Detailed information for compound 701161

Basic information

Technical information
  • TDR Targets ID: 701161
  • Name: N-(3-chlorophenyl)-2-[[1-(3-morpholin-4-ylpro pyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimi din-4-yl]sulfanyl]acetamide
  • MW: 462.993 | Formula: C22H27ClN4O3S
  • H donors: 1 H acceptors: 2 LogP: 2.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)Cl)CSc1nc(=O)n(c2c1CCC2)CCCN1CCOCC1
  • InChi: 1S/C22H27ClN4O3S/c23-16-4-1-5-17(14-16)24-20(28)15-31-21-18-6-2-7-19(18)27(22(29)25-21)9-3-8-26-10-12-30-13-11-26/h1,4-5,14H,2-3,6-13,15H2,(H,24,28)
  • InChiKey: ULGDRVLNGHDBGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-2-[[1-(3-morpholinopropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]acetamide
  • N-(3-chlorophenyl)-2-[[1-(3-morpholinopropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(3-chlorophenyl)-2-[[2-keto-1-(3-morpholinopropyl)-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]thio]acetamide
  • N-(3-chlorophenyl)-2-[[1-(3-morpholin-4-ylpropyl)-2-oxo-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0351 0.2696 0.64
Toxoplasma gondii glycyl-tRNA synthetase 0.0017 0.0038 0.0048
Loa Loa (eye worm) hypothetical protein 0.0078 0.0522 0.1229
Echinococcus granulosus Sugar transporter ERD6 protein 0.0042 0.0238 0.0433
Plasmodium vivax CDK-related protein kinase 6, putative 0.1268 1 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.0194 0.0698
Echinococcus granulosus calcium dependent protein kinase 0.0086 0.0587 0.1067
Schistosoma mansoni lamin 0.0047 0.0281 0.0511
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0639 0.499 1
Toxoplasma gondii sugar transporter ST1 0.0042 0.0238 0.0351
Brugia malayi Transient-receptor-potential like protein 0.0063 0.0409 0.1498
Trypanosoma cruzi importin beta-1 subunit, putative 0.0041 0.0231 0.2925
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0092 0.0633 0.0947
Schistosoma mansoni glycyl-tRNA synthetase 0.0017 0.0038 0.0069
Brugia malayi Importin beta-1 subunit 0.0051 0.0307 0.112
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0041 0.0231 0.0989
Onchocerca volvulus 0.0054 0.0335 0.2069
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0017 0.0038 0.0119
Leishmania major hypothetical protein, conserved 0.0042 0.0238 0.303
Echinococcus multilocularis L aminoadipate semialdehyde 0.0054 0.0335 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0238 0.1021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0037 0.0201 0.0725
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.023 0.0533
Schistosoma mansoni loxhd1 0.0013 0.0006 0.0011
Leishmania major protein kinase, putative 0.0091 0.0632 0.855
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.023 0.0418
Echinococcus multilocularis lysyl tRNA synthetase 0.0067 0.0435 0.079
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0067 0.0435 0.0737
Brugia malayi Sugar transporter family protein 0.0042 0.0238 0.0865
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0058 0.0369 0.1597
Loa Loa (eye worm) isocitrate dehydrogenase 0.0023 0.0086 0.0191
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0017 0.0038 0.0028
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0079 0.0534 0.0528
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0541 0.4209 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0043 0.0138
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0047 0.0281 0.0655
Mycobacterium leprae conserved hypothetical protein 0.0015 0.0025 0.005
Loa Loa (eye worm) hypothetical protein 0.0114 0.0809 0.191
Echinococcus granulosus intermediate filament protein 0.0047 0.0281 0.0511
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0017 0.0038 0.0031
Echinococcus multilocularis 0.0079 0.0534 0.0971
Echinococcus granulosus glycyl tRNA synthetase 0.0017 0.0038 0.0069
Plasmodium falciparum proline--tRNA ligase 0.0104 0.0736 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0103 0.0724 0.1316
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0067 0.0435 0.1884
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0042 0.0238 0.0433
Onchocerca volvulus 0.0042 0.0238 0.1461
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0043 0.0078
Echinococcus multilocularis solute carrier family 22 0.0042 0.0238 0.0433
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0015 0.0022 0.0025
Schistosoma mansoni rab6-interacting 0.0013 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0067 0.0435 0.6849
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0043 0.0088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.0534 0.103
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.009 0.0618 0.2274
Schistosoma mansoni aldehyde dehydrogenase 0.0048 0.0289 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0043 0.0138
Entamoeba histolytica protein kinase, putative 0.0091 0.0632 1
Leishmania major importin beta-1 subunit, putative 0.0041 0.0231 0.2925
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0042 0.0238 0.0232
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0042 0.0238 0.0386
Plasmodium falciparum lysine--tRNA ligase 0.0067 0.0435 0.0429
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0079 0.0534 0.0914
