Detailed information for compound 703163

Basic information

Technical information
  • TDR Targets ID: 703163
  • Name: 1-(2-hydroxyethyl)-3-[1-(4-methylphenyl)-5-ox opyrrolidin-3-yl]-1-(phenylmethyl)urea
  • MW: 367.442 | Formula: C21H25N3O3
  • H donors: 2 H acceptors: 3 LogP: 1.56 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(C(=O)NC1CC(=O)N(C1)c1ccc(cc1)C)Cc1ccccc1
  • InChi: 1S/C21H25N3O3/c1-16-7-9-19(10-8-16)24-15-18(13-20(24)26)22-21(27)23(11-12-25)14-17-5-3-2-4-6-17/h2-10,18,25H,11-15H2,1H3,(H,22,27)
  • InChiKey: PAYPBPHMLKFNSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-hydroxyethyl)-3-[1-(4-methylphenyl)-5-oxo-pyrrolidin-3-yl]-1-(phenylmethyl)urea
  • 1-(2-hydroxyethyl)-3-[1-(4-methylphenyl)-5-oxo-3-pyrrolidinyl]-1-(phenylmethyl)urea
  • 1-(benzyl)-1-(2-hydroxyethyl)-3-[5-keto-1-(4-methylphenyl)pyrrolidin-3-yl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cell death protein 3 precursor 0.0065 0.0645 0.2813
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0 0.0014
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0254 0.0254
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0054 0.0054
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0262 0.0395
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0385 0.1677
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.007 0.0305
Brugia malayi 6-phosphofructokinase 0.0113 0.1186 0.5169
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0262 0.5824
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0632 0.5177
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0254 0.1107
Brugia malayi Sugar transporter family protein 0.003 0.0254 0.1107
Entamoeba histolytica hypothetical protein 0.0037 0.0339 0.2859
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0 0.0003
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0137 0.1152
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0262 0.221
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0619 0.2414
Brugia malayi hypothetical protein 0.003 0.0254 0.1107
Leishmania major glucose transporter, lmgt3 0.0066 0.0656 0.5535
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1186 0.5169
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0 0.0002
Leishmania major hypothetical protein, conserved 0.0011 0.0038 0.0322
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0315 0.1374
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0593 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.001
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0054 0.0453
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0054 0.0234
Trypanosoma cruzi sugar transporter, putative 0.003 0.0254 0.2141
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0138 0.0208
Echinococcus granulosus histidyl tRNA synthetase 0.0007 0 0.0002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Toxoplasma gondii protein kinase, putative 0.06 0.6632 1
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0172 0.3815
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1186 0.5169
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0305
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0322
Echinococcus multilocularis lamin dm0 0.0028 0.0231 0.1005
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0315 0.1374
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.045 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0602 0.2625
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0138 0.0208
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0098
Echinococcus granulosus General substrate transporter 0.0182 0.196 0.8545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0459 0.2
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0656 0.2861
Brugia malayi MH2 domain containing protein 0.0117 0.123 0.5363
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.1152
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0619 0.2699
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Schistosoma mansoni sugar transporter 0.003 0.0254 0.1107
Entamoeba histolytica hypothetical protein 0.0037 0.0339 0.2859
Trypanosoma cruzi metacaspase, putative 0.0019 0.0138 0.1164
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0602 0.2625
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0098
Onchocerca volvulus Cell death protein 3 homolog 0.0065 0.0645 1
Mycobacterium ulcerans sugar transporter 0.003 0.0254 0.2141
Toxoplasma gondii sugar transporter ST3 0.003 0.0254 0.0383
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.045 0.3795
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0054 0.0054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0231 0.1005
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Schistosoma mansoni protein kinase 0.0065 0.0653 0.2845
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0086 0.0377
Leishmania major glucose transporter, lmgt1 0.0066 0.0656 0.5535
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0653 0.2845
Onchocerca volvulus 0.003 0.0254 0.0564
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Trypanosoma brucei Metacaspase-4 0.0019 0.0138 0.1164
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.045 0.0678
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0653 0.0985
Brugia malayi hypothetical protein 0.003 0.0254 0.1107
Plasmodium falciparum proline--tRNA ligase 0.0074 0.075 0.075
Schistosoma mansoni cpg binding protein 0.0031 0.027 0.1175
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0054 0.0453
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0262 0.0395
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.1186 0.5169
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.123 0.5363
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0632 0.2756
Echinococcus multilocularis General substrate transporter 0.0182 0.196 0.8545
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0009 0.0041
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0262 0.1142
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.045 0.3795
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0212 0.0926
Mycobacterium ulcerans beta-lactamase 0.0035 0.0315 0.2659
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0009 0.0041
Echinococcus granulosus solute carrier family 22 0.003 0.0254 0.1107
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0653 0.0653
Leishmania major glucose transporter, lmgt2 0.0066 0.0656 0.5535
Loa Loa (eye worm) Smad1 0.0008 0.0009 0.0041
Treponema pallidum glycyl-tRNA synthetase 0.0007 0 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0137 0.1152
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0054 0.0849
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0653 0.2845
