Detailed information for compound 722708

Basic information

Technical information
  • TDR Targets ID: 722708
  • Name: 1-(5-chloro-2-methoxy-4-methylphenyl)sulfonyl imidazole
  • MW: 286.735 | Formula: C11H11ClN2O3S
  • H donors: 0 H acceptors: 3 LogP: 2.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)c(cc1S(=O)(=O)n1cncc1)Cl
  • InChi: 1S/C11H11ClN2O3S/c1-8-5-10(17-2)11(6-9(8)12)18(15,16)14-4-3-13-7-14/h3-7H,1-2H3
  • InChiKey: JSRLZQBPCVRPQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-chloro-2-methoxy-4-methyl-phenyl)sulfonylimidazole
  • 1-[(5-chloro-2-methoxy-4-methylphenyl)sulfonyl]-1H-imidazole
  • MLS000676368
  • SMR000301151
  • ST5171487
  • AP-263/43028288

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0277 0.0862
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0499 0.0499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Brugia malayi Matrixin family protein 0.0155 0.0962 0.3207
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0032 0.01
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0324 0.1014
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0027 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0271 0.0903
Giardia lamblia Aldose reductase 0.0364 0.2446 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.034 0.034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.01 0.0333
Schistosoma mansoni phd/f-box containing protein 0.0028 0.006 0.0063
Schistosoma mansoni cpg binding protein 0.0033 0.0097 0.0101
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.003 0.0077 0.0242
Brugia malayi Phospholipase A2 family protein 0.0091 0.0509 0.1698
Echinococcus multilocularis cysteine protease 0.0033 0.0098 0.0098
Brugia malayi hypothetical protein 0.0442 0.2998 1
Leishmania major cathepsin L-like protease 0.0033 0.0098 0.0401
Entamoeba histolytica alcohol dehydrogenase, putative 0.0106 0.061 0.2495
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0364 0.2446 0.8159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.01 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.01 0.0333
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.031
Schistosoma mansoni loxhd1 0.002 0.0001 0.0001
Brugia malayi Doublecortin family protein 0.002 0.0001 0.0005
Mycobacterium leprae PROBABLE HYDROLASE 0.0189 0.1201 0.3712
Trichomonas vaginalis aldo-keto reductase, putative 0.0106 0.061 0.1901
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Echinococcus granulosus FTZ F1 alpha 0.0034 0.01 0.01
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0112 0.0112
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0031 0.0031
Onchocerca volvulus 0.0155 0.0962 0.2992
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0023 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0477 0.1496
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.01 0.0104
Trypanosoma brucei cytosolic malate dehydrogenase 0.0046 0.0191 0.0779
Schistosoma mansoni lozenge 0.0055 0.0255 0.0266
Brugia malayi Hemopexin family protein 0.022 0.1421 0.474
Echinococcus multilocularis cysteine protease atg4b 0.0058 0.0277 0.0277
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0469 0.3191 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0098 0.0307
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0038 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.002 0.0062
Loa Loa (eye worm) glutathione reductase 0.0037 0.0125 0.0417
Echinococcus granulosus cytosolic malate dehydrogenase 0.0046 0.0191 0.0191
Plasmodium vivax aldehyde reductase, putative 0.0106 0.061 0.1913
Brugia malayi RNA binding protein 0.0073 0.0381 0.1272
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0034 0.01 0.0104
Toxoplasma gondii exonuclease III APE 0.0023 0.0023 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.01 0.0333
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0125 0.0391
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0477 0.0477
Onchocerca volvulus 0.0033 0.0098 0.0301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus granulosus aldo keto reductase 0.0364 0.2446 0.2446
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0219 0.0894
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0106 0.061 0.2036
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.006 0.006
Onchocerca volvulus 0.0088 0.0488 0.1517
Onchocerca volvulus 0.0022 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0155 0.0962 0.3207
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0098 0.0301
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.012 0.0373
Brugia malayi Cathepsin L-like precursor 0.0022 0.002 0.0067
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1189 0.1189
Brugia malayi Augmenter of liver regeneration 0.0034 0.01 0.0335
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0288 0.0288
Leishmania major prostaglandin f synthase, putative 0.0364 0.2446 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0112 0.0369
Trichomonas vaginalis aldo/keto reductase, putative 0.0364 0.2446 0.7619
Loa Loa (eye worm) hypothetical protein 0.0155 0.0962 0.3207
Entamoeba histolytica peptidase, C54 family 0.0023 0.0024 0.0096
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0477 0.0497
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0046 0.0191 0.0191
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0369
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0529 0.2089
Echinococcus multilocularis peregrin 0.0087 0.0477 0.0477
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0107
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.268 0.268
Trichomonas vaginalis aldo/keto reductase, putative 0.0364 0.2446 0.7619
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0112 0.0374
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.01 0.0104
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0112 0.0459
Mycobacterium ulcerans hydrolase 0.0189 0.1201 0.372