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0043 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0079 0.0534 0.0528
Loa Loa (eye worm) hypothetical protein 0.0212 0.1596 0.3782
Giardia lamblia Prolyl-tRNA synthetase 0.009 0.0618 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.009 0.0618 0.1455
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0037 0.0201 0.0195
Leishmania major lysyl-tRNA synthetase, putative 0.0067 0.0435 0.5783
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0043 0.0078
Echinococcus granulosus geminin 0.0135 0.0978 0.1777
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0022 0.006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0023 0.0086 0.0128
Trypanosoma cruzi sugar transporter, putative 0.0042 0.0238 0.303
Schistosoma mansoni hypothetical protein 0.0078 0.0522 0.0949
Brugia malayi major facilitator superfamily protein 0.0042 0.0238 0.0865
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0017 0.0038 0.014
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0017 0.0038 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0043 0.0244 0.036
Onchocerca volvulus 0.0042 0.0238 0.1461
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0092 0.0633 0.0947
Brugia malayi hypothetical protein 0.0043 0.0244 0.0885
Onchocerca volvulus 0.0042 0.0238 0.1461
Schistosoma mansoni lipoxygenase 0.0077 0.0515 0.0937
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.009 0.0618 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0043 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0691 0.541 0.9832
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0718 0.5621 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0244 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0642 0.2793
Toxoplasma gondii histone lysine-specific demethylase 0.0079 0.0534 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni transient receptor potential channel 0.0113 0.0802 0.1457
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0037 0.0201 0.2502
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0017 0.0038 0.0076
Entamoeba histolytica hypothetical protein 0.0041 0.0232 0.3607
Schistosoma mansoni polycystin 1-related 0.0013 0.0006 0.0011
Trichomonas vaginalis ran, putative 0.0037 0.0201 0.0856
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0086 0.0121
Plasmodium falciparum threonine--tRNA ligase 0.0017 0.0038 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni hypothetical protein 0.0013 0.0006 0.0011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0043 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Loa Loa (eye worm) hypothetical protein 0.0125 0.0898 0.2122
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0037 0.0197 0.0455
Schistosoma mansoni rab6-interacting 0.0013 0.0006 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0043 0.0078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0056 0.0103
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0718 0.5621 1
Schistosoma mansoni hypothetical protein 0.0072 0.0473 0.086
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0043 0.0078
Brugia malayi SWIRM domain containing protein 0.0212 0.1596 0.591
Brugia malayi amine oxidase, flavin-containing family protein 0.0092 0.0636 0.2342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0043 0.0078
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0043 0.0078
Echinococcus granulosus importin subunit beta 1 0.0051 0.0307 0.0558
Loa Loa (eye worm) hypothetical protein 0.0125 0.0898 0.2122
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.009 0.0618 0.2274
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0023 0.0086 0.0156
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0048 0.0289 0.3736
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0232 0.0421
Schistosoma mansoni hypothetical protein 0.0036 0.019 0.0346
Echinococcus multilocularis musashi 0.0047 0.0281 0.0511
Echinococcus multilocularis RUN 0.0013 0.0006 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0809 0.2984
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0043 0.0078
Trypanosoma cruzi hexose transporter, putative 0.0042 0.0238 0.303
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0043 0.0078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0238 0.1021
Echinococcus multilocularis transient receptor potential gamma protein 0.017 0.1261 0.2293
Brugia malayi Doublecortin family protein 0.0013 0.0006 0.0001
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0131
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0042 0.0238 0.303
Trypanosoma brucei THT1 - hexose transporter, putative 0.0093 0.0642 0.868
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0023 0.0086 0.0894
Echinococcus multilocularis solute carrier family 22 0.0042 0.0238 0.0433
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0043 0.0138
Schistosoma mansoni cpg binding protein 0.0049 0.0291 0.0528
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Onchocerca volvulus 0.0042 0.0238 0.1461
Trichomonas vaginalis sugar transport protein, putative 0.0042 0.0238 0.1021
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.009 0.0618 0.1122
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.009 0.0618 0.1122
