Detailed information for compound 686892

Basic information

Technical information
  • TDR Targets ID: 686892
  • Name: 4-[(3-methylphenyl)amino]-2-(3-morpholin-4-yl propylamino)-4-oxobutanoic acid
  • MW: 349.425 | Formula: C18H27N3O4
  • H donors: 3 H acceptors: 3 LogP: -1.11 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC(C(=O)O)NCCCN1CCOCC1)Nc1cccc(c1)C
  • InChi: 1S/C18H27N3O4/c1-14-4-2-5-15(12-14)20-17(22)13-16(18(23)24)19-6-3-7-21-8-10-25-11-9-21/h2,4-5,12,16,19H,3,6-11,13H2,1H3,(H,20,22)(H,23,24)
  • InChiKey: WAKQTQWCGBBHGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(3-methylphenyl)amino]-2-(3-morpholinopropylamino)-4-oxo-butanoic acid
  • 4-[(3-methylphenyl)amino]-2-(3-morpholinopropylamino)-4-oxobutanoic acid
  • 4-keto-4-[(3-methylphenyl)amino]-2-(3-morpholinopropylamino)butyric acid
  • 4-[(3-methylphenyl)amino]-2-(3-morpholin-4-ylpropylamino)-4-oxo-butanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0065 0.0283
Chlamydia trachomatis thioredoxin reductase 0.0157 0.0771 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.015 0.0734 0.3224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Echinococcus granulosus pyruvate kinase 0.0019 0.0004 0.0018
Echinococcus multilocularis peregrin 0.003 0.0065 0.0283
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.073 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.0768 0.5909
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0117 0.0904
Leishmania major hypothetical protein, conserved 0.006 0.0233 0.3186
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.0235
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.013 0.0571
Schistosoma mansoni DNA polymerase eta 0.0021 0.0016 0.0069
Toxoplasma gondii sugar transporter ST3 0.006 0.0233 0.0351
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0131 0.0627 0.236
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0105 0.0804
Mycobacterium ulcerans integral membrane transport protein 0.006 0.0233 0.2873
Schistosoma mansoni lysyl-tRNA synthetase 0.0095 0.0429 0.1885
Trichomonas vaginalis myo-inositol transporter, putative 0.006 0.0233 0.096
Trypanosoma cruzi hexose transporter, putative 0.006 0.0233 0.3186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0059
Echinococcus granulosus solute carrier family 22 0.006 0.0233 0.1022
Trichomonas vaginalis sugar transport protein, putative 0.006 0.0233 0.096
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.0729 0.2746
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0048 0.0048
Echinococcus multilocularis GPCR, family 2 0.015 0.0734 0.3224
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0428 0.2278 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Onchocerca volvulus 0.006 0.0233 0.967
Echinococcus multilocularis pyruvate kinase 0.0029 0.0061 0.0268
Schistosoma mansoni hypothetical protein 0.015 0.0734 0.3224
Onchocerca volvulus 0.006 0.0233 0.967
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0016 0.0121
Plasmodium falciparum calcium-dependent protein kinase 1 0.0131 0.0627 0.0627
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0117 0.1347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0729 0.3201
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0024 0.0032 0.012
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0084 0.0364 0.1539
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0131 0.0627 0.0627
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.021
Schistosoma mansoni hypothetical protein 0.0042 0.013 0.0571
Mycobacterium ulcerans sugar transporter 0.006 0.0233 0.2873
Echinococcus multilocularis solute carrier family 22 0.006 0.0233 0.1022
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0048 0.0048
Schistosoma mansoni glucose transport protein 0.0428 0.2278 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.0987 0.3714
Entamoeba histolytica hypothetical protein 0.0042 0.013 0.0572
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0209 0.0315
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0239 0.0898
Brugia malayi Latrophilin receptor protein 2 0.015 0.0734 0.2765
Plasmodium falciparum phd finger protein, putative 0.003 0.0065 0.0065
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.006 0.0233 0.1792
Schistosoma mansoni transient receptor potential channel 0.0206 0.1044 0.4584
Echinococcus granulosus peregrin 0.003 0.0065 0.0283
Loa Loa (eye worm) hypothetical protein 0.0056 0.0209 0.0786
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0095 0.0429 0.1828
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0105 0.2296
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0042 0.0132
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0233 0.0351
Echinococcus multilocularis General substrate transporter 0.0368 0.1944 0.8531
Giardia lamblia Hexose transporter 0.006 0.0233 0.1137
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0016 0.0225
