Detailed information for compound 696492

Basic information

Technical information
  • TDR Targets ID: 696492
  • Name: N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3 ,4-d]pyrazol-3-yl]-N'-(2-hydroxyethyl)oxamide
  • MW: 360.431 | Formula: C17H20N4O3S
  • H donors: 3 H acceptors: 4 LogP: 1.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNC(=O)C(=O)Nc1c2CSCc2nn1c1ccc(cc1C)C
  • InChi: 1S/C17H20N4O3S/c1-10-3-4-14(11(2)7-10)21-15(12-8-25-9-13(12)20-21)19-17(24)16(23)18-5-6-22/h3-4,7,22H,5-6,8-9H2,1-2H3,(H,18,23)(H,19,24)
  • InChiKey: OQFKITUGFIRXCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-d]pyrazol-3-yl]-N'-(2-hydroxyethyl)ethanediamide
  • ZINC05437860

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0027 0.0027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.012 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0379 0.0422
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2313 0.2305
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0049 0.0593 0.3205
Entamoeba histolytica protein kinase, putative 0.0018 0.0099 0.025
Trichomonas vaginalis STE family protein kinase 0.0018 0.0099 0.025
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0722 0.4309
Echinococcus multilocularis lysosomal alpha glucosidase 0.0502 0.7827 0.7827
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0015 0.006 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0072 0.0072
Entamoeba histolytica protein kinase, putative 0.0018 0.0099 0.025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0379 0.0379
Schistosoma mansoni ran 0.0022 0.0169 0.0169
Schistosoma mansoni ran 0.0022 0.0169 0.0169
Brugia malayi intermediate filament protein 0.0027 0.025 0.0257
Trichomonas vaginalis sucrase-isomaltase, putative 0.0111 0.1596 1
Echinococcus granulosus intermediate filament protein 0.0027 0.025 0.025
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0394 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0394 0.0394
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.1013 0.1013
Trypanosoma brucei aurora B kinase 0.0057 0.0722 0.439
Trypanosoma cruzi aurora B kinase, putative 0.0057 0.0722 0.408
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0169 0.0169
Trichomonas vaginalis STE family protein kinase 0.0018 0.0099 0.025
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0616 0.0727
Onchocerca volvulus 0.0134 0.1951 0.405
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0394 0.1858
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0379 1
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0015 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0034 0.0364 0.0364
Brugia malayi Inositol-1 0.0036 0.0394 0.0442
Echinococcus multilocularis lamin 0.0027 0.025 0.025
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.012 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0037
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0042 0.0481 0.055
Loa Loa (eye worm) intermediate filament protein 0.0027 0.025 0.024
Entamoeba histolytica hypothetical protein 0.0037 0.0417 0.232
Loa Loa (eye worm) inositol-1 0.0036 0.0394 0.0384
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0593 0.3466
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0481 0.274
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0224 0.0224
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.012 0.0387
Brugia malayi MAP kinase sur-1 0.0055 0.069 0.0822
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0593 0.3468
Loa Loa (eye worm) hypothetical protein 0.005 0.0616 0.0606
Schistosoma mansoni hypothetical protein 0.0342 0.5264 0.5264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0072 0.0072
Echinococcus multilocularis importin subunit beta 1 0.006 0.0773 0.0773
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.069 0.386
Onchocerca volvulus 0.0035 0.0379 0.0306
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.069 0.068
Schistosoma mansoni cell adhesion molecule 0.0012 0.001 0.001
Leishmania major glycosyl hydrolase-like protein 0.0042 0.0481 0.2448
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.012 0.0387
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0179 0.2676 0.2669
Schistosoma mansoni protein kinase 0.0018 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0072
Brugia malayi WH1 domain containing protein 0.0015 0.006 0.0013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0169 0.0333
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0364 0.0403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0593 0.3466
Onchocerca volvulus 0.0035 0.0379 0.0306
Schistosoma mansoni alpha-glucosidase 0.0433 0.6712 0.6712
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.006
Entamoeba histolytica protein kinase, putative 0.0057 0.0722 0.4309
Schistosoma mansoni lamin 0.0027 0.025 0.025
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.069 0.069
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0164 0.2435 0.2435
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0379 0.0791
Onchocerca volvulus Tyrosine kinase homolog 0.0137 0.2001 0.4169
Schistosoma mansoni alpha glucosidase 0.0111 0.1596 0.1596
Entamoeba histolytica protein kinase , putative 0.0057 0.0722 0.4309
Echinococcus granulosus PAK box P21 Rho binding 0.0015 0.006 0.006
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0057 0.0722 0.4309
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.005
Trichomonas vaginalis STE family protein kinase 0.0018 0.0099 0.025
Schistosoma mansoni inositol monophosphatase 0.0036 0.0394 0.0394
Leishmania major alpha glucosidase II subunit, putative 0.0111 0.1596 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0017
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0593 0.7928
Echinococcus granulosus twitchin 0.0014 0.0038 0.0038
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0593 0.3468
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Entamoeba histolytica hypothetical protein 0.0037 0.0417 0.232
Echinococcus granulosus flap endonuclease 1 0.0025 0.0224 0.0224
