Detailed information for compound 74412

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 246.305 | Formula: C14H18N2O2
  • H donors: 0 H acceptors: 2 LogP: 1.02 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C(N2CCCC2)C(=CC1=O)N1CCCC1
  • InChi: 1S/C14H18N2O2/c17-13-9-11(15-5-1-2-6-15)12(10-14(13)18)16-7-3-4-8-16/h9-10H,1-8H2
  • InChiKey: UHHHWVGYYDXSNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei RNA helicase, putative 0.0135 0.2817 0.5315
Schistosoma mansoni hypothetical protein 0.0243 0.5137 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0529 0.456
Loa Loa (eye worm) G-protein coupled receptor 0.0243 0.5137 0.5114
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Brugia malayi Cytochrome P450 family protein 0.0012 0.0165 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Entamoeba histolytica hypothetical protein 0.002 0.0332 0.0643
Echinococcus multilocularis ryanodine receptor 44f 0.0076 0.1546 0.1788
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus g protein coupled receptor 0.0243 0.5137 0.6204
Brugia malayi cation channel family protein 0.0163 0.3412 0.3352
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0356 0.0604
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0324 0.0459
Loa Loa (eye worm) neuropeptide F receptor 0.0243 0.5137 0.5114
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.2454 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0243 0.5137 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0243 0.5137 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.0224 0.0345
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0332 0.0296
Echinococcus granulosus g-protein coupled receptor 0.0243 0.5137 0.6204
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.5137 1
Brugia malayi neuropeptide F receptor 0.0243 0.5137 0.5092
Brugia malayi MIR domain containing protein 0.0017 0.0265 0.0175
Schistosoma mansoni amine GPCR 0.0243 0.5137 1
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.084 0.9002
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi G protein-coupled receptor F59B2.13 0.0243 0.5137 0.5092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0243 0.5137 0.6204
Brugia malayi intermediate filament protein 0.0027 0.0475 0.0387
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.009 0.184 0.35
Schistosoma mansoni neuropeptide receptor 0.0243 0.5137 1
Echinococcus multilocularis O glycosyltransferase 0.0041 0.0779 0.0846
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0224 0.0345
Loa Loa (eye worm) hypothetical protein 0.0104 0.2139 0.2102
Loa Loa (eye worm) hypothetical protein 0.0009 0.009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0165 0.0231
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0008 0.0082 0.0407
Echinococcus granulosus alpha 1A adrenergic receptor 0.0243 0.5137 0.6204
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0015 0.0224 0.0195
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0253 0.2393
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0091 0.0515
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0243 0.5137 0.6204
Echinococcus granulosus orexin receptor type 2 0.0243 0.5137 0.6204
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0332 0.0296
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0224 0.0163
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0324 0.0627
Echinococcus granulosus sex peptide receptor 0.0243 0.5137 0.6204
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2216 0.4211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0243 0.5137 1
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.004 0.077 0.8454
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.091 0.1007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0146 0.0194
Trypanosoma brucei thymidine kinase 0.0245 0.517 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0332 0.0296
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.2198 0.8837
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Echinococcus multilocularis musashi 0.0027 0.0475 0.0472
Brugia malayi AKH receptor 0.0243 0.5137 0.5092
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0224 0.0178
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0253 0.0403
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0324 0.0355
Echinococcus multilocularis neuropeptide receptor 0.0243 0.5137 0.6204
Echinococcus granulosus tm gpcr rhodopsin 0.0243 0.5137 0.6204
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0332 0.0296
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.091 0.1007
Toxoplasma gondii exonuclease III APE 0.002 0.0324 0.3561
Echinococcus multilocularis neuropeptides capa receptor 0.0243 0.5137 0.6204
Brugia malayi Cytochrome P450 family protein 0.0012 0.0165 0.0075
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0243 0.5137 0.6204
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0224 0.0134
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0332 0.0296
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.2216 0.4234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0023 0.0409 0.0706
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Loa Loa (eye worm) hypothetical protein 0.0026 0.0465 0.042
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0023 0.0409 0.0706
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0074 0.149 0.2578
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0332 0.0243
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0243 0.5137 0.6204
Brugia malayi hypothetical protein 0.002 0.0332 0.0243
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.091 0.1686
Onchocerca volvulus 0.0243 0.5137 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0161 0.007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.2198 0.8837