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0043 0.0231
Schistosoma mansoni amine oxidase 0.0079 0.0534 0.0971
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0048 0.0289 0.0525
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.019 0.0439
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0043 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.023 0.0418
Plasmodium vivax sugar transporter, putative 0.0042 0.0238 0.0232
Echinococcus multilocularis transient receptor potential ion channel A 0.0165 0.1216 0.221
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0079 0.0534 0.8597
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0048 0.0289 0.0476
Echinococcus granulosus lamin dm0 0.0047 0.0281 0.0511
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0017 0.0038 0.0119
Echinococcus multilocularis GPCR, family 2 0.0036 0.019 0.0346
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0131
Brugia malayi CXXC zinc finger family protein 0.0049 0.0291 0.1058
Echinococcus granulosus lysyl tRNA synthetase 0.0067 0.0435 0.079
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0023 0.0086 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0043 0.0078
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0043 0.0078
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0015 0.0025 0.0006
Onchocerca volvulus 0.0042 0.0238 0.1461
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0037 0.0201 0.0464
Brugia malayi intermediate filament protein 0.0047 0.0281 0.1023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0244 0.0566
Schistosoma mansoni survival motor neuron protein 0.0072 0.0473 0.086
Plasmodium falciparum calcium-dependent protein kinase 2 0.0092 0.0633 0.0627
Loa Loa (eye worm) hypothetical protein 0.0051 0.0307 0.0717
Echinococcus granulosus GPCR family 2 0.0036 0.019 0.0346
Toxoplasma gondii HEAT repeat-containing protein 0.0051 0.0307 0.0455
Loa Loa (eye worm) hypothetical protein 0.0073 0.0484 0.1137
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0037 0.0201 0.2502
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Plasmodium falciparum calcium-dependent protein kinase 3 0.0092 0.0633 0.0627
Schistosoma mansoni glucose transport protein 0.0299 0.2283 0.4149
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0038 0.0218
Schistosoma mansoni amine oxidase 0.0079 0.0534 0.0971
Loa Loa (eye worm) hypothetical protein 0.02 0.1494 0.354
Echinococcus multilocularis synaptic vesicle 2 protein 0.0042 0.0238 0.0433
Trypanosoma cruzi hexose transporter, putative 0.0093 0.0642 0.868
Leishmania major glucose transporter, lmgt1 0.0093 0.0642 0.868
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0091 0.0632 0.2329
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0086 0.0894
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0043 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0093 0.0642 0.2793
Echinococcus granulosus solute carrier family 22 0.0042 0.0238 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0043 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Onchocerca volvulus 0.0042 0.0238 0.1461
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0042 0.0238 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0017 0.0038 0.0262
Onchocerca volvulus 0.0042 0.0238 0.1461
Plasmodium falciparum calcium-dependent protein kinase 4 0.0092 0.0633 0.0627
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Plasmodium falciparum calcium-dependent protein kinase 5 0.0092 0.0633 0.0627
Leishmania major glucose transporter, lmgt2 0.0093 0.0642 0.868
Onchocerca volvulus 0.0042 0.0238 0.1461
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0238 0.1021
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0299 0.2283 0.4149
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0043 0.0078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0023 0.0086 0.0156
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0043 0.0078
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0042 0.0238 0.0435
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.019 0.0346
Onchocerca volvulus 0.0042 0.0238 0.1461
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0103
Leishmania major glucose transporter, lmgt3 0.0093 0.0642 0.868
Leishmania major hypothetical protein, conserved 0.0043 0.0244 0.3107
Onchocerca volvulus 0.0042 0.0238 0.1461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.023 0.0418
Mycobacterium tuberculosis Possible oxidoreductase 0.0079 0.0534 0.103
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0067 0.0435 0.5783
Brugia malayi Cam kinase protein 1 0.0091 0.0632 0.2329
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0091 0.0632 0.855
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0023 0.0086 0.0156
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0063 0.0409 0.0743
Loa Loa (eye worm) hypothetical protein 0.0107 0.0757 0.1786
Treponema pallidum threonyl-tRNA synthetase 0.0017 0.0038 0.0963
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.0265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0043 0.0078
Onchocerca volvulus 0.0042 0.0238 0.1461
Echinococcus multilocularis cpg binding protein 0.0051 0.0313 0.0568
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Echinococcus granulosus Threonyl tRNA synthetase C 0.0017 0.0038 0.0069