Loa Loa (eye worm) hypothetical protein 0.0131 0.0627 0.236
Mycobacterium leprae Probable lipase LipE 0.0039 0.0117 0.1338
Brugia malayi hypothetical protein 0.0036 0.0099 0.0372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0475 0.2541 0.9567
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0048 0.018
Echinococcus granulosus solute carrier family 22 0.006 0.0233 0.1022
Brugia malayi intermediate filament protein 0.0061 0.0239 0.0898
Chlamydia trachomatis proline--tRNA ligase 0.0045 0.015 0.1601
Loa Loa (eye worm) beta-lactamase 0.0039 0.0117 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0233 0.096
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0117 0.0904
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0116 0.0543 0.2382
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Leishmania major pyruvate kinase 0.0037 0.0105 0.1431
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0233 0.0876
Schistosoma mansoni transient receptor potential channel 0.0206 0.1044 0.4584
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Toxoplasma gondii facilitative glucose transporter GT1 0.0428 0.2278 0.344
Brugia malayi MH2 domain containing protein 0.0496 0.2656 1
Echinococcus multilocularis solute carrier family 22 0.006 0.0233 0.1022
Schistosoma mansoni hypothetical protein 0.003 0.0065 0.0283
Brugia malayi beta-lactamase family protein 0.0039 0.0117 0.0442
Mycobacterium ulcerans lipase LipD 0.0039 0.0117 0.1347
Brugia malayi jmjC domain containing protein 0.0036 0.01 0.0375
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0024 0.0032 0.0216
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0209 0.2859
Schistosoma mansoni smad1 5 8 and 0.0034 0.0086 0.0378
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0024 0.0032 0.0216
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.1678 0.8323
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Brugia malayi hypothetical protein 0.0042 0.013 0.049
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0048 0.0218
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0211
Loa Loa (eye worm) hypothetical protein 0.0026 0.0042 0.0158
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0157 0.0771 0.5936
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0331 0.1454
Brugia malayi MH2 domain containing protein 0.0034 0.0086 0.0324
Trypanosoma cruzi hexose transporter 0.0133 0.0636 0.871
Leishmania major glucose transporter/membrane transporter D2, putative 0.0133 0.0636 0.871
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0095 0.0429 0.5471
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0117 0.0904
Toxoplasma gondii ABC1 family protein 0.0039 0.0117 0.0177
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0128 0.0612 0.2636
Schistosoma mansoni hypothetical protein 0.015 0.0734 0.3224
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Brugia malayi hypothetical protein 0.0056 0.0209 0.0786
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0024 0.0032 0.0438
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.013 0.057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.015 0.0734 0.2765
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0016 0.0214
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0086 0.0378
Trypanosoma brucei glucose transporter 1E 0.0133 0.0636 0.871
Loa Loa (eye worm) hypothetical protein 0.015 0.0734 0.2765
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.073 1
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0636 0.2743
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0729 0.3201
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0636 0.871
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0037 0.0164
Echinococcus multilocularis solute carrier family 22 0.006 0.0233 0.1022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0117 0.0442
Loa Loa (eye worm) hypothetical protein 0.0051 0.0184 0.0691
Onchocerca volvulus 0.006 0.0233 0.967
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0105 0.0158
Schistosoma mansoni lamin 0.0061 0.0239 0.1047
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Loa Loa (eye worm) sugar transporter 0.006 0.0233 0.0876
Brugia malayi jmjC domain containing protein 0.0098 0.0443 0.1669
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0233 0.0876
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0105 0.1431
Brugia malayi beta-lactamase 0.0039 0.0117 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Echinococcus granulosus glycyl tRNA synthetase 0.0024 0.0032 0.014
Schistosoma mansoni smad1 5 8 and 0.0034 0.0086 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.0003
Schistosoma mansoni hypothetical protein 0.015 0.0734 0.3224
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Loa Loa (eye worm) hypothetical protein 0.0312 0.1631 0.614
Plasmodium falciparum calcium-dependent protein kinase 3 0.0131 0.0627 0.0627
