Detailed information for compound 704696

Basic information

Technical information
  • TDR Targets ID: 704696
  • Name: [4-(7-chloro-4-methoxy-1,3-benzothiazol-2-yl) piperazin-1-yl]-(3-methylsulfonylphenyl)metha none
  • MW: 465.974 | Formula: C20H20ClN3O4S2
  • H donors: 0 H acceptors: 4 LogP: 3.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1nc(s2)N1CCN(CC1)C(=O)c1cccc(c1)S(=O)(=O)C)Cl
  • InChi: 1S/C20H20ClN3O4S2/c1-28-16-7-6-15(21)18-17(16)22-20(29-18)24-10-8-23(9-11-24)19(25)13-4-3-5-14(12-13)30(2,26)27/h3-7,12H,8-11H2,1-2H3
  • InChiKey: SXDWNZXZHPEIQG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(7-chloro-4-methoxy-1,3-benzothiazol-2-yl)-1-piperazinyl]-(3-methylsulfonylphenyl)methanone
  • [4-(7-chloro-4-methoxy-1,3-benzothiazol-2-yl)piperazin-1-yl]-(3-mesylphenyl)methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0136 0.2861
Onchocerca volvulus 0.0011 0.0012 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0006 0.0043
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.096
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0012 0.1722
Brugia malayi Kringle domain containing protein 0.0022 0.0053 0.0053
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0678 0.2364 0.2364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0119 0.0134
Leishmania major hypothetical protein, conserved 0.0022 0.0053 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0355 0.1223 1
Brugia malayi CHE-14 protein 0.0046 0.0136 0.0136
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0046 0.7073
Echinococcus multilocularis plexin a4 0.0013 0.0022 0.0024
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.3171
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0678 0.2364 0.4525
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0065
Schistosoma mansoni smad1 5 8 and 0.0013 0.0021 0.0165
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0136 0.0136
Leishmania major carnitine/choline acetyltransferase, putative 0.0355 0.1223 0.2341
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0119 0.0119
Schistosoma mansoni topbp1 0.0011 0.0012 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0065 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0136 0.0152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0046 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0234
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0021 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0046 0.0087
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0042 0.7821
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0053 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Schistosoma mansoni DNA ligase IV 0.0011 0.0012 0.009
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0355 0.1223 0.5173
Echinococcus multilocularis protein patched 0.0046 0.0136 0.0152
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0355 0.1223 0.2341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0006 0.0006
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0012 0.0234
Leishmania major carnitine palmitoyltransferase-like protein 0.0678 0.2364 0.4525
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Echinococcus granulosus nibrin 0.0011 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0172 0.0172
Toxoplasma gondii exonuclease III APE 0.002 0.0046 0.8615
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0053 0.0101
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0678 0.2364 0.2364
Onchocerca volvulus 0.013 0.0431 0.3516
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0006 0.0006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0021 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0053 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0021 0.0021
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0006 0.0043
Brugia malayi TAR-binding protein 0.0126 0.0417 0.0417
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0136 0.0258
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0512 0.0578
Schistosoma mansoni patched 1 0.0046 0.0136 0.1102
Echinococcus granulosus choline O acetyltransferase 0.0355 0.1223 0.2341
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0042 0.6421
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0012 0.009
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0053 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0065 0.0065
Loa Loa (eye worm) Smad1 0.0013 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0006 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0006 0.0043
Brugia malayi hypothetical protein 0.0039 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0275
Echinococcus multilocularis protein dispatched 1 0.0052 0.0158 0.0178
Brugia malayi Smad1 0.0013 0.0021 0.0021
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0356 0.2906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.037
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0417 0.047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0065 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0006 0.0043
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0065 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0016 0.0032 0.5891
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0163 0.1327
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0012 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0165 0.0165
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0006 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0065 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0006 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0034 0.0034
Echinococcus multilocularis expressed conserved protein 0.01 0.0327 0.0369
Echinococcus multilocularis GPCR, family 2 0.0017 0.0034 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0065 0.0122
Brugia malayi MH2 domain containing protein 0.0195 0.066 0.066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0046 0.8615
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0119 0.0227
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.3171
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0065
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0046 0.0087
Echinococcus multilocularis nibrin 0.0011 0.0012 0.0012
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0012 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0417 0.3403
Brugia malayi DKFZp564C0469 protein 0.0011 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0038 0.5844
Plasmodium vivax SET domain protein, putative 0.0016 0.0032 0.5891
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0012 0.0021
Loa Loa (eye worm) choline O-acetyltransferase 0.0355 0.1223 0.1223
Loa Loa (eye worm) MH2 domain-containing protein 0.0195 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) RNA binding protein 0.0126 0.0417 0.0417
Schistosoma mansoni smad 0.0013 0.0021 0.0165
Loa Loa (eye worm) hypothetical protein 0.2845 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0065 1