Echinococcus multilocularis snurportin 1 0.0541 0.4209 0.765
Schistosoma mansoni hypothetical protein 0.0036 0.019 0.0346
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0079 0.0534 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0041 0.0231 0.0989
Chlamydia trachomatis threonine--tRNA ligase 0.0017 0.0038 0.0248
Trypanosoma cruzi hexose transporter, putative 0.0051 0.0307 0.3994
Brugia malayi Major Facilitator Superfamily protein 0.0042 0.0238 0.0865
Plasmodium vivax hexose transporter 0.0299 0.2283 0.2278
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0037 0.0201 0.2502
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0043 0.0078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0048 0.0289 0.0525
Schistosoma mansoni lysyl-tRNA synthetase 0.0067 0.0435 0.079
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus granulosus dnaJ subfamily B 0.0691 0.541 0.9832
Echinococcus granulosus neuropeptide s receptor 0.0368 0.2835 0.5152
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni hypothetical protein 0.0299 0.2283 0.4149
Brugia malayi MH2 domain containing protein 0.0137 0.0992 0.3666
Leishmania major GTP-binding protein, putative 0.0037 0.0201 0.2502
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Mycobacterium ulcerans monoamine oxidase 0.0079 0.0534 0.0914
Trichomonas vaginalis importin beta-1, putative 0.0041 0.0231 0.0989
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Onchocerca volvulus 0.0042 0.0238 0.1461
Schistosoma mansoni hypothetical protein 0.0135 0.0978 0.1777
Schistosoma mansoni hypothetical protein 0.0541 0.4209 0.765
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0043 0.0231
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0013 0.0006 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0047 0.0281 0.1023
Onchocerca volvulus 0.0042 0.0238 0.1461
Schistosoma mansoni protein kinase 0.0091 0.0632 0.1149
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0017 0.0038 0.051
Loa Loa (eye worm) hypothetical protein 0.0067 0.0435 0.1021
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0043 0.0078
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Echinococcus granulosus snurportin 1 0.0541 0.4209 0.765
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0091 0.0632 0.149
Schistosoma mansoni sugar transporter 0.0042 0.0238 0.0433
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0017 0.0038 0.0218
Echinococcus granulosus transient receptor potential ion channel A 0.0165 0.1216 0.221
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0043 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0642 0.2793
Schistosoma mansoni cpg binding protein 0.0051 0.0313 0.0568
Echinococcus granulosus synaptic vesicle 2 protein 0.0042 0.0238 0.0433
Echinococcus multilocularis solute carrier family 22 0.0042 0.0238 0.0433
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0483 0.3748 0.3744
Loa Loa (eye worm) doublecortin family protein 0.0013 0.0006 0.0001
Echinococcus multilocularis lamin 0.0047 0.0281 0.0511
Echinococcus multilocularis neuropeptide receptor A26 0.0368 0.2835 0.5152
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0043 0.0078
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Trypanosoma cruzi hexose transporter, putative 0.0093 0.0642 0.868
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0043 0.0088
Onchocerca volvulus Putative transporter 0.0042 0.0238 0.1461
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0082 0.0558 0.0834
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0047 0.0274 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0093 0.0642 0.2793
Echinococcus multilocularis glycyl tRNA synthetase 0.0017 0.0038 0.0069
Plasmodium vivax importin-beta 2, putative 0.0051 0.0307 0.0301
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0056 0.0103
Entamoeba histolytica hypothetical protein 0.0015 0.0025 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0043 0.0088
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0809 0.191
Trichomonas vaginalis glucose transporter, putative 0.0093 0.0642 0.2793
Loa Loa (eye worm) hypothetical protein 0.0022 0.0079 0.0174
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0042 0.0238 1
Onchocerca volvulus 0.0072 0.0473 0.294
Schistosoma mansoni intermediate filament proteins 0.0047 0.0281 0.0511
Schistosoma mansoni hypothetical protein 0.0036 0.019 0.0346
Echinococcus multilocularis protoporphyrinogen oxidase 0.0079 0.0534 0.0971
Brugia malayi hypothetical protein 0.0042 0.0238 0.0865
Echinococcus granulosus solute carrier family 22 0.0042 0.0238 0.0433
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0043 0.0078
Brugia malayi Sugar transporter family protein 0.0042 0.0238 0.0865
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0042 0.0238 0.0435
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0104 0.0736 1
Echinococcus granulosus transient receptor potential gamma protein 0.017 0.1261 0.2293
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Brugia malayi ecdysteroid receptor 0.0017 0.0043 0.0138
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0037 0.0201 0.0195
Chlamydia trachomatis lysine--tRNA ligase 0.0067 0.0435 0.8052