Brugia malayi PXA domain containing protein 0.002 0.0332 0.0243
Schistosoma mansoni hypothetical protein 0.0243 0.5137 1
Echinococcus multilocularis sex peptide receptor 0.0243 0.5137 0.6204
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0243 0.5137 0.6204
Leishmania major trypanothione reductase 0.0047 0.091 0.1686
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0433
Brugia malayi sulfakinin receptor protein 0.0243 0.5137 0.5092
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0332 0.0296
Echinococcus granulosus tm gpcr rhodopsin 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.021 0.012
Loa Loa (eye worm) hypothetical protein 0.0013 0.018 0.0134
Brugia malayi Thioredoxin reductase 0.0047 0.091 0.0827
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0332 0.0243
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0332 0.0296
Loa Loa (eye worm) TYRA-2 protein 0.0243 0.5137 0.5114
Onchocerca volvulus 0.0243 0.5137 1
Brugia malayi Dopamine receptor protein 1 0.0243 0.5137 0.5092
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.091 1
Brugia malayi neuropeptide F receptor 0.0243 0.5137 0.5092
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0332 0.0287
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0332 0.0287
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0356 0.0267
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0165 0.0119
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0332 0.0243
Echinococcus granulosus O glycosyltransferase 0.0041 0.0779 0.0846
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0324 0.0286
Echinococcus multilocularis g-protein coupled receptor 0.0243 0.5137 0.6204
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0253 0.0619
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0015 0.0224 0.0195
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0529 0.5588
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2216 0.2179
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0356 0.0326
Giardia lamblia O-linked GlcNAc transferase 0.0024 0.0411 0.063
Brugia malayi 6-phosphofructokinase 0.0108 0.2216 0.2144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2216 0.4234
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0107 0.2199 0.2127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.0224 0.0345
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0054 0.1058 0.1916
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0332 0.0296
Schistosoma mansoni neuropeptide receptor 0.0243 0.5137 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.5137 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0356 0.0604
Schistosoma mansoni amine GPCR 0.0243 0.5137 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0243 0.5137 0.5114
Schistosoma mansoni axis inhibition protein axin 0.002 0.0332 0.0478
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.2454 1
Schistosoma mansoni histamine h1 receptor 0.0243 0.5137 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus serotonin receptor 0.0243 0.5137 0.6204
Schistosoma mansoni neuropeptide receptor 0.0243 0.5137 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0015 0.0224 0.0261
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Plasmodium falciparum glutathione reductase 0.0047 0.091 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.017 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Onchocerca volvulus 0.0027 0.0475 0.0512
Echinococcus granulosus axis inhibition protein axin 0.002 0.0332 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0253 0.0431
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0332 0.0296
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0224 0.0345
Echinococcus granulosus peptide allatostatin:somatostatin 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus multilocularis neuropeptide Y receptor 0.0243 0.5137 0.6204
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Echinococcus multilocularis stromal cell derived factor 2 0.0017 0.0265 0.0213
Echinococcus granulosus lamin 0.0027 0.0475 0.0472
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0023 0.0409 0.0522
Echinococcus granulosus g protein coupled receptor 0.0243 0.5137 0.6204
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0332 0.0478
Schistosoma mansoni amine GPCR 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0243 0.5137 0.6204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Loa Loa (eye worm) glutathione reductase 0.0047 0.091 0.0868
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Loa Loa (eye worm) hypothetical protein 0.0008 0.0082 0.0035
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0332 0.0296
Onchocerca volvulus 0.0243 0.5137 1
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0029 0.0525 0.0859
Schistosoma mansoni myosin xvIII 0.0243 0.5137 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0332 0.0478
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0253 0.2784
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0243 0.5137 0.5092
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.0224 0.2458
Schistosoma mansoni regulator of G protein signaling 0.002 0.0332 0.0478
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Echinococcus multilocularis serotonin receptor 0.0243 0.5137 0.6204
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Loa Loa (eye worm) hypothetical protein 0.0012 0.017 0.0124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0324 0.0541
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0253 0.0403
Echinococcus granulosus neuropeptide FF receptor 2 0.0243 0.5137 0.6204
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.091 0.2985