Echinococcus granulosus phd:f box containing protein 0.0028 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus multilocularis aldo keto reductase 0.0364 0.2446 0.2446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0499 0.0499
Echinococcus granulosus muscleblind protein 0.0149 0.092 0.092
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.01 0.0333
Entamoeba histolytica peptidase, C54 family 0.0023 0.0024 0.0096
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.015 0.0502
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0488 0.1628
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0112 0.027
Trypanosoma brucei RNA helicase, putative 0.0115 0.0676 0.2764
Brugia malayi Thioredoxin reductase 0.0037 0.0125 0.0417
Echinococcus granulosus Peptidase C54 0.0058 0.0277 0.0277
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0032 0.0131
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0114 0.0671 0.0671
Brugia malayi Muscleblind-like protein 0.0149 0.092 0.3067
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0529 0.2089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0112 0.0117
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.019 0.0635
Onchocerca volvulus 0.0033 0.0098 0.0301
Plasmodium falciparum thioredoxin reductase 0.0037 0.0125 0.0391
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0112 0.035
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0277 0.1131
Loa Loa (eye worm) hypothetical protein 0.0091 0.0509 0.1698
Schistosoma mansoni rab6-interacting 0.002 0.0001 0.0001
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0032 0.01
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.006 0.0247
Echinococcus multilocularis RUN 0.002 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0034 0.01 0.0104
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0219 0.0686
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0381 0.0397
Leishmania major cytosolic malate dehydrogenase 0.0046 0.0191 0.0779
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0046 0.0191 0.0692
Entamoeba histolytica hypothetical protein 0.0025 0.0038 0.0155
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0381 0.1272
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0001 0.0004
Schistosoma mansoni transient receptor potential channel 0.01 0.0571 0.0595
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0381 0.1272
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0112 0.0112
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0381 0.0381
Schistosoma mansoni aldo-keto reductase 0.0364 0.2446 0.2547
Onchocerca volvulus 0.0034 0.01 0.0307
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0522 0.0522
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0364 0.2446 0.7619
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0288 0.0903
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0112 0.0369
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.006 0.019
Echinococcus multilocularis aldo keto reductase 0.0364 0.2446 0.2446
Brugia malayi PHD-finger family protein 0.003 0.0076 0.0255
Entamoeba histolytica malate dehydrogenase, putative 0.0046 0.0191 0.0779
Toxoplasma gondii aminopeptidase N, putative 0.031 0.2063 0.6466
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Schistosoma mansoni hypothetical protein 0.0087 0.0477 0.0497
Schistosoma mansoni cpg binding protein 0.0035 0.0111 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0027 0.0012
Brugia malayi jmjC domain containing protein 0.0284 0.1878 0.6265
Schistosoma mansoni ap endonuclease 0.0023 0.0023 0.0024
Echinococcus granulosus geminin 0.0336 0.2249 0.2249
Trichomonas vaginalis aldo-keto reductase, putative 0.0106 0.061 0.1901
Echinococcus multilocularis aldo keto reductase 0.0364 0.2446 0.2446
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0364 0.2446 1
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.01 0.0333
Schistosoma mansoni polycystin 1-related 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0114 0.0671 0.2239
Echinococcus multilocularis aldo keto reductase 0.0364 0.2446 0.2446
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0137 0.0143
Echinococcus multilocularis Peptidase C54 0.0058 0.0277 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 0.0127
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.019 0.019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0284 0.1878 0.1878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.006 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0023 0.0093
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Schistosoma mansoni lipoxygenase 0.0082 0.0446 0.0464
Onchocerca volvulus Matrilysin homolog 0.0155 0.0962 0.2992
Plasmodium falciparum glutathione reductase 0.0037 0.0125 0.0391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Onchocerca volvulus 0.0033 0.0098 0.0301
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.006 0.006
Loa Loa (eye worm) matrixin family protein 0.0375 0.2521 0.8409
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0023 0.0093
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0027 0.0109
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.0401
Echinococcus granulosus cathepsin l1 0.0022 0.002 0.002
Brugia malayi mbt repeat family protein 0.0046 0.019 0.0635
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0027 0.0089
Brugia malayi CXXC zinc finger family protein 0.0033 0.0097 0.0325
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0236 0.0236
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.006 0.006
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Onchocerca volvulus 0.006 0.0288 0.0894
Chlamydia trachomatis malate dehydrogenase 0.0046 0.0191 0.0484
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0031 0.0097
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Schistosoma mansoni hypothetical protein 0.0039 0.0141 0.0147
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0038 0.0155
Schistosoma mansoni pol-related 0.0364 0.2446 0.2547
