Detailed information for compound 699331

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.329 | Formula: C20H17BrN2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)S(=O)(=O)Nc1ccc2c(c1)N(CCC2)C(=O)c1ccco1
  • InChi: 1S/C20H17BrN2O4S/c21-15-6-9-17(10-7-15)28(25,26)22-16-8-5-14-3-1-11-23(18(14)13-16)20(24)19-4-2-12-27-19/h2,4-10,12-13,22H,1,3,11H2
  • InChiKey: VWSPRCDPZMZONZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0168 0.3309 0.4558
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0965 0.1363
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0232 0.0102
Brugia malayi PHD-finger family protein 0.0025 0.0191 0.0219
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0146 0.2834 1
Echinococcus multilocularis geminin 0.034 0.7078 0.9749
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1651 0.1888
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.052 0.0716
Schistosoma mansoni importin beta-1 0.003 0.0305 0.0431
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0305 0.1077
Loa Loa (eye worm) hypothetical protein 0.003 0.0305 0.0349
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0691
Toxoplasma gondii NADPH-glutathione reductase 0.0041 0.0549 0.2434
Schistosoma mansoni inositol monophosphatase 0.0038 0.0476 0.0673
Schistosoma mansoni alpha glucosidase 0.0072 0.1222 0.1726
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0232 0.0817
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0041 0.0549 0.1939
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0956 0.1317
Loa Loa (eye worm) hypothetical protein 0.004 0.052 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0093 0.0106
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0923 0.1304
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0476 0.1279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0093 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0426 0.0602
Schistosoma mansoni rab6-interacting 0.004 0.052 0.0735
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0949 0.1307
Brugia malayi hypothetical protein 0.0025 0.0196 0.0224
Trichomonas vaginalis mercuric reductase, putative 0.0041 0.0549 0.0424
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0426 0.0587
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0232 0.014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.1222 0.4035
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.1222 0.431
Schistosoma mansoni hypothetical protein 0.0036 0.0426 0.0602
Brugia malayi glutaminase DH11.1 0.0272 0.5588 0.6392
Brugia malayi Pre-SET motif family protein 0.006 0.0949 0.1085
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0146 0.2834 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0093 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0093 0.0106
Loa Loa (eye worm) doublecortin family protein 0.004 0.052 0.0595
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0146 0.2834 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0097 0.0111
Trichomonas vaginalis set domain proteins, putative 0.0473 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0759 0.1072
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.052 0.0716
Leishmania major trypanothione reductase 0.0119 0.2257 0.7964
Onchocerca volvulus 0.006 0.0949 0.0864
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0093 0.0131
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0549 0.1939
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0093 0.0131
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0041 0.0549 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.1139 0.1022
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0146 0.2834 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.1222 0.1105
Schistosoma mansoni alpha-glucosidase 0.028 0.5764 0.8144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0093 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0949 0.1341
Echinococcus granulosus zinc finger protein 0.002 0.0074 0.0102
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0131 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.1139 0.1022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0476 0.1681
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.052 0.0716
Echinococcus multilocularis lamin 0.0027 0.0234 0.0323
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0146 0.2834 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.018 0.005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0041 0.0549 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0234 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0093 0.0106
Echinococcus multilocularis thioredoxin glutathione reductase 0.0119 0.2257 0.3109
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0093 0.0131
Treponema pallidum NADH oxidase 0.0041 0.0549 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.1324 0.1823
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0041 0.0549 0.1939
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0041 0.0549 0.5
Brugia malayi RNA, U transporter 1 0.0086 0.1525 0.1744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1651 0.2274
Schistosoma mansoni hypothetical protein 0.0323 0.6705 0.9474
Schistosoma mansoni hypothetical protein 0.034 0.7078 1
Schistosoma mansoni ran 0.0022 0.0131 0.0185
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0476 0.1681
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.052 0.0716
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0476 0.0656
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0891 0.1228
Loa Loa (eye worm) hypothetical protein 0.0077 0.1324 0.1514
Echinococcus granulosus lamin dm0 0.0027 0.0234 0.0323
Onchocerca volvulus Huntingtin homolog 0.0123 0.2336 0.2264
Giardia lamblia NADH oxidase lateral transfer candidate 0.0041 0.0549 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0093 0.0106
Loa Loa (eye worm) glutaminase 2 0.0272 0.5588 0.6392
Plasmodium falciparum LCCL domain-containing protein 0.004 0.052 0.1835
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0476 0.1681
Loa Loa (eye worm) hypothetical protein 0.0041 0.0539 0.0617
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0146 0.2834 0.4004
Brugia malayi jmjC domain containing protein 0.006 0.0965 0.1104
Plasmodium vivax glutathione reductase, putative 0.0119 0.2257 0.7964
Plasmodium falciparum thioredoxin reductase 0.0119 0.2257 0.7964
Brugia malayi Bromodomain containing protein 0.0038 0.0486 0.0555
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.1222 0.1105