Schistosoma mansoni biogenic amine (5HT) receptor 0.0243 0.5137 1
Schistosoma mansoni hypothetical protein 0.0135 0.2817 0.5401
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2216 0.4234
Schistosoma mansoni biogenic amine (5HT) receptor 0.0243 0.5137 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0253 0.0431
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0253 0.0319
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0146 0.0194
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0041 0.0776 0.0691
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0332 0.0478
Loa Loa (eye worm) hypothetical protein 0.0074 0.149 0.145
Echinococcus multilocularis neuropeptide receptor A26 0.0243 0.5137 0.6204
Loa Loa (eye worm) phosphofructokinase 0.0108 0.2216 0.2179
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0253 0.0403
Echinococcus multilocularis g protein coupled receptor 0.0243 0.5137 0.6204
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0301 0.2948
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.5137 1
Echinococcus multilocularis neuropeptides capa receptor 0.0243 0.5137 0.6204
Brugia malayi ORL1-like opioid receptor 0.0243 0.5137 0.5092
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0146 0.0194
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0165 0.0119
Brugia malayi Serotonin receptor 0.0243 0.5137 0.5092
Brugia malayi putative neuropeptide receptor 0.0243 0.5137 0.5092
Schistosoma mansoni opsin-like receptor 0.0243 0.5137 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Schistosoma mansoni opsin-like receptor 0.0243 0.5137 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0243 0.5137 0.6204
Loa Loa (eye worm) RecQ helicase 0.0021 0.0356 0.0311
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0324 0.3212
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0161 0.007
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0224 0.0163
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0243 0.5137 0.6204
Echinococcus granulosus biogenic amine 5HT receptor 0.0243 0.5137 0.6204
Brugia malayi G-protein coupled receptor 0.0243 0.5137 0.5092
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0475 0.043
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0332 0.0287
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0332 0.0478
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0332 0.0287
Brugia malayi glutathione reductase 0.0047 0.091 0.0827
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0332 0.0296
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0091 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Onchocerca volvulus 0.0017 0.0265 0.0083
Echinococcus granulosus 7TM GPCR rhodopsin 0.0243 0.5137 0.6204
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0332 0.0243
Plasmodium falciparum thioredoxin reductase 0.0047 0.091 1
Leishmania major thymidine kinase, putative 0.0245 0.517 1
Schistosoma mansoni neuropeptide F-like receptor 0.0243 0.5137 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.2198 0.8837
Onchocerca volvulus 0.0243 0.5137 1
Schistosoma mansoni amine GPCR 0.0243 0.5137 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2216 0.4234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0133 0.2759 0.5287
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus multilocularis expressed protein 0.0387 0.8224 1
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2216 0.4211
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0345
Schistosoma mansoni ap endonuclease 0.002 0.0324 0.0462
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.0224 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0199
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0253 0.0403
Brugia malayi PXA domain containing protein 0.002 0.0332 0.0243
Echinococcus granulosus dro:myosuppressin receptor 0.0243 0.5137 0.6204
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0091 0.1003
Loa Loa (eye worm) RGS-3 protein 0.002 0.0332 0.0287
Leishmania major hypothetical protein, conserved 0.0061 0.122 0.2291
Brugia malayi putative neuropeptide receptor NPR1 0.0243 0.5137 0.5092
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0529 0.5815
Plasmodium falciparum thioredoxin reductase 0.0016 0.0253 0.2393
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0324 0.0235
Echinococcus multilocularis g protein coupled receptor 0.0243 0.5137 0.6204
Entamoeba histolytica MIR domain protein 0.0017 0.0265 0.0512
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0224 0.0262
Echinococcus multilocularis allatostatin A receptor 0.0243 0.5137 0.6204
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis neuropeptide s receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis neuropeptide FF receptor 2 0.0243 0.5137 0.6204
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0529 0.0863
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0007 0.0047 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Echinococcus multilocularis neuropeptide Y receptor 0.0243 0.5137 0.6204
Echinococcus granulosus neuropeptides capa receptor 0.0243 0.5137 0.6204
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.009 0.184 0.3371
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0261 0.0337
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0324 0.0279
Onchocerca volvulus 0.0243 0.5137 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0345
Echinococcus granulosus biogenic amine 5HT receptor 0.0243 0.5137 0.6204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0224 0.0345
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0054 0.1058 0.1189
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0041 0.0776 0.0733
Trypanosoma cruzi thymidine kinase, putative 0.0245 0.517 1