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.061 0.1901
Echinococcus granulosus cysteine protease atg4b 0.0058 0.0277 0.0277
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0529 0.1587
Plasmodium vivax vivapain-2 0.0033 0.0098 0.0307
Schistosoma mansoni transient receptor potential channel 0.0067 0.034 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0471
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Echinococcus multilocularis muscleblind protein 1 0.0149 0.092 0.092
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0032 0.0101
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0038 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Brugia malayi jmjC domain containing protein 0.0028 0.006 0.0202
Toxoplasma gondii ABC1 family protein 0.0035 0.0112 0.0352
Schistosoma mansoni hypothetical protein 0.0114 0.0671 0.0699
Brugia malayi nuclear hormone receptor 0.0034 0.01 0.0333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Loa Loa (eye worm) hypothetical protein 0.0058 0.0271 0.0903
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.019 0.0198
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0488 0.0508
Schistosoma mansoni hypothetical protein 0.0336 0.2249 0.2342
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.01 0.0104
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Loa Loa (eye worm) hypothetical protein 0.0058 0.0277 0.0923
Leishmania major cathepsin L-like protease 0.0033 0.0098 0.0401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Brugia malayi steroid hormone receptor 0.0034 0.01 0.0333
Schistosoma mansoni autophagin-1 (C54 family) 0.0058 0.0277 0.0288
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0067
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0001 0.0001
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0477 0.0477
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0074 0.0074
Trichomonas vaginalis esterase, putative 0.0035 0.0112 0.035
Loa Loa (eye worm) RNA binding protein 0.0073 0.0381 0.1272
Onchocerca volvulus 0.022 0.1421 0.4424
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.01 0.01
Echinococcus multilocularis cysteine protease 0.0033 0.0098 0.0098
Brugia malayi beta-lactamase family protein 0.0035 0.0112 0.0374
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0268 0.0268
Onchocerca volvulus 0.0033 0.0098 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0288 0.03
Schistosoma mansoni apoptosis regulator bax 0.0114 0.0671 0.0699
Onchocerca volvulus 0.0033 0.0098 0.0301
Mycobacterium ulcerans oxidoreductase 0.0364 0.2446 0.7649
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0462 0.1812
Schistosoma mansoni ap endonuclease 0.0023 0.0023 0.0024
Schistosoma mansoni hypothetical protein 0.002 0.0001 0.0001
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0032 0.0131
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0488 0.0488
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1462 0.5938
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.041
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0499 0.0519
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0189 0.1201 0.4007
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus multilocularis cpg binding protein 0.0035 0.0111 0.0111
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0571 0.0571
Brugia malayi jmjC domain containing protein 0.0107 0.062 0.2069
Onchocerca volvulus 0.0033 0.0097 0.0299
Loa Loa (eye worm) cysteine protease 0.0033 0.0098 0.0327
Loa Loa (eye worm) hypothetical protein 0.0149 0.092 0.3067
Echinococcus multilocularis voltage gated potassium channel subunit 0.0106 0.061 0.061
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.01 0.0333
Echinococcus multilocularis aldehyde reductase 0.0259 0.1698 0.1698
Schistosoma mansoni hypothetical protein 0.0114 0.0671 0.0699
Toxoplasma gondii aminopeptidase n, putative 0.031 0.2063 0.6466
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.019 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0032 0.0107
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0098 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.01 0.0333
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0106 0.061 0.1913
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0116 0.0684 0.2797
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.0719 0.0719
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0277 0.0288
Plasmodium vivax hypothetical protein, conserved 0.003 0.0077 0.0242
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0098 0.0098
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0112 0.0369
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0001 0.0001
Onchocerca volvulus 0.0442 0.2998 0.9339
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.019 0.019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.01 0.0333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.01 0.01
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0113 0.0662 0.2639
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0112 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0023 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0027 0.0089
Echinococcus multilocularis phd:f box containing protein 0.0028 0.006 0.006
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1189 0.1189
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0364 0.2446 0.8159
Echinococcus granulosus cpg binding protein 0.0035 0.0111 0.0111
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0529 0.2089
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0032 0.0131
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0364 0.2446 0.8159
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0522 0.0522
Onchocerca volvulus 0.0033 0.0098 0.0301
Entamoeba histolytica alcohol dehydrogenase, putative 0.0106 0.061 0.2495
Brugia malayi jmjC domain containing protein 0.0028 0.006 0.0202
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.057 0.2328