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0 0.0002
Trypanosoma brucei glucose transporter 2A 0.0066 0.0656 0.5535
Leishmania major hypothetical protein, conserved 0.0011 0.0038 0.0322
Onchocerca volvulus 0.003 0.0254 0.0564
Onchocerca volvulus 0.003 0.0254 0.0564
Mycobacterium ulcerans lipase LipD 0.0035 0.0315 0.2659
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.075 0.6327
Trypanosoma brucei protein kinase, putative 0.006 0.0593 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Trypanosoma brucei metacaspase 0.0019 0.0138 0.1164
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.007 0.0305
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0323 0.272
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0343 0.3761 0.3761
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.001
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0593 0.2585
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.045 0.3795
Onchocerca volvulus 0.003 0.0254 0.0564
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0653 0.0653
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0054 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0166
Trypanosoma brucei metacaspase MCA3 0.0019 0.0138 0.1164
Echinococcus multilocularis solute carrier family 22 0.003 0.0254 0.1107
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0315 0.0315
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0427 0.1863
Schistosoma mansoni sugar transporter 0.003 0.0254 0.1107
Toxoplasma gondii facilitative glucose transporter GT1 0.0212 0.2294 0.3459
Echinococcus granulosus solute carrier family 22 0.003 0.0254 0.1107
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.075 0.6327
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.123 0.5363
Onchocerca volvulus 0.0045 0.0427 0.4747
Entamoeba histolytica hypothetical protein 0.0037 0.0339 0.2859
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0137 0.0595
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0315 0.1374
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1186 0.5169
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0231 0.1005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0621 0.2708
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis esterase, putative 0.0035 0.0315 0.1374
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0656 0.2861
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0254 0.2141
Schistosoma mansoni glucose transport protein 0.0212 0.2294 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0009 0.0041
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0656 0.5535
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0653 0.0653
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0254 0.0897
Mycobacterium ulcerans hypothetical protein 0.0011 0.0038 0.0322
Brugia malayi Cam kinase protein 1 0.0065 0.0653 0.2845
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0653 0.0653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0137 0.1152
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0656 0.2861
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1186 1
Echinococcus multilocularis musashi 0.0028 0.0231 0.1005
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0315 0.1374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2444 1
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1186 0.5169
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0138 0.0602
Trypanosoma cruzi glucose transporter, putative 0.003 0.0254 0.2141
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0138 0.0602
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0254 0.1107
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0098
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0 0.0001
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0593 0.9377
Brugia malayi phosphofructokinase 0.0113 0.1186 0.5169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Brugia malayi beta-lactamase 0.0035 0.0315 0.1374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0459 0.2
Mycobacterium ulcerans hypothetical protein 0.0035 0.0315 0.2659
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0054 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0254 0.1107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0137 0.0409
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0138 0.0208
Loa Loa (eye worm) hypothetical protein 0.0064 0.0632 0.2756
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.045 0.1962
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0656 0.2861
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Echinococcus multilocularis solute carrier family 22 0.003 0.0254 0.1107
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0593 0.2585
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0656 0.5535
Brugia malayi intermediate filament protein 0.0028 0.0231 0.1005
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0054 0.0234
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0254 0.1107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0656 0.5535
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0138 0.0602
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.037 0.138
Echinococcus granulosus caspase 0.0019 0.0138 0.0602
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0593 0.5
Onchocerca volvulus 0.0035 0.0315 0.2043
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.2659
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.045 0.1962
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1186 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0315 0.0475
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.045 0.3795
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Plasmodium falciparum protein kinase 7 0.06 0.6632 0.6632
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1186 0.5169
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.075 0.6327
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1186 0.5169
Echinococcus multilocularis caspase 0.0019 0.0138 0.0602
Leishmania major glycyl tRNA synthetase, putative 0.0007 0 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0656 0.5535
Plasmodium falciparum metacaspase 1 0.0019 0.0138 0.0138
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0653 0.0653
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.0595
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Brugia malayi hypothetical protein 0.003 0.0254 0.1107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0632 0.2756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0138 0.1164
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.045 0.1962
Schistosoma mansoni Smad4 0.0008 0.0009 0.0041
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0593 0.2585