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0008 0.0082 0.0035
Toxoplasma gondii DNA polymerase family B protein 0.0007 0.0047 0.0515
Onchocerca volvulus 0.0243 0.5137 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.2216 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0253 0.0214
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0243 0.5137 1
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2216 0.4286
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0431
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Trypanosoma brucei trypanothione reductase 0.0047 0.091 0.1521
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0332 0.0478
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0091 0.1003
Echinococcus granulosus somatostatin receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0332 0.0296
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0332 0.0243
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0243 0.5137 1
Echinococcus granulosus lamin dm0 0.0027 0.0475 0.0472
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0195
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi Dopamine receptor 0.0243 0.5137 0.5092
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0529 0.1434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0324 0.0541
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0224 0.0163
Schistosoma mansoni regulator of G protein signaling 0.002 0.0332 0.0478
Echinococcus multilocularis G protein coupled receptor 139 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2216 0.2179
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.2216 0.2613
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0332 0.0296
Mycobacterium ulcerans hypothetical protein 0.0016 0.0247 0.0399
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0253 0.0228
Echinococcus granulosus neuropeptide s receptor 0.0243 0.5137 0.6204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0243 0.5137 0.6204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0017 0.0265 0.0343
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0008 0.0082 0.0069
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0041 0.0779 0.1364
Loa Loa (eye worm) hypothetical protein 0.0102 0.2097 0.206
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0324 0.0541
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0253 0.2784
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.021 0.0164
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Trichomonas vaginalis mannosyltransferase 1, putative 0.0017 0.0265 0.0425
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0475 0.043
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2216 0.4286
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Loa Loa (eye worm) melatonin receptor type 1A 0.0243 0.5137 0.5114
Echinococcus multilocularis dro:myosuppressin receptor 0.0243 0.5137 0.6204
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2216 0.412
Schistosoma mansoni alpha-1 adrenergic receptor 0.0243 0.5137 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0332 0.0557
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0243 0.5137 1
Onchocerca volvulus 0.0243 0.5137 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.018 0.0109
Loa Loa (eye worm) MIR domain-containing protein 0.0017 0.0265 0.0219
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0243 0.5137 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0324 0.0541
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0324 0.0322
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0529 1
Echinococcus granulosus g protein coupled receptor 0.0243 0.5137 0.6204
Toxoplasma gondii thioredoxin reductase 0.0047 0.091 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0009 0.0091 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0324 0.0286
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0243 0.5137 0.5114
Trichomonas vaginalis thymidine kinase, putative 0.0245 0.517 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0224 0.0262
Schistosoma mansoni regulator of G protein signaling 0.002 0.0332 0.0478
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0332 0.0557
Entamoeba histolytica thymidine kinase, putative 0.0245 0.517 1
Brugia malayi Melatonin receptor type 1A 0.0243 0.5137 0.5092
Plasmodium falciparum glutathione reductase 0.0016 0.0253 0.2393
Loa Loa (eye worm) hypothetical protein 0.0076 0.1546 0.1506
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Onchocerca volvulus 0.0243 0.5137 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0253 0.0834
Schistosoma mansoni lamin 0.0027 0.0475 0.0761
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0253 0.0403
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0332 0.0296
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0529 0.5815
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0224 0.0163
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0243 0.5137 0.5092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0214
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0324 0.0541
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni neuropeptide F-like receptor 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0232 0.2141
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0253 0.0834
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus fmrfamide receptor 0.0243 0.5137 0.6204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0332 0.0296
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0165 0.0119
Echinococcus granulosus intermediate filament protein 0.0027 0.0475 0.0472
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0243 0.5137 0.6204
