TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.164 | Formula: C15H11BrN2O2
H donors: 1 H acceptors: 3 LogP: 3.42 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)c1cc(O)c2c(n1)nccc2Br
InChi: 1S/C15H11BrN2O2/c1-20-10-4-2-3-9(7-10)12-8-13(19)14-11(16)5-6-17-15(14)18-12/h2-8H,1H3,(H,17,18,19)
InChiKey: AWSXNOSBASSXLV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Tubulin alpha chain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Candida albicans	cytoskeletal structural protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma cruzi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha-tubulin II, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha-tubulin I, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1C chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium parvum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin epsilon chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei gambiense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-2/alpha-4 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium berghei	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium knowlesi	alpha tubulin, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	ko:K07374 tubulin alpha, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 1	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania infantum	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania braziliensis	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania donovani	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha-1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma mansoni	tubulin subunit alpha	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium falciparum	alpha tubulin 2	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Babesia bovis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin isotype 2	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin alpha-1 chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	Tubulin/FtsZ family, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Schistosoma japonicum	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha-3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Entamoeba histolytica	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Trichomonas vaginalis	tubulin beta chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	Tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma congolense	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania mexicana	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	tubulin alpha chain - mouse	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha 3 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Brugia malayi	Tubulin alpha-2 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Cryptosporidium hominis	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium vivax	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Plasmodium yoelii	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Leishmania major	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha 1C chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Neospora caninum	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Toxoplasma gondii	alpha tubulin TUBA1	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin subunit TubB	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus granulosus	Tubulin alpha 1 chain	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	tubulin alpha chain	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	tubulin alpha 2	Get druggable targets OG5_126605	All targets in OG5_126605
Loa Loa (eye worm)	alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Giardia lamblia	Alpha-tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Trypanosoma brucei	alpha tubulin	Get druggable targets OG5_126605	All targets in OG5_126605
Theileria parva	tubulin alpha chain, putative	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	hypothetical protein	Get druggable targets OG5_126605	All targets in OG5_126605
Echinococcus multilocularis	peroxisome assembly protein 26	Get druggable targets OG5_126605	All targets in OG5_126605

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	tubulin gamma chain	Tubulin alpha chain	451 aa	434 aa	30.9 %
Plasmodium yoelii	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.3 %
Schistosoma mansoni	tubulin subunit gamma	Tubulin alpha chain	451 aa	451 aa	31.5 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	40.1 %
Plasmodium vivax	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Onchocerca volvulus	Putative methyltransferase KIAA1456	Tubulin alpha chain	451 aa	441 aa	31.7 %
Babesia bovis	tubulin, putative	Tubulin alpha chain	451 aa	463 aa	20.7 %
Loa Loa (eye worm)	BEN-1 protein	Tubulin alpha chain	451 aa	434 aa	41.5 %