Plasmodium falciparum glutathione reductase 0.0041 0.0549 0.1939
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Schistosoma mansoni inositol monophosphatase 0.0038 0.0476 0.0673
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0041 0.0549 0.0757
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0476 0.035
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0093 0.0128
Plasmodium falciparum thioredoxin reductase 0.0041 0.0549 0.1939
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0093 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0232 0.0102
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Leishmania major importin beta-1 subunit, putative 0.0025 0.018 0.0636
Loa Loa (eye worm) hypothetical protein 0.0123 0.2336 0.2672
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.1222 0.1397
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0965 0.1363
Loa Loa (eye worm) hypothetical protein 0.0071 0.1198 0.137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0433 0.0597
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0146 0.2834 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1222 0.431
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.018 0.0636
Echinococcus granulosus snurportin 1 0.0323 0.6705 0.9237
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0949 0.1341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0093 0.0128
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0305 0.1353
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0146 0.2834 0.2739
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0146 0.2834 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0041 0.0549 0.0143
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1222 0.1105
Echinococcus multilocularis snurportin 1 0.0323 0.6705 0.9237
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.1222 0.1397
Schistosoma mansoni lipoxygenase 0.004 0.052 0.0735
Brugia malayi nuclear receptor NHR-88 0.0021 0.0093 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0232 0.0102
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0041 0.0549 0.1939
Schistosoma mansoni hypothetical protein 0.004 0.052 0.0735
Brugia malayi Glycosyl hydrolases family 31 protein 0.0325 0.6754 0.7725
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0019 0.0026
Brugia malayi intermediate filament protein 0.0027 0.0234 0.0268
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.052 0.1835
Schistosoma mansoni hypothetical protein 0.0087 0.1548 0.2188
Echinococcus multilocularis zinc finger protein 0.002 0.0074 0.0102
Schistosoma mansoni zinc finger protein 0.002 0.0074 0.0105
Schistosoma mansoni hypothetical protein 0.034 0.7078 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0093 0.0106
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0196 0.0691
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0093 0.0106
Loa Loa (eye worm) hypothetical protein 0.0146 0.2834 0.3242
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.8743 1
Brugia malayi Thioredoxin reductase 0.0119 0.2257 0.2582
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0041 0.0549 0.1939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.0026
Schistosoma mansoni lamin 0.0027 0.0234 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0119 0.2257 0.7964
Entamoeba histolytica hypothetical protein 0.0036 0.0426 0.1093
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0234 0.0268
Onchocerca volvulus Huntingtin homolog 0.0123 0.2336 0.2264
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0131 0.018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0093 0.0131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.1324 0.1823
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0093 0.0128
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0549 0.1939
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0093 0.0131
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.6754 0.9303
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0019 0.0026
Schistosoma mansoni alkaline phosphatase 0.0168 0.3309 0.4676
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0131 0.0461
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0146 0.2834 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0139 0.0197
Plasmodium falciparum glutathione reductase 0.0119 0.2257 0.7964
Echinococcus multilocularis RUN 0.004 0.052 0.0716
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0068 0.1139 0.1022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1651 0.2274
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0901 0.1241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1651 0.2332
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1222 0.1105
Brugia malayi hypothetical protein 0.0123 0.2336 0.2672
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0232 0.0102
Schistosoma mansoni intermediate filament proteins 0.0027 0.0234 0.0331
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0093 0.0106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0093 0.0128
Onchocerca volvulus 0.0027 0.0234 0.0143
Brugia malayi Pre-SET motif family protein 0.0416 0.8743 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0041 0.0549 0.0757
Leishmania major GTP-binding protein, putative 0.0022 0.0131 0.0461
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0168 0.3309 0.4558
Schistosoma mansoni loxhd1 0.004 0.052 0.0735
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0232 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0093 0.0106
Plasmodium vivax importin-beta 2, putative 0.003 0.0305 0.1077
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0093 0.0131
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0234 0.0268
Echinococcus granulosus intestinal type alkaline phosphatase 0.0168 0.3309 0.4558
Loa Loa (eye worm) aspartyl aminopeptidase 0.0146 0.2834 0.3242
Echinococcus granulosus RUN 0.004 0.052 0.0716
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0093 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1651 0.2332
Loa Loa (eye worm) hypothetical protein 0.0027 0.0232 0.0265
Onchocerca volvulus 0.004 0.052 0.0431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0093 0.0128
Trichomonas vaginalis importin beta-1, putative 0.0025 0.018 0.005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0041 0.0549 0.0628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.1324 0.187
Brugia malayi Aspartyl aminopeptidase 0.0146 0.2834 0.3242