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0048 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0636 0.871
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0636 0.871
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0105 0.1176
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0443 0.1946
Echinococcus granulosus calcium dependent protein kinase 0.0123 0.0582 0.2554
Echinococcus granulosus short transient receptor potential channel 6 0.0206 0.1044 0.4584
Echinococcus multilocularis glycyl tRNA synthetase 0.0024 0.0032 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0117 0.045
Leishmania major hypothetical protein, conserved 0.0056 0.0209 0.2859
Schistosoma mansoni pyruvate kinase 0.0037 0.0105 0.0459
Onchocerca volvulus 0.006 0.0233 0.967
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0729 0.3201
Echinococcus granulosus TRP transient receptor potential channel 0.0116 0.0543 0.2382
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0656
Chlamydia trachomatis lysine--tRNA ligase 0.0095 0.0429 0.5375
Giardia lamblia Sugar-proton symporter 0.006 0.0233 0.1137
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0042 0.0158
Chlamydia trachomatis pyruvate kinase 0.0037 0.0105 0.0981
Mycobacterium ulcerans hypothetical protein 0.0021 0.0016 0.001
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Leishmania major myo-inositol/proton symporter (MIT) 0.006 0.0233 0.3186
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0086 0.0324
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.0729 0.2746
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0117 0.1607
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0024 0.0032 0.0206
Brugia malayi latrophilin 2 splice variant baaae 0.0325 0.1705 0.6419
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1195 0.4498
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0131 0.0627 0.0947
Trypanosoma cruzi sugar transporter, putative 0.006 0.0233 0.3186
Mycobacterium ulcerans hypothetical protein 0.0039 0.0117 0.1347
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0381 0.2016 1
Onchocerca volvulus Putative transporter 0.006 0.0233 0.967
Schistosoma mansoni hypothetical protein 0.0025 0.0037 0.0164
Brugia malayi major facilitator superfamily protein 0.006 0.0233 0.0876
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0016 0.0069
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0131 0.0627 0.236
Brugia malayi MH1 domain containing protein 0.0034 0.0086 0.0324
Echinococcus granulosus muscleblind protein 0.0164 0.0808 0.3547
Trypanosoma cruzi glucose transporter, putative 0.006 0.0233 0.3186
Trichomonas vaginalis chaperonin, putative 0.0027 0.0048 0.0142
Onchocerca volvulus 0.006 0.0233 0.967
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.0003
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0636 0.871
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1678 0.8314
Plasmodium falciparum lysine--tRNA ligase 0.0095 0.0429 0.0429
Giardia lamblia PHD finger protein 15 0.003 0.0065 0.0301
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0691 0.3744 0.5653
Brugia malayi hypothetical protein 0.006 0.0233 0.0876
Echinococcus granulosus pyruvate kinase 0.0019 0.0004 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0016 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Schistosoma mansoni sugar transporter 0.006 0.0233 0.1022
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0048 0.018
Echinococcus multilocularis muscleblind protein 0.0164 0.0808 0.3547
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0105 0.0393
Onchocerca volvulus 0.006 0.0233 0.967
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0233 0.096
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.021
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0086 0.0324
Trypanosoma brucei glucose transporter 2A 0.0133 0.0636 0.871
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0105 0.0393
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0117 0.0904
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0016 0.0225
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0105 0.0393
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0157 0.0771 0.334
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0065 0.0243
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0438
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0808 0.3547
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0105 0.0393
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0209 0.2859
Loa Loa (eye worm) hypothetical protein 0.0105 0.0485 0.1825
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0053 0.0191 0.072
Loa Loa (eye worm) hypothetical protein 0.006 0.0232 0.0874
Leishmania major glucose transporter, lmgt3 0.0133 0.0636 0.871
Entamoeba histolytica hypothetical protein 0.0042 0.013 0.0572
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Brugia malayi Bromodomain containing protein 0.003 0.0065 0.0243
