Detailed information for compound 71253

Basic information

Technical information
  • TDR Targets ID: 71253
  • Name: 4-N-acridin-9-yl-1-N-hexylbenzene-1,4-diamine
  • MW: 369.502 | Formula: C25H27N3
  • H donors: 2 H acceptors: 1 LogP: 7.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCNc1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C25H27N3/c1-2-3-4-9-18-26-19-14-16-20(17-15-19)27-25-21-10-5-7-12-23(21)28-24-13-8-6-11-22(24)25/h5-8,10-17,26H,2-4,9,18H2,1H3,(H,27,28)
  • InChiKey: JATOTVFVQYRPDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N4-acridin-9-yl-N1-hexyl-benzene-1,4-diamine
  • N4-(9-acridinyl)-N1-hexylbenzene-1,4-diamine
  • acridin-9-yl-[4-(hexylamino)phenyl]amine
  • N'-acridin-9-yl-N-hexylbenzene-1,4-diamine
  • N'-acridin-9-yl-N-hexyl-benzene-1,4-diamine
  • N'-(9-acridinyl)-N-hexylbenzene-1,4-diamine
  • [4-(acridin-9-ylamino)phenyl]-hexyl-amine
  • 75775-91-6
  • 9-(p-(Hexylamino)anilino)acridine
  • ACRIDINE, 9-(p-(HEXYLAMINO)ANILINO)-
  • BRN 0434661

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00276396 0.0514613 0.125603
Echinococcus granulosus protein kinase c epsilon type 0.00153087 0.0158599 0.0387096
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.00937236 0.242257 0.591281
Echinococcus granulosus neurogenic locus notch protein 0.00256021 0.0455784 0.111244
Echinococcus granulosus short transient receptor potential channel 6 0.000991717 0.000293513 0.000716384
Loa Loa (eye worm) hypothetical protein 0.00398352 0.086672 0.302922
Loa Loa (eye worm) hypothetical protein 0.00146016 0.0138183 0.0482952
Schistosoma mansoni notch 0.00257037 0.045872 0.045872
Brugia malayi orphan nuclear receptor NR2E1 0.0013038 0.009304 0.0191675
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Plasmodium vivax hypothetical protein, conserved 0.00160963 0.0181337 0.07036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.00146016 0.0138183 0.0337265
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00276396 0.0514613 0.0514613
Echinococcus multilocularis notch 0.00256021 0.0455784 0.111244
Echinococcus granulosus neurogenic locus protein delta 0.00256021 0.0455784 0.111244
Brugia malayi Animal haem peroxidase family protein 0.00792444 0.200453 0.42579
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00276396 0.0514613 0.0514613
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0356175 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0055144 0.130871 0.130871
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00276396 0.0514613 0.108847
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.00256021 0.0455784 0.0455784
Echinococcus granulosus neurogenic locus notch protein 0.00256021 0.0455784 0.111244
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00276396 0.0514613 0.179859
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00276396 0.0514613 0.108847
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013038 0.009304 0.0191675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00276396 0.0514613 0.108847
Brugia malayi Calcium binding EGF domain containing protein 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) hypothetical protein 0.00821245 0.208768 0.729652
Echinococcus granulosus fibropellin Ia 0.00256021 0.0455784 0.111244
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Brugia malayi Nuclear hormone receptor-like 1 0.00276396 0.0514613 0.108847
Onchocerca volvulus Peroxidase homolog 0.00792444 0.200453 0.27848
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.00114079 0.00459745 0.0112211
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013038 0.009304 0.009304
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Onchocerca volvulus 0.00256021 0.0455784 0.0528473
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0103539 0.270596 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni cell polarity protein 0.00256021 0.0455784 0.0455784
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Schistosoma mansoni sodium/chloride dependent transporter 0.00821245 0.208768 0.208768
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00114079 0.00459745 0.0112211
Brugia malayi Blistered cuticle protein 3 0.00792444 0.200453 0.42579
Schistosoma mansoni RAR-like nuclear receptor 0.00276396 0.0514613 0.0514613
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.00114079 0.00459745 0.00459745
Echinococcus granulosus protein kinase c iota type 0.00147423 0.0142245 0.0347182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013038 0.009304 0.0227085
Onchocerca volvulus 0.00160963 0.0181337 0.0128637
Echinococcus granulosus thyroid hormone receptor alpha 0.0013038 0.009304 0.0227085
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00276396 0.0514613 0.0514613