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0077 0.0515 0.0937
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.019 0.0346
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0015 0.0025 0.0029
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0057 0.0355 0.5587
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.019 0.0346
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0017 0.0038 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0043 0.0138
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0041 0.0084
Schistosoma mansoni ran 0.0037 0.0201 0.0365
Trypanosoma cruzi glucose transporter, putative 0.0042 0.0238 0.303
Loa Loa (eye worm) CXXC zinc finger family protein 0.0049 0.0291 0.0677
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0077 0.0515 0.0937
Brugia malayi hypothetical protein 0.0013 0.0006 0.0001
Schistosoma mansoni SWI/SNF complex-related 0.0013 0.0006 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni hypothetical protein 0.0691 0.541 0.9832
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0042 0.0238 0.0433
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.023 0.0832
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0067 0.0435 0.5783
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.5502 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0023 0.0086 0.008
Schistosoma mansoni protein kinase 0.0091 0.0632 0.1149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Chlamydia trachomatis protoporphyrinogen oxidase 0.0079 0.0534 1
Schistosoma mansoni sugar transporter 0.0042 0.0238 0.0433
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Leishmania major threonyl-tRNA synthetase, putative 0.0017 0.0038 0.0218
Leishmania major myo-inositol/proton symporter (MIT) 0.0042 0.0238 0.303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0043 0.0088
Schistosoma mansoni transient receptor potential channel 0.0113 0.0802 0.1457
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0104 0.0736 0.1103
Toxoplasma gondii transporter, major facilitator family protein 0.0042 0.0238 0.0351
Schistosoma mansoni lipoxygenase 0.0054 0.0331 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0238 0.1021
Loa Loa (eye worm) hypothetical protein 0.017 0.1261 0.2987
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0017 0.0038 0.0048
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.009 0.0618 0.1122
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0244 0.3107
Brugia malayi steroid hormone receptor 0.0017 0.0043 0.0138
Toxoplasma gondii sugar transporter ST2 0.0042 0.0238 0.0351
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.0006 0.0011
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0104 0.0736 1
Schistosoma mansoni coup transcription factor 0.0017 0.0043 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0072
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0084
Treponema pallidum prolyl-tRNA synthetase 0.0032 0.0156 1
Schistosoma mansoni glucose transport protein 0.0299 0.2283 0.4149
Plasmodium falciparum calcium-dependent protein kinase 1 0.0092 0.0633 0.0627
Onchocerca volvulus 0.0047 0.0281 0.173
Brugia malayi hypothetical protein 0.0351 0.2696 1
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0043 0.0078
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0104 0.0736 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0079 0.0534 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.023 0.0418
Echinococcus multilocularis short transient receptor potential channel 6 0.0113 0.0802 0.1457
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0054 0.0335 0.0609
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0017 0.0038 0.0591
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0232 0.0421
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0015 0.0025 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0534 0.0528
Trypanosoma cruzi hexose transporter, putative 0.0093 0.0642 0.868
Schistosoma mansoni transient receptor potential channel 0.017 0.1261 0.2293
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0038 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0047 0.0281 0.0655
Onchocerca volvulus 0.0047 0.0281 0.173
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0024 0.0042
Echinococcus multilocularis lysine specific histone demethylase 1A 0.02 0.1494 0.2715
Schistosoma mansoni sugar transporter 0.0042 0.0238 0.0433
Loa Loa (eye worm) hypothetical protein 0.0079 0.0534 0.1257
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0043 0.0231
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0092 0.0633 0.0627
Giardia lamblia Sugar-proton symporter 0.0042 0.0238 0.3802
Giardia lamblia Hexose transporter 0.0042 0.0238 0.3802
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0086 0.0894
Trypanosoma brucei glucose transporter, putative 0.0093 0.0642 0.868
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0104 0.0736 1
Brugia malayi hypothetical protein 0.0013 0.0006 0.0001
Toxoplasma gondii sugar transporter ST3 0.0042 0.0238 0.0351
Trypanosoma brucei PAB1-binding protein , putative 0.0043 0.0244 0.3107
Schistosoma mansoni protein kinase 0.0091 0.0632 0.1149
Echinococcus multilocularis neuropeptide s receptor 0.0368 0.2835 0.5152