Brugia malayi Peptidase family C54 containing protein 0.0058 0.0277 0.0923
Brugia malayi glutathione reductase 0.0037 0.0125 0.0417
Schistosoma mansoni hypothetical protein 0.0115 0.0676 0.0704
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0219 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.002 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Loa Loa (eye worm) hypothetical protein 0.0442 0.2998 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0112 0.0369
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Trypanosoma cruzi cruzipain precursor, putative 0.0127 0.0762 0.3116
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0024 0.0096
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.01 0.0104
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0032 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Leishmania major hypothetical protein, conserved 0.0035 0.0112 0.0459
Onchocerca volvulus 0.0035 0.0112 0.0345
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0033 0.0098 0.0327
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.019 0.0198
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0032 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0023 0.0023
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.01 0.01
Toxoplasma gondii thioredoxin reductase 0.0037 0.0125 0.0391
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.006 0.0202
Schistosoma mansoni jumonji domain containing protein 0.0226 0.1464 0.1524
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.006 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.01 0.0333
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.006 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Echinococcus granulosus RUN 0.002 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0028 0.006 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Leishmania major hypothetical protein, conserved 0.0028 0.006 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0114 0.0671 0.0699
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0027 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0219 0.0894
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.006 0.006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0098 0.0327
Loa Loa (eye worm) matrixin family protein 0.0344 0.2301 0.7675
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0038 0.0062
Loa Loa (eye worm) oxidoreductase 0.0364 0.2446 0.8159
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0189 0.1201 0.4863
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0098 0.0327
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.034 0.034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0022 0.0022
Mycobacterium ulcerans lipase LipD 0.0035 0.0112 0.0282
Brugia malayi mbt repeat family protein 0.0046 0.019 0.0635
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0027 0.0109
Onchocerca volvulus 0.0364 0.2446 0.7618
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.01 0.0333
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0106 0.061 0.2036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.01 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0288 0.03
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.01 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.006 0.0202
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0564 0.3861 0.3861
Loa Loa (eye worm) runx1 0.0055 0.0255 0.0851
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0098 0.0301
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0098 0.0098
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0063 0.0197
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0762 0.3116
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0462 0.1812
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0315
Trichomonas vaginalis aldo/keto reductase, putative 0.0364 0.2446 0.7619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.01 0.0333
Echinococcus granulosus tar DNA binding protein 0.0073 0.0381 0.0381
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.002 0.0067
Brugia malayi AF-10 protein 0.0028 0.0063 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.006 0.0202
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0098 0.0098
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0114 0.0671 0.2239
Echinococcus granulosus lysine specific demethylase 5A 0.0107 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0202
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.062 0.0646
Giardia lamblia Malate dehydrogenase 0.0046 0.0191 0.0692
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.035
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.035
Schistosoma mansoni malate dehydrogenase 0.0046 0.0191 0.0198
Mycobacterium leprae Probable lipase LipE 0.0035 0.0112 0.027
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0277 0.0862
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0023 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0112 0.035
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0097 0.0325
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0032 0.01
Brugia malayi beta-lactamase 0.0035 0.0112 0.0374
Loa Loa (eye worm) hypothetical protein 0.0155 0.0962 0.3207
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0277 0.0862
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0141 0.0471
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0469 0.3191 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0027 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Schistosoma mansoni transient receptor potential channel 0.0067 0.034 0.0354
Trypanosoma cruzi aldo/keto reductase, putative 0.0106 0.061 0.2495
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0477 0.1592
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Trypanosoma brucei aldo-keto reductase, putative 0.0364 0.2446 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0477 0.1592