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	Tubulin alpha chain	451 aa	436 aa	38.8 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.6 %
Echinococcus granulosus	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Plasmodium falciparum	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	465 aa	25.8 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Echinococcus multilocularis	tubulin gamma 1 chain	Tubulin alpha chain	451 aa	455 aa	31.4 %
Leishmania infantum	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	434 aa	40.1 %
Leishmania mexicana	beta tubulin	Tubulin alpha chain	451 aa	434 aa	42.4 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Echinococcus multilocularis	tubulin, beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Dictyostelium discoideum	beta tubulin	Tubulin alpha chain	451 aa	443 aa	40.4 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.5 %
Schistosoma japonicum	ko:K10389 tubulin gamma, putative	Tubulin alpha chain	451 aa	434 aa	31.8 %
Leishmania donovani	epsilon tubulin, putative	Tubulin alpha chain	451 aa	471 aa	27.0 %
Echinococcus multilocularis	tubulin delta chain	Tubulin alpha chain	451 aa	401 aa	22.9 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	438 aa	84.7 %
Plasmodium berghei	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	431 aa	31.1 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Giardia lamblia	Gamma tubulin	Tubulin alpha chain	451 aa	467 aa	29.6 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	441 aa	74.4 %
Giardia lamblia	Epsilon tubulin	Tubulin alpha chain	451 aa	457 aa	29.3 %
Onchocerca volvulus		Tubulin alpha chain	451 aa	434 aa	41.5 %
Leishmania mexicana	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.7 %
Entamoeba histolytica	tubulin family protein	Tubulin alpha chain	451 aa	434 aa	39.4 %
Onchocerca volvulus	Regulatory-associated protein of mTOR homolog	Tubulin alpha chain	451 aa	439 aa	76.3 %
Onchocerca volvulus	Putative cytochrome c-type heme lyase	Tubulin alpha chain	451 aa	434 aa	39.2 %
Theileria parva	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	462 aa	29.7 %
Plasmodium knowlesi	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	429 aa	30.8 %
Leishmania braziliensis	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	29.4 %
Echinococcus multilocularis	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	41.5 %
Trypanosoma brucei	epsilon tubulin	Tubulin alpha chain	451 aa	478 aa	25.7 %
Drosophila melanogaster	gamma-Tubulin at 23C	Tubulin alpha chain	451 aa	446 aa	32.3 %
Loa Loa (eye worm)	tubulin beta-1 chain	Tubulin alpha chain	451 aa	437 aa	39.4 %
Onchocerca volvulus	Tyrosine kinase homolog	Tubulin alpha chain	451 aa	439 aa	87.7 %
Plasmodium knowlesi	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	454 aa	26.2 %
Plasmodium vivax	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	458 aa	26.2 %
Schistosoma mansoni	tubulin subunit epsilon	Tubulin alpha chain	451 aa	469 aa	27.9 %
Leishmania major	epsilon tubulin, putative	Tubulin alpha chain	451 aa	469 aa	27.5 %
Trypanosoma brucei gambiense	epsilon tubulin	Tubulin alpha chain	451 aa	479 aa	25.7 %
Babesia bovis	tubulin gamma chain	Tubulin alpha chain	451 aa	429 aa	31.7 %
Echinococcus multilocularis	tubulin alpha	Tubulin alpha chain	451 aa	436 aa	40.1 %
Dictyostelium discoideum	gamma tubulin	Tubulin alpha chain	451 aa	436 aa	32.8 %
Cryptosporidium hominis	gamma-tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Neospora caninum	tubulin alpha chain, putative	Tubulin alpha chain	451 aa	436 aa	37.4 %
Cryptosporidium parvum	gamma tubulin	Tubulin alpha chain	451 aa	443 aa	30.9 %
Trichomonas vaginalis	tubulin gamma chain, putative	Tubulin alpha chain	451 aa	422 aa	28.4 %
Drosophila melanogaster	beta-Tubulin at 60D	Tubulin alpha chain	451 aa	439 aa	39.2 %
Echinococcus granulosus	tubulin beta 4A class IVa	Tubulin alpha chain	451 aa	388 aa	38.9 %
Brugia malayi	Tubulin beta-1 chain	Tubulin alpha chain	451 aa	434 aa	39.6 %
Plasmodium yoelii	tubulin beta chain	Tubulin alpha chain	451 aa	455 aa	26.8 %
Trypanosoma cruzi	epsilon tubulin, putative	Tubulin alpha chain	451 aa	474 aa	27.4 %
Echinococcus granulosus	Tubulin beta 2C chain	Tubulin alpha chain	451 aa	434 aa	40.3 %
Echinococcus granulosus	tubulin alpha	Tubulin alpha chain	451 aa	433 aa	40.0 %
Plasmodium falciparum	tubulin gamma chain	Tubulin alpha chain	451 aa	431 aa	31.8 %
Trypanosoma congolense	epsilon tubulin	Tubulin alpha chain	451 aa	472 aa	26.5 %
Plasmodium berghei	tubulin epsilon chain, putative	Tubulin alpha chain	451 aa	455 aa	27.7 %
Neospora caninum	Beta-tubulin, related	Tubulin alpha chain	451 aa	417 aa	31.4 %
Schistosoma mansoni	tubulin subunit beta	Tubulin alpha chain	451 aa	435 aa	40.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	alpha tubulin	0.0039	0.0077	0.1043
Echinococcus multilocularis	serotonin transporter	0.0506	0.4024	0.5534
