Detailed information for compound 691326

Basic information

Technical information
  • TDR Targets ID: 691326
  • Name: N'-(3-fluorophenyl)-N-[2-[2-(4-methylphenyl)- [1,3]thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl ]oxamide
  • MW: 423.463 | Formula: C21H18FN5O2S
  • H donors: 2 H acceptors: 4 LogP: 3.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nn2c(n1)scc2CCNC(=O)C(=O)Nc1cccc(c1)F
  • InChi: 1S/C21H18FN5O2S/c1-13-5-7-14(8-6-13)18-25-21-27(26-18)17(12-30-21)9-10-23-19(28)20(29)24-16-4-2-3-15(22)11-16/h2-8,11-12H,9-10H2,1H3,(H,23,28)(H,24,29)
  • InChiKey: LKSXEFQJYNUVSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-(3-fluorophenyl)-N-[2-[2-(4-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]oxamide
  • N'-(3-fluorophenyl)-N-[2-[2-(4-methylphenyl)-6-thiazolo[2,3-e][1,2,4]triazolyl]ethyl]oxamide
  • N'-(3-fluorophenyl)-N-[2-[2-(4-methylphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0048 0.0048
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0888 0.1961
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.2011 0.4581
Entamoeba histolytica hypothetical protein 0.0036 0.0462 0.1101
Chlamydia trachomatis metal transport ATPase 0.0008 0.0048 0.5
Schistosoma mansoni lamin 0.0026 0.0318 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0048 0.0048
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0068
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0073 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.2247 1
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0048 0.0048
Echinococcus granulosus muscleblind protein 0.0292 0.4336 0.4319
Toxoplasma gondii P-type ATPase PMA1 0.0008 0.0048 0.0592
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.016 0.0261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0669 0.1448
Entamoeba histolytica hypothetical protein 0.0036 0.0462 0.1101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0811 0.347
Schistosoma mansoni protein kinase 0.0204 0.3009 0.3009
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.0048 0.0592
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0283 0.0631
Schistosoma mansoni DNA helicase recq1 0.001 0.0073 0.0073
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0008 0.0048 0.0592
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0318 0.063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0888 0.2119
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0204 0.3009 0.2989
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.068 0.1475
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0054 0.0015
Echinococcus multilocularis muscleblind protein 1 0.0292 0.4336 0.4319
Echinococcus granulosus lamin dm0 0.0026 0.0318 0.029
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0669 0.1448
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0811 0.0811
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0048 0.0068
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0811 0.178
Echinococcus multilocularis lamin dm0 0.0026 0.0318 0.029
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0008 0.0048 0.0592
Echinococcus granulosus GPCR family 2 0.0016 0.016 0.0132
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0888 0.1961
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0073 0.0057
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0048 0.0114
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0048 0.0068
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0048 0.0019
Echinococcus granulosus bloom syndrome protein 0.0024 0.0283 0.0255
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0858 0.189
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.4192 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.2247 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0048 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0811 0.0811
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0283 0.0548
Loa Loa (eye worm) hypothetical protein 0.0016 0.016 0.0261
Onchocerca volvulus 0.0028 0.0344 0.1259
Entamoeba histolytica hypothetical protein 0.0036 0.0462 0.1101
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0669 0.1448
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0048 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0811 0.347
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0114
Onchocerca volvulus 0.0026 0.0318 0.115
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0115 0.0086
Echinococcus multilocularis cpg binding protein 0.0029 0.0368 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0048 0.0048
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0048 0.0019
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0048 0.0048
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0048 0.0019
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0048 0.0068
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0116 0.0159
Schistosoma mansoni ATPase 0.0008 0.0048 0.0048
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.3695 0.8506
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0048 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0814 0.0814
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0008 0.0048 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0719 0.8864
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0164 0.2023
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4192 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.5897 0.5885
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.3695 0.8506
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.016
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0048 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0811 0.347
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Loa Loa (eye worm) hypothetical protein 0.0204 0.3004 0.6894
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.5897 0.5885
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0136 0.0204
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0068
Loa Loa (eye worm) hypothetical protein 0.0292 0.4336 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0482 0.0455
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0048 0.0068
Loa Loa (eye worm) hypothetical protein 0.0026 0.0318 0.063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.00000000014621
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0048 0.0019
Schistosoma mansoni hypothetical protein 0.0396 0.5897 0.5897
Schistosoma mansoni eyes absent homolog 0.0085 0.1211 0.1211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4334 1
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0008 0.0048 0.0592
Schistosoma mansoni ATPase 0.0008 0.0048 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0462 0.0434
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0048 0.0019
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0048 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0073 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0545 0.1159
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0139
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2532 0.6021
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0048 0.0019
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0283 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0888 0.196
Schistosoma mansoni protein kinase 0.0204 0.3009 0.3009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.2009 0.8917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0008 0.0048 0.0114
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.016 0.0132
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0116 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0888 0.0862
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.2009 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1211 0.2713
Loa Loa (eye worm) hypothetical protein 0.0085 0.1211 0.2713
Schistosoma mansoni lamin 0.0026 0.0318 0.0318
Onchocerca volvulus 0.0026 0.0318 0.115
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.0048 0.0592
