Detailed information for compound 69619

Basic information

Technical information
  • TDR Targets ID: 69619
  • Name: N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan- 2-yl)naphthalen-1-yl]-3-nitrobenzamide
  • MW: 458.311 | Formula: C20H12F6N2O4
  • H donors: 2 H acceptors: 4 LogP: 5.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1c2ccccc2ccc1C(C(F)(F)F)(C(F)(F)F)O
  • InChi: 1S/C20H12F6N2O4/c21-19(22,23)18(30,20(24,25)26)15-9-8-11-4-1-2-7-14(11)16(15)27-17(29)12-5-3-6-13(10-12)28(31)32/h1-10,30H,(H,27,29)
  • InChiKey: HOIHZGNFCAITAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-nitro-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1-naphthyl]benzamide
  • N-[2-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)naphthalen-1-yl]-3-nitro-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 Starlite/ChEMBL References
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 8 References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.1675 0.259
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.1266 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.3865 0.3865
Loa Loa (eye worm) hypothetical protein 0.0204 0.5523 0.5523
Brugia malayi Trypsin family protein 0.0081 0.1933 0.1933
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0319 0.0493
Brugia malayi MH2 domain containing protein 0.013 0.3363 0.3363
Echinococcus granulosus acetylcholinesterase 0.0066 0.1509 0.2334
Echinococcus multilocularis enteropeptidase 0.0081 0.1933 0.2989
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0204 0.5523 0.5523
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0081 0.1933 0.2989
Brugia malayi Protein kinase domain containing protein 0.0014 0.000000058894 0.000000058894
Brugia malayi Trypsin family protein 0.0081 0.1933 0.1933
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0319 0.0493
Echinococcus multilocularis lamin 0.0026 0.0356 0.055
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Brugia malayi Death domain containing protein 0.0014 0.000000058894 0.000000058894
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0319
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0319 0.0493
Loa Loa (eye worm) hypothetical protein 0.0036 0.0643 0.0643
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1509 0.2334
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0437 0.0676
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0319 0.0825
Onchocerca volvulus 0.0081 0.1933 0.3072
Brugia malayi Uncoordinated protein 44 0.0014 0.000000058894 0.000000058894
Loa Loa (eye worm) hypothetical protein 0.0029 0.0437 0.0437
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.1266 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Brugia malayi Carboxylesterase family protein 0.0066 0.1509 0.1509
Toxoplasma gondii hypothetical protein 0.0204 0.5523 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.1266 0.124
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0319 0.0493
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0319 0.0825
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1463 0.2263
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.3865 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0356 0.0356
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0549 0.0549
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni transient receptor potential channel 0.0097 0.2415 0.6249
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1509 0.2334
Brugia malayi Cytochrome P450 family protein 0.0036 0.0631 0.0631
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.1266 0.124
Brugia malayi Pre-SET motif family protein 0.0029 0.0437 0.0437
Brugia malayi Trypsin family protein 0.0081 0.1933 0.1933
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1463 0.2263
Schistosoma mansoni hypothetical protein 0.0081 0.1933 0.5002
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.2321 0.3589
Echinococcus granulosus intermediate filament protein 0.0026 0.0356 0.055
Echinococcus multilocularis musashi 0.0026 0.0356 0.055
Loa Loa (eye worm) hypothetical protein 0.0204 0.5523 0.5523
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.1266 0.124
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0319 0.0825
Schistosoma mansoni hypothetical protein 0.0015 0.0029 0.0075
Echinococcus multilocularis 0.0015 0.0029 0.0045
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0631 0.0631
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0319 0.0493
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0029 0.0045
Brugia malayi hypothetical protein 0.0237 0.6467 0.6467
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0319 0.0493
Brugia malayi Carboxylesterase family protein 0.0066 0.1509 0.1509
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0066 0.1509 0.1509
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0319
Brugia malayi Pre-SET motif family protein 0.0202 0.5475 0.5475
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000000058894 0.0000001524
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0527
Onchocerca volvulus 0.0025 0.0319 0.0507