Echinococcus granulosus bloom syndrome protein 0.0021 0.0356 0.0326
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0253 0.0619
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0332 0.0478
Brugia malayi GnHR receptor homolog 0.0243 0.5137 0.5092
Trichomonas vaginalis thymidine kinase, putative 0.0245 0.517 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0332 0.0296
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0087 0.1772 0.333
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus multilocularis ryanodine receptor 44f 0.0059 0.1178 0.1336
Echinococcus granulosus hypothetical protein 0.0243 0.5137 0.6204
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0253 0.0403
Brugia malayi Tachykinin-like peptides receptor 99D 0.0243 0.5137 0.5092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0243 0.5137 0.6204
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0165 0.0038
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi RE15519p 0.0243 0.5137 0.5092
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Mycobacterium tuberculosis Probable reductase 0.0107 0.2198 0.8837
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi G-protein coupled receptor 0.0243 0.5137 0.5092
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0155
Echinococcus multilocularis g protein coupled receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0243 0.5137 0.6204
Echinococcus granulosus ryanodine receptor 44f 0.0059 0.1178 0.1336
Onchocerca volvulus 0.0243 0.5137 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0529 0.456
Echinococcus granulosus tm gpcr rhodopsin 0.0243 0.5137 0.6204
Echinococcus multilocularis G-protein coupled receptor, putative 0.0243 0.5137 0.6204
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0243 0.5137 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0324 0.163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Echinococcus granulosus neuropeptide receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis neuropeptide receptor 0.0243 0.5137 0.6204
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.2198 0.8837
Brugia malayi larval opioid receptor 0.0243 0.5137 0.5092
Echinococcus granulosus neuropeptides capa receptor 0.0243 0.5137 0.6204
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Giardia lamblia O-linked GlcNAc transferase 0.004 0.077 0.1336
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.2454 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.084 0.0756
Giardia lamblia Thymidine kinase 0.0245 0.517 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni ryanodine receptor related 0.0107 0.2199 0.4178
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0243 0.5137 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0015 0.0224 0.0261
Echinococcus multilocularis fmrfamide receptor 0.0243 0.5137 0.6204
Echinococcus granulosus stromal cell derived factor 2 0.0017 0.0265 0.0213
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0243 0.5137 0.5092
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2216 0.4286
Loa Loa (eye worm) neuropeptide F receptor 0.0243 0.5137 0.5114
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.2216 0.2613
Loa Loa (eye worm) G-protein coupled receptor 0.0243 0.5137 0.5114
Schistosoma mansoni biogenic amine receptor 0.0243 0.5137 1
Schistosoma mansoni lamin 0.0027 0.0475 0.0761
Schistosoma mansoni adenoreceptor 0.0243 0.5137 1
Schistosoma mansoni neuropeptide receptor 0.0243 0.5137 1
Echinococcus granulosus G protein coupled receptor 139 0.0243 0.5137 0.6204
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.091 0.0868
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0324 0.0392
Echinococcus multilocularis somatostatin receptor 0.0243 0.5137 0.6204
Schistosoma mansoni biogenic amine receptor 0.0243 0.5137 1
Trypanosoma cruzi thymidine kinase, putative 0.0245 0.517 1
Echinococcus granulosus neuropeptide Y receptor 0.0243 0.5137 0.6204
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0206 0.2268
Echinococcus multilocularis serotonin receptor 0.0243 0.5137 0.6204
Onchocerca volvulus 0.0243 0.5137 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus 7tm_1 domain containing protein 0.0243 0.5137 0.6204
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.2198 0.8837
Echinococcus multilocularis orexin receptor type 2 0.0243 0.5137 0.6204
Brugia malayi Dopamine receptor protein 2 0.0243 0.5137 0.5092
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi G protein-coupled receptor 0.0243 0.5137 0.5092
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Echinococcus granulosus axis inhibition protein axin 0.002 0.0332 0.0296
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0529 1
Onchocerca volvulus 0.0243 0.5137 1
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0016 0.0247 0.0004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis fmrfamide receptor 0.0243 0.5137 0.6204
Trichomonas vaginalis thymidine kinase, putative 0.0245 0.517 1
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0015 0.0224 0.2048
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus ryanodine receptor 44f 0.0076 0.1546 0.1788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0253 0.0403
Schistosoma mansoni amine GPCR 0.0243 0.5137 1
Entamoeba histolytica hypothetical protein 0.002 0.0332 0.0643
Brugia malayi Serotonin receptor 0.0243 0.5137 0.5092
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0224 0.0163
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.2454 1
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0265 0.0219
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus neuropeptide receptor A26 0.0243 0.5137 0.6204
Brugia malayi phosphofructokinase 0.0108 0.2216 0.2144