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0067 0.0435 0.0737
Schistosoma mansoni ran 0.0037 0.0201 0.0365
Loa Loa (eye worm) hypothetical protein 0.0091 0.0632 0.149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0043 0.0138
Brugia malayi nuclear receptor NHR-88 0.0017 0.0043 0.0138
Brugia malayi Major Facilitator Superfamily protein 0.0042 0.0238 0.0865
Toxoplasma gondii histone lysine methyltransferase SET1 0.0092 0.0636 0.0953
Loa Loa (eye worm) sugar transporter 0.0042 0.0238 0.0553
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0632 0.1149
Brugia malayi Isocitrate dehydrogenase 0.0023 0.0086 0.0298
Echinococcus multilocularis survival motor neuron protein 1 0.0351 0.2696 0.49
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0043 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0534 0.0528
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0017 0.0038 0.0069
Brugia malayi hypothetical protein 0.0125 0.0898 0.3316
Trichomonas vaginalis conserved hypothetical protein 0.0299 0.2283 1
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0025 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0048 0.0289 0.0476
Toxoplasma gondii protein kinase, putative 0.0844 0.6625 1
Echinococcus granulosus RUN 0.0013 0.0006 0.0011
Brugia malayi isocitrate dehydrogenase 0.0023 0.0086 0.0298
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0017 0.0038 0.051
Loa Loa (eye worm) sugar transporter 0.0299 0.2283 0.5417
Brugia malayi hypothetical protein 0.0041 0.0232 0.084
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0054 0.0335 0.1223
Echinococcus granulosus solute carrier family 22 0.0042 0.0238 0.0433
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0534 0.0528
Mycobacterium ulcerans aldehyde dehydrogenase 0.0048 0.0289 0.0476
Echinococcus multilocularis calcium dependent protein kinase 0.0086 0.0587 0.1067
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.0265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0043 0.0138
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0015 0.0025 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0439
Leishmania major cytochrome p450-like protein 0.0017 0.0041 0.0265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0043 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0084
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0106 0.0372
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.0006 0.0011
Loa Loa (eye worm) major facilitator superfamily transporter 0.0042 0.0238 0.0553
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Echinococcus multilocularis short transient receptor potential channel 6 0.0113 0.0802 0.1457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0043 0.0078
Brugia malayi Major Facilitator Superfamily protein 0.0042 0.0238 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0043 0.0138
Toxoplasma gondii lysine-tRNA ligase 0.0067 0.0435 0.0648
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.019 0.0346
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0043 0.0088
Echinococcus granulosus GTP binding nuclear protein Ran 0.0037 0.0201 0.0365
Plasmodium falciparum mitogen-activated protein kinase 2 0.0483 0.3748 0.3744
Echinococcus multilocularis lamin dm0 0.0047 0.0281 0.0511
Entamoeba histolytica protein kinase, putative 0.0091 0.0632 1
Schistosoma mansoni hypothetical protein 0.0036 0.019 0.0346
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Echinococcus granulosus lamin 0.0047 0.0281 0.0511
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0191
Loa Loa (eye worm) hypothetical protein 0.0092 0.0636 0.1499
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0092 0.0633 0.0627
Mycobacterium ulcerans integral membrane transport protein 0.0042 0.0238 0.0386
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0104 0.0736 1
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Plasmodium vivax threonine--tRNA ligase, putative 0.0017 0.0038 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0043 0.0078
Loa Loa (eye worm) hypothetical protein 0.0047 0.0281 0.0655
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0072 0.0473 0.1738
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0086 0.0121
Echinococcus granulosus L aminoadipate semialdehyde 0.0054 0.0335 0.0609
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Mycobacterium ulcerans dehydrogenase 0.0079 0.0534 0.0914
Plasmodium falciparum hexose transporter 0.0299 0.2283 0.2278
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0057 0.0355 0.067
Trypanosoma brucei glucose transporter 1E 0.0093 0.0642 0.868
Onchocerca volvulus Huntingtin homolog 0.0125 0.0898 0.561
Entamoeba histolytica hypothetical protein 0.0041 0.0232 0.3607
Brugia malayi major facilitator superfamily protein 0.0042 0.0238 0.0865
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0086 0.0156
Plasmodium vivax calcium-dependent protein kinase, putative 0.0092 0.0633 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0092 0.0633 0.0627
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0043 0.0078
Brugia malayi Sugar transporter family protein 0.0299 0.2283 0.8464
Echinococcus granulosus Polycystic kidney disease protein 0.0013 0.0006 0.0011