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Plasmodium falciparum metacaspase-like protein 0.0019 0.0138 0.0138
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0251 0.1093
Schistosoma mansoni glucose transporter 0.003 0.0254 0.1107
Brugia malayi beta-lactamase family protein 0.0035 0.0315 0.1374
Trypanosoma cruzi hexose transporter 0.0066 0.0656 0.5535
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0619 0.2699
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0315 0.1152
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0593 0.2585
Brugia malayi MH2 domain containing protein 0.0008 0.0009 0.0041
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0138 0.0602
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0339 0.1478
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.028
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.045 0.1962
Entamoeba histolytica protein kinase, putative 0.0065 0.0653 0.5504
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0315 0.1152
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0009 0.0041
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0054 0.0065
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0254 0.2141
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0254 0.1107
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0315 0.1152
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0339 0.1478
Toxoplasma gondii sugar transporter ST2 0.003 0.0254 0.0383
Toxoplasma gondii exonuclease III APE 0.0019 0.0137 0.0206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0459 0.2
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0262 0.0395
Echinococcus granulosus caspase 2 0.0065 0.0645 0.2813
Echinococcus granulosus intermediate filament protein 0.0028 0.0231 0.1005
Echinococcus multilocularis caspase 8 0.0019 0.0138 0.0602
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0593 0.5
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0593 0.2585
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.2659
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0315 0.1374
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0656 0.5535
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Schistosoma mansoni glucose transport protein 0.0212 0.2294 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1186 0.5169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0593 0.2585
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.075 0.1131
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0172 0.1448
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0054 0.0234
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0137 0.0595
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0546 0.0824
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0315 0.2659
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0315 0.1374
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.1186 0.5169
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0254 0.2141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0137 0.538
Echinococcus multilocularis caspase 2 0.0065 0.0645 0.2813
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0138 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0653 0.0653
Brugia malayi MH2 domain containing protein 0.0008 0.0009 0.0041
Brugia malayi 6-phosphofructokinase 0.0113 0.1186 0.5169
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.1186 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.045 0.3795
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1374
Leishmania major protein kinase, putative 0.0065 0.0653 0.5504
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0656 0.2861
Loa Loa (eye worm) sugar transporter 0.003 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0166
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0315 0.1152
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1186 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0593 0.2585
Onchocerca volvulus Putative transporter 0.003 0.0254 0.0564
Giardia lamblia Hexose transporter 0.003 0.0254 0.4016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0593 0.5
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.075 0.6327
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0041
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.1186 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0254 0.1107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Echinococcus granulosus cpg binding protein 0.0031 0.027 0.1175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Echinococcus granulosus lamin 0.0028 0.0231 0.1005
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0054 0.0234
Schistosoma mansoni threonyl-tRNA synthetase 0.0007 0 0.0002
Brugia malayi CXXC zinc finger family protein 0.003 0.0251 0.1093
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0343 0.3761 0.5671
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1186 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0054 0.0234
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0427 0.1863
Echinococcus multilocularis histidyl tRNA synthetase 0.0007 0 0.0002
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0632 0.2756
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0054 0.0135
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0315 0.1152
Plasmodium vivax sugar transporter, putative 0.003 0.0254 0.0254
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0656 0.5535
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0595
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0593 0.2585
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0 0.0002
Onchocerca volvulus 0.003 0.0254 0.0564
Trypanosoma cruzi metacaspase, putative 0.0019 0.0138 0.1164
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Brugia malayi major facilitator superfamily protein 0.003 0.0254 0.1107
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0234
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0254 0.1107
Trypanosoma brucei glucose transporter 1E 0.0066 0.0656 0.5535
Trypanosoma cruzi metacaspase, putative 0.0019 0.0138 0.1164
Echinococcus multilocularis lamin 0.0028 0.0231 0.1005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0137 0.1152
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0619 0.522
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0137 0.216
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Brugia malayi Smad1 0.0008 0.0009 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0593 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0343 0.3761 0.3761
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0254 0.1107
Schistosoma mansoni protein kinase 0.0065 0.0653 0.2845