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0012 0.1722
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0275
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0012 0.0315
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0355 0.1223 0.1223
Schistosoma mansoni hypothetical protein 0.0044 0.013 0.1055
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0006 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0136
Echinococcus granulosus expressed conserved protein 0.01 0.0327 0.0625
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0006 0.001
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0355 0.1223 0.2341
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0234
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0046 0.0191
Brugia malayi Pre-SET motif family protein 0.0114 0.0375 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0016 0.0032 0.0035
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.035 0.0395
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0417 0.0417
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0032 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0065 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0119 0.0119
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0112 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0006 0.0006
Echinococcus granulosus GPCR family 2 0.0017 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0119 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0023 0.0055 0.0055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0042 0.6421
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0012 0.2098
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0044 0.013 0.1055
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0065 1
Schistosoma mansoni hypothetical protein 0.0044 0.013 0.1055
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0012 0.0021
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0012 0.0234
Brugia malayi nuclear receptor NHR-88 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0046 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0417 0.3403
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0165 0.0165
Trichomonas vaginalis set domain proteins, putative 0.013 0.0431 0.9125
Echinococcus multilocularis geminin 0.0097 0.0317 0.0358
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0006 0.0006
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0053 1
Echinococcus granulosus geminin 0.0097 0.0317 0.0606
Echinococcus multilocularis Smad4 0.0013 0.0021 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0355 0.1223 0.2341
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0006 0.0043
Loa Loa (eye worm) oxidoreductase 0.0008 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.3171
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0512 0.0978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0112 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0016 0.0032 0.0253
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0678 0.2364 0.4525
Loa Loa (eye worm) hypothetical protein 0.0355 0.1223 0.1223
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0065 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0065 1
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0034 0.0034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0046 0.0087
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0355 0.1223 0.1223
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0006 0.0043
Onchocerca volvulus 0.0011 0.0014 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0038 0.5844
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0046 0.0087
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0046 0.8615
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0318 0.674
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0016 0.003 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0006 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0006 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0054 0.0163 0.0163
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0006 0.0006
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0012 0.2098
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0119 0.0968
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0065 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0318 0.674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0038 0.5844
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0006 0.0006
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.035 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0355 0.1223 0.2341
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.096
Brugia malayi MH2 domain containing protein 0.0013 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0032
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0012 0.2098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0114 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0065 0.183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0006 0.0006
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0042 0.7821
Schistosoma mansoni coup transcription factor 0.0009 0.0006 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0119 0.0968
Loa Loa (eye worm) hypothetical protein 0.0107 0.035 0.035
Schistosoma mansoni plexin 0.0011 0.0014 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0097 0.0317 0.2588
Schistosoma mansoni Smad4 0.0013 0.0021 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0006 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0006 0.0043
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0065 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0006 0.001
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0012 0.0012
Echinococcus granulosus tumor protein p63 0.0366 0.1265 0.242
Entamoeba histolytica hypothetical protein 0.0039 0.0112 0.3171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0006 0.0006
Brugia malayi ecdysteroid receptor 0.0009 0.0006 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0046 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Brugia malayi steroid hormone receptor 0.0009 0.0006 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0006 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0355 0.1223 0.2341
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0039 0.0112 0.0906
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0021 0.0023
Brugia malayi nuclear hormone receptor 0.0009 0.0006 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0046 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0104 0.0104
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0006 0.001
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0021 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0006 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0006 0.001
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0355 0.1223 0.2341