Schistosoma mansoni transient receptor potential channel 4 0.017 0.1261 0.2293
Trypanosoma cruzi UDP-galactopyranose mutase 0.0079 0.0534 0.7172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.023 0.0418
Loa Loa (eye worm) hypothetical protein 0.0063 0.0409 0.0959
Toxoplasma gondii aldehyde dehydrogenase 0.0048 0.0289 0.0427
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0024 0.0043
Brugia malayi hypothetical protein 0.0028 0.0123 0.0437
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0086 0.0156
Onchocerca volvulus 0.0017 0.0043 0.0231
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0015 0.0025 0.0005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0037 0.0201 0.0294
Schistosoma mansoni aldehyde dehydrogenase 0.0048 0.0289 0.0525
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0079 0.0534 0.0971
Echinococcus multilocularis importin subunit beta 1 0.0051 0.0307 0.0558
Loa Loa (eye worm) hypothetical protein 0.02 0.1494 0.354
Entamoeba histolytica hypothetical protein 0.0041 0.0231 0.3593
Schistosoma mansoni importin beta-1 0.0051 0.0307 0.0558
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.009 0.0618 0.1122
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.009 0.0618 0.2687
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0067 0.0435 0.6932
Echinococcus granulosus short transient receptor potential channel 6 0.0113 0.0802 0.1457
Echinococcus granulosus survival motor neuron protein 1 0.0351 0.2696 0.49
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0043 0.0088
Echinococcus granulosus lysine specific histone demethylase 1A 0.02 0.1494 0.2715
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0017 0.0038 0.0591
Chlamydia trachomatis proline--tRNA ligase 0.0032 0.0156 0.2571
Echinococcus granulosus solute carrier family 22 0.0042 0.0238 0.0433
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0086 0.0156
Trypanosoma cruzi UDP-galactopyranose mutase 0.0079 0.0534 0.7172
Entamoeba histolytica hypothetical protein 0.0041 0.0232 0.3607
Trypanosoma brucei THT1 - hexose transporter, putative 0.0093 0.0642 0.868
Schistosoma mansoni lamin 0.0047 0.0281 0.0511
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0015 0.0026 0.0049
Trypanosoma brucei sugar transporter, putative 0.0042 0.0238 0.303
Plasmodium vivax glycine--tRNA ligase, putative 0.0017 0.0038 0.0032
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0041 0.0265
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0088
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0017 0.0038 0.0076
Schistosoma mansoni sugar transporter 0.0042 0.0238 0.0433
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0244 0.3107
Trypanosoma brucei importin beta-1 subunit, putative 0.0051 0.0307 0.3994
Brugia malayi lysyl-tRNA synthetase 0.0067 0.0435 0.1595
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.0992 0.2346
Trypanosoma brucei importin beta-1 subunit, putative 0.0051 0.0307 0.3994
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0091 0.0632 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0238 0.1021
Echinococcus granulosus cpg binding protein 0.0051 0.0313 0.0568
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.009 0.0618 0.9765
Loa Loa (eye worm) hypothetical protein 0.0022 0.0079 0.0174
Giardia lamblia Lysyl-tRNA synthetase 0.0067 0.0435 0.7014
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0043 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0086 0.0156
Mycobacterium ulcerans oxidoreductase 0.0079 0.0534 0.0914
Leishmania major glucose transporter/membrane transporter D2, putative 0.0093 0.0642 0.868
Onchocerca volvulus 0.0049 0.0291 0.1789
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0106 0.0238
Loa Loa (eye worm) hypothetical protein 0.0079 0.0534 0.1257
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0194 0.0446
Loa Loa (eye worm) hypothetical protein 0.009 0.0618 0.1455
Giardia lamblia Threonyl-tRNA synthetase 0.0017 0.0038 0.0522
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0037 0.0201 0.0365
Echinococcus granulosus short transient receptor potential channel 6 0.0113 0.0802 0.1457
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0483 0.3748 0.5653
Plasmodium vivax ataxin-2 like protein, putative 0.0043 0.0244 0.0238
Mycobacterium ulcerans sugar transporter 0.0042 0.0238 0.0386
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0043 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0013 0.0006 0.0011
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0015 0.0025 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.0992 0.2346
Trypanosoma brucei glucose transporter 2A 0.0093 0.0642 0.868
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0037 0.0201 0.3186
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0043 0.0078
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.019 0.0685
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Leishmania major phosphopantetheinyl transferase-like protein 0.0015 0.0025 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Plasmodium falciparum importin beta, putative 0.0051 0.0307 0.0301
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Schistosoma mansoni cpg binding protein 0.0051 0.0313 0.0568
Brugia malayi hypothetical protein 0.0079 0.0534 0.1963