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0024 0.0032 0.012
Entamoeba histolytica hypothetical protein 0.0108 0.0501 0.2425
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0233 0.0876
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.006 0.0233 0.1022
Echinococcus multilocularis Smad4 0.0034 0.0086 0.0378
Brugia malayi major facilitator superfamily protein 0.006 0.0233 0.0876
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0128 0.0612 0.2687
Loa Loa (eye worm) latrophilin receptor protein 2 0.015 0.0734 0.2765
Plasmodium falciparum mitogen-activated protein kinase 2 0.0691 0.3744 0.3744
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Loa Loa (eye worm) hypothetical protein 0.0475 0.2541 0.9567
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0024 0.0032 0.012
Plasmodium vivax calcium-dependent protein kinase, putative 0.0131 0.0627 0.0627
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0131 0.0627 0.0627
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0128 0.0612 0.2305
Onchocerca volvulus 0.006 0.0233 0.967
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0016 0.0214
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0636 0.2743
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0128 0.0612 0.2687
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0081 0.0349 0.2688
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0636 0.2743
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.013 0.0571
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0117 0.1607
Brugia malayi MH1 domain containing protein 0.0019 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0174 0.0866 0.38
Giardia lamblia Glycyl-tRNA synthetase 0.0024 0.0032 0.0139
Toxoplasma gondii lysine-tRNA ligase 0.0095 0.0429 0.0648
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0105 0.1431
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Loa Loa (eye worm) hypothetical protein 0.0095 0.0429 0.1616
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.073 1
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0004 0.0004
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0024 0.0032 0.0048
Entamoeba histolytica thioredoxin reductase, putative 0.0157 0.0771 0.3778
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.021
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Plasmodium falciparum calcium-dependent protein kinase 5 0.0131 0.0627 0.0627
Plasmodium falciparum calcium-dependent protein kinase 4 0.0131 0.0627 0.0627
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0016 0.0214
Schistosoma mansoni sugar transporter 0.006 0.0233 0.1022
Brugia malayi lysyl-tRNA synthetase 0.0095 0.0429 0.1616
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Leishmania major hypothetical protein, conserved 0.0039 0.0117 0.1607
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0024 0.0032 0.0246
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0117 0.0904
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0117 0.0442
Brugia malayi Sugar transporter family protein 0.006 0.0233 0.0876
Plasmodium vivax lysine--tRNA ligase, putative 0.0095 0.0429 0.0429
Echinococcus multilocularis lysyl tRNA synthetase 0.0095 0.0429 0.1885
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0117 0.1607
Echinococcus multilocularis Sugar transporter ERD6 protein 0.006 0.0233 0.1022
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0131 0.0627 0.8582
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0117 0.0515
Echinococcus granulosus pyruvate kinase 0.0019 0.0004 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0636 0.2743
Plasmodium falciparum pyruvate kinase 0.0037 0.0105 0.0105
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0157 0.0771 0.334
Echinococcus multilocularis calcium activated potassium channel 0.0019 0.0001 0.0006
Onchocerca volvulus 0.006 0.0233 0.967
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0233 0.0876
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0016 0.0003
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.0627 0.2752
Brugia malayi PHD-finger family protein 0.003 0.0065 0.0243
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0086 0.0378
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0239 0.0898
Brugia malayi beta-lactamase family protein 0.0039 0.0117 0.0442
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0349 0.2688
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0475 0.2541 0.9567
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.006 0.0233 0.2873
Schistosoma mansoni protein kinase 0.0131 0.0627 0.2752
Plasmodium vivax CDK-related protein kinase 6, putative 0.1816 1 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0105 0.1167
Treponema pallidum prolyl-tRNA synthetase 0.0045 0.015 0.0719
Brugia malayi Transient-receptor-potential like protein 0.0116 0.0543 0.2043