Loa Loa (eye worm) animal heme peroxidase 0.00792444 0.200453 0.70059
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00114079 0.00459745 0.0112211
Schistosoma mansoni serine/threonine protein kinase 0.0055144 0.130871 0.130871
Loa Loa (eye worm) hypothetical protein 0.00821245 0.208768 0.729652
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00276396 0.0514613 0.0514613
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00160963 0.0181337 0.0442592
Onchocerca volvulus 0.00256021 0.0455784 0.0528473
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Brugia malayi Nuclear hormone receptor-like 1 0.00146016 0.0138183 0.0287705
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Brugia malayi bZIP transcription factor family protein 0.0111399 0.293288 0.623273
Echinococcus multilocularis fat cadherin tumor suppressor 0.00256021 0.0455784 0.111244
Trichomonas vaginalis conserved hypothetical protein 0.00114079 0.00459745 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni notch 0.00256021 0.0455784 0.0455784
Echinococcus granulosus slit 2 protein 0.00256021 0.0455784 0.111244
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0111399 0.293288 0.715835
Plasmodium falciparum transporter, putative 0.00160963 0.0181337 0.07036
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.025078 0.695705 1
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00276396 0.0514613 0.0514613
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.00114079 0.00459745 0.00459745
Brugia malayi hypothetical protein 0.00792444 0.200453 0.42579
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.00114079 0.00459745 0.0112211
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00160963 0.0181337 0.0442592
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.00823157 0.20932 0.510892
Brugia malayi nuclear hormone receptor 0.0013038 0.009304 0.0191675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Loa Loa (eye worm) hypothetical protein 0.00114079 0.00459745 0.0160682
Plasmodium vivax amine transporter, putative 0.00160963 0.0181337 0.07036
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0633778
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.00114079 0.00459745 0.0112211
Echinococcus granulosus serotonin transporter 0.00160963 0.0181337 0.0442592
Echinococcus granulosus transient receptor potential cation channel 0.000991717 0.000293519 0.000716399
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Echinococcus multilocularis slit 2 protein 0.00256021 0.0455784 0.111244
Onchocerca volvulus Dual oxidase homolog 0.00792444 0.200453 0.27848
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0508883
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Brugia malayi GCC2 and GCC3 family protein 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00160963 0.0181337 0.0442592
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00276396 0.0514613 0.125603
Echinococcus multilocularis short transient receptor potential channel 6 0.000991717 0.000293513 0.000716384
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013038 0.009304 0.0325178
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.00146016 0.0138183 0.0337265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00276396 0.0514613 0.179859
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00160963 0.0181337 0.0442592
Schistosoma mansoni nuclear receptor 0.0013038 0.009304 0.009304
Loa Loa (eye worm) blistered cuticle protein 3 0.00792444 0.200453 0.70059
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Brugia malayi hypothetical protein 0.0013038 0.009304 0.0191675
Brugia malayi steroid hormone receptor 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) hypothetical protein 0.00114079 0.00459745 0.0160682
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Echinococcus granulosus notch 0.00256021 0.0455784 0.111244
Echinococcus multilocularis nuclear receptor nhr 48 0.0013038 0.009304 0.0227085
Echinococcus multilocularis FTZ F1 alpha 0.00276396 0.0514613 0.125603
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Schistosoma mansoni steroid hormone receptor ad4bp 0.00276396 0.0514613 0.0514613
Brugia malayi Calcium binding EGF domain containing protein 0.00256021 0.0455784 0.0963323
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.00937236 0.242257 0.591281
Onchocerca volvulus 0.00276396 0.0514613 0.0614178
Brugia malayi nuclear receptor NHR-88 0.00276396 0.0514613 0.108847
Trichomonas vaginalis conserved hypothetical protein 0.00114079 0.00459745 0.5
Loa Loa (eye worm) hypothetical protein 0.00459414 0.104301 0.364537
Brugia malayi Animal haem peroxidase family protein 0.00792444 0.200453 0.42579
Echinococcus multilocularis RNA directed DNA polymerase 0.00398352 0.086672 0.211542