Brugia malayi	Tubulin alpha chain	0.0039	0.0077	0.0064
Echinococcus multilocularis	tubulin subunit TubB	0.0039	0.0077	0.0036
Brugia malayi	alpha-tubulin	0.0039	0.0077	0.0064
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.0544	0.1241
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0086	0.0474	0.059
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0815	0.1246
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Entamoeba histolytica	carbonic anhydrase, putative	0.0503	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.0544	0.0805
Echinococcus multilocularis	jun protein	0.0087	0.0484	0.0603
Brugia malayi	Serotonin receptor	0.0472	0.3731	0.9262
Toxoplasma gondii	hypothetical protein	0.0086	0.0474	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0202	0.1458	1
Onchocerca volvulus		0.0202	0.1458	0.3103
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0086	0.0474	0.059
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0506	0.4024	0.6483
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0086	0.0474	0.059
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0815	0.1246
Brugia malayi	glutaminase DH11.1	0.0273	0.2051	0.5035
Onchocerca volvulus		0.0506	0.4024	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.0544	0.1193
Plasmodium falciparum	LCCL domain-containing protein	0.0202	0.1458	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0039	0.0077	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0077	0.019
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0039	0.0077	0.019
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0086	0.0474	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Loa Loa (eye worm)	alpha-tubulin	0.0039	0.0077	0.019
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0202	0.1458	0.1959
Echinococcus granulosus	sodium and chloride dependent glycine	0.0086	0.0474	0.0691
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0087	0.0484	0.0706
Schistosoma mansoni	alpha tubulin	0.0039	0.0077	0.0042
Plasmodium falciparum	alpha tubulin 1	0.0039	0.0077	0.0379
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Echinococcus granulosus	RUN	0.0202	0.1458	0.2295
Plasmodium vivax	tubulin alpha chain, putative	0.0039	0.0077	0.0379
Echinococcus granulosus	tubulin alpha 3 chain	0.0039	0.0077	0.0042
Entamoeba histolytica	tubulin alpha-1 chain	0.0039	0.0077	0.0065
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.0544	0.0805
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0143	0.0143
Loa Loa (eye worm)	glutaminase	0.0273	0.2051	0.5098
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0039	0.0077	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Schistosoma mansoni	alpha tubulin	0.0039	0.0077	0.0042
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0086	0.0474	0.059
Loa Loa (eye worm)	hypothetical protein	0.0506	0.4024	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Echinococcus granulosus	jun protein	0.0087	0.0484	0.0706
Trypanosoma brucei	alpha tubulin	0.0039	0.0077	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Plasmodium falciparum	transporter, putative	0.0086	0.0474	0.315
Brugia malayi	hypothetical protein	0.0086	0.0474	0.1065
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0086	0.0474	0.0691
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Echinococcus multilocularis	Polycystic kidney disease protein	0.0202	0.1458	0.1959
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0506	0.4024	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0086	0.0474	0.0691
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0762	0.6179	0.8536
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Plasmodium vivax	tubulin alpha chain, putative	0.0039	0.0077	0.0379
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0086	0.0474	0.1065
Trypanosoma brucei	polo-like protein kinase	0.0094	0.0544	1
Plasmodium falciparum	alpha tubulin 2	0.0039	0.0077	0.0379
Plasmodium falciparum	amino acid transporter, putative	0.0086	0.0474	0.315
Schistosoma mansoni	tubulin subunit alpha	0.0039	0.0077	0.0042
Brugia malayi	RNA binding protein	0.0126	0.0815	0.1922
Treponema pallidum	sodium- and chloride- dependent transporter	0.0506	0.4024	0.5
Mycobacterium ulcerans	hypothetical protein	0.0108	0.0662	0.0641
Echinococcus granulosus	tar DNA binding protein	0.0126	0.0815	0.1246
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0202	0.1458	0.1959
Schistosoma mansoni	sodium/chloride dependent transporter	0.0506	0.4024	0.6483
Schistosoma mansoni	tubulin subunit alpha	0.0039	0.0077	0.0042
Schistosoma mansoni	loxhd1	0.0202	0.1458	0.2295
Echinococcus multilocularis	tubulin alpha chain	0.0039	0.0077	0.0036
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Echinococcus multilocularis	tubulin alpha 3 chain	0.0039	0.0077	0.0036