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0006 0.0006
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.035 1
Onchocerca volvulus 0.0054 0.0163 0.1327
Schistosoma mansoni topbp1 0.0011 0.0012 0.009
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0006 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0065 0.183
Onchocerca volvulus Glucosylceramidase homolog 0.0093 0.0301 0.2453
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0042 1
Brugia malayi Choline O-acetyltransferase 0.0355 0.1223 0.1223
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.149 0.5225 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0038 0.5844
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0275
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0141 0.0472 0.0472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0046 0.0046
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0355 0.1223 0.5173
Echinococcus granulosus plexin a4 0.0013 0.0022 0.004
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0136 0.0258
Schistosoma mansoni hypothetical protein 0.0037 0.0104 0.0847
Schistosoma mansoni smad1 5 8 and 0.0013 0.0021 0.0165
Brugia malayi RNA binding protein 0.0126 0.0417 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0032 0.0253
Brugia malayi topoisomerase 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0006 0.0043
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.149 0.5225 0.5907
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0032 0.0253
Loa Loa (eye worm) plexin A 0.0013 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0119 0.0968
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0417 0.3403
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0417 0.0417
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0141 0.0472 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0417 0.3403
Brugia malayi Choline O-acetyltransferase 0.0355 0.1223 0.1223
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0065 0.183
Schistosoma mansoni hypothetical protein 0.0017 0.0034 0.0275
Loa Loa (eye worm) transcription factor SMAD2 0.0195 0.066 0.066
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0053 1
Brugia malayi Plexin repeat family protein 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0472 1
Echinococcus granulosus tar DNA binding protein 0.0126 0.0417 0.0796
Entamoeba histolytica hypothetical protein 0.0011 0.0012 0.0315
Onchocerca volvulus 0.0355 0.1223 1
Trypanosoma cruzi hypothetical protein, conserved 0.0355 0.1223 0.2341
Trypanosoma cruzi hypothetical protein, conserved 0.0355 0.1223 0.2341
Mycobacterium ulcerans hypothetical protein 0.0026 0.0065 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0034 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0034 0.0038
Onchocerca volvulus 0.0022 0.0053 0.043
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0355 0.1223 0.2341
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0012 0.2098
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0046 0.1295
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0006 0.0043
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0034 0.0064
Brugia malayi MH1 domain containing protein 0.0013 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Onchocerca volvulus 0.0355 0.1223 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0021 0.0165
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0006 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2518 0.8845 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0678 0.2364 0.2672
Echinococcus granulosus Smad4 0.0013 0.0021 0.0039
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0012 0.0021
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.149 0.5225 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0417 0.3403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0012 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0006 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0112 0.0125
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0012 0.0234
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0012 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0165 0.0165
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0678 0.2364 1
Brugia malayi MH2 domain containing protein 0.0013 0.0021 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0006 0.0043
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0021 0.0021
Echinococcus multilocularis tumor protein p63 0.0366 0.1265 0.1429
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0065 1
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0355 0.1223 0.5173
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0355 0.1223 0.5173
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.149 0.5225 1
Schistosoma mansoni hypothetical protein 0.0097 0.0317 0.2588
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0016 0.0032 0.0253
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0006 0.0043
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0065
Schistosoma mansoni choline o-acyltransferase 0.0355 0.1223 1
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0355 0.1223 0.2341
Onchocerca volvulus 0.0355 0.1223 1
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.149 0.5225 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0006 0.001
Onchocerca volvulus 0.0009 0.0006 0.0043
Echinococcus multilocularis choline O acetyltransferase 0.0355 0.1223 0.1382
Onchocerca volvulus 0.0026 0.0065 0.0523
Trichomonas vaginalis glucosylceramidase, putative 0.0093 0.0301 0.6367
Brugia malayi MH1 domain containing protein 0.0013 0.0021 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.035 0.0669
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Echinococcus granulosus smad 0.0013 0.0021 0.0039
Schistosoma mansoni choline o-acyltransferase 0.0355 0.1223 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0032 0.0253
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0006 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0006 0.001
Echinococcus multilocularis smad 0.0013 0.0021 0.0023
Brugia malayi Pre-SET motif family protein 0.0016 0.0032 0.0032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0046 0.7073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.037
Schistosoma mansoni smad1 5 8 and 0.0013 0.0021 0.0165
Brugia malayi plexin A 0.0013 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0012 0.0234
Brugia malayi hypothetical protein 0.0011 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0119 0.0227
Schistosoma mansoni hypothetical protein 0.0044 0.013 0.1055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0034 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0006 0.001
Brugia malayi hypothetical protein 0.0011 0.0012 0.0012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0012 0.0234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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