Echinococcus multilocularis sodium and chloride dependent glycine 0.00821245 0.208768 0.509545
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013038 0.009304 0.0227085
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Onchocerca volvulus Neurogenic locus notch protein homolog 0.00256021 0.0455784 0.0528473
Schistosoma mansoni notch 0.00256021 0.0455784 0.0455784
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.00114079 0.00459745 0.00915555
Echinococcus multilocularis transient receptor potential cation channel 0.000991717 0.000293519 0.000716399
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00276396 0.0514613 0.108847
Echinococcus multilocularis neurogenic locus protein delta 0.00256021 0.0455784 0.111244
Echinococcus granulosus nuclear receptor nhr 48 0.0013038 0.009304 0.0227085
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.00114079 0.00459745 0.0112211
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00160963 0.0181337 0.0181337
Schistosoma mansoni sodium-dependent amino acid transporter 0.00160963 0.0181337 0.0181337
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.00114079 0.00459745 0.00915555
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Onchocerca volvulus Protein ultraspiracle homolog 0.00276396 0.0514613 0.0614178
Schistosoma mansoni notch 0.00256021 0.0455784 0.0455784
Brugia malayi tailless protein 0.0013038 0.009304 0.0191675
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus multilocularis neurogenic locus protein delta 0.00256021 0.0455784 0.111244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00276396 0.0514613 0.125603
Echinococcus multilocularis sodium and chloride dependent glycine 0.00821245 0.208768 0.509545
Onchocerca volvulus Neurogenic locus notch homolog 0.00257037 0.045872 0.0532749
Loa Loa (eye worm) hypothetical protein 0.00146016 0.0138183 0.0482952
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00821245 0.208768 0.443478
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013038 0.009304 0.0227085
Echinococcus multilocularis neurogenic locus notch protein 0.00256021 0.0455784 0.111244
Loa Loa (eye worm) hypothetical protein 0.0108916 0.28612 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.00398352 0.086672 0.211542
Schistosoma mansoni serine/threonine protein kinase 0.00153087 0.0158599 0.0158599
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) animal heme peroxidase 0.00792444 0.200453 0.70059
Treponema pallidum sodium- and chloride- dependent transporter 0.00160963 0.0181337 0.5
Toxoplasma gondii RNA-directed DNA polymerase 0.00780424 0.196983 0.723256
Echinococcus granulosus protein jagged 2 0.00256021 0.0455784 0.111244
Brugia malayi Telomerase reverse transcriptase 0.0172738 0.470384 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00160963 0.0181337 0.0442592
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni jun-related protein 0.00910504 0.234539 0.234539
Echinococcus multilocularis neurogenic locus notch protein 4 0.00256021 0.0455784 0.111244
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00937236 0.242257 0.242257
Echinococcus multilocularis fibropellin Ia 0.00256021 0.0455784 0.111244
Brugia malayi notch-like transmembrane receptor 0.00256021 0.0455784 0.0963323
Schistosoma mansoni zinc finger protein 0.0013038 0.009304 0.009304
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) solute carrier family 6 member 4 0.00160963 0.0181337 0.0633778
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00276396 0.0514613 0.0514613
Loa Loa (eye worm) hypothetical protein 0.000991717 0.000293519 0.00102586
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Trichomonas vaginalis conserved hypothetical protein 0.00114079 0.00459745 0.5
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.00114079 0.00459745 0.0160682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00276396 0.0514613 0.179859
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00276396 0.0514613 0.125603
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Onchocerca volvulus Bile acid receptor homolog 0.00276396 0.0514613 0.0614178
Echinococcus granulosus protein jagged 1 0.00256021 0.0455784 0.111244
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013038 0.009304 0.0191675
Onchocerca volvulus 0.00885677 0.227371 0.317696
Echinococcus granulosus jun protein 0.0111399 0.293288 0.715835
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00160963 0.0181337 0.0442592
Onchocerca volvulus 0.00792444 0.200453 0.27848
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) PDE1B protein 0.00114079 0.00459745 0.0160682
Onchocerca volvulus 0.00160963 0.0181337 0.0128637
Brugia malayi hypothetical protein 0.0013038 0.009304 0.0191675