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Brugia malayi	hypothetical protein	0.0066	0.0303	0.0634
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Schistosoma mansoni	sodium/chloride dependent transporter	0.0086	0.0474	0.0691
Echinococcus multilocularis	tubulin alpha chain	0.0039	0.0077	0.0036
Echinococcus granulosus	tubulin alpha 1C chain	0.0039	0.0077	0.0042
Echinococcus granulosus	peroxisome assembly protein 26	0.0039	0.0077	0.0042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0133	0.0134
Schistosoma mansoni	polycystin 1-related	0.0202	0.1458	0.2295
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.0544	0.0648
Schistosoma mansoni	carbonic anhydrase	0.0503	0.3996	0.6439
Trypanosoma cruzi	alpha tubulin, putative	0.0039	0.0077	0.1043
Echinococcus granulosus	Tubulin alpha 1 chain	0.0039	0.0077	0.0042
Echinococcus granulosus	lipoxygenase domain containing protein	0.0202	0.1458	0.2295
Loa Loa (eye worm)	tubulin alpha chain	0.0039	0.0077	0.019
Echinococcus multilocularis	tubulin alpha chain	0.0039	0.0077	0.0036
Schistosoma mansoni	jun-related protein	0.0071	0.0351	0.049
Echinococcus multilocularis	tubulin alpha 3 chain	0.0039	0.0077	0.0036
Echinococcus multilocularis	RUN	0.0202	0.1458	0.1959
Onchocerca volvulus		0.0086	0.0474	0.046
Echinococcus granulosus	Tubulin alpha 1 chain	0.0039	0.0077	0.0042
Echinococcus granulosus	Tubulin alpha 1 chain	0.0039	0.0077	0.0042
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.0815	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Echinococcus granulosus	tubulin alpha chain	0.0039	0.0077	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0506	0.4024	1
Brugia malayi	TAR-binding protein	0.0126	0.0815	0.1922
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0086	0.0474	0.0691
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0258	0.1924	0.031
Echinococcus granulosus	tubulin alpha chain	0.0039	0.0077	0.0042
Loa Loa (eye worm)	doublecortin family protein	0.0202	0.1458	0.3623
Echinococcus granulosus	tubulin subunit TubB	0.0039	0.0077	0.0042
Brugia malayi	Tubulin alpha-2 chain	0.0039	0.0077	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0133	0.0134
Leishmania major	carbonic anhydrase family protein, putative	0.0503	0.3996	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.0544	0.0687
Echinococcus granulosus	alpha tubulin	0.0039	0.0077	0.0042
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Schistosoma mansoni	lipoxygenase	0.0397	0.3103	0.498
Onchocerca volvulus		0.0202	0.1458	0.3103
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	0.1065
Mycobacterium ulcerans	carbonic anhydrase	0.0503	0.3996	0.3983
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0143	0.0143
Brugia malayi	tubulin alpha chain - mouse	0.0039	0.0077	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1458	0.3623
Loa Loa (eye worm)	hypothetical protein	0.0202	0.1458	0.3623
Echinococcus multilocularis	tubulin alpha 1C chain	0.0039	0.0077	0.0036
Schistosoma mansoni	glutaminase	0.0273	0.2051	0.3264
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0815	0.1246
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0815	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.1214	1	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0039	0.0077	0.1204
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.0544	1
Plasmodium vivax	amine transporter, putative	0.0086	0.0474	0.315
Echinococcus granulosus	lipoxygenase domain containing protein	0.0202	0.1458	0.2295
Toxoplasma gondii	alpha tubulin TUBA1	0.0039	0.0077	0.1204
Schistosoma mansoni	kinase	0.0048	0.0153	0.0166
Echinococcus granulosus	sodium and chloride dependent glycine	0.0086	0.0474	0.0691
Brugia malayi	bZIP transcription factor family protein	0.0087	0.0484	0.1089
Trypanosoma brucei	alpha tubulin	0.0039	0.0077	0.1043
Echinococcus granulosus	tubulin alpha chain	0.0039	0.0077	0.0042
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0039	0.0077	0.0077
Schistosoma mansoni	rab6-interacting	0.0202	0.1458	0.2295
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0762	0.6179	1
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.048	0.3804	0.3344
Echinococcus multilocularis	conserved hypothetical protein	0.0677	0.5466	0.7543
Entamoeba histolytica	tubulin alpha chain, putative	0.0039	0.0077	0.0065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0133	0.0134
Loa Loa (eye worm)	alpha-tubulin	0.0039	0.0077	0.019
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0039	0.0077	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0474	0.1179
Brugia malayi	tubulin alpha-2 chain	0.0039	0.0077	0.0064
Loa Loa (eye worm)	norepinephrine transporter	0.0506	0.4024	1
Onchocerca volvulus		0.0086	0.0474	0.046
Loa Loa (eye worm)	hypothetical protein	0.0506	0.4024	1
Schistosoma mansoni	tubulin subunit alpha	0.0039	0.0077	0.0042