Trichomonas vaginalis conserved hypothetical protein 0.0428 0.2278 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0072
Plasmodium vivax sugar transporter, putative 0.006 0.0233 0.0233
Echinococcus granulosus lamin 0.0061 0.0239 0.1047
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0016 0.0214
Echinococcus granulosus synaptic vesicle 2 protein 0.006 0.0233 0.1022
Schistosoma mansoni intermediate filament proteins 0.0061 0.0239 0.1047
Onchocerca volvulus 0.0039 0.0117 0.3037
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0438
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0117 0.0515
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0117 0.0904
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Echinococcus granulosus short transient receptor potential channel 6 0.0206 0.1044 0.4584
Plasmodium falciparum hexose transporter 0.0428 0.2278 0.2278
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0117 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0729 0.3201
Giardia lamblia Threonyl-tRNA synthetase 0.0024 0.0032 0.0139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.015 0.0734 0.3224
Schistosoma mansoni glycyl-tRNA synthetase 0.0024 0.0032 0.014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0016 0.0214
Echinococcus granulosus solute carrier family 22 0.006 0.0233 0.1022
Plasmodium falciparum proline--tRNA ligase 0.015 0.073 0.073
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0016 0.0059
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Toxoplasma gondii glycyl-tRNA synthetase 0.0024 0.0032 0.0048
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0157 0.0771 1
Schistosoma mansoni hypothetical protein 0.0174 0.0866 0.38
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0242 0.091
Mycobacterium tuberculosis Conserved protein 0.0039 0.0117 0.0904
Echinococcus granulosus solute carrier family 22 0.006 0.0233 0.1022
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Giardia lamblia DNA repair protein RAD52 0.0381 0.2016 1
Schistosoma mansoni lamin 0.0061 0.0239 0.1047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Onchocerca volvulus 0.006 0.0233 0.967
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0131 0.0627 0.0947
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0729 0.3201
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0016 0.0225
Brugia malayi glycyl-tRNA synthetase 0.0024 0.0032 0.012
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Schistosoma mansoni Smad4 0.0034 0.0086 0.0378
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.01 0.0375
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.006 0.0233 0.1792
Brugia malayi Sugar transporter family protein 0.006 0.0233 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Loa Loa (eye worm) MH2 domain-containing protein 0.0496 0.2656 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0016 0.0214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1678 0.8314
Schistosoma mansoni pyruvate kinase 0.0019 0.0004 0.0018
Onchocerca volvulus 0.0061 0.0239 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0016 0.0069
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0131 0.0627 0.2752
Echinococcus multilocularis lamin 0.0061 0.0239 0.1047
Echinococcus granulosus lysyl tRNA synthetase 0.0095 0.0429 0.1885
Brugia malayi MH2 domain containing protein 0.0034 0.0086 0.0324
Loa Loa (eye worm) hypothetical protein 0.0164 0.0808 0.3042
Echinococcus granulosus Smad4 0.0034 0.0086 0.0378
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0048 0.021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0117 0.0515
Onchocerca volvulus 0.0039 0.0117 0.3037
Brugia malayi Muscleblind-like protein 0.0164 0.0808 0.3042
Plasmodium falciparum calcium-dependent protein kinase 2 0.0131 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.01 0.0437
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0128 0.0612 0.2687
Echinococcus multilocularis geminin 0.0174 0.0866 0.38
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0081 0.0349 0.441
Schistosoma mansoni smad1 5 8 and 0.0034 0.0086 0.0378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0105 0.1431
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0048 0.021
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0004 0.0006
Leishmania major glucose transporter, lmgt1 0.0133 0.0636 0.871
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0211
Echinococcus multilocularis pyruvate kinase 0.0037 0.0105 0.0459
Schistosoma mansoni hypothetical protein 0.015 0.0734 0.3224
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0105 0.0393
Echinococcus multilocularis short transient receptor potential channel 6 0.0206 0.1044 0.4584
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0008
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0021 0.0016 0.0025
Schistosoma mansoni transient receptor potential channel 4 0.0312 0.1631 0.7159