Loa Loa (eye worm) Notch2 0.00256021 0.0455784 0.159298
Giardia lamblia High cysteine protein 0.00256021 0.0455784 0.172436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00276396 0.0514613 0.179859
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Schistosoma mansoni nuclear hormone receptor 0.0013038 0.009304 0.009304
Echinococcus multilocularis neurogenic locus notch protein 0.00256021 0.0455784 0.111244
Brugia malayi conserved hypotetical protein 0.0013038 0.009304 0.0191675
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0111399 0.293288 0.715835
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.000991717 0.000293519 0.000716399
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.00114079 0.00459745 0.00915555
Brugia malayi Animal haem peroxidase family protein 0.00792444 0.200453 0.42579
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00276396 0.0514613 0.108847
Echinococcus multilocularis neural cadherin 0.00256021 0.0455784 0.111244
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Brugia malayi Muscle positioning protein 4 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00276396 0.0514613 0.108847
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus multilocularis protein jagged 1 0.00256021 0.0455784 0.111244
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Trypanosoma brucei telomerase reverse transcriptase 0.00780424 0.196983 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.00114079 0.00459745 0.0112211
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013038 0.009304 0.0227085
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus calcium activated potassium channel 0.00100018 0.000537848 0.00131274
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus multilocularis protein jagged 1 0.00256021 0.0455784 0.111244
Echinococcus multilocularis protein kinase c epsilon type 0.00153087 0.0158599 0.0387096
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus multilocularis sodium channel protein 0.0151724 0.409715 1
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Echinococcus granulosus sodium and chloride dependent glycine 0.00821245 0.208768 0.509545
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00276396 0.0514613 0.108847
Schistosoma mansoni thyroid hormone receptor 0.00276396 0.0514613 0.0514613
Schistosoma mansoni laminin gamma-3 chain 0.00256021 0.0455784 0.0455784
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Loa Loa (eye worm) notch protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni notch 0.00256021 0.0455784 0.0455784
Brugia malayi hypothetical protein 0.00160963 0.0181337 0.0379504
Toxoplasma gondii hypothetical protein 0.00160963 0.0181337 0.0508883
Loa Loa (eye worm) DR-78 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00276396 0.0514613 0.179859
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0379504
Schistosoma mansoni coup transcription factor 0.00276396 0.0514613 0.0514613
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.00937236 0.242257 0.591281
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.00780424 0.196983 1
Leishmania major telomerase reverse transcriptase, putative 0.00780424 0.196983 0.474887
Loa Loa (eye worm) norepinephrine transporter 0.00160963 0.0181337 0.0633778
Toxoplasma gondii hypothetical protein 0.00160963 0.0181337 0.0508883
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.00780424 0.196983 1
Onchocerca volvulus Peroxidasin homolog 0.00792444 0.200453 0.27848
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Echinococcus multilocularis protein jagged 2 0.00256021 0.0455784 0.111244
Schistosoma mansoni transient receptor potential channel 0.000991717 0.000293513 0.000293513
Echinococcus granulosus neural cadherin 0.00256021 0.0455784 0.111244
Brugia malayi Cadherin domain containing protein 0.00256021 0.0455784 0.0963323
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.00114079 0.00459745 0.00915555
Loa Loa (eye worm) steroid hormone receptor 0.00276396 0.0514613 0.179859
Echinococcus multilocularis ecdysone induced protein 78C 0.00276396 0.0514613 0.125603
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00276396 0.0514613 0.125603
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00276396 0.0514613 0.108847
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.00114079 0.00459745 0.0112211
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013038 0.009304 0.0227085
Brugia malayi Delta serrate ligand family protein 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0040588 0.0888453 0.310517
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.00823157 0.20932 0.510892
Brugia malayi Protein kinase c protein 2 0.00466941 0.106475 0.225874
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.00114079 0.00459745 0.0112211