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0049 0.0593 0.0593
Brugia malayi RNA, U transporter 1 0.017 0.2531 0.3191
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0394 0.0394
Echinococcus granulosus geminin 0.0342 0.5264 0.5264
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0379 0.0379
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.069 0.386
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0072
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0164 0.2435 0.2435
Echinococcus granulosus lamin 0.0027 0.025 0.025
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0722 0.4309
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1677 0.1669
Echinococcus multilocularis rho associated protein kinase 0.0143 0.2102 0.2102
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0481 0.274
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.069 0.386
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0169 0.1126
Brugia malayi Fli-1 protein 0.0227 0.3441 0.4361
Echinococcus granulosus aurora kinase A 0.0057 0.0722 0.0722
Schistosoma mansoni ap endonuclease 0.0019 0.012 0.012
Schistosoma mansoni hypothetical protein 0.0639 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0616 0.0727
Mycobacterium tuberculosis Conserved protein 0.0035 0.0379 0.0791
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.012 0.0387
Echinococcus multilocularis lysosomal alpha glucosidase 0.0502 0.7827 0.7827
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0722 0.0713
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0049 0.0593 0.3205
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.069 0.386
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.012 0.012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.012 0.5
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0242 0.0233
Leishmania major protein kinase, putative 0.0057 0.0722 0.408
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1677 0.1669
Trichomonas vaginalis alpha-glucosidase, putative 0.0111 0.1596 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0417 0.0417
Brugia malayi hypothetical protein 0.0037 0.0417 0.0471
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0593 0.3466
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0049 0.0593 0.0593
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0072 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.2102 0.2102
Echinococcus granulosus lamin dm0 0.0027 0.025 0.025
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0049 0.0593 0.3205
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.012 0.012
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0057 0.0722 0.0722
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0169 0.0753
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0379 0.0379
Brugia malayi serine/threonine kinase 12 0.0057 0.0722 0.0864
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0156 0.2313 0.2313
Entamoeba histolytica protein kinase, putative 0.0018 0.0099 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0379 0.1753
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0224 0.1065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0072 0.0061
Loa Loa (eye worm) beta-lactamase 0.0035 0.0379 0.0369
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0394 0.1858
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.012 0.0524
Echinococcus multilocularis PAK box P21 Rho binding 0.0015 0.006 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.069 0.4098
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.2313 0.2313
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0169 0.0839
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0072 0.0027
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0394 0.2173
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.069 0.386
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0593 0.3468
Brugia malayi P21-Rho-binding domain containing protein 0.0015 0.006 0.0013
Schistosoma mansoni protein kinase 0.0057 0.0722 0.0722
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0072 0.0061
Brugia malayi beta-lactamase 0.0035 0.0379 0.0422
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0593 0.0584
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0015 0.006 0.005
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0394 0.1858
Entamoeba histolytica hypothetical protein 0.0037 0.0417 0.232
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0379 0.2072
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.069 0.4098
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.012 0.0337
Echinococcus granulosus neutral alpha glucosidase AB 0.0111 0.1596 0.1596
Entamoeba histolytica hypothetical protein 0.0037 0.0417 0.232
Schistosoma mansoni ets-related 0.0227 0.3441 0.3441
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0379 0.3962
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0481 0.274
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0169 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0111 0.1596 1
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0074 0.0074
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0018 0.0099 0.0099
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0334 0.0654
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0722 0.4309
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0156 0.2313 0.291
Schistosoma mansoni gabp alpha 0.0075 0.1013 0.1013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.069 0.386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0111 0.1596 1
Trypanosoma brucei protein kinase, putative 0.0049 0.0593 0.3561
Echinococcus granulosus lysosomal alpha glucosidase 0.0502 0.7827 0.7827
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0481 0.274
Trichomonas vaginalis esterase, putative 0.0035 0.0379 0.2072
Entamoeba histolytica p21-activated kinase 0.0018 0.0099 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.069 0.4098
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0169 0.0159
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0009
