0.0155 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Schistosoma mansoni hypothetical protein 0.0171 0.648 1
Schistosoma mansoni polycystin 1-related 0.0024 0.0619 0.0955
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1367 0.1231
Echinococcus multilocularis GPCR, family 2 0.0015 0.0283 0.0311
Echinococcus multilocularis geminin 0.0171 0.648 0.712
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0619 0.068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0992 0.109
Trypanosoma brucei protein kinase, putative 0.0062 0.2126 1
Schistosoma mansoni chromobox protein 0.0076 0.2699 0.4166
Plasmodium vivax SET domain protein, putative 0.0033 0.0992 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0992 0.109
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0155 0.024
Brugia malayi Pre-SET motif family protein 0.0227 0.8749 0.9613
Brugia malayi SET domain containing protein 0.0014 0.0237 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2597 0.2999
Brugia malayi Muscleblind-like protein 0.018 0.6874 0.7553
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0164 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1874 0.2059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0822 0.0903
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.2126 0.2336
Mycobacterium tuberculosis Probable aminotransferase 0.0184 0.7001 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0155 0.024
Brugia malayi hypothetical protein 0.0024 0.0619 0.068
Brugia malayi nuclear receptor NHR-88 0.0012 0.0155 0.0171
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0068 0.0075
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.2126 0.2336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0155 0.0171
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0619 0.068
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0425 0.0266
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0619 0.068
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.2126 0.5
Echinococcus granulosus ornithine aminotransferase 0.0026 0.071 0.078
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0155 0.0171
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2699 0.2578
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0155 0.0171
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0164 0.018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0155 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0285 0.0123
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0164 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1874 0.2893
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.5357 0.5887
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0283 0.0311
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0164 0.0253
Brugia malayi CXXC zinc finger family protein 0.0029 0.0822 0.0903
Echinococcus multilocularis cpg binding protein 0.0031 0.0888 0.0976
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0155 0.0171
Loa Loa (eye worm) hypothetical protein 0.018 0.6874 0.7553
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0283 0.0311
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2126 0.1995
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1403 0.1542
Echinococcus multilocularis muscleblind protein 0.018 0.6874 0.7553
Schistosoma mansoni hypothetical protein 0.0015 0.0283 0.0436
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0164 0.018
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0283 0.0311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Brugia malayi MH2 domain containing protein 0.0122 0.4546 0.4995
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0155 0.0171
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.2126 0.7384
Schistosoma mansoni survival motor neuron protein 0.0048 0.1592 0.2456
Echinococcus granulosus geminin 0.0171 0.648 0.712
Mycobacterium ulcerans hypothetical protein 0.0184 0.7001 1
Brugia malayi hypothetical protein 0.0043 0.1403 0.1542
Echinococcus granulosus GPCR family 2 0.0015 0.0283 0.0311
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.023 0.0252
Loa Loa (eye worm) hypothetical protein 0.0024 0.0619 0.068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0155 0.0171
Entamoeba histolytica hypothetical protein 0.0043 0.1403 1
Entamoeba histolytica hypothetical protein 0.0028 0.0796 0.5098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1403 0.1542
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0992 0.3403
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1592 0.1749
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.1367 0.1223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0155 0.0171
Onchocerca volvulus 0.0048 0.1592 0.1459
Schistosoma mansoni chromobox protein 0.0012 0.0164 0.0253
Echinococcus granulosus RUN 0.0024 0.0619 0.068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0283 0.0311
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0619 0.5495
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.1488 0.2296
Echinococcus granulosus Chromo domain 0.0012 0.0164 0.018
Echinococcus multilocularis chromobox protein 1 0.0076 0.2699 0.2966
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0164 0.018
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.3679 0.4042
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0155 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0155 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0155 0.0171
Echinococcus multilocularis RUN 0.0024 0.0619 0.068
Onchocerca volvulus 0.0029 0.0822 0.0678
Brugia malayi hypothetical protein 0.0024 0.0619 0.068
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.023 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0283 0.0311
Echinococcus multilocularis chromobox protein 2 0.0012 0.0164 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.2126 0.3281
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.2699 0.2966
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2699 0.2578
Schistosoma mansoni cpg binding protein 0.0031 0.0888 0.137
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0619 0.068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Onchocerca volvulus 0.0024 0.0619 0.0471
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0796 0.0136
Entamoeba histolytica hypothetical protein 0.0043 0.1403 1
Schistosoma mansoni rab6-interacting 0.0024 0.0619 0.0955
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0796 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.2126 0.2336
Echinococcus multilocularis Chromo domain 0.0012 0.0164 0.018
Brugia malayi hypothetical protein 0.0236 0.9101 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0155 0.0171
Loa Loa (eye worm) hypothetical protein 0.0043 0.1367 0.1502
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0155 0.0171
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.2597 0.2999
Echinococcus multilocularis Aminotransferase class III 0.0026 0.071 0.078
Loa Loa (eye worm) hypothetical protein 0.0236 0.9101 1
Brugia malayi MAP kinase sur-1 0.0062 0.2126 0.2336