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0459 0.2
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0086 0.0377
Schistosoma mansoni sugar transporter 0.003 0.0254 0.1107
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0021 0.0092
Brugia malayi Sugar transporter family protein 0.003 0.0254 0.1107
Entamoeba histolytica hypothetical protein 0.0047 0.045 0.3795
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0254 0.1107
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Onchocerca volvulus 0.003 0.0254 0.0564
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0653 0.0653
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0427 0.1863
Onchocerca volvulus 0.003 0.0254 0.0564
Entamoeba histolytica hypothetical protein 0.0037 0.0339 0.2859
Leishmania major metacaspase, putative 0.0019 0.0138 0.1164
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0593 0.2585
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0009 0.0041
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0656 0.2861
Onchocerca volvulus 0.003 0.0251 0.0486
Loa Loa (eye worm) hypothetical protein 0.0028 0.0231 0.1005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0632 0.2756
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0 0.0008
Onchocerca volvulus 0.003 0.0254 0.0564
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0619 0.522
Brugia malayi lysyl-tRNA synthetase 0.0047 0.045 0.1962
Loa Loa (eye worm) hypothetical protein 0.0047 0.045 0.1962
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0593 0.2585
Loa Loa (eye worm) phosphofructokinase 0.0113 0.1186 0.5169
Leishmania major hypothetical protein, conserved 0.003 0.0254 0.2141
Giardia lamblia Sugar-proton symporter 0.003 0.0254 0.4016
Schistosoma mansoni lamin 0.0028 0.0231 0.1005
Echinococcus granulosus Smad4 0.0008 0.0009 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0339 0.1478
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0593 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0459 0.2
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0315 0.2415
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.0499 0.2174
Echinococcus multilocularis cpg binding protein 0.0031 0.027 0.1175
Echinococcus granulosus smad 0.0008 0.0009 0.0041
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0653 0.0985
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.037 0.138
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0054 0.0234
Loa Loa (eye worm) beta-lactamase 0.0035 0.0315 0.1374
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0137 0.0595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0459 0.2
Plasmodium vivax hexose transporter 0.0212 0.2294 0.2294
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0262 0.221
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0138 0.1164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0619 0.522
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0254 0.1107
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0593 0.0894
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0231 0.1005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Schistosoma mansoni hypothetical protein 0.0037 0.0339 0.1478
Trypanosoma cruzi metacaspase, putative 0.0019 0.0138 0.1164
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0653 0.5504
Brugia malayi MH1 domain containing protein 0.0008 0.0009 0.0041
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0315 0.2659
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.1152
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0137 0.1152
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0315 0.2659
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0254 1
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.045 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.2294 1
Schistosoma mansoni smad 0.0008 0.0009 0.0041
Onchocerca volvulus 0.003 0.0254 0.0564
Brugia malayi MAP kinase sur-1 0.006 0.0593 0.2585
Plasmodium vivax CDK-related protein kinase 6, putative 0.0901 1 1
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0138 0.0138
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0262 0.5824
Onchocerca volvulus 0.0035 0.0315 0.2043
Echinococcus multilocularis solute carrier family 22 0.003 0.0254 0.1107
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0212 0.2294 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Brugia malayi major facilitator superfamily protein 0.003 0.0254 0.1107
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.037 0.2893
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.0595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0459 0.2
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Onchocerca volvulus 0.003 0.0254 0.0564
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.001
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0054 0.0054
Echinococcus granulosus solute carrier family 22 0.003 0.0254 0.1107
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0254 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0653 0.2845
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0054 0.0849
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.001
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.028
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0593 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0 0.0003
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0054 0.0234
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0653 0.0985
Mycobacterium leprae Probable lipase LipE 0.0035 0.0315 0.2415
Schistosoma mansoni hypothetical protein 0.0212 0.2294 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0262 0.1142
Plasmodium falciparum hexose transporter 0.0212 0.2294 0.2294
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0234
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Loa Loa (eye worm) hypothetical protein 0.0065 0.0645 0.2813
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0254 0.1107
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Onchocerca volvulus 0.003 0.0254 0.0564
Brugia malayi Sugar transporter family protein 0.0212 0.2294 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0632 0.2756
Onchocerca volvulus 0.003 0.0254 0.0564
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.075 0.6327
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0254 0.0897
Schistosoma mansoni caspase-7 (C14 family) 0.0065 0.0645 0.2813
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0054 0.0234
Mycobacterium tuberculosis Conserved protein 0.0035 0.0315 0.1152
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0254 0.1107
Onchocerca volvulus 0.003 0.0254 0.0564
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0656 0.5535