Brugia malayi hypothetical protein 0.0042 0.0238 0.0865
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0522 0.192
Echinococcus multilocularis General substrate transporter 0.0257 0.1948 0.3541
Echinococcus granulosus microtubule associated protein 2 0.0703 0.5502 1
Plasmodium falciparum protein kinase 7 0.0844 0.6625 0.6623
Echinococcus granulosus General substrate transporter 0.0257 0.1948 0.3541
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0232 0.0421
Schistosoma mansoni Lysine-specific histone demethylase 1 0.02 0.1494 0.2715
Onchocerca volvulus Huntingtin homolog 0.0125 0.0898 0.561
Entamoeba histolytica hypothetical protein 0.0041 0.0232 0.3607
Onchocerca volvulus 0.0042 0.0238 0.1461
Brugia malayi glycyl-tRNA synthetase 0.0017 0.0038 0.0119
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0086 0.0894
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0809 0.2984
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0086 0.0156
Schistosoma mansoni lysyl-tRNA synthetase 0.0067 0.0435 0.079
Loa Loa (eye worm) hypothetical protein 0.0058 0.0364 0.0851
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0632 0.2752
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0041 0.0034
Entamoeba histolytica Ran family GTPase 0.0037 0.0201 0.3111
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0023 0.0086 0.0894
Onchocerca volvulus 0.0042 0.0238 0.1461
Plasmodium vivax lysine--tRNA ligase, putative 0.0067 0.0435 0.0429
Schistosoma mansoni hypothetical protein 0.0135 0.0978 0.1777
Echinococcus granulosus lysine specific histone demethylase 1A 0.0079 0.0534 0.0971
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0092 0.0633 0.0947
Brugia malayi Latrophilin receptor protein 2 0.0036 0.019 0.0685
Schistosoma mansoni glucose transporter 0.0042 0.0238 0.0433
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0091 0.0632 0.149
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0043 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0244 0.0238
Brugia malayi nuclear hormone receptor 0.0017 0.0043 0.0138
Trichomonas vaginalis glucose transporter, putative 0.0042 0.0238 0.1021
Trichomonas vaginalis myo-inositol transporter, putative 0.0042 0.0238 0.1021
Trypanosoma cruzi hexose transporter 0.0093 0.0642 0.868
Onchocerca volvulus 0.0212 0.1596 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Echinococcus multilocularis Polycystic kidney disease protein 0.0013 0.0006 0.0011
Leishmania major UDP-galactopyranose mutase 0.0079 0.0534 0.7172
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0048 0.0289 0.0537
Onchocerca volvulus 0.0042 0.0238 0.1461
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0057 0.0355 0.067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0043 0.0138
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0013 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.0335 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0072
Schistosoma mansoni glucose transport protein 0.0299 0.2283 0.4149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0043 0.0088
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.5502 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0043 0.0138
Loa Loa (eye worm) hypothetical protein 0.0042 0.0238 0.0553
Echinococcus multilocularis solute carrier family 22 0.0042 0.0238 0.0433
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0032 0.0156 0.0239
Echinococcus multilocularis isocitrate dehydrogenase 0.0023 0.0086 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0043 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Trichomonas vaginalis glucose transporter, putative 0.0093 0.0642 0.2793
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0015 0.0025 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0043 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0093 0.0642 0.2793
Echinococcus granulosus lipoxygenase domain containing protein 0.0013 0.0006 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0043 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.023 0.0418
Trypanosoma brucei THT1 - hexose transporter, putative 0.0093 0.0642 0.868
Toxoplasma gondii facilitative glucose transporter GT1 0.0299 0.2283 0.344
Brugia malayi RNA, U transporter 1 0.0144 0.1051 0.3884
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Schistosoma mansoni hypothetical protein 0.0041 0.0232 0.0421
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0299 0.2283 0.4149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.023 0.0418
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0091 0.0632 0.1149
Brugia malayi hypothetical protein 0.0042 0.0238 0.0865
Echinococcus granulosus TRP transient receptor potential channel 0.0063 0.0409 0.0743
Echinococcus granulosus neuropeptide receptor A26 0.0368 0.2835 0.5152
Echinococcus multilocularis geminin 0.0135 0.0978 0.1777
Trichomonas vaginalis sugar transporter, putative 0.0042 0.0238 0.1021
Plasmodium vivax proline--tRNA ligase, putative 0.0104 0.0736 0.073
Giardia lamblia Glycyl-tRNA synthetase 0.0017 0.0038 0.0522
Loa Loa (eye worm) major facilitator superfamily transporter 0.0042 0.0238 0.0553

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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