Brugia malayi	hypothetical protein	0.0202	0.1458	0.354
Echinococcus granulosus	Polycystic kidney disease protein	0.0202	0.1458	0.2295
Schistosoma mansoni	hypothetical protein	0.0071	0.0351	0.049
Schistosoma mansoni	sodium/chloride dependent transporter	0.0086	0.0477	0.0695
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	0.1179
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0503	0.3996	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0087	0.0484	0.0603
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0086	0.0474	0.0691
Loa Loa (eye worm)	tubulin alpha chain	0.0039	0.0077	0.019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0133	0.0331
Echinococcus granulosus	tubulin alpha 1C chain	0.0039	0.0077	0.0042
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.0544	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0133	0.0134
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	0.1179
Brugia malayi	Tubulin alpha-2 chain	0.0039	0.0077	0.0064
Loa Loa (eye worm)	glutaminase 2	0.0273	0.2051	0.5098
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0039	0.0077	0.0036
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	1
Schistosoma mansoni	lipoxygenase	0.0762	0.6179	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Loa Loa (eye worm)	serotonin transporter b	0.0506	0.4024	1
Trichomonas vaginalis	glutaminase, putative	0.0273	0.2051	0.2051
Trypanosoma brucei	alpha tubulin	0.0039	0.0077	0.1043
Brugia malayi	Doublecortin family protein	0.0202	0.1458	0.354
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0506	0.4024	1
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.0544	0.125
Trichomonas vaginalis	tubulin beta chain, putative	0.0039	0.0077	0.0077
Echinococcus multilocularis	hypothetical protein	0.0039	0.0077	0.0036
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0133	0.0134
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0133	0.0207
Mycobacterium ulcerans	glutaminase	0.0273	0.2051	0.2034
Onchocerca volvulus		0.0203	0.1466	0.3125
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0086	0.0474	0.0691
Schistosoma mansoni	rab6-interacting	0.0202	0.1458	0.2295
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0039	0.0077	0.0077
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0133	0.0114
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0086	0.0474	0.0691
Schistosoma mansoni	alpha tubulin	0.0039	0.0077	0.0042
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0086	0.0474	0.0691
Echinococcus granulosus	serotonin transporter	0.0506	0.4024	0.6483
Onchocerca volvulus		0.0086	0.0474	0.046
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.0544	0.0544
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.0815	0.2025
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	0.1065
Brugia malayi	hypothetical protein	0.0202	0.1458	0.354
Toxoplasma gondii	hypothetical protein	0.0086	0.0474	1
Echinococcus granulosus	tubulin alpha chain	0.0039	0.0077	0.0042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0133	0.0114
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0969	0.7928	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0886	0.723	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.0815	0.2025
Echinococcus granulosus	hypothetical protein	0.0697	0.5636	0.9115
Schistosoma mansoni	hypothetical protein	0.0202	0.1458	0.2295
Onchocerca volvulus	Putative sulfate transporter	0.0203	0.1466	0.3125
Echinococcus multilocularis	tubulin alpha chain	0.0039	0.0077	0.0036
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	0.1065
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.0815	0.1922
Loa Loa (eye worm)	RNA binding protein	0.0126	0.0815	0.2025
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.0544	0.1353
Giardia lamblia	Kinase, PLK	0.0094	0.0544	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0039	0.0077	0.0077
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0815	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.1214	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0039	0.0077	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0474	0.315
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0086	0.0474	0.059
Echinococcus multilocularis	tubulin alpha chain	0.0039	0.0077	0.0036
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0086	0.0474	1
Echinococcus granulosus	tubulin alpha chain	0.0039	0.0077	0.0042
Echinococcus multilocularis	tubulin alpha 1C chain	0.0039	0.0077	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0435	0.1082

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.82	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	10649972
Log IC50 (binding)	= 5.82	Inhibition of tubulin polymerization interacting at the colchicine binding site.	ChEMBL.	10649972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 72118