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.00114079 0.00459745 0.00915555
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00821245 0.208768 0.729652
Schistosoma mansoni nuclear receptor nhr-48 0.0013038 0.009304 0.009304
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus delta-like protein 1 0.00256021 0.0455784 0.111244
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.00823157 0.20932 0.731581
Onchocerca volvulus 0.00256021 0.0455784 0.0528473
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Echinococcus granulosus protein kinase C gamma type 0.00490378 0.113242 0.276391
Brugia malayi Nuclear hormone receptor-like 1 0.00146016 0.0138183 0.0287705
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Brugia malayi Nuclear hormone receptor E75 0.0013038 0.009304 0.0191675
Schistosoma mansoni notch 0.00256021 0.0455784 0.0455784
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) nuclear hormone receptor 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Schistosoma mansoni nuclear hormone receptor 0.0013038 0.009304 0.009304
Onchocerca volvulus 0.00160963 0.0181337 0.0128637
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.00114079 0.00459745 0.00459745
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.00937236 0.242257 0.591281
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0151724 0.409715 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.00114079 0.00459745 0.00915555
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013038 0.009304 0.0325178
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus neurogenic locus notch protein 4 0.00256021 0.0455784 0.111244
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.00256021 0.0455784 0.0963323
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Brugia malayi protein kinase C II. 0.00153087 0.0158599 0.0331136
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi ecdysteroid receptor 0.00276396 0.0514613 0.108847
Echinococcus granulosus protein jagged 1 0.00256021 0.0455784 0.111244
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi Animal haem peroxidase family protein 0.00792444 0.200453 0.42579
Schistosoma mansoni nuclear receptor 0.0013038 0.009304 0.009304
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni retinoic acid receptor RXR 0.00276396 0.0514613 0.0514613
Schistosoma mansoni sodium/chloride dependent transporter 0.00823108 0.209306 0.209306
Onchocerca volvulus 0.00792444 0.200453 0.27848
Schistosoma mansoni peroxidasin 0.00792444 0.200453 0.200453
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni peroxidasin 0.00792444 0.200453 0.200453
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Echinococcus granulosus sodium channel protein 0.0151724 0.409715 1
Loa Loa (eye worm) hypothetical protein 0.00937236 0.242257 0.846695
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus protein jagged 2 0.00256021 0.0455784 0.111244
Schistosoma mansoni nuclear hormone receptor 0.00276396 0.0514613 0.0514613
Onchocerca volvulus Slit protein homolog 0.00256021 0.0455784 0.0528473
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Loa Loa (eye worm) animal heme peroxidase 0.00792444 0.200453 0.70059
Brugia malayi Calcium binding EGF domain containing protein 0.00256021 0.0455784 0.0963323
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.00160963 0.0181337 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013038 0.009304 0.0227085
Loa Loa (eye worm) hypothetical protein 0.00114079 0.00459745 0.0160682
Schistosoma mansoni hypothetical protein 0.00910504 0.234539 0.234539
Loa Loa (eye worm) hypothetical protein 0.00146016 0.0138183 0.0482952
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00276396 0.0514613 0.125603
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.00114079 0.00459745 0.0112211
Echinococcus granulosus FTZ F1 alpha 0.00276396 0.0514613 0.125603
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.00146016 0.0138183 0.0138183
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi hypothetical protein 0.00885677 0.227371 0.48305
Brugia malayi nuclear hormone receptor family member odr-7 0.0013038 0.009304 0.0191675
Loa Loa (eye worm) hypothetical protein 0.0013038 0.009304 0.0325178
Brugia malayi Peroxidasin 0.00792444 0.200453 0.42579
Echinococcus multilocularis serotonin transporter 0.00160963 0.0181337 0.0442592
Brugia malayi nuclear receptor RXR 0.00146016 0.0138183 0.0287705
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.00276396 0.0514613 0.0614178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00276396 0.0514613 0.125603
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Brugia malayi nuclear receptor NHR-67 0.0013038 0.009304 0.0191675
