TDR Targets

Basic information

Technical information

TDR Targets ID: 715381
Name: 3-[(4-tert-butylphenyl)methyl]-6-methyl-5-phe nylthieno[4,5-e]pyrimidin-4-one
MW: 388.525 | Formula: C24H24N2OS
H donors: 0 H acceptors: 1 LogP: 6.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1sc2c(c1c1ccccc1)c(=O)n(cn2)Cc1ccc(cc1)C(C)(C)C
InChi: 1S/C24H24N2OS/c1-16-20(18-8-6-5-7-9-18)21-22(28-16)25-15-26(23(21)27)14-17-10-12-19(13-11-17)24(2,3)4/h5-13,15H,14H2,1-4H3
InChiKey: ZMAWHMUVGKKBPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(4-tert-butylphenyl)methyl]-6-methyl-5-phenyl-thieno[4,5-e]pyrimidin-4-one
3-[(4-tert-butylphenyl)methyl]-6-methyl-5-phenyl-4-thieno[4,5-e]pyrimidinone
3-(4-tert-butylbenzyl)-6-methyl-5-phenyl-thieno[4,5-e]pyrimidin-4-one
ST5206532
ZINC01971245

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0073	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0435	0.0901
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0161	0.0132
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0008	0.0048	0.0068
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0008	0.0048	0.0589
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0318	0.0629
Echinococcus multilocularis	muscleblind protein	0.0295	0.4342	0.4326
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0463	0.0463
Brugia malayi	Neuronal symmetry protein 1	0.0207	0.3018	0.6916
Echinococcus multilocularis	musashi	0.0026	0.0318	0.029
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0208	0.0208
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0135	0.0204
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0435	0.0901
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Leishmania major	mitochondrial DNA polymerase beta	0.0295	0.4334	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0318	0.0629
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0073	0.0044
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0207	0.3018	0.2998
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0116	0.016
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Schistosoma mansoni	hypothetical protein	0.0036	0.0463	0.0463
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0544	0.1159
Treponema pallidum	fructose-bisphosphate aldolase	0.0285	0.4192	1
Toxoplasma gondii	hypothetical protein	0.0048	0.0636	0.7838
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0295	0.4334	1
Brugia malayi	Muscleblind-like protein	0.0295	0.4342	1
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0008	0.0048	0.0019
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0073	0.0897
Echinococcus granulosus	cation transporting ATPase 13A1	0.0008	0.0048	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1734	0.3926
Schistosoma mansoni	DNA helicase recq5	0.001	0.0073	0.0073
Brugia malayi	hypothetical protein	0.0036	0.0463	0.0967
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.0048	0.0048
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2011	0.4581
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0073	0.1299
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0008	0.0048	0.0019
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0073	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0107	0.0138
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0167	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0029	0.0029
Echinococcus granulosus	lamin	0.0026	0.0318	0.029
Entamoeba histolytica	hypothetical protein	0.0036	0.0463	0.1105
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0068
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.086	0.1896
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0114
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.2011	0.4581
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0888	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0114	0.0155
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0068
Schistosoma mansoni	hypothetical protein	0.0034	0.0435	0.0435
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.2398	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0116	0.016
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0008	0.0048	0.0589
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0463	0.0436
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0544	0.1159
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0544	0.1159
Echinococcus granulosus	cation transporting ATPase 13A3	0.0008	0.0048	0.0019
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0284	0.055
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0811	0.0785
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.0048	0.0114
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0048	0.0068
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0161	0.0263
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0054	0.0026
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0888	0.0862
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0284	0.0634
Schistosoma mansoni	hypothetical protein	0.0016	0.0161	0.0161
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0008	0.0048	0.0114
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.4192	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0888	0.1961
Echinococcus multilocularis	microtubule associated protein 2	0.0674	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0161	0.0132
Schistosoma mansoni	atpase class VI type 11c	0.0008	0.0048	0.0048
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0008	0.0048	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0311	0.0613
Brugia malayi	intermediate filament protein	0.0026	0.0318	0.0629
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0073	0.0058
Schistosoma mansoni	hypothetical protein	0.0016	0.0161	0.0161