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0093 0.0131
Entamoeba histolytica hypothetical protein 0.0025 0.018 0.0183
Loa Loa (eye worm) hypothetical protein 0.0026 0.0224 0.0256
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0041 0.0549 0.0776
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0891 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0093 0.0106
Brugia malayi ecdysteroid receptor 0.0021 0.0093 0.0106
Entamoeba histolytica hypothetical protein 0.0036 0.0426 0.1093
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0196 0.0691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0093 0.0106
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0093 0.0128
Toxoplasma gondii thioredoxin reductase 0.0119 0.2257 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1222 0.1105
Onchocerca volvulus 0.0027 0.0234 0.0143
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1222 0.1105
Trichomonas vaginalis glutaminase, putative 0.0272 0.5588 0.553
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0041 0.0549 0.1939
Mycobacterium ulcerans glutaminase 0.0272 0.5588 1
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0965 0.1329
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0476 0.0656
Entamoeba histolytica aminopeptidase, putative 0.0146 0.2834 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0093 0.0128
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0232 0.0373
Schistosoma mansoni alpha-glucosidase 0.028 0.5764 0.8144
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.1222 0.1683
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0146 0.2834 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0093 0.0106
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1222 0.1105
Schistosoma mansoni ran 0.0022 0.0131 0.0185
Echinococcus granulosus lamin 0.0027 0.0234 0.0323
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0891 0.0812
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0168 0.3309 0.4558
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0027 0.0037
Schistosoma mansoni coup transcription factor 0.0021 0.0093 0.0131
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0232 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.052 0.0716
Echinococcus granulosus geminin 0.034 0.7078 0.9749
Brugia malayi hypothetical protein 0.004 0.052 0.0595
Echinococcus multilocularis tumor protein p63 0.0348 0.726 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0093 0.0106
Schistosoma mansoni bromodomain containing protein 0.0064 0.1034 0.1462
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0461
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0965 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0093 0.0106
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0325 0.6754 0.7725
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0032 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0923 0.1271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1651 0.2274
Onchocerca volvulus 0.0051 0.0759 0.0672
Schistosoma mansoni hypothetical protein 0.0021 0.0097 0.0137
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.052 0.0716
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0093 0.0128
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0461
Loa Loa (eye worm) glutathione reductase 0.0119 0.2257 0.2582
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0549 0.1939
Loa Loa (eye worm) hypothetical protein 0.004 0.052 0.0595
Plasmodium falciparum importin beta, putative 0.003 0.0305 0.1077
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0923 0.1271
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0389 0.1373
Brugia malayi Doublecortin family protein 0.004 0.052 0.0595
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0093 0.0128
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0196 0.0867
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0426 0.0587
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0146 0.2834 0.4004
Plasmodium vivax SET domain protein, putative 0.006 0.0949 0.3348
Echinococcus multilocularis alkaline phosphatase 0.0168 0.3309 0.4558
Echinococcus multilocularis aspartyl aminopeptidase 0.0146 0.2834 0.3904
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0891 0.3145
Brugia malayi Importin beta-1 subunit 0.003 0.0305 0.0349
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0146 0.2834 0.2739
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0093 0.0128
Trypanosoma brucei trypanothione reductase 0.0119 0.2257 0.7964
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0956 0.1317
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0891 0.3145
Brugia malayi steroid hormone receptor 0.0021 0.0093 0.0106
Brugia malayi glutathione reductase 0.0119 0.2257 0.2582
Onchocerca volvulus 0.0188 0.3756 0.3698
Echinococcus granulosus importin subunit beta 1 0.003 0.0305 0.0421
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0476 0.1681
Loa Loa (eye worm) glutaminase 0.0272 0.5588 0.6392
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0232 0.0817
Schistosoma mansoni lamin 0.0027 0.0234 0.0331
Onchocerca volvulus 0.004 0.052 0.0431
Entamoeba histolytica hypothetical protein 0.0036 0.0426 0.1093
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.6705 0.7669
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0891 0.1228
Echinococcus granulosus thioredoxin glutathione reductase 0.0119 0.2257 0.3109
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0139 0.0192
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0476 0.2111
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0041 0.0549 0.1939
Echinococcus multilocularis importin subunit beta 1 0.003 0.0305 0.0421
Loa Loa (eye worm) hypothetical protein 0.0051 0.0759 0.0868
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1222 0.431
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0041 0.0549 0.2434
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0549 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0112 0.2097 0.2888
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0476 0.035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0093 0.0106
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0093 0.0131
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0433 0.0597
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.1222 0.1105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.018 0.005
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0196 0.0691
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0027 0.0037