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.00937236 0.242257 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.00114079 0.00459745 0.0112211
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00160963 0.0181337 0.0442592
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00153087 0.0158599 0.0554309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00276396 0.0514613 0.179859
Echinococcus multilocularis protein kinase c iota type 0.00147423 0.0142245 0.0347182
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Echinococcus granulosus peroxidasin 0.00792444 0.200453 0.48925
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0379504
Loa Loa (eye worm) serotonin transporter b 0.00160963 0.0181337 0.0633778
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.00276396 0.0514613 0.125603
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Brugia malayi Steroid receptor seven-up type 2 0.00276396 0.0514613 0.108847
Echinococcus granulosus sodium and chloride dependent glycine 0.00821245 0.208768 0.509545
Onchocerca volvulus 0.00792444 0.200453 0.27848
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00160963 0.0181337 0.0379504
Plasmodium vivax telomerase reverse transcriptase, putative 0.00780424 0.196983 1
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00276396 0.0514613 0.125603
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni atypical protein kinase C 0.00147423 0.0142245 0.0142245
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Plasmodium falciparum amino acid transporter, putative 0.00160963 0.0181337 0.07036
Plasmodium falciparum telomerase reverse transcriptase 0.00780424 0.196983 1
Echinococcus granulosus RNA directed DNA polymerase 0.00398352 0.086672 0.211542
Brugia malayi Cadherin domain containing protein 0.00256021 0.0455784 0.0963323
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00276396 0.0514613 0.125603
Brugia malayi ecdysone receptor 0.0013038 0.009304 0.0191675
Echinococcus multilocularis peroxidasin 0.00792444 0.200453 0.48925
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00160963 0.0181337 0.0181337
Giardia lamblia Telomerase catalytic subunit 0.00780424 0.196983 0.809499
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Toxoplasma gondii EGF family domain-containing protein 0.00256021 0.0455784 0.154065
Loa Loa (eye worm) hypothetical protein 0.00146016 0.0138183 0.0482952
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.00114079 0.00459745 0.0112211
Brugia malayi nuclear receptor RXR 0.0013038 0.009304 0.0191675
Onchocerca volvulus Peroxidasin homolog 0.00792444 0.200453 0.27848
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00276396 0.0514613 0.108847
Onchocerca volvulus Putative cubilin 0.00256021 0.0455784 0.0528473
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0508883
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00146016 0.0138183 0.0138183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00276396 0.0514613 0.125603
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.00823157 0.20932 0.444652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00276396 0.0514613 0.179859
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.00114079 0.00459745 0.5
Loa Loa (eye worm) animal heme peroxidase 0.00792444 0.200453 0.70059
Onchocerca volvulus 0.00256021 0.0455784 0.0528473
Brugia malayi nuclear hormone receptor 0.00276396 0.0514613 0.108847
Onchocerca volvulus 0.00256021 0.0455784 0.0528473
Onchocerca volvulus Chorion peroxidase homolog 0.00792444 0.200453 0.27848
Loa Loa (eye worm) hypothetical protein 0.00146016 0.0138183 0.0482952
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0055144 0.130871 0.31942
Brugia malayi photoreceptor-specific nuclear receptor 0.00276396 0.0514613 0.108847
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Brugia malayi Nuclear hormone receptor E75 0.0013038 0.009304 0.0191675
Echinococcus multilocularis serine threonine protein kinase 0.00490378 0.113242 0.276391
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013038 0.009304 0.0227085
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.00212234 0.0329365 0.106538
Echinococcus granulosus Protein kinase C brain isozyme 0.0055144 0.130871 0.31942
Brugia malayi hypothetical protein 0.00146016 0.0138183 0.0287705
Brugia malayi nuclear receptor NHR-88 0.0013038 0.009304 0.0191675
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni thyroid hormone receptor 0.00276396 0.0514613 0.0514613
Echinococcus multilocularis jun protein 0.0111399 0.293288 0.715835
Echinococcus multilocularis thyroid hormone receptor alpha 0.00276396 0.0514613 0.125603
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Onchocerca volvulus Peroxidase homolog 0.00792444 0.200453 0.27848