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0888	0.1957
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.0048	0.0019
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0161	0.0263
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0344	0.0689
Treponema pallidum	hypothetical protein	0.0008	0.0048	0.0114
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0888	0.1961
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0063	0.086	0.1896
Echinococcus granulosus	cation transporting atpase worm	0.0008	0.0048	0.0019
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0318	0.0318
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0008	0.0048	0.0114
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0344	0.0689
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.0048	0.0114
Echinococcus granulosus	cpg binding protein	0.003	0.0368	0.034
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0811	0.347
Schistosoma mansoni	cpg binding protein	0.003	0.0368	0.0368
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2532	0.6021
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0008	0.0048	0.0019
Loa Loa (eye worm)	STE/STE11/ASK protein kinase	0.0063	0.086	0.1892
Brugia malayi	hypothetical protein	0.0086	0.1211	0.2709
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0482	0.0455
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0073	0.006
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0811	1
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0116	0.0278
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.2009	0.8917
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0008	0.0048	0.0068
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0811	0.0785
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0114	0.0086
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0008	0.0048	0.0019
Schistosoma mansoni	cpg binding protein	0.003	0.0368	0.0368
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0161	0.0132
Schistosoma mansoni	cpg binding protein	0.0028	0.0344	0.0344
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0008	0.0048	0.0114
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0052	0.0011
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0161	0.0132
Schistosoma mansoni	hypothetical protein	0.0016	0.0161	0.0161
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0114
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0671	0.1451
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Toxoplasma gondii	cation-transporting atpase family protein	0.0008	0.0048	0.0589
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0073	0.0044
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0019	0.00000000014665
Echinococcus multilocularis	lamin	0.0026	0.0318	0.029
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0008	0.0048	0.0019
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.4334	1
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0008	0.0048	0.0019
Echinococcus granulosus	intermediate filament protein	0.0026	0.0318	0.029
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Toxoplasma gondii	P-type ATPase4, putative	0.0008	0.0048	0.0589
Onchocerca volvulus		0.0028	0.0344	0.1259
Entamoeba histolytica	hypothetical protein	0.0036	0.0463	0.1105
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0284	0.055
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0161	0.0263
Giardia lamblia	Fructose-bisphosphate aldolase	0.0285	0.4192	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0856	0.1882
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0008	0.0048	0.0019
Mycobacterium ulcerans	hypothetical protein	0.0155	0.2247	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0811	0.0811
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0811	0.347
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0008	0.0048	0.0019
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0671	0.1451
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0008	0.0048	0.0589
Echinococcus multilocularis	lamin dm0	0.0026	0.0318	0.029
Loa Loa (eye worm)	hypothetical protein	0.005	0.0671	0.1451
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0048	0.0068
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0811	0.0811
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0811	0.178
Echinococcus multilocularis	cation transporting atpase worm	0.0008	0.0048	0.0019
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0284	0.0256
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0073	0.0058
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0048	0.0068
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0008	0.0048	0.0114
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0888	0.1961
Echinococcus granulosus	GPCR family 2	0.0016	0.0161	0.0132
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.068	0.1475
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0207	0.3018	0.2998
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0318	0.0629
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0888	0.2119
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0284	0.0634
Schistosoma mansoni	DNA helicase recq1	0.001	0.0073	0.0073
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0008	0.0048	0.0589
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.024	1
Echinococcus granulosus	lamin dm0	0.0026	0.0318	0.029
Echinococcus multilocularis	muscleblind protein 1	0.0295	0.4342	0.4326
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0054	0.0026
Echinococcus granulosus	muscleblind protein	0.0295	0.4342	0.4326
Toxoplasma gondii	P-type ATPase PMA1	0.0008	0.0048	0.0589
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0068
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.2247	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0073	0.0058
