Detailed information for compound 705338

Basic information

Technical information
  • TDR Targets ID: 705338
  • Name: 3-fluoro-4-methoxy-N-[2-(4-methylphenyl)sulfo nyl-2-thiophen-2-ylethyl]benzenesulfonamide
  • MW: 469.57 | Formula: C20H20FNO5S3
  • H donors: 1 H acceptors: 4 LogP: 3.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1F)S(=O)(=O)NCC(S(=O)(=O)c1ccc(cc1)C)c1cccs1
  • InChi: 1S/C20H20FNO5S3/c1-14-5-7-15(8-6-14)29(23,24)20(19-4-3-11-28-19)13-22-30(25,26)16-9-10-18(27-2)17(21)12-16/h3-12,20,22H,13H2,1-2H3
  • InChiKey: RRNAVLFTEPEEHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-fluoro-4-methoxy-N-[2-(4-methylphenyl)sulfonyl-2-(2-thienyl)ethyl]benzenesulfonamide
  • 3-fluoro-4-methoxy-N-[2-(4-methylphenyl)sulfonyl-2-thiophen-2-yl-ethyl]benzenesulfonamide
  • G857-1624
  • NCGC00137426-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.001 0.0116 0.0116
Echinococcus multilocularis caspase 0.0018 0.0288 0.0263
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3095 0.4112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0601 0.0939
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0925 0.0902
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0422 0.0398
Schistosoma mansoni lamin 0.0033 0.062 0.062
Loa Loa (eye worm) Smad1 0.001 0.0116 0.013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0249 0.1017
Brugia malayi MH2 domain containing protein 0.0144 0.3095 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.1812
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0249 0.0236
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0249 0.1017
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Schistosoma mansoni smad1 5 8 and 0.001 0.0116 0.0116
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1064 0.4488
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) histone methyltransferase 0.001 0.0118 0.0132
Trypanosoma brucei metacaspase MCA3 0.0018 0.0288 0.1182
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3559 0.3731
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0249 0.1017
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.1812
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0641
Brugia malayi MH1 domain containing protein 0.001 0.0116 0.0316
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2357 1
Brugia malayi Cam kinase protein 1 0.0032 0.06 0.189
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0547 0.0523
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0562 0.0567
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0601 0.0607
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0403 0.0378
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2357 0.2337
Plasmodium vivax hexose transporter 0.0102 0.2158 0.2251
Plasmodium falciparum protein kinase 7 0.0288 0.6292 0.6616
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2467 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0641
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0403 0.0624
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Schistosoma mansoni importin beta-1 0.0032 0.061 0.061
Echinococcus multilocularis translational activator gcn1 0.0006 0.0033 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0945 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Echinococcus granulosus caspase 2 0.0058 0.1195 0.1173
Trypanosoma brucei protein kinase, putative 0.0053 0.1064 0.4488
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0599 0.2508
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0422 0.0419
Trypanosoma cruzi hexose transporter 0.0032 0.0599 0.2508
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0249 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0156 0.0447
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0249 0.1017
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Plasmodium falciparum metacaspase 1 0.0018 0.0288 0.0277
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0249 0.1017
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0025 0.0063
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2467 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0449 0.0575
Brugia malayi 6-phosphofructokinase 0.0111 0.2357 0.76
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0249 0.1017
Echinococcus multilocularis importin 5 0.0006 0.0033 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Echinococcus multilocularis Smad4 0.001 0.0116 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0945 0.0922
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0911 0.1193
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0025 0.0022
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0249 0.0224
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0562 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0116 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Brugia malayi hypothetical protein 0.0014 0.0216 0.0641
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0403 0.1671
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.3824
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Schistosoma mansoni importin-beta 2 0.0006 0.0033 0.0033
Plasmodium falciparum transportin 0.0006 0.0033 0.0008
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0576 0.241
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.0552
Brugia malayi hypothetical protein 0.0041 0.0806 0.2558
Plasmodium vivax sugar transporter, putative 0.0014 0.0216 0.0201
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Echinococcus granulosus cpg binding protein 0.0034 0.0648 0.0624
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Brugia malayi glutathione reductase 0.0046 0.0911 0.2901
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0403 0.1671
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2357 1
Echinococcus granulosus Smad4 0.001 0.0116 0.0091
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0216 0.0875
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0547 0.0523
Trypanosoma brucei sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0249 0.1017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0118 0.0093
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0911 0.3839
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Schistosoma mansoni hypothetical protein 0.0102 0.2158 0.2158
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.06 0.0576
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0562 0.0879
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0422 0.0656
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0281 0.1154
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0562 0.2304
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Brugia malayi Smad1 0.001 0.0116 0.0316
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2357 0.3125
Treponema pallidum NADH oxidase 0.0016 0.0249 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0641
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0641
Echinococcus granulosus translational activator gcn1 0.0006 0.0033 0.0008
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0247 0.0305
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0216 0.0191
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0216 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0234 0.0287
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis cpg binding protein 0.0034 0.0648 0.0624
Leishmania major protein kinase, putative 0.0032 0.06 0.2513