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0001 0.0001
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Schistosoma mansoni jumonji/arid domain-containing protein 0.0107 0.062 0.0646
Echinococcus granulosus microtubule associated protein 2 0.1373 0.9603 0.9603
Trypanosoma cruzi aldo-keto reductase 0.0364 0.2446 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0098 0.0098
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0032 0.0038
Plasmodium falciparum phd finger protein, putative 0.0087 0.0477 0.1496
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.01 0.0307
Onchocerca volvulus 0.0035 0.0112 0.0345
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0027 0.0109
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.01 0.01
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.01 0.0307
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0128 0.0128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Onchocerca volvulus 0.0364 0.2446 0.7618
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0098 0.0102
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0046 0.0191 0.0635
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0288 0.03
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0024 0.0096
Echinococcus granulosus voltage gated potassium channel subunit 0.0106 0.061 0.061
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0236 0.0246
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0098 0.0307
Loa Loa (eye worm) MBCTL1 0.0053 0.0236 0.0787
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0277 0.1131
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.034 0.034
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0125 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.01 0.0333
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0023 0.0071
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.01 0.0333
Entamoeba histolytica aldose reductase, putative 0.0364 0.2446 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0236 0.0787
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0046 0.0191 0.0779
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0381 0.0397
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0364 0.2446 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0462 0.1376
Onchocerca volvulus Phospholipase A2 homolog 0.0433 0.2936 0.9145
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0112 0.0459
Brugia malayi Pre-SET motif family protein 0.0415 0.2805 0.9354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Leishmania major cathepsin L-like protease 0.0033 0.0098 0.0401
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.01 0.01
Leishmania major hypothetical protein, conserved 0.0024 0.0031 0.0127
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0125 0.0421
Trypanosoma cruzi aldo/keto reductase, putative 0.0364 0.2446 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0635
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0074 0.0074
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0236 0.0236
Echinococcus multilocularis geminin 0.0336 0.2249 0.2249
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0277 0.0862
Entamoeba histolytica aldose reductase, putative 0.0364 0.2446 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Loa Loa (eye worm) fibroinase 0.0033 0.0098 0.0327
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0128 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0027 0.0016
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0038 0.0119
Mycobacterium leprae Conserved hypothetical protein 0.0259 0.1698 0.5281
Brugia malayi cathepsin L-like precursor 0.0022 0.002 0.0067
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.01 0.0307
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0564 0.3861 0.3861
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0112 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0112 0.0352
Trichomonas vaginalis aldo-keto reductase, putative 0.0106 0.061 0.1901
Schistosoma mansoni microtubule-associated protein tau 0.1373 0.9603 1
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0058 0.0277 0.0862
Schistosoma mansoni hypothetical protein 0.0114 0.0671 0.0699
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0112 0.0117
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0027 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0001 0.0001
Brugia malayi Matrixin family protein 0.0155 0.0962 0.3207
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0038 0.0048
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0098 0.0301
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0106 0.061 0.1913
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0364 0.2446 0.7647
Mycobacterium ulcerans malate dehydrogenase 0.0046 0.0191 0.0529
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0112 0.0369
Echinococcus multilocularis muscleblind protein 0.0149 0.092 0.092
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0106 0.061 0.1901
Brugia malayi ecdysteroid receptor 0.0034 0.01 0.0333
Brugia malayi Matrixin family protein 0.0375 0.2521 0.8409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0499 0.0519
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0046 0.0191 0.0191
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0024 0.0074
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0024 0.0074
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0364 0.2446 0.7619
Onchocerca volvulus 0.0024 0.0031 0.0092
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0032 0.0131
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0098 0.0098
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0125 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.01 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0112 0.035
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0063 0.0258
Echinococcus granulosus dnaJ subfamily B 0.0397 0.268 0.268
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0119
