TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 239.276 | Formula: C13H13N5
H donors: 1 H acceptors: 3 LogP: 0.91 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NN(c1ccc(nn1)c1ccccc1)CCC#N
InChi: 1S/C13H13N5/c14-9-4-10-18(15)13-8-7-12(16-17-13)11-5-2-1-3-6-11/h1-3,5-8H,4,10,15H2
InChiKey: NIHSETRKYXSHDI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0129	0.289	0.2637
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0343	0.027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0394	0.0328
Brugia malayi	Steroid receptor seven-up type 2	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1719	0.1719
Mycobacterium ulcerans	carboxylesterase, LipT	0.006	0.1004	0.0684
Schistosoma mansoni	neuroligin 3 (S09 family)	0.006	0.1004	0.1124
Echinococcus multilocularis	ecdysone induced protein 78C	0.0037	0.0394	0.0328
Echinococcus granulosus	acetylcholinesterase	0.0352	0.8928	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0352	0.8928	0.8928
Entamoeba histolytica	hypothetical protein	0.0129	0.289	0.2637
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1235	0.1235
Brugia malayi	beta-lactamase family protein	0.0035	0.0343	0.0343
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0037	0.0394	0.0441
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0394	0.0394
Onchocerca volvulus		0.0035	0.0343	0.0857
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0394	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0129	0.289	0.289
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Mycobacterium tuberculosis	Probable oxidoreductase	0.0273	0.6782	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0037	0.0394	0.1038
Loa Loa (eye worm)	carboxylesterase	0.0352	0.8928	0.8928
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0129	0.289	0.3237
Schistosoma mansoni	hypothetical protein	0.0035	0.0343	0.0384
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0392	1	1
Echinococcus multilocularis	neuroligin	0.006	0.1004	0.1019
Echinococcus granulosus	synaptic glycoprotein sc2	0.0129	0.289	0.3156
Trichomonas vaginalis	spcc417.12 protein, putative	0.006	0.1004	0.0684
Echinococcus multilocularis	BC026374 protein (S09 family)	0.006	0.1004	0.1019
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0394	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0037	0.0394	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Mycobacterium tuberculosis	Carboxylesterase LipT	0.006	0.1004	0.1026
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0394	0.0328
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Schistosoma mansoni	coup transcription factor	0.0037	0.0394	0.0441
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0037	0.0394	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Schistosoma mansoni	gliotactin	0.006	0.1004	0.1124
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0343	0.027
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Plasmodium vivax	polyprenol reductase, putative	0.0129	0.289	1
Brugia malayi	Carboxylesterase family protein	0.0352	0.8928	0.8928
Echinococcus granulosus	BC026374 protein S09 family	0.006	0.1004	0.1019
Schistosoma mansoni	neprilysin	0.0024	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0392	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Echinococcus multilocularis	carboxylesterase 5A	0.0352	0.8928	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1886	0.1886
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0037	0.0394	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0037	0.0394	0.0394
Echinococcus granulosus	neuroligin	0.006	0.1004	0.1019
Onchocerca volvulus	Bile acid receptor homolog	0.0037	0.0394	0.1038
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0392	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0129	0.289	0.289
Brugia malayi	hypothetical protein	0.006	0.1004	0.1004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0037	0.0394	0.0394
Brugia malayi	Peptidase family M13 containing protein	0.0092	0.1886	0.1886
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0129	0.289	0.3156
Onchocerca volvulus		0.006	0.1004	0.3228
Schistosoma mansoni	RAR-like nuclear receptor	0.0037	0.0394	0.0441
Onchocerca volvulus		0.006	0.1004	0.3228
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0129	0.289	0.2637
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0394	0.0394
Brugia malayi	hypothetical protein	0.0086	0.1719	0.1719
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0394	0.0394
Schistosoma mansoni	acetylcholinesterase	0.006	0.1004	0.1124
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0046	0.0651	0.0729
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0046	0.0651	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0043	0.0049
Onchocerca volvulus		0.006	0.1004	0.3228
Onchocerca volvulus		0.006	0.1004	0.3228
Brugia malayi	Synaptic glycoprotein SC2	0.0129	0.289	0.289
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0037	0.0394	0.0394
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0068	0.1235	0.1235
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0392	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0037	0.0394	0.0328
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0037	0.0394	0.0328
Echinococcus multilocularis	acetylcholinesterase	0.0352	0.8928	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1719	0.1719
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0037	0.0394	0.0328
Echinococcus granulosus	acetylcholinesterase	0.0352	0.8928	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0394	0.0394
Mycobacterium ulcerans	short chain dehydrogenase	0.0273	0.6782	0.6668
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.006	0.1004	0.1026
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1235	0.1235
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0343	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0105	0.0105
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0392	1	1
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0129	0.289	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0037	0.0394	0.0394
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Brugia malayi	Carboxylesterase family protein	0.006	0.1004	0.1004
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0129	0.289	0.3237
Echinococcus granulosus	carboxylesterase 5A	0.0352	0.8928	1
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0392	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0037	0.0394	0.0328
Brugia malayi	hypothetical protein	0.0035	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0037	0.0394	0.0441
Schistosoma mansoni	eyes absent homolog	0.0086	0.1719	0.1926
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0392	1	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0343	0.0384
Toxoplasma gondii	peptidase family M13 protein	0.0092	0.1886	0.1597
Brugia malayi	Carboxylesterase family protein	0.006	0.1004	0.1004
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.289	0.2637
Onchocerca volvulus		0.0129	0.289	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0037	0.0394	0.0328