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.1678 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0105 0.0459
Loa Loa (eye worm) transcription factor SMAD2 0.0496 0.2656 1
Toxoplasma gondii protein kinase, putative 0.1209 0.6623 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0108 0.0501 0.2425
Onchocerca volvulus 0.006 0.0233 0.967
Loa Loa (eye worm) hypothetical protein 0.0325 0.1705 0.6419
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0128 0.0612 0.2983
Onchocerca volvulus 0.006 0.0233 0.967
Toxoplasma gondii sugar transporter ST2 0.006 0.0233 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0233 0.096
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.015 0.0734 0.3224
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0128 0.0612 0.7892
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0082
Loa Loa (eye worm) Smad1 0.0034 0.0086 0.0324
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0065 0.0098
Leishmania major lysyl-tRNA synthetase, putative 0.0095 0.0429 0.5878
Schistosoma mansoni protein kinase 0.0131 0.0627 0.2752
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trichomonas vaginalis glucose transporter, putative 0.0133 0.0636 0.2743
Onchocerca volvulus 0.006 0.0233 0.967
Echinococcus multilocularis short transient receptor potential channel 6 0.0206 0.1044 0.4584
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0045 0.015 0.1782
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Echinococcus granulosus pyruvate kinase 0.0037 0.0105 0.0459
Plasmodium vivax hexose transporter 0.0428 0.2278 0.2278
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0157 0.0771 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0438
Leishmania major protein kinase, putative 0.0131 0.0627 0.8582
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0105 0.1431
Echinococcus multilocularis calcium dependent protein kinase 0.0123 0.0582 0.2554
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0086 0.0378
Trypanosoma brucei sugar transporter, putative 0.006 0.0233 0.3186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0117 0.0515
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.073 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0131 0.0627 0.236
Schistosoma mansoni smad 0.0034 0.0086 0.0378
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.013 0.0571
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.01 0.0437
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0016 0.0069
Schistosoma mansoni lysyl-tRNA synthetase 0.0095 0.0429 0.1885
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0239 0.0898
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0016 0.0121
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0016 0.0126
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0233 0.0876
Plasmodium falciparum threonine--tRNA ligase 0.0024 0.0032 0.0032
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0065 0.0098
Echinococcus multilocularis pyruvate kinase 0.0019 0.0004 0.0018
Schistosoma mansoni transient receptor potential channel 0.0312 0.1631 0.7159
Onchocerca volvulus 0.006 0.0233 0.967
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Echinococcus granulosus pyruvate kinase 0.0037 0.0105 0.0459
Leishmania major DNA polymerase eta, putative 0.0021 0.0016 0.0214
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0656
Echinococcus multilocularis smad 0.0034 0.0086 0.0378
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.01 0.0437
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus granulosus calcium activated potassium channel 0.0019 0.0001 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0117 0.045
Echinococcus granulosus transient receptor potential ion channel A 0.0301 0.1573 0.6906
Trypanosoma cruzi hexose transporter, putative 0.0073 0.0302 0.4129
Entamoeba histolytica protein kinase, putative 0.0131 0.0627 0.3056
Echinococcus granulosus transient receptor potential gamma protein 0.0312 0.1631 0.7159
Toxoplasma gondii sugar transporter ST1 0.006 0.0233 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Schistosoma mansoni glucose transport protein 0.0428 0.2278 1
Entamoeba histolytica hypothetical protein 0.0095 0.0429 0.2069
Treponema pallidum thioredoxin reductase (trxB) 0.0157 0.0771 0.449
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Entamoeba histolytica protein kinase, putative 0.0131 0.0627 0.3056
Schistosoma mansoni protein kinase 0.0131 0.0627 0.2752
Onchocerca volvulus 0.006 0.0233 0.967
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0117 0.0904
Echinococcus granulosus geminin 0.0174 0.0866 0.38
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0729 0.3201
Echinococcus multilocularis lamin dm0 0.0061 0.0239 0.1047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Giardia lamblia Prolyl-tRNA synthetase 0.0128 0.0612 0.3023
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus granulosus intermediate filament protein 0.0061 0.0239 0.1047