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Loa Loa (eye worm) doublecortin family protein 0.002 0.0001 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0462 0.1812
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0462 0.1812
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.01 0.0335
Schistosoma mansoni malate dehydrogenase 0.0046 0.0191 0.0198
Schistosoma mansoni rab6-interacting 0.002 0.0001 0.0001
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.01
Leishmania major cathepsin L-like protease 0.0033 0.0098 0.0401
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0098 0.0098
Brugia malayi Matrixin family protein 0.0155 0.0962 0.3207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0023
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.01 0.0333
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Mycobacterium leprae Possible oxidoreductase 0.0106 0.061 0.1845
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0023 0.0072
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0469 0.3191 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.006 0.019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Plasmodium vivax JmjC domain containing protein 0.0028 0.006 0.019
Brugia malayi Protein kinase domain containing protein 0.0024 0.0031 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0291 0.0969
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0284 0.1878 0.1878
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0022 0.0022
Brugia malayi jmjC domain containing protein 0.0028 0.006 0.0202
Onchocerca volvulus Matrix metalloproteinase homolog 0.0344 0.2301 0.7166
Plasmodium vivax SET domain protein, putative 0.006 0.0288 0.0903
Schistosoma mansoni thyroid hormone receptor 0.0034 0.01 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.0401
Loa Loa (eye worm) hypothetical protein 0.0088 0.0488 0.1628
Leishmania major cathepsin L-like protease 0.0033 0.0098 0.0401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0032 0.0101
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0032 0.0131
Echinococcus granulosus jumonji domain containing protein 0.0121 0.0719 0.0719
Brugia malayi TAR-binding protein 0.0073 0.0381 0.1272
Loa Loa (eye worm) hypothetical protein 0.0149 0.0917 0.306
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.01 0.01
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0032 0.0029
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0697 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Plasmodium falciparum aldo-keto reductase, putative 0.0106 0.061 0.1913
Mycobacterium tuberculosis Conserved protein 0.0106 0.061 0.2424
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0288 0.0288
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0114 0.0671 0.0671
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0219 0.0686
Toxoplasma gondii aminopeptidase N protein 0.031 0.2063 0.6466
Schistosoma mansoni hypothetical protein 0.0024 0.0031 0.0032
Toxoplasma gondii aldose reductase, putative 0.0364 0.2446 0.7666
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0032 0.0032
Plasmodium vivax glutathione reductase, putative 0.0037 0.0125 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0762 0.3116
Loa Loa (eye worm) matrix metalloproteinase 0.0155 0.0962 0.3207
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0381 0.0397
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0499 0.1663
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0023 0.0093
Schistosoma mansoni hypothetical protein 0.0336 0.2249 0.2342
Entamoeba histolytica peptidase, C54 family 0.0023 0.0024 0.0096
Onchocerca volvulus 0.0364 0.2446 0.7618
Echinococcus multilocularis Protein lozenge 0.0055 0.0255 0.0255
Brugia malayi hypothetical protein 0.002 0.0001 0.0005
Giardia lamblia PHD finger protein 15 0.0087 0.0477 0.1876
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0469 0.3191 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0271 0.0903
Loa Loa (eye worm) hypothetical protein 0.0433 0.2936 0.9793
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0381 0.1272
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0288 0.03
Loa Loa (eye worm) hypothetical protein 0.0149 0.092 0.3067
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.041
Onchocerca volvulus 0.0046 0.019 0.0589
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.01 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0255
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0219 0.0686
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.01 0.0104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.01 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0762 0.3116
Onchocerca volvulus 0.0035 0.0112 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0179 0.1133 0.3779
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0364 0.2446 0.8159
Brugia malayi hypothetical protein 0.002 0.0001 0.0005
Echinococcus granulosus aldo keto reductase 0.0364 0.2446 0.2446
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0032 0.0038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.01 0.01
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.01 0.01
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0027 0.0012
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0063 0.0258
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0032 0.0096
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0469 0.3191 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1201 0.4007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0098 0.0306
Mycobacterium ulcerans hypothetical protein 0.0023 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Leishmania major trypanothione reductase 0.0037 0.0125 0.0511
Plasmodium vivax vivapain-2 0.0033 0.0098 0.0307
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0046 0.0191 0.0779
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0001 0.0004