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Schistosoma mansoni ran 0.0024 0.0422 0.0422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0945 0.0922
Brugia malayi MH2 domain containing protein 0.001 0.0116 0.0316
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0116 0.0116
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0116 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0599 0.2508
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1064 0.1041
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Plasmodium falciparum glutathione reductase 0.0046 0.0911 0.0935
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Trichomonas vaginalis helicase, putative 0.0007 0.0059 0.0206
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0033 0.0019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1064 0.4488
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0249 0.1017
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Leishmania major trypanothione reductase 0.0046 0.0911 0.3839
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0249 0.2157
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0074 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0712 0.0712
Loa Loa (eye worm) sugar transporter 0.0014 0.0216 0.0264
Trypanosoma brucei metacaspase 0.0018 0.0288 0.1182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0288 0.036
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1064 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0688 0.1079
Schistosoma mansoni glucose transporter 0.0014 0.0216 0.0216
Echinococcus granulosus smad 0.001 0.0116 0.0091
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0641
Brugia malayi Cell death protein 3 precursor 0.0058 0.1195 0.3824
Echinococcus multilocularis caspase 8 0.0018 0.0288 0.0263
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0025 0.006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0249 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.0419
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0138 0.2091
Plasmodium falciparum glutathione reductase 0.0016 0.0249 0.0236
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0288 0.0875
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0285 0.0866
Toxoplasma gondii sugar transporter ST2 0.0014 0.0216 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0288 0.1182
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.06 0.2513
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0249 0.0224
Loa Loa (eye worm) hypothetical protein 0.0041 0.0806 0.1052
Toxoplasma gondii protein kinase, putative 0.0288 0.6292 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Echinococcus granulosus intermediate filament protein 0.0033 0.062 0.0597
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis ran, putative 0.0024 0.0422 0.1755
Schistosoma mansoni hypothetical protein 0.0343 0.7501 0.7501
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1064 0.1041
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0206
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2357 0.9552
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Giardia lamblia Sugar-proton symporter 0.0014 0.0216 0.1836
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Toxoplasma gondii thioredoxin reductase 0.0046 0.0911 0.1434
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2357 0.2357
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Trichomonas vaginalis hypothetical protein 0.0006 0.0033 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0074 0.0074
Echinococcus granulosus lamin dm0 0.0033 0.062 0.0597
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0249 0.1017
Echinococcus multilocularis lamin 0.0033 0.062 0.0597
Brugia malayi hypothetical protein 0.0014 0.0216 0.0641
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2209 0.895
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0138 0.0482
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0601 0.0607
Plasmodium falciparum protein kinase 6 0.0433 0.9497 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0249 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1242 0.1961
Giardia lamblia Hexose transporter 0.0014 0.0216 0.1836
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0601 0.0607
Plasmodium vivax transportin, putative 0.0006 0.0033 0.0008
Brugia malayi hypothetical protein 0.0037 0.0712 0.2254
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.0576
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0116 0.0091
Loa Loa (eye worm) hypothetical protein 0.0058 0.1195 0.1572
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Entamoeba histolytica hypothetical protein 0.0026 0.0476 0.1932
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Plasmodium vivax metacaspase 1, putative 0.0018 0.0288 0.0277
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Brugia malayi MH1 domain containing protein 0.001 0.0116 0.0316
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0216 0.8511
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0216 0.0191
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Loa Loa (eye worm) hypothetical protein 0.0032 0.06 0.0777
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0288 0.0288
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0403 0.0398
Echinococcus granulosus lamin 0.0033 0.062 0.0597
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.061 0.2557
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0033 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3095 0.4112
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0403 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Brugia malayi CXXC zinc finger family protein 0.0032 0.0608 0.1914
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.1195 0.1195
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Trypanosoma brucei metacaspase MCA2 0.0018 0.0288 0.1182
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0601 0.0607
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Schistosoma mansoni ran 0.0024 0.0422 0.0422
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0249 0.0249
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3559 0.565
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0249 0.1017
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis dnaJ subfamily B 0.0456 1 1
Toxoplasma gondii sugar transporter ST1 0.0014 0.0216 0.0327
Echinococcus granulosus transportin 1 0.0006 0.0033 0.0008
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0216 0.0875
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0806 0.0782
Echinococcus granulosus caspase 8 0.0018 0.0288 0.0263
Leishmania major glucose transporter, lmgt1 0.0032 0.0599 0.2508
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0025 0.0063
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0288 0.0288
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0562 0.2352
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0216 0.0875
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0576 0.2302
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.034 0.1406
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0249 0.0236
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2209 0.895
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0249 0.1017
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.06 0.2513
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2158 0.9151