Echinococcus granulosus General substrate transporter 0.0368 0.1944 0.8531
Echinococcus granulosus Threonyl tRNA synthetase C 0.0024 0.0032 0.014
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0233 0.096
Trypanosoma cruzi hexose transporter, putative 0.0133 0.0636 0.871
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0086 0.0378
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Onchocerca volvulus 0.0039 0.0117 0.3037
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0636 0.2743
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.006 0.0233 0.3186
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0086 0.0378
Schistosoma mansoni hypothetical protein 0.0325 0.1705 0.7484
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0105 0.0393
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0062 0.0274
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0095 0.0429 0.5878
Onchocerca volvulus 0.006 0.0233 0.967
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0065 0.0283
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0016 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0209 0.2859
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.0768 0.9954
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0037 0.0164
Echinococcus granulosus dna polymerase kappa 0.0021 0.0016 0.0069
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0157 0.0771 0.334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.0636 0.871
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0233 0.096
Loa Loa (eye worm) sugar transporter 0.0428 0.2278 0.8577
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0016 0.0225
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0105 0.0393
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0105 0.2296
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0095 0.0429 0.5475
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Echinococcus multilocularis dna polymerase eta 0.0021 0.0016 0.0069
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0128 0.0612 0.2305
Echinococcus multilocularis musashi 0.0061 0.0239 0.1047
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0117 0.1338
Mycobacterium tuberculosis Conserved protein 0.0039 0.0117 0.0904
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0048 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1678 0.7349
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.008 0.0303
Plasmodium falciparum protein kinase 7 0.1209 0.6623 0.6623
Schistosoma mansoni sugar transporter 0.006 0.0233 0.1022
Echinococcus granulosus smad 0.0034 0.0086 0.0378
Leishmania major hypothetical protein, conserved 0.0021 0.0016 0.0225
Leishmania major hypothetical protein, conserved 0.0021 0.0016 0.0225
Echinococcus multilocularis solute carrier family 22 0.006 0.0233 0.1022
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0065 0.0283
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0105 0.0105
Trypanosoma brucei unspecified product 0.0021 0.0016 0.0214
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0048 0.0161
Leishmania major DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Brugia malayi Cam kinase protein 1 0.0131 0.0627 0.236
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0729 0.3201
Mycobacterium ulcerans beta-lactamase 0.0039 0.0117 0.1347
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0016 0.0225
Plasmodium vivax threonine--tRNA ligase, putative 0.0024 0.0032 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0393
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0095 0.0429 0.5878
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.006 0.0233 0.0233
Brugia malayi Sugar transporter family protein 0.0428 0.2278 0.8577
Leishmania major glucose transporter, lmgt2 0.0133 0.0636 0.871
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Loa Loa (eye worm) nuclear factor I 0.0019 0.0002 0.0008
Schistosoma mansoni glucose transport protein 0.0428 0.2278 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.0808 0.3042
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0048 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0627 0.2702
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.012
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0131 0.0627 0.0947
Trichomonas vaginalis glucose transporter, putative 0.006 0.0233 0.096
Brugia malayi Smad1 0.0034 0.0086 0.0324
Echinococcus multilocularis transient receptor potential gamma protein 0.0312 0.1631 0.7159
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0016 0.0059
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.006 0.0233 0.2873
Plasmodium vivax hypothetical protein, conserved 0.003 0.0065 0.0065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1195 0.4498
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.015 0.073 0.1103
Loa Loa (eye worm) hypothetical protein 0.0128 0.0612 0.2305