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0111 0.1596 1
Brugia malayi beta-lactamase family protein 0.0035 0.0379 0.0422
Entamoeba histolytica hypothetical protein 0.0049 0.0593 0.3466
Brugia malayi serine/threonine-protein kinase PAK 7 0.0179 0.2676 0.3377
Schistosoma mansoni protein kinase 0.0018 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Trichomonas vaginalis alpha-glucosidase, putative 0.0111 0.1596 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0379 0.9437
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0441 0.684 0.6837
Trypanosoma brucei glycosyl hydrolase-like protein 0.0042 0.0481 0.2843
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0379 0.2185
Schistosoma mansoni hypothetical protein 0.0037 0.0417 0.0417
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0018 0.0099 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0481 0.274
Brugia malayi P21-Rho-binding domain containing protein 0.0015 0.006 0.0013
Trichomonas vaginalis ran, putative 0.0022 0.0169 0.0708
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0722 0.4309
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0502 0.7827 0.7824
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.069 0.069
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0593 0.0584
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0224 0.1192
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0018 0.0099 0.0099
Leishmania major GTP-binding protein, putative 0.0022 0.0169 0.0333
Loa Loa (eye worm) hypothetical protein 0.006 0.0773 0.0764
Brugia malayi Ets-domain containing protein 0.0075 0.1013 0.1237
Mycobacterium tuberculosis Conserved protein 0.0035 0.0379 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1596 1
Echinococcus multilocularis roundabout 2 0.0014 0.0047 0.0047
Brugia malayi intracellular kinase 0.0049 0.0593 0.0698
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0379 0.0369
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0379 0.0791
Echinococcus multilocularis protein kinase shaggy 0.0049 0.0593 0.0593
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0169 0.0753
Trichomonas vaginalis alpha-glucosidase, putative 0.0111 0.1596 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0394 0.2173
Onchocerca volvulus 0.0291 0.4451 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0417 0.0417
Leishmania major hypothetical protein, conserved 0.0035 0.0379 0.1753
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0111 0.1596 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0018 0.0099 0.0099
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0072 0.0027
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0224 0.0705
Brugia malayi Glycosyl hydrolases family 31 protein 0.0502 0.7827 1
Trichomonas vaginalis STE family protein kinase 0.0018 0.0099 0.025
Brugia malayi serine/threonine protein kinase 6 0.0057 0.0722 0.0864
Schistosoma mansoni importin beta-1 0.006 0.0773 0.0773
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2313 0.2305
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0049 0.0593 0.0593
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0379 0.2072
Schistosoma mansoni tyrosine kinase 0.0016 0.0074 0.0074
Brugia malayi Protein kinase domain 0.0018 0.0099 0.0063
Giardia lamblia Aurora kinase 0.0057 0.0722 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0049 0.0593 0.7244
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0057 0.0722 0.9221
Schistosoma mansoni alpha-glucosidase 0.0433 0.6712 0.6712
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0773 0.4717
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0379 0.0791
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3392 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0224 0.0705
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0481 0.2448
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0111 0.1596 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0379 0.0791
Echinococcus multilocularis aurora kinase A 0.0057 0.0722 0.0722
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.069 0.069
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0224 0.1065
Schistosoma mansoni protein kinase 0.0015 0.006 0.006
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0064 0.0839 0.083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0379 0.0379
Mycobacterium ulcerans beta-lactamase 0.0035 0.0379 0.9437
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0018 0.0099 0.0099
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.005 0.004
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0057 0.0722 0.0722
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0481 0.274
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0169 0.0333
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0379 0.9437
Entamoeba histolytica protein kinase, putative 0.0049 0.0593 0.3468
Echinococcus multilocularis geminin 0.0342 0.5264 0.5264
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.069 0.4181
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0111 0.1596 1
Echinococcus granulosus roundabout 2 0.0014 0.0047 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0379 0.2072
Toxoplasma gondii aurora kinase 0.0057 0.0722 0.408
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0224 0.0214
Leishmania major importin beta-1 subunit, putative 0.0049 0.0593 0.3203
Brugia malayi beta-lactamase family protein 0.0035 0.0379 0.0422
Plasmodium falciparum importin beta, putative 0.006 0.0773 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0111 0.1596 0.1596
Trichomonas vaginalis alpha-glucosidase, putative 0.0111 0.1596 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0072 0.0072
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0481 0.274
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0722 0.0722
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0394 1
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0722 0.0713
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0147 0.2155 0.2147
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.2155 0.2707