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Trichomonas vaginalis set domain proteins, putative 0.0259 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1874 0.2059
Loa Loa (eye worm) helicase 0.0012 0.0164 0.018
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0619 0.068
Echinococcus granulosus chromobox protein 2 0.0012 0.0164 0.018
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.3679 0.4042
Schistosoma mansoni chromobox protein 0.0012 0.0164 0.0253
Brugia malayi CHD4 protein 0.0014 0.023 0.0252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.2597 0.2853
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0155 0.0171
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1496 0.1354
Plasmodium falciparum ornithine aminotransferase 0.0026 0.071 0.8647
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0155 0.024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1903 0.7147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0155 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0155 0.0171
Schistosoma mansoni rab6-interacting 0.0024 0.0619 0.0955
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1403 0.2166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0155 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0155 0.0171
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 0.7001 0.6951
Schistosoma mansoni hypothetical protein 0.0033 0.0997 0.1538
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.071 0.078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0796 0.0136
Loa Loa (eye worm) hypothetical protein 0.0033 0.1 0.1099
Echinococcus granulosus cpg binding protein 0.0031 0.0888 0.0976
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.071 0.1096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0155 0.0171
Onchocerca volvulus 0.0012 0.0164 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0155 0.024
Brugia malayi ecdysteroid receptor 0.0012 0.0155 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0155 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0155 0.0171
Echinococcus granulosus chromobox protein 1 0.0076 0.2699 0.2966
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.2126 0.7384
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0619 0.068
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0796 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0155 0.0171
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0919 0.101
Loa Loa (eye worm) histone methyltransferase 0.001 0.0073 0.008
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0164 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0155 0.024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0796 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0619 0.068
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.023 0.0354
Schistosoma mansoni loxhd1 0.0024 0.0619 0.0955
Entamoeba histolytica hypothetical protein 0.0043 0.1403 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.2126 0.2336
Brugia malayi chromobox protein homolog 3 0.0043 0.1367 0.1502
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0155 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2126 0.1995
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0796 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0155 0.024
Schistosoma mansoni lipoxygenase 0.0142 0.5357 0.8268
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0164 0.0253
Echinococcus granulosus muscleblind protein 0.018 0.6874 0.7553
Loa Loa (eye worm) hypothetical protein 0.0033 0.0997 0.1095
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2126 0.1995
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0992 0.1531
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Brugia malayi Doublecortin family protein 0.0024 0.0619 0.068
Schistosoma mansoni chromobox protein 0.0076 0.2699 0.4166
Echinococcus granulosus Aminotransferase class III 0.0026 0.071 0.078
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0997 0.1095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0155 0.024
Schistosoma mansoni cpg binding protein 0.0031 0.0888 0.137
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0155 0.0171
Schistosoma mansoni hypothetical protein 0.0015 0.0283 0.0436
Brugia malayi steroid hormone receptor 0.0012 0.0155 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0992 0.1531
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0155 0.024
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2597 0.4008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0155 0.0171
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2597 0.4008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0002
Echinococcus granulosus chromobox protein 1 0.0076 0.2699 0.2966
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2126 0.1995
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0155 0.0171
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0155 0.0171
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0155 0.024
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.3679 0.4042
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0155 0.0171
Echinococcus multilocularis muscleblind protein 1 0.018 0.6874 0.7553
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0155 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1874 0.2059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0283 0.0311
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0619 0.068
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0992 0.109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1612 0.1771
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.1496 0.1362
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0796 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1612 0.1771
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0048 0.1592 0.2456
Schistosoma mansoni coup transcription factor 0.0012 0.0155 0.024
Brugia malayi hypothetical protein 0.0012 0.0164 0.018
Schistosoma mansoni hypothetical protein 0.0012 0.0164 0.0253
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0796 0.2597
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0871 0.0719
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0155 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0155 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0155 0.024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.2597 1
Schistosoma mansoni cpg binding protein 0.0029 0.0822 0.1269
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1496 0.1354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0425 0.0266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0283 0.0311
Brugia malayi Pre-SET motif family protein 0.0033 0.0992 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1874 0.2893
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.071 0.6599
Onchocerca volvulus 0.01 0.3679 0.3579
Loa Loa (eye worm) hypothetical protein 0.0012 0.0155 0.0171
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.2126 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0155 0.0171

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 0.544 uM PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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