Detailed information for compound 672636

Basic information

Technical information
  • TDR Targets ID: 672636
  • Name: N-(2,3-dimethylphenyl)-2-[(2-nitrophenyl)-phe nylsulfonylamino]acetamide
  • MW: 439.484 | Formula: C22H21N3O5S
  • H donors: 1 H acceptors: 5 LogP: 4.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccccc1)c1ccccc1[N+](=O)[O-])Nc1cccc(c1C)C
  • InChi: 1S/C22H21N3O5S/c1-16-9-8-12-19(17(16)2)23-22(26)15-24(20-13-6-7-14-21(20)25(27)28)31(29,30)18-10-4-3-5-11-18/h3-14H,15H2,1-2H3,(H,23,26)
  • InChiKey: WVKHLOGGXFZIEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dimethylphenyl)-2-[(2-nitrophenyl)-phenylsulfonyl-amino]acetamide
  • N-(2,3-dimethylphenyl)-2-[(2-nitrophenyl)-phenylsulfonyl-amino]ethanamide
  • Oprea1_813853

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0023 0.0265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0138
Echinococcus multilocularis GPCR, family 2 0.0016 0.0043 0.003
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0012 0.0029 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.008 0.171
Brugia malayi AMP-binding enzyme family protein 0.0026 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0012
Echinococcus granulosus GPCR family 2 0.0016 0.0043 0.003
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0023 0.0265
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0023 0.0657
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0408 0.1317
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0172 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.0138
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0013 0.0012
Mycobacterium leprae Probable monophosphatase 0.0012 0.0029 0.0464
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.008 0.171
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0116 0.0408 0.5
Brugia malayi hypothetical protein 0.0146 0.0516 0.0516
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0016
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0023 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.008 0.171
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0029 0.0028
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0029 0.0412
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0052 0.1223
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.008 0.171
Echinococcus multilocularis Smad4 0.0008 0.0013 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0151 0.015
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.011
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0012 0.0029 0.1765
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.008 0.2015
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0169 0.0169
Echinococcus granulosus inositol monophosphatase 0.0012 0.0029 0.0016
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.001
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0012 0.0029 0.0464
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0411 0.0411
Brugia malayi AMP-binding enzyme family protein 0.0026 0.008 0.008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.008 0.171
Schistosoma mansoni hypothetical protein 0.0188 0.0668 0.0657
Echinococcus granulosus muscleblind protein 0.0455 0.1641 0.163
Onchocerca volvulus 0.0029 0.0091 0.096
Loa Loa (eye worm) hypothetical protein 0.0455 0.1641 0.1643
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0023 0.001
Toxoplasma gondii hypothetical protein 0.0012 0.0029 0.0412
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0172 0.053
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.008 0.171
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0029 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Echinococcus multilocularis muscleblind protein 0.0455 0.1641 0.163
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0016
Schistosoma mansoni inositol monophosphatase 0.0116 0.0408 0.0396
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0012 0.0029 0.0412
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0012 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.008
Mycobacterium tuberculosis Probable monophosphatase 0.0012 0.0029 0.0569
Brugia malayi Smad1 0.0008 0.0013 0.0013
Brugia malayi Muscleblind-like protein 0.0455 0.1641 0.164
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0116 0.0408 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.008 0.171
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0068 0.0056
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.003
Echinococcus multilocularis inositol monophosphatase 0.0012 0.0029 0.0016
Loa Loa (eye worm) hypothetical protein 0.0236 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0408 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0013 0.011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.2898 0.2889
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0023 0.0657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0052 0.1223
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0845 0.0833
Echinococcus multilocularis geminin 0.0188 0.0668 0.0657
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.001
Mycobacterium ulcerans monophosphatase 0.0012 0.0029 0.0412
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0029 0.0412
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0116 0.0408 0.4833
Plasmodium vivax SET domain protein, putative 0.0029 0.0091 0.4935
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0023 0.001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.011
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0029 0.0199
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0023 0.0022
Mycobacterium tuberculosis Monophosphatase CysQ 0.0012 0.0029 0.0569
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.008 0.171
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.008
Brugia malayi MH2 domain containing protein 0.0008 0.0013 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0172 1
Onchocerca volvulus 0.0026 0.008 0.0827
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0029 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0091 0.0079
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0012 0.0029 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0169 0.0169
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0091 0.1986
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0013 0.011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.008 0.1926
Schistosoma mansoni hypothetical protein 0.0035 0.0111 0.0098
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.008 0.1926
Echinococcus multilocularis inositol monophosphatase 1 0.0116 0.0408 0.0396
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0023 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.0138
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0012 0.0029 0.0412
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.008 0.171
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0013 0.011
Schistosoma mansoni survival motor neuron protein 0.0048 0.016 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.0138
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0013 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0023 0.0657
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.008 0.171
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0056 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0056 0.2728
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0029 0.0412
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0012 0.0029 0.0412