Schistosoma mansoni	cation-transporting atpase worm	0.0008	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0036	0.0463	0.1105
Schistosoma mansoni	lamin	0.0026	0.0318	0.0318
Chlamydia trachomatis	metal transport ATPase	0.0008	0.0048	0.5
Schistosoma mansoni	phosphoserine phosphatase	0.0008	0.0048	0.0048
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Schistosoma mansoni	type V p-type atpase isoform	0.0008	0.0048	0.0048
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.2011	0.4581
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0888	0.1961
Schistosoma mansoni	protein kinase	0.0207	0.3018	0.3018
Toxoplasma gondii	haloacid dehalogenase family hydrolase domain-containing protein	0.0008	0.0048	0.0589
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0161	0.0263
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0671	0.1451
Entamoeba histolytica	hypothetical protein	0.0036	0.0463	0.1105
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0811	0.347
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0888	0.0862
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0008	0.0048	0.0114
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0161	0.0132
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0116	0.0233
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.2009	0.8917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2532	0.6021
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0008	0.0048	0.0019
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0284	0.0256
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0888	0.1957
Schistosoma mansoni	protein kinase	0.0207	0.3018	0.3018
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4342	1
Treponema pallidum	cation-transporting ATPase, P-type	0.0008	0.0048	0.0114
Onchocerca volvulus		0.0026	0.0318	0.115
Toxoplasma gondii	phospholipid-translocating P-type ATPase, flippase subfamily protein	0.0008	0.0048	0.0589
Schistosoma mansoni	lamin	0.0026	0.0318	0.0318
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.2009	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1211	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1211	0.2709
Schistosoma mansoni	cation-transporting ATPase	0.0008	0.0048	0.0048
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0008	0.0048	0.0019
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0463	0.0436
Schistosoma mansoni	ATPase	0.0008	0.0048	0.0048
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0068
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0107	0.0138
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0073	0.0044
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0544	0.1159
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0811	0.347
Echinococcus multilocularis	dnaJ subfamily B	0.0399	0.5896	0.5885
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Loa Loa (eye worm)	hypothetical protein	0.0207	0.3013	0.6905
Echinococcus granulosus	copper transporting ATPase 1	0.0008	0.0048	0.0019
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0252	0.3695	0.8493
Schistosoma mansoni	hypothetical protein	0.0016	0.0161	0.0161
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.2398	0.5702
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.4192	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3695	0.881
Echinococcus granulosus	dnaJ subfamily B	0.0399	0.5896	0.5885
Schistosoma mansoni	hypothetical protein	0.0399	0.5896	0.5896
Schistosoma mansoni	eyes absent homolog	0.0086	0.1211	0.1211
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Schistosoma mansoni	microtubule-associated protein tau	0.0674	1	1
Toxoplasma gondii	heavy metal translocating P-type ATPase subfamily protein	0.0008	0.0048	0.0589
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.4334	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0019	0.00000000014665
Echinococcus multilocularis	copper transporting ATPase 1	0.0008	0.0048	0.0019
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0482	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4342	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0068
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0048	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0318	0.0629
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0135	0.0204
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.4192	1
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0008	0.0048	0.0019
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0054	0.0015
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0008	0.0048	0.0048
Echinococcus multilocularis	phosphoserine phosphatase	0.0008	0.0048	0.0019
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0008	0.0048	0.0068
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0019	0.00000000014665
Schistosoma mansoni	copper ABC transporter ATPase	0.0008	0.0048	0.0048
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0008	0.0048	0.0114
Onchocerca volvulus		0.0026	0.0318	0.115
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0114	0.0086
Echinococcus multilocularis	cpg binding protein	0.003	0.0368	0.034
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0719	0.8864
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0165	0.2029
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0814	0.0814
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0008	0.0048	0.0068
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0252	0.3695	0.8493
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0008	0.0048	0.0048
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0116	0.016
Schistosoma mansoni	ATPase	0.0008	0.0048	0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 715381