Schistosoma mansoni hypothetical protein 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Echinococcus granulosus transmembrane protease serine 3 0.0081 0.1933 0.2989
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1509 0.2334
Schistosoma mansoni survival motor neuron protein 0.0048 0.0996 0.2577
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0437 0.1132
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0003 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.3363 0.3363
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0643 0.0994
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.2321 0.3589
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Plasmodium vivax SET domain protein, putative 0.0029 0.0437 0.1253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Echinococcus granulosus lamin dm0 0.0026 0.0356 0.055
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1509 0.3906
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0097 0.2415 0.2415
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0406 0.0628
Loa Loa (eye worm) hypothetical protein 0.0026 0.0356 0.0356
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Onchocerca volvulus 0.0025 0.0319 0.0507
Schistosoma mansoni hypothetical protein 0.0048 0.0996 0.2577
Loa Loa (eye worm) carboxylesterase 0.0066 0.1509 0.1509
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0319 0.0493
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.1266 0.6496
Onchocerca volvulus 0.0048 0.0996 0.1583
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Onchocerca volvulus 0.0026 0.0356 0.0566
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0643 0.0994
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0527
Schistosoma mansoni intermediate filament proteins 0.0026 0.0356 0.0921
Onchocerca volvulus 0.0147 0.3865 0.6143
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1509 0.2334
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0319 0.0319
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.1266 0.1957
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0204 0.5523 0.5523
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni transient receptor potential channel 0.0064 0.1463 0.3786
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.1266 0.5
Brugia malayi Cytochrome P450 family protein 0.0015 0.0029 0.0029
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0319 0.0493
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0437 0.0743
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.1266 0.1266
Echinococcus granulosus Ankyrin 0.0014 0.0003 0.0005
Onchocerca volvulus 0.0081 0.1933 0.3072
Loa Loa (eye worm) trypsin family protein 0.0081 0.1933 0.1933
Loa Loa (eye worm) cytochrome P450 0.0015 0.0029 0.0029
Brugia malayi Cytochrome P450 family protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.3363 0.3363
Toxoplasma gondii exonuclease III APE 0.0058 0.1266 0.2251
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1509 0.1509
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0081 0.1933 0.1933
Echinococcus multilocularis serotonin transporter 0.0147 0.3865 0.5975
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.146 0.2257
Brugia malayi intermediate filament protein 0.0026 0.0356 0.0356
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0029 0.5
Mycobacterium leprae putative cytochrome p450 0.0015 0.0029 0.5
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.146 0.2257
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0319 0.0825
Onchocerca volvulus 0.0025 0.0319 0.0507
Loa Loa (eye worm) hypothetical protein 0.0081 0.1933 0.1933
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.1675 0.259
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Onchocerca volvulus 0.0029 0.0437 0.0695
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0527
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.3865 1
Echinococcus granulosus Mastin 0.0081 0.1933 0.2989
Loa Loa (eye worm) hypothetical protein 0.0026 0.0342 0.0342
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.3865 1
Mycobacterium ulcerans hypothetical protein 0.0081 0.1933 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0081 0.1933 0.2989
Onchocerca volvulus 0.0081 0.1933 0.3072
Brugia malayi Cytochrome P450 family protein 0.0015 0.0029 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.3865 0.3865
Loa Loa (eye worm) serotonin transporter b 0.0147 0.3865 0.3865
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0643 0.0643
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0319 0.5
Echinococcus multilocularis transmembrane protease serine 3 0.0081 0.1933 0.2989
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0319 0.0493
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.2415 0.3734
Loa Loa (eye worm) hypothetical protein 0.0358 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0437 0.0676
Echinococcus granulosus enteropeptidase 0.0081 0.1933 0.2989
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0319 0.0493
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0996 0.0996
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0437 0.1132