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0172 0.053
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0023 0.0022
Schistosoma mansoni Smad4 0.0008 0.0013 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.016 0.0148
Brugia malayi Pre-SET motif family protein 0.0204 0.0728 0.0727
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0116 0.0408 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2751 1 1
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0029 0.0028
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0013 0.011
Onchocerca volvulus 0.0232 0.0831 1
Loa Loa (eye worm) Smad1 0.0008 0.0013 0.0013
Brugia malayi Inositol-1 0.0116 0.0408 0.0407
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0091 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.0138
Mycobacterium ulcerans hypothetical protein 0.0026 0.008 0.171
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0832 0.3015 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.001
Brugia malayi hypothetical protein 0.0236 0.0845 0.0844
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0013 0.011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0104 0.0363 1
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0029 0.0412
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0013 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.008 0.2015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0052 0.1223
Brugia malayi MH2 domain containing protein 0.0117 0.0411 0.041
Echinococcus granulosus smad 0.0008 0.0013 0.0001
Brugia malayi MH1 domain containing protein 0.0008 0.0013 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0172 0.4025
Onchocerca volvulus 0.0048 0.016 0.1801
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.003
Echinococcus multilocularis muscleblind protein 1 0.0455 0.1641 0.163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0056 0.1098
Schistosoma mansoni brg-1 associated factor 0.0011 0.0023 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0091 0.0079
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0408 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0056 0.1333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.016 0.0159
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0028
Schistosoma mansoni smad 0.0008 0.0013 0.0001
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0023 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0043 0.0042
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0012 0.0029 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0138
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0023 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0091 0.0079
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0091
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0111 0.011
Brugia malayi hypothetical protein 0.0033 0.0105 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0091 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0023 0.0657
Brugia malayi AMP-binding enzyme family protein 0.0026 0.008 0.008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.008 0.171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0043 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.003
Echinococcus granulosus geminin 0.0188 0.0668 0.0657
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0151 0.0151
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0104 0.0363 1
Loa Loa (eye worm) brahma associated protein 0.0011 0.0023 0.0023
Brugia malayi Pre-SET motif family protein 0.0029 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0091 0.0079
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0012 0.0029 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0138
Schistosoma mansoni hypothetical protein 0.0188 0.0668 0.0657
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0013 0.0001
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0012 0.0029 0.0412
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0001
Echinococcus granulosus Smad4 0.0008 0.0013 0.0001
Onchocerca volvulus 0.0011 0.0023 0.0128
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0023 0.001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0013 0.011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0068 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.008
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0012 0.0029 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0169 0.0169
Schistosoma mansoni protein kinase 0.2751 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2751 1 1
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0832 0.3015 0.3019
Brugia malayi MH2 domain containing protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0023 0.0023
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.008 0.171
Loa Loa (eye worm) hypothetical protein 0.0828 0.3 0.3004
Echinococcus multilocularis smad 0.0008 0.0013 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0013 0.0013
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0056 0.2728
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0455 0.1641 0.1643
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0091 0.0079
Loa Loa (eye worm) hypothetical protein 0.2747 0.9985 1
Echinococcus granulosus inositol monophosphatase 1 0.0116 0.0408 0.0396
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0408 0.1317
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0146 0.0516 0.0517
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0012 0.0029 0.0199
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0116 0.0408 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0728 0.0728
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.0408 0.4833
Schistosoma mansoni protein kinase 0.2751 1 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Onchocerca volvulus 0.0146 0.0516 0.6161
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0029 0.0016
Leishmania major myo-inositol-1 phosphatase, putative 0.0012 0.0029 0.0412
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0087 0.0075
Loa Loa (eye worm) oxidoreductase 0.0008 0.0013 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0013 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.008 0.171
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0411 0.0411
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0832 0.3015 1
Brugia malayi MH1 domain containing protein 0.0008 0.0013 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0052 0.1223
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0013 0.0001
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0172 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0169 0.0169
Brugia malayi hypothetical protein 0.0051 0.0172 0.0171
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0172 0.4025
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0043 0.0042
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0845 0.0833
Loa Loa (eye worm) inositol-1 0.0116 0.0408 0.0408
Giardia lamblia Hypothetical protein 0.0012 0.0029 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0172 0.0171
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0013 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0831 1
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.0408 0.4833
Leishmania major hypothetical protein, conserved 0.0051 0.0172 0.4025
Schistosoma mansoni inositol monophosphatase 0.0116 0.0408 0.0396

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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