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.06 0.189
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1064 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0118 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Entamoeba histolytica Ran family GTPase 0.0024 0.0422 0.1703
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0601 0.0939
Brugia malayi MAP kinase sur-1 0.0053 0.1064 0.3396
Loa Loa (eye worm) hypothetical protein 0.0015 0.0234 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Entamoeba histolytica protein kinase, putative 0.0032 0.06 0.2466
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0025 0.0025
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.062 0.0804
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0562 0.0567
Echinococcus multilocularis importin subunit beta 1 0.0032 0.061 0.0587
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0288 0.0288
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.0875
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0116 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0249 0.1017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1403 0.1403
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.062 0.1956
Onchocerca volvulus 0.0032 0.0608 0.3999
Echinococcus multilocularis caspase 2 0.0058 0.1195 0.1173
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.06 0.0777
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0712 0.0688
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Loa Loa (eye worm) sugar transporter 0.0102 0.2158 0.2859
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Brugia malayi MH2 domain containing protein 0.001 0.0116 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0264
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Onchocerca volvulus 0.0033 0.062 0.413
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0945 0.0922
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0025 0.0022
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0216 0.0875
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0115 0.0313
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0327 0.1286
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0601 0.0607
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0562 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0562 0.0567
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0288 0.0263
Echinococcus granulosus snurportin 1 0.0343 0.7501 0.7494
Schistosoma mansoni hypothetical protein 0.0456 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2209 0.895
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Mycobacterium tuberculosis Probable reductase 0.0104 0.2209 0.895
Brugia malayi hypothetical protein 0.0014 0.0216 0.0641
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1064 0.4488
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1064 0.4488
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0249 0.038
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0216 0.0836
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Plasmodium falciparum thioredoxin reductase 0.0046 0.0911 0.0935
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0216 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2357 0.2337
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0264
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0288 0.1182
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0688 0.07
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0601 0.0939
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2357 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0327 0.1286
Brugia malayi RNA, U transporter 1 0.0091 0.1923 0.6191
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0403 0.0403
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2209 0.895
Echinococcus multilocularis lamin dm0 0.0033 0.062 0.0597
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0925 0.0902
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0327 0.1286
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0403 0.3633
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0033 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0641
Loa Loa (eye worm) hypothetical protein 0.0032 0.0607 0.0786
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0025 0.006
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.0576
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.7501 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.2209 0.895
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0288 0.1182
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0562 0.0879
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.06 0.06
Brugia malayi Importin beta-1 subunit 0.0032 0.061 0.1923
Leishmania major hypothetical protein, conserved 0.0014 0.0216 0.0875
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2158 0.3418
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.0745
Schistosoma mansoni smad1 5 8 and 0.001 0.0116 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium vivax importin-beta 2, putative 0.0032 0.061 0.0618
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Brugia malayi intermediate filament protein 0.0033 0.062 0.1956
Echinococcus multilocularis musashi 0.0033 0.062 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0562 0.5173
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1064 0.4488
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.0875
Brugia malayi Sugar transporter family protein 0.0102 0.2158 0.6953
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2357 0.9552
Loa Loa (eye worm) hypothetical protein 0.0032 0.061 0.0791
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.0552
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2357 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0599 0.2508
Echinococcus multilocularis General substrate transporter 0.0088 0.184 0.1819
Trypanosoma brucei trypanothione reductase 0.0046 0.0911 0.3839
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Plasmodium vivax glutathione reductase, putative 0.0046 0.0911 0.0935
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0403 0.1248
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Schistosoma mansoni hypothetical protein 0.0041 0.0806 0.0806
Brugia malayi kap beta 3 protein 0.0006 0.0033 0.0046
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2357 0.2357
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0576 0.5304
Echinococcus granulosus importin subunit beta 1 0.0032 0.061 0.0587
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0403 0.0378
Schistosoma mansoni cpg binding protein 0.0034 0.0648 0.0648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0945 0.301
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0562 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Echinococcus granulosus importin 5 0.0006 0.0033 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0599 0.2508
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium falciparum importin beta, putative 0.0032 0.061 0.0618
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0216 0.0191
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0249 0.0236
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Schistosoma mansoni intermediate filament proteins 0.0033 0.062 0.062
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2467 1
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.1195 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0247 0.0222