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0224 0.2007
Brugia malayi Protein kinase domain containing protein 0.0441 0.684 0.8731
Echinococcus multilocularis lamin dm0 0.0027 0.025 0.025
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0379 0.0791
Plasmodium vivax importin-beta 2, putative 0.006 0.0773 1
Echinococcus multilocularis snurportin 1 0.0639 1 1
Brugia malayi Importin beta-1 subunit 0.006 0.0773 0.093
Schistosoma mansoni flap endonuclease-1 0.0023 0.0185 0.0185
Entamoeba histolytica protein kinase, putative 0.0018 0.0099 0.025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 1 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0379 0.9437
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0481 0.274
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0481 0.0554
Echinococcus granulosus protein kinase shaggy 0.0049 0.0593 0.0593
Trypanosoma brucei protein kinase, putative 0.0055 0.069 0.4181
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0224 0.0705
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0224 0.1593
Mycobacterium leprae Probable lipase LipE 0.0035 0.0379 1
Plasmodium falciparum glycogen synthase kinase 3 0.0049 0.0593 0.7244
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0593 0.3203
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0027 0.0027
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0018 0.0099 0.0099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0616 0.0606
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0379 0.1753
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0593 0.3468
Onchocerca volvulus 0.0049 0.0593 0.0816
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0394 0.2173
Loa Loa (eye worm) fli-1 protein 0.0227 0.3441 0.3435
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.069 0.069
Schistosoma mansoni ap endonuclease 0.0019 0.012 0.012
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0156 0.2313 0.2313
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0394 0.1858
Trichomonas vaginalis STE family protein kinase 0.0018 0.0099 0.025
Echinococcus granulosus importin subunit beta 1 0.006 0.0773 0.0773
Trichomonas vaginalis maltase-glucoamylase, putative 0.0111 0.1596 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0379 0.9437
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0072 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0722 0.4309
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0379 0.2072
Toxoplasma gondii ABC1 family protein 0.0035 0.0379 0.1753
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0773 0.4425
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.069 0.069
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.069 0.9479
Brugia malayi Flap endonuclease-1 0.0025 0.0224 0.0223
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0015 0.006 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0379 0.2072
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0379 0.0791
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.025 0.024
Schistosoma mansoni hypothetical protein 0.0016 0.0072 0.0072
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0169 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.025 0.0257
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0481 0.2448
Brugia malayi Protein kinase domain containing protein 0.0156 0.2313 0.291
Echinococcus granulosus GPCR family 2 0.0016 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0379 0.0369
Brugia malayi Ets-domain containing protein 0.0075 0.1013 0.1237
Entamoeba histolytica Ran family GTPase 0.0022 0.0169 0.0708
Onchocerca volvulus 0.0143 0.2102 0.4409
Brugia malayi Glycosyl hydrolases family 31 protein 0.0111 0.1596 0.1988
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0034 0.0364 0.0354
Echinococcus granulosus rho-associated protein kinase 1 0.0143 0.2102 0.2102
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0057 0.0722 0.4309
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0394 0.2284
Schistosoma mansoni lamin 0.0027 0.025 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1596 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0394 0.0394
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0057 0.0722 0.4309
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0773 0.4717
Brugia malayi MH2 domain containing protein 0.0117 0.1677 0.2092
Plasmodium falciparum serine/threonine protein kinase, putative 0.0057 0.0722 0.9221
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.1013 0.1003
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0015 0.006 0.006
Entamoeba histolytica protein kinase, putative 0.0057 0.0722 0.4309
Schistosoma mansoni protein kinase 0.0018 0.0099 0.0099
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0593 0.7928
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0481 0.274
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0379 0.0791
Onchocerca volvulus 0.0035 0.0379 0.0306
Schistosoma mansoni intermediate filament proteins 0.0027 0.025 0.025
Echinococcus multilocularis musashi 0.0027 0.025 0.025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0394 0.2173
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.006
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0722 0.0713
Onchocerca volvulus 0.0141 0.2064 0.4317
Loa Loa (eye worm) hypothetical protein 0.0042 0.0481 0.0472
Mycobacterium tuberculosis Conserved protein 0.0035 0.0379 0.0791
Plasmodium falciparum flap endonuclease 1 0.0025 0.0224 0.1593
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.069 0.4098
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.069 0.386
Trypanosoma brucei glucosidase, putative 0.0111 0.1596 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0156 0.2313 0.4911
Schistosoma mansoni hypothetical protein 0.0342 0.5264 0.5264
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0111 0.1596 0.1588
Brugia malayi serine/threonine-protein kinase 6 0.0057 0.0722 0.0864

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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