Echinococcus multilocularis synaptic vesicle 2 protein 0.006 0.0233 0.1022
Echinococcus multilocularis pyruvate kinase 0.0019 0.0004 0.0018
Mycobacterium tuberculosis Conserved protein 0.0039 0.0117 0.0904
Brugia malayi hypothetical protein 0.006 0.0233 0.0876
Schistosoma mansoni glucose transporter 0.006 0.0233 0.1022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0209 0.0209
Giardia lamblia Thioredoxin reductase 0.0157 0.0771 0.3814
Plasmodium vivax proline--tRNA ligase, putative 0.015 0.073 0.073
Brugia malayi MH1 domain containing protein 0.0034 0.0086 0.0324
Loa Loa (eye worm) hypothetical protein 0.0039 0.0117 0.0442
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0117 0.1347
Trypanosoma brucei glucose transporter, putative 0.0133 0.0636 0.871
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0243
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0128 0.0612 0.2687
Trichomonas vaginalis esterase, putative 0.0039 0.0117 0.045
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.01 0.0437
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0016 0.0069
Echinococcus multilocularis pyruvate kinase 0.0019 0.0004 0.0018
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0024 0.0032 0.0082
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0157 0.0771 0.334
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.073 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0042 0.013 0.0572
Plasmodium vivax glycine--tRNA ligase, putative 0.0024 0.0032 0.0032
Echinococcus granulosus lamin dm0 0.0061 0.0239 0.1047
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0157 0.0771 0.334
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0117 0.045
Loa Loa (eye worm) hypothetical protein 0.0128 0.0612 0.2305
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.0768 0.9954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0024 0.0032 0.014
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Trichomonas vaginalis sugar transporter, putative 0.0133 0.0636 0.2743
Schistosoma mansoni hypothetical protein 0.0428 0.2278 1
Schistosoma mansoni sugar transporter 0.006 0.0233 0.1022
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Entamoeba histolytica hypothetical protein 0.0042 0.013 0.0572
Loa Loa (eye worm) hypothetical protein 0.0116 0.0543 0.2043
Giardia lamblia DINP protein human, muc B family 0.0021 0.0016 0.0058
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0627 0.2752
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.008 0.0303
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0691 0.3744 0.3744
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0095 0.0429 0.5475
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0117 0.045
Brugia malayi hypothetical protein 0.006 0.0233 0.0876
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0876
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0131 0.0627 0.0627
Onchocerca volvulus 0.0061 0.0239 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.006 0.0233 0.1022
Echinococcus granulosus jumonji domain containing protein 0.0042 0.013 0.057
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.1299 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0024 0.0032 0.012
Echinococcus granulosus GPCR family 2 0.015 0.0734 0.3224
Echinococcus granulosus dna polymerase eta 0.0021 0.0016 0.0069
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0157 0.0771 1
Trichomonas vaginalis sugar transporter, putative 0.006 0.0233 0.096
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0062 0.0274
Brugia malayi MH1 domain containing protein 0.0019 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0061 0.0239 0.0898
Schistosoma mansoni pyruvate kinase 0.0037 0.0105 0.0459
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0428 0.2278 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0478 0.18
Giardia lamblia Lysyl-tRNA synthetase 0.0095 0.0429 0.2114
Leishmania major pyruvate kinase 0.0037 0.0105 0.1431
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0209 0.0209
Echinococcus multilocularis transient receptor potential ion channel A 0.0301 0.1573 0.6906
Brugia malayi Calcitonin receptor-like protein seb-1 0.0475 0.2541 0.9567
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.006 0.0233 0.2716
Onchocerca volvulus 0.006 0.0233 0.967
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0443 0.1946
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0214
Giardia lamblia Pyruvate kinase 0.0037 0.0105 0.0499
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0209 0.0209
Leishmania major threonyl-tRNA synthetase, putative 0.0024 0.0032 0.0438
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0656
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.015 0.0734 0.3224
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0105 0.2296

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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