Mycobacterium ulcerans	hypothetical protein	0.0392	1	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0394	0.0394
Loa Loa (eye worm)	carboxylesterase	0.006	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1235	0.1235
Echinococcus granulosus	para nitrobenzyl esterase	0.006	0.1004	0.1019
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0394	0.0441
Brugia malayi	beta-lactamase family protein	0.0035	0.0343	0.0343
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0129	0.289	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0037	0.0394	0.0328
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0092	0.1886	0.1886
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0129	0.289	0.2637
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0129	0.289	0.2637
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1886	0.1886
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.289	0.2637
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.5466	0.7955
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0037	0.0394	0.0328
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0129	0.289	0.2637
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0343	0.0343
Loa Loa (eye worm)	steroid hormone receptor	0.0037	0.0394	0.0394
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0392	1	1
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0129	0.289	0.3156
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0352	0.8928	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.006	0.1004	0.1019
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0343	0.027
Brugia malayi	nuclear hormone receptor	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1235	0.1235
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0037	0.0394	0.0394
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.0651	0.0729
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0394	0.0394
Schistosoma mansoni	lamin	0.0026	0.0105	0.0117
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0129	0.289	0.2637
Giardia lamblia	Synaptic glycoprotein SC2	0.0129	0.289	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0105	0.0105
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0129	0.289	0.3156
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0068	0.1235	0.1235
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0129	0.289	0.2637
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.006	0.1004	0.1019
Loa Loa (eye worm)	hypothetical protein	0.006	0.1004	0.1004
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0037	0.0394	0.0328
Brugia malayi	steroid hormone receptor	0.0037	0.0394	0.0394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0037	0.0394	0.0394
Onchocerca volvulus		0.0037	0.0394	0.1038
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0037	0.0394	0.0394
Plasmodium falciparum	polyprenol reductase, putative	0.0129	0.289	0.5
Brugia malayi	ecdysteroid receptor	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0392	1	1
Onchocerca volvulus		0.0046	0.0628	0.1879
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0037	0.0394	0.0394
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.1886	0.2112
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0105	0.0105
Loa Loa (eye worm)	carboxylesterase	0.006	0.1004	0.1004
Loa Loa (eye worm)	hypothetical protein	0.007	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0394	0.0394
Echinococcus granulosus	endothelin converting enzyme 1	0.0092	0.1886	0.2019
Mycobacterium leprae	probable zinc metalloprotease	0.0092	0.1886	1
Brugia malayi	intermediate filament protein	0.0026	0.0105	0.0105
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0343	0.0384
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0037	0.0394	0.0441
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.1004	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0352	0.8928	0.8928
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0037	0.0394	0.0441
Echinococcus multilocularis	endothelin converting enzyme 1	0.0092	0.1886	0.2019
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0105	0.0105
Schistosoma mansoni	lamin	0.0026	0.0105	0.0117
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0037	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1886	0.1886
Onchocerca volvulus		0.0035	0.0343	0.0857
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0392	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0037	0.0394	0.0441
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0037	0.0394	0.0394
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0129	0.289	0.2637
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0037	0.0394	0.0394
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0046	0.0651	0.0729
Echinococcus granulosus	FTZ F1 alpha	0.0037	0.0394	0.0328
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0129	0.289	0.2637
Schistosoma mansoni	BC026374 protein (S09 family)	0.006	0.1004	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0628	0.0628
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0343	0.027
Brugia malayi	photoreceptor-specific nuclear receptor	0.0037	0.0394	0.0394
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0129	0.289	0.2637
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0105	0.0117
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0343	0.0343
Onchocerca volvulus		0.0035	0.0343	0.0857
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.1004	0.1124
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0037	0.0394	0.0441
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0343	0.0343
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0049
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0092	0.1886	0.2396
Onchocerca volvulus		0.006	0.1004	0.3228
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0394	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0092	0.0092
Brugia malayi	Carboxylesterase family protein	0.006	0.1004	0.1004
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0046	0.0651	0.0729
Mycobacterium ulcerans	zinc metalloprotease	0.0092	0.1886	0.1597
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.006	0.1004	0.0684
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.006	0.1004	0.1124
Echinococcus multilocularis	para nitrobenzyl esterase	0.006	0.1004	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Brugia malayi	Carboxylesterase family protein	0.0352	0.8928	0.8928
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.006	0.1004	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0343	0.0343
Brugia malayi	beta-lactamase	0.0035	0.0343	0.0343
Loa Loa (eye worm)	acetylcholinesterase 1	0.0352	0.8928	0.8928
Echinococcus multilocularis	acetylcholinesterase	0.0352	0.8928	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0037	0.0394	0.0394
Brugia malayi	Carboxylesterase family protein	0.006	0.1004	0.1004

Activities

Activity type	Activity value	Assay description	Source	Reference
ED40 (functional)	= 672 uM kg-1	Effective dose required for 40% inhibition of rat dermal reverse passive Arthus reaction (RPAR)	ChEMBL.	2970549

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 69537