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0216 0.0216
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0422 0.0398
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0601 0.0607
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0156 0.0447
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.0745
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0403 0.1596
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0025 0.0022
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0025 0.0024
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 0.9497 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0216 0.0201
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0576 0.2362
Trypanosoma brucei glucose transporter 1E 0.0032 0.0599 0.2508
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0216 0.0875
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0116 0.013
Toxoplasma gondii sugar transporter ST3 0.0014 0.0216 0.0327
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0116 0.0091
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0033 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0601 0.0607
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0288 0.0277
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0216 0.0327
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0249 0.1017
Leishmania major glucose transporter, lmgt2 0.0032 0.0599 0.2508
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0688 0.07
Brugia malayi phosphofructokinase 0.0111 0.2357 0.76
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0206
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0911 0.0935
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Loa Loa (eye worm) intermediate filament protein 0.0033 0.062 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0599 0.2508
Echinococcus multilocularis smad 0.001 0.0116 0.0091
Loa Loa (eye worm) hypothetical protein 0.0033 0.062 0.0804
Loa Loa (eye worm) hypothetical protein 0.0023 0.0403 0.0513
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2357 0.3125
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0562 0.0567
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Echinococcus granulosus General substrate transporter 0.0088 0.184 0.1819
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0712 0.0688
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2357 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Plasmodium falciparum metacaspase-like protein 0.0018 0.0288 0.0277
Onchocerca volvulus 0.0041 0.0806 0.6021
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0176 0.0211
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0476 0.1983
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0009
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0249 0.0749
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.061 0.2557
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1064 0.4488
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0025 0.0024
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0086 0.0323
Echinococcus multilocularis transportin 1 0.0006 0.0033 0.0008
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Leishmania major hypothetical protein, conserved 0.0006 0.0033 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0216 0.0191
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0288 0.0263
Schistosoma mansoni cpg binding protein 0.0034 0.0648 0.0648
Leishmania major importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2467 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Trypanosoma brucei Metacaspase-4 0.0018 0.0288 0.1182
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0608 0.0787
Echinococcus multilocularis snurportin 1 0.0343 0.7501 0.7494
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0249 0.0972
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0025 0.0009
Schistosoma mansoni lamin 0.0033 0.062 0.062
Schistosoma mansoni cpg binding protein 0.0032 0.0608 0.0608
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0403 0.7023
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Onchocerca volvulus 0.0033 0.062 0.413
Entamoeba histolytica hypothetical protein 0.0023 0.0403 0.1618
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0403 0.0398
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1064 0.1041
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1064 0.4488
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0025 0.0009
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2158 0.2138
Plasmodium falciparum thioredoxin reductase 0.0016 0.0249 0.0236
Leishmania major glucose transporter, lmgt3 0.0032 0.0599 0.2508
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0249 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0249 0.4169
Plasmodium falciparum hexose transporter 0.0102 0.2158 0.2251
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.061 0.0955
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0599 0.2508
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.06 0.0777
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0074 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0945 0.1238
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Schistosoma mansoni smad 0.001 0.0116 0.0116
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0285 0.0356
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3559 0.3731
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0562 0.2304
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0911 0.3667
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Mycobacterium ulcerans sugar transporter 0.0014 0.0216 0.0875
Leishmania major metacaspase, putative 0.0018 0.0288 0.1182
Echinococcus granulosus caspase 0.0018 0.0288 0.0263
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2209 0.895
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.1312
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0138 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0806 0.0782
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0216 0.0836
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0249 0.1017
Schistosoma mansoni Smad4 0.001 0.0116 0.0116
Entamoeba histolytica protein kinase, putative 0.0032 0.06 0.2466
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0249 0.1017
Leishmania major GTP-binding protein, putative 0.0024 0.0422 0.1755
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1064 0.1064
Loa Loa (eye worm) glutathione reductase 0.0046 0.0911 0.1193
Brugia malayi Thioredoxin reductase 0.0046 0.0911 0.2901
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0247 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0033 0.0095
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0033 0.0033
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2357 0.3125
Schistosoma mansoni hypothetical protein 0.0037 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0264
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1064 0.1041
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0601 0.0607
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Brugia malayi 6-phosphofructokinase 0.0111 0.2357 0.76
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1064 0.1676
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0601 0.0607

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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