Loa Loa (eye worm) hypothetical protein 0.0292 0.4336 1
Treponema pallidum cation-transporting ATPase, P-type 0.0008 0.0048 0.0114
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0048 0.0114
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0048 0.0068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0811 0.0785
Brugia malayi Latrophilin receptor protein 2 0.0016 0.016 0.0261
Loa Loa (eye worm) RecQ helicase 0.0024 0.0283 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0545 0.1159
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0048 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0545 0.1159
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.016
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0283 0.0631
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0026
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0888 0.0862
Entamoeba histolytica hypothetical protein 0.0036 0.0462 0.1101
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0858 0.189
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0068
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0114
Echinococcus granulosus lamin 0.0026 0.0318 0.029
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0167 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0107 0.0139
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0116 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0008 0.0048 0.0592
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0462 0.0434
Schistosoma mansoni hypothetical protein 0.0034 0.0433 0.0433
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.2399 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0013 0.0115 0.0155
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2011 0.4581
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0048 0.0019
Loa Loa (eye worm) hypothetical protein 0.012 0.1729 0.392
Brugia malayi Muscleblind-like protein 0.0292 0.4336 1
Toxoplasma gondii P-type ATPase4, putative 0.0008 0.0048 0.0592
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0073 0.0894
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0545 0.1159
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.4192 1
Toxoplasma gondii hypothetical protein 0.0047 0.0636 0.7838
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.4334 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.3695 0.881
Schistosoma mansoni hypothetical protein 0.0036 0.0462 0.0462
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.2011 0.4581
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0073 0.1282
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0048 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0073 0.0894
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0048 0.0048
Schistosoma mansoni DNA helicase recq5 0.001 0.0073 0.0073
Brugia malayi hypothetical protein 0.0036 0.0462 0.0965
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0208 0.0208
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0136 0.0204
Brugia malayi Neuronal symmetry protein 1 0.0204 0.3009 0.6905
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0462 0.0462
Echinococcus multilocularis musashi 0.0026 0.0318 0.029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.016 0.0132
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0008 0.0048 0.0068
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0008 0.0048 0.0592
Echinococcus multilocularis muscleblind protein 0.0292 0.4336 0.4319
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0318 0.063
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0073 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0433 0.0899
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0204 0.3009 0.2989
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0073 0.0057
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0318 0.063
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.4334 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0073 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0433 0.0899
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0073 0.0044
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0048 0.0019
Toxoplasma gondii cation-transporting atpase family protein 0.0008 0.0048 0.0592
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0669 0.1448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0054 0.0026
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.016
Echinococcus multilocularis GPCR, family 2 0.0016 0.016 0.0132
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0008 0.0048 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0048 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.4334 1
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0048 0.0019
Echinococcus granulosus intermediate filament protein 0.0026 0.0318 0.029
Echinococcus multilocularis lamin 0.0026 0.0318 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.00000000014621
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0008 0.0048 0.0068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0811 0.0785
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0811 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0116 0.0277
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.2009 0.8917
Brugia malayi hypothetical protein 0.0085 0.1211 0.2713
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0482 0.0455
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0073 0.0059
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0008 0.0048 0.0114
Schistosoma mansoni cpg binding protein 0.0028 0.0344 0.0344
Schistosoma mansoni cpg binding protein 0.0029 0.0368 0.0368
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.016 0.0132
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0115 0.0086
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0048 0.0019
Brugia malayi CXXC zinc finger family protein 0.0028 0.0344 0.069
Schistosoma mansoni intermediate filament proteins 0.0026 0.0318 0.0318
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0053 0.0011
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0008 0.0048 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.016 0.0261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0344 0.069
Treponema pallidum hypothetical protein 0.0008 0.0048 0.0114
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0888 0.1961
Loa Loa (eye worm) hypothetical protein 0.0062 0.0853 0.1878
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0048 0.0019
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0048 0.0019
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0062 0.0858 0.1889
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2532 0.6021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0811 0.347
Schistosoma mansoni cpg binding protein 0.0029 0.0368 0.0368
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0008 0.0048 0.0114
Echinococcus granulosus cpg binding protein 0.0029 0.0368 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.4192 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.00000000014621
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0008 0.0048 0.0068
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.016 0.0132
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0048 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2399 0.5702
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.4192 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0888 0.1961
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0008 0.0048 0.0114
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0048 0.0019
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0888 0.196
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0073 0.0057
Schistosoma mansoni hypothetical protein 0.0016 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0311 0.0614
Brugia malayi intermediate filament protein 0.0026 0.0318 0.063

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.