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni slit 0.00256021 0.0455784 0.0455784
Loa Loa (eye worm) hypothetical protein 0.00792444 0.200453 0.70059
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Loa Loa (eye worm) hypothetical protein 0.00276396 0.0514613 0.179859
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0151724 0.409715 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.00146016 0.0138183 0.0482952
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00276396 0.0514613 0.125603
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0379504
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.00114079 0.00459745 0.00459745
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013038 0.009304 0.0227085
Loa Loa (eye worm) hypothetical protein 0.00160963 0.0181337 0.0633778
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.00114079 0.00459745 0.5
Schistosoma mansoni septate junction protein 0.00256021 0.0455784 0.0455784
Brugia malayi Animal haem peroxidase family protein 0.00792444 0.200453 0.42579
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Schistosoma mansoni hypothetical protein 0.00256021 0.0455784 0.0455784
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.00114079 0.00459745 0.5
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00160963 0.0181337 0.0508883
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00160963 0.0181337 0.0181337
Onchocerca volvulus 0.00160963 0.0181337 0.0128637
Brugia malayi hypothetical protein 0.00146016 0.0138183 0.0287705
Schistosoma mansoni sodium/chloride dependent transporter 0.00160963 0.0181337 0.0181337
Loa Loa (eye worm) hypothetical protein 0.00256021 0.0455784 0.159298
Echinococcus multilocularis calcium activated potassium channel 0.00100018 0.000537848 0.00131274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00276396 0.0514613 0.125603
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00276396 0.0514613 0.125603
Brugia malayi EGF-like domain containing protein 0.00256021 0.0455784 0.0963323
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013038 0.009304 0.0227085
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00160963 0.0181337 0.0181337

Activities

Activity type Activity value Assay description Source Reference
C50 (functional) = 1.6 uM Inhibitory concentration against ethidium binding to DNA ChEMBL. 7205885
ED50 (functional) = 2.2 uM Concentration required to reduce the number of macrophages infected with T. cruzi amastigotes to 50% of untreated controls. ChEMBL. 9258370
ED50 (functional) = 2.2 uM Concentration required to reduce the number of macrophages infected with T. cruzi amastigotes to 50% of untreated controls. ChEMBL. 9258370
ED50 (functional) = 3.9 uM Concentration required to inhibit the growth of extracellular Trypanosoma brucei tryptomastigotes to 50% of untreated controls. ChEMBL. 9258370
ED50 (functional) = 3.9 uM Concentration required to inhibit the growth of extracellular Trypanosoma brucei tryptomastigotes to 50% of untreated controls. ChEMBL. 9258370
ED50 (functional) = 12.3 uM Concentration required to reduce the number of macrophages infected with L. donovani amastigotes to 50% of untreated controls. ChEMBL. 9258370
ED50 (functional) = 12.3 uM Concentration required to reduce the number of macrophages infected with L. donovani amastigotes to 50% of untreated controls. ChEMBL. 9258370
IC50 (functional) = 0.55 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
IC50 (functional) = 0.55 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
IC50 (functional) = 17 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
IC50 (functional) = 17 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
ILS (functional) NA 0 % Maximum percent increase in life span of mice ChEMBL. 7205885
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
Index = 2.38 Lipophilicity index (substitution method) ChEMBL. 9258370
LD10 (ADMET) = 90 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
LD10 (ADMET) = 90 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
Log 1/D50 (functional) < 3.69 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 3.69 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706
Log K (binding) = 6.38 Association constant for binding to poly [d(G-C)] ChEMBL. 7205885
Log K (binding) = 6.43 Association constant for binding to poly [d(A-T)] ChEMBL. 7205885
pKa = 8.24 Ionisation constant (pKa) ChEMBL. 7205885
Therapeutic index (ADMET) = 31 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370
Therapeutic index (ADMET) = 31 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania major ChEMBL23 9258370
Homo sapiens ChEMBL23 9258370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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