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0106 0.061 0.2495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.019 0.0589
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0032 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0028 0.006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0112 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0499 0.1663
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0938 0.6515 0.6515
Trypanosoma brucei trypanothione reductase 0.0037 0.0125 0.0511
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0027 0.0109
Mycobacterium ulcerans hypothetical protein 0.0106 0.061 0.1854
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0027 0.0012
Onchocerca volvulus 0.0472 0.3211 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.01 0.0104
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0038 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0477 0.1496
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0024 0.0096
Loa Loa (eye worm) hypothetical protein 0.006 0.0288 0.0961
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.0401
Schistosoma mansoni hypothetical protein 0.0397 0.268 0.2791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.01 0.01
Echinococcus granulosus aldehyde reductase 0.0259 0.1698 0.1698
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0063 0.0197
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.002 0.0082
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0106 0.061 0.061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.01 0.0104
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0571 0.0571
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0032 0.0101
Onchocerca volvulus Alhambra homolog 0.0087 0.0477 0.1484
Loa Loa (eye worm) apoptosis regulator protein 0.0114 0.0671 0.2239
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0112 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0499 0.0519
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0027 0.0109
Trypanosoma brucei prostaglandin f synthase 0.0364 0.2446 1
Brugia malayi PHD-finger family protein 0.0087 0.0477 0.1592
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2805 0.9354
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Onchocerca volvulus 0.0033 0.0098 0.0301
Brugia malayi NADH-dependent xylose reductase 0.0106 0.061 0.2036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0103
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0046 0.0191 0.0593
Brugia malayi Matrixin family protein 0.0155 0.0962 0.3207
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0288 0.0288
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0027 0.0089
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1429 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0031 0.0103
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0697 0.0697
Mycobacterium ulcerans beta-lactamase 0.0035 0.0112 0.0282
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0023 0.0093
Onchocerca volvulus 0.0364 0.2446 0.7618
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0219 0.0686
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0098 0.0401
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.01 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.01 0.0333
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.006 0.0063
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.031 0.2063 0.6466
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0023 0.0072
Mycobacterium tuberculosis Probable reductase 0.0085 0.0462 0.1812
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0112 0.0282
Schistosoma mansoni lipoxygenase 0.0118 0.0697 0.0726
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0364 0.2446 0.2446
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0377 0.0393
Onchocerca volvulus 0.0106 0.061 0.1898
Loa Loa (eye worm) hypothetical protein 0.01 0.0571 0.1905
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.019 0.019
Schistosoma mansoni hypothetical protein 0.022 0.1421 0.148
Loa Loa (eye worm) oxidoreductase 0.0364 0.2446 0.8159
Echinococcus granulosus hypothetical protein 0.0364 0.2446 0.2446
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0058 0.0277 0.1131
Mycobacterium tuberculosis Conserved protein 0.0035 0.0112 0.0369
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0364 0.2446 0.2446
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0469 0.3191 1
Trichomonas vaginalis set domain proteins, putative 0.0472 0.3211 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0364 0.2446 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0315
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Leishmania major cathepsin L-like protease 0.0127 0.0762 0.3116
Loa Loa (eye worm) oxidoreductase 0.0364 0.2446 0.8159
Entamoeba histolytica aldose reductase, putative 0.0364 0.2446 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0027 0.0012
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0155 0.0962 0.1001
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.034 0.034
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.006 0.019
Toxoplasma gondii aldo-keto reductase 0.0106 0.061 0.1913
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.0509 0.1582
Entamoeba histolytica peptidase, C54 family 0.0023 0.0024 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0023 0.0071
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0571 0.0595
Leishmania major cathepsin L-like protease 0.0127 0.0762 0.3116
Brugia malayi beta-lactamase family protein 0.0035 0.0112 0.0374
Leishmania major hypothetical protein, conserved 0.005 0.0219 0.0894
Leishmania major cathepsin L-like protease 0.0127 0.0762 0.3116
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.01
Onchocerca volvulus Matrilysin homolog 0.0344 0.2301 0.7166
Schistosoma mansoni aldo-keto reductase 0.0364 0.2446 0.2547
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.01 0.0333