Loa Loa (eye worm) hypothetical protein 0.0237 0.6467 0.6467
Schistosoma mansoni cytochrome P450 0.0015 0.0029 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.1266 0.1957
Schistosoma mansoni ap endonuclease 0.0058 0.1266 0.3275
Echinococcus granulosus glycoprotein Antigen 5 0.0081 0.1933 0.2989
Toxoplasma gondii hypothetical protein 0.0025 0.0319 0.0527
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.2989
Onchocerca volvulus 0.0081 0.1933 0.3072
Onchocerca volvulus 0.0081 0.1933 0.3072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.1266 0.124
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0029 0.0029
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Brugia malayi Trypsin family protein 0.0081 0.1933 0.1933
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000000058894 0.000000091063
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.3865 0.3865
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Onchocerca volvulus 0.0026 0.0356 0.0566
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0356 0.0356
Brugia malayi hypothetical protein 0.0025 0.0319 0.0319
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0319 0.0825
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0319 0.0493
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.1266 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0061 0.1366 0.1366
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0319
Toxoplasma gondii hypothetical protein 0.0025 0.0319 0.0527
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1266 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0147 0.3865 0.3865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0437 0.1132
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Schistosoma mansoni lamin 0.0026 0.0356 0.0921
Loa Loa (eye worm) hypothetical protein 0.0183 0.4912 0.4912
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000000058894 0.000000091063
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.3865 0.3865
Trichomonas vaginalis set domain proteins, putative 0.023 0.6288 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Schistosoma mansoni ap endonuclease 0.0058 0.1266 0.3275
Onchocerca volvulus 0.0081 0.1933 0.3072
Loa Loa (eye worm) hypothetical protein 0.0066 0.1509 0.1509
Brugia malayi cytochrome P450 0.0015 0.0029 0.0029
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0319 0.0825
Brugia malayi Trypsin-like protease protein 5 0.0081 0.1933 0.1933
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0081 0.1933 0.2989
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.2415 0.3734
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.6467 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0081 0.1933 0.5002
Loa Loa (eye worm) hypothetical protein 0.0147 0.3865 0.3865
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.2415 0.6249
Schistosoma mansoni cercarial elastase (S01 family) 0.0081 0.1933 0.5002
Leishmania major C-8 sterol isomerase-like protein 0.0358 1 1
Brugia malayi hypothetical protein 0.0081 0.1933 0.1933
Echinococcus granulosus lamin 0.0026 0.0356 0.055
Echinococcus granulosus serotonin transporter 0.0147 0.3865 0.5975
Echinococcus multilocularis Mastin 0.0081 0.1933 0.2989
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0437 0.0676
Schistosoma mansoni transient receptor potential channel 0.0064 0.146 0.3778
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0437 0.1132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0025 0.0319 0.0319
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 1 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0081 0.1933 0.2989
Echinococcus multilocularis lamin dm0 0.0026 0.0356 0.055
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.6467 1
Schistosoma mansoni lamin 0.0026 0.0356 0.0921
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.5475 0.5475
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0319 0.0319
Onchocerca volvulus 0.0231 0.6291 1
Echinococcus granulosus acetylcholinesterase 0.0066 0.1509 0.2334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0003
Echinococcus multilocularis Ankyrin 0.0014 0.0003 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1266 1
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.1266 0.1266

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -6.37 Potent effective concentration was evaluated for KATP channel opening activity in pig bladder strips ChEMBL. 12729655
EC50 (binding) = 0.117 uM Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 ChEMBL. 12729655
EC50 (binding) = 0.117 uM Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 ChEMBL. 12729655
Efficacy (functional) = 99 % Maximal efficacy was expressed in comparison to P1075 using KATP activity in pig bladder strips ChEMBL. 12729655
Efficacy (functional) = 99 % Maximal efficacy was expressed in comparison to P1075 using KATP activity in pig bladder strips ChEMBL. 12729655
Log EC50 (functional) = 6.37 uM Potent effective concentration was evaluated for KATP channel opening activity in pig bladder strips ChEMBL. 12729655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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