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0054 0.0081
Trypanosoma cruzi hexose transporter, putative 0.003 0.0254 0.2141
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0262 0.0262
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0619 0.2699
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0322
Toxoplasma gondii sugar transporter ST1 0.003 0.0254 0.0383
Echinococcus multilocularis smad 0.0008 0.0009 0.0041
Brugia malayi beta-lactamase family protein 0.0035 0.0315 0.1374
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0653 0.2845
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0656 0.2861
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0254 0.1107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.1186 1
Schistosoma mansoni glucose transport protein 0.0212 0.2294 1
Loa Loa (eye worm) sugar transporter 0.0212 0.2294 1
Onchocerca volvulus 0.003 0.0254 0.0564
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0138 0.1164
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.045 0.045
Trypanosoma brucei metacaspase MCA2 0.0019 0.0138 0.1164
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Trypanosoma brucei sugar transporter, putative 0.003 0.0254 0.2141
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0254 0.1107
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0315 0.1152
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0054 0.0234
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0254 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2294 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0315 0.1374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0459 0.2
Schistosoma mansoni lamin 0.0028 0.0231 0.1005
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0038 0.0166
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0137 0.0595
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.1186 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0315 0.1374
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0262 0.0262
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Entamoeba histolytica protein kinase, putative 0.0065 0.0653 0.5504
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.045 0.1962
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0172 0.1448
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0619 0.0933
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0619 0.522
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1374
Onchocerca volvulus 0.0035 0.0315 0.2043
Echinococcus granulosus caspase 8 0.0019 0.0138 0.0602
Trypanosoma brucei glucose transporter, putative 0.0066 0.0656 0.5535
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0054 0.2114
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0054 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0038 0.0322
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0254 0.2141
Loa Loa (eye worm) hypothetical protein 0.003 0.0254 0.1107
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1186 1
Echinococcus multilocularis Smad4 0.0008 0.0009 0.0041
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0009 0.0041
Echinococcus multilocularis solute carrier family 22 0.003 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0254 0.2141
Plasmodium vivax metacaspase 1, putative 0.0019 0.0138 0.0138
Echinococcus granulosus lamin dm0 0.0028 0.0231 0.1005
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0054 0.0081
Onchocerca volvulus 0.003 0.0254 0.0564
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0038 0.0322
Trichomonas vaginalis glucose transporter, putative 0.003 0.0254 0.1107
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0632 0.5332
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0653 0.0653
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0632 0.2756
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0653 0.2845
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0632 0.2756
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0653 0.2845
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0065 0.0653 0.2845
Onchocerca volvulus 0.003 0.0254 0.0564
Echinococcus granulosus solute carrier family 22 0.003 0.0254 0.1107
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0038 0.0058
Brugia malayi hypothetical protein 0.0045 0.0427 0.1863
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0138 0.0602
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0619 0.2699
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0632 0.2756
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1186 0.5169
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0054 0.2114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0459 0.2
Schistosoma mansoni protein kinase 0.0065 0.0653 0.2845
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.1186 0.4769
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0 0.0002
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0595
Brugia malayi MH1 domain containing protein 0.0008 0.0009 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0137 0.1152
Schistosoma mansoni cpg binding protein 0.003 0.0251 0.1093
Schistosoma mansoni hypothetical protein 0.0045 0.0427 0.1863
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0262 0.4145
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0315 0.1374
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0632 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0602
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0315 0.1374
Trichomonas vaginalis sugar transporter, putative 0.003 0.0254 0.1107
Leishmania major hypothetical protein, conserved 0.0035 0.0315 0.2659
Schistosoma mansoni cpg binding protein 0.0031 0.027 0.1175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0138 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0038 0.0322
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0315 0.1152
Brugia malayi hypothetical protein 0.0037 0.0339 0.1478
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0054 0.0453
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0653 0.2845
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.045 0.3589
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0137 0.1152
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0262 0.0262
Schistosoma mansoni sugar transporter 0.003 0.0254 0.1107
Schistosoma mansoni intermediate filament proteins 0.0028 0.0231 0.1005
Schistosoma mansoni smad1 5 8 and 0.0008 0.0009 0.0041
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.075 0.075
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.045 0.7117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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