Plasmodium falciparum M1-family alanyl aminopeptidase 0.031 0.2063 0.6466
Brugia malayi hypothetical protein 0.005 0.0219 0.073
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0058 0.0277 0.0288
Brugia malayi Kringle domain containing protein 0.0024 0.0031 0.0103
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0098 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0381 0.0397
Brugia malayi Pre-SET motif family protein 0.006 0.0288 0.0961
Loa Loa (eye worm) beta-lactamase 0.0035 0.0112 0.0374
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0442 0.2998 1
Loa Loa (eye worm) oxidoreductase 0.0364 0.2446 0.8159
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0023 0.0076
Echinococcus granulosus aldo keto reductase 0.0364 0.2446 0.2446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0499 0.0499
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0038 0.0035
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0112 0.0374
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.01 0.01
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0469 0.3191 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0098 0.0306
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Loa Loa (eye worm) malate dehydrogenase 0.0046 0.0191 0.0635
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0027 0.0109
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.002 0.0021
Trypanosoma brucei aldo/keto reductase, putative 0.0106 0.061 0.2495
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0469 0.3191 1
Schistosoma mansoni potassium channel beta 0.0106 0.061 0.0636
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0762 0.3116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0236 0.0236
Schistosoma mansoni protein phosphatase 2C 0.0028 0.006 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.01 0.01
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0381 0.0397
Brugia malayi Transient-receptor-potential like protein 0.004 0.0142 0.0474
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0477 0.1496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0499 0.0499
Echinococcus multilocularis microtubule associated protein 2 0.1373 0.9603 0.9603
Trichomonas vaginalis aldo-keto reductase, putative 0.0364 0.2446 0.7619
Loa Loa (eye worm) hypothetical protein 0.005 0.0219 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0098 0.0306
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0112 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0142 0.0474
Giardia lamblia Aldose reductase 0.0364 0.2446 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0098 0.0307
Echinococcus granulosus cytosolic malate dehydrogenase 0.0046 0.0191 0.0191
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.006 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0098 0.0306
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis malate dehydrogenase, putative 0.0046 0.0191 0.0593
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0364 0.2446 0.7619
Leishmania major hypothetical protein, conserved 0.0034 0.01 0.041
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0024 0.0096
Loa Loa (eye worm) ctsf protein 0.0033 0.0098 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0089
Echinococcus granulosus cathepsin l1 0.0033 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0286 0.1892 0.197
Onchocerca volvulus 0.0364 0.2446 0.7618
Loa Loa (eye worm) oxidoreductase 0.0364 0.2446 0.8159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0023 0.0093
Onchocerca volvulus 0.0364 0.2446 0.7618
Loa Loa (eye worm) hypothetical protein 0.0364 0.2446 0.8159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.01 0.0333
Entamoeba histolytica peptidase, C54 family 0.0058 0.0277 0.1131
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0142 0.0142
Leishmania major aldo-keto reductase-like protein 0.0364 0.2446 1
Schistosoma mansoni cpg binding protein 0.0035 0.0111 0.0115
Mycobacterium ulcerans hypothetical protein 0.0035 0.0112 0.0282
Brugia malayi Cathepsin L-like precursor 0.0033 0.0098 0.0327
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0106 0.061 0.1913
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0067
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0046 0.0191 0.0593
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.01 0.0104
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0046 0.0191 0.0518
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0038 0.0155
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0046 0.0191 0.0779
Echinococcus granulosus peregrin 0.0087 0.0477 0.0477
Brugia malayi Bromodomain containing protein 0.0087 0.0477 0.1592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0271 0.0903
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0098 0.0401
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0236 0.0787
Onchocerca volvulus 0.0023 0.0027 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.01 0.0333
Brugia malayi nuclear receptor NHR-88 0.0034 0.01 0.0333
Brugia malayi hypothetical protein 0.0032 0.0092 0.0308
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0315
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.01 0.01
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0031 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0333
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0031 0.0097
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0462 0.1812
Brugia malayi Cathepsin L-like precursor 0.0022 0.002 0.0067
Schistosoma mansoni coup transcription factor 0.0034 0.01 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.01 0.0333
Plasmodium falciparum aldehyde reductase, putative 0.0106 0.061 0.1913
Toxoplasma gondii cathepsin CPL 0.0033 0.0098 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.062 0.2069

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0141 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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