Trichomonas vaginalis hypothetical protein 0.0068 0.1139 0.1022
Schistosoma mansoni rab6-interacting 0.004 0.052 0.0735
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0093 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0487 0.0557
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0232 0.0265
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0807 0.0923
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0041 0.0549 0.1939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Echinococcus granulosus intermediate filament protein 0.0027 0.0234 0.0323
Brugia malayi jmjC domain containing protein 0.0058 0.0923 0.1056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1651 0.2332
Loa Loa (eye worm) inositol-1 0.0038 0.0476 0.0545
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0041 0.0549 0.1939
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.0691
Entamoeba histolytica hypothetical protein 0.0036 0.0426 0.1093
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.1222 0.1683
Loa Loa (eye worm) hypothetical protein 0.0146 0.2834 0.3242
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0232 0.0102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.1222 0.4035
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0093 0.0106
Leishmania major hypothetical protein, conserved 0.0025 0.0196 0.0691
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0093 0.0131
Brugia malayi nuclear hormone receptor 0.0021 0.0093 0.0106
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0549 0.1939
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0146 0.2834 0.2739
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1651 0.1888
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0232 0.0817
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1651 0.2274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0234 0.0268
Echinococcus multilocularis musashi 0.0027 0.0234 0.0323
Brugia malayi Inositol-1 0.0038 0.0476 0.0545
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0068 0.1139 0.1022
Schistosoma mansoni glutaminase 0.0272 0.5588 0.7896
Schistosoma mansoni lipoxygenase 0.0112 0.2097 0.2963
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.1222 0.1105
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0119 0.2257 0.7964
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0168 0.3309 0.4558
Trypanosoma brucei glucosidase, putative 0.0072 0.1222 0.431
Brugia malayi hypothetical protein 0.004 0.052 0.0595
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0232 0.0102
Plasmodium vivax thioredoxin reductase, putative 0.0119 0.2257 0.7964
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0093 0.0128
Loa Loa (eye worm) thioredoxin reductase 0.0119 0.2257 0.2582
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0305 0.1077
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.003 0.0309 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0093 0.0106
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0068 0.1139 0.1022
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0146 0.2834 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.6754 0.9303
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0093 0.0128
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0168 0.3309 0.4558
Trichomonas vaginalis glutathione reductase, putative 0.0041 0.0549 0.0424
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0041 0.0549 0.1939
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0891 0.0812
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0232 0.0817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0093 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0093 0.0128
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0093 0.0131
Schistosoma mansoni alkaline phosphatase 0.0168 0.3309 0.4676
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.1324 0.187
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0549 0.1939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0196 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0093 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.1139 0.1022
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0891 0.102
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0131 0.0461
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0923 0.1271
Echinococcus granulosus aspartyl aminopeptidase 0.0146 0.2834 0.3904
Brugia malayi Bromodomain containing protein 0.0075 0.1292 0.1478
Loa Loa (eye worm) hypothetical protein 0.0123 0.2336 0.2672
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0549 0.1939
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0093 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0196 0.0691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0093 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0093 0.0106
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0093 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0949 0.4205
Echinococcus granulosus lysosomal alpha glucosidase 0.0325 0.6754 0.9303
Echinococcus multilocularis lamin dm0 0.0027 0.0234 0.0323
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0139 0.0192
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0019 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0549 0.1939
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0476 0.035
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0041 0.0549 0.1939
Echinococcus granulosus tumor protein p63 0.0348 0.726 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0112 0.2097 0.2888
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0131 0.0461
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0041 0.0549 0.0656
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0131 0.018
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.1222 0.5412
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.003 0.0309 0.0354
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0093 0.0128
Brugia malayi hypothetical protein 0.0036 0.0426 0.0488
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0093 0.0128
Echinococcus granulosus alkaline phosphatase 0.0168 0.3309 0.4558
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0093 0.0106
Schistosoma mansoni polycystin 1-related 0.004 0.052 0.0735
Loa Loa (eye worm) hypothetical protein 0.0043 0.0581 0.0665
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0041 0.0549 0.1939

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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