Schistosoma mansoni biogenic amine receptor 0.0243 0.5137 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0332 0.0478
Leishmania major cytochrome p450-like protein 0.0012 0.0165 0.0231
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0243 0.5137 0.5114
Onchocerca volvulus 0.0027 0.0475 0.0512
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0243 0.5137 0.6204
Echinococcus multilocularis lamin 0.0027 0.0475 0.0472
Loa Loa (eye worm) hypothetical protein 0.0087 0.1772 0.1733
Loa Loa (eye worm) follicle stimulating hormone receptor 0.047 1 1
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0232 0.0448
Trichomonas vaginalis DNA polymerase II, putative 0.0023 0.0409 0.0706
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0332 0.0478
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0529 0.5815
Schistosoma mansoni neuropeptide f receptor 76f 0.0243 0.5137 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.0224 0.0345
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0529 0.5588
Echinococcus multilocularis lamin dm0 0.0027 0.0475 0.0472
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0023 0.0409 0.0706
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0253 0.0164
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0146 0.0283
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0165 0.0231
Schistosoma mansoni hypothetical protein 0.0243 0.5137 1
Echinococcus granulosus allatostatin A receptor 0.0243 0.5137 0.6204
Echinococcus granulosus neuropeptide Y receptor 0.0243 0.5137 0.6204
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0243 0.5137 0.6204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.5137 1
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0224 0.0163
Plasmodium vivax glutathione reductase, putative 0.0047 0.091 1
Brugia malayi hypothetical protein 0.002 0.0332 0.0243
Schistosoma mansoni opsin-like receptor 0.0243 0.5137 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0332 0.0478
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0337 0.0487
Onchocerca volvulus 0.0243 0.5137 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0475 0.043
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0224 0.0262
Schistosoma mansoni intermediate filament proteins 0.0027 0.0475 0.0761
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0475 0.0387
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.2216 0.0695
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.2216 0.8918
Giardia lamblia DNA polymerase alpha subunit A 0.0045 0.0881 0.1556
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0529 0.0942
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0224 0.0155
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0224 0.0134
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0253 0.2393
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0224 0.0134
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0199
Brugia malayi 6-phosphofructokinase 0.0108 0.2216 0.2144
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0253 0.0321
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0253 0.0214
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0243 0.5137 0.6204
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.018 0.0109
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0243 0.5137 0.5092
Echinococcus granulosus neuropeptide receptor 0.0243 0.5137 0.6204
Toxoplasma gondii DNA polymerase 0.0015 0.0224 0.2458
Echinococcus granulosus tachykinin peptides receptor 99D 0.0243 0.5137 0.6204
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0529 0.0942
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.084 0.9232
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.2216 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0082 0.0035
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0054 0.1058 0.1189
Schistosoma mansoni ap endonuclease 0.002 0.0324 0.0462
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0243 0.5137 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Onchocerca volvulus Neuropeptide F receptor homolog 0.0243 0.5137 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.5137 0.6204
Entamoeba histolytica hypothetical protein 0.002 0.0332 0.0643
Treponema pallidum NADH oxidase 0.0016 0.0253 0.0033
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0332 0.0296
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0243 0.5137 0.5114
Schistosoma mansoni hypothetical protein 0.0243 0.5137 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0243 0.5137 0.5092
Brugia malayi hypothetical protein 0.0243 0.5137 0.5092
Loa Loa (eye worm) ryanodine receptor 0.0029 0.0525 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2216 0.4234
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0253 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0324 0.0776
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2216 0.4234
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Echinococcus granulosus expressed protein 0.0387 0.8224 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.5137 0.5114
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0529 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0332 0.0478
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0332 0.0243
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0243 0.5137 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 500 uM Tested for 50% inhibition against EMT-6 murine mammary carcinoma cell under normal oxygenated condition ChEMBL. 8515418
IC50 (functional) > 500 uM Tested for 50% inhibition against EMT-6 murine mammary carcinoma cell under hypoxia condition ChEMBL. 8515418
IC50 (functional) > 500 uM Tested for 50% inhibition against EMT-6 murine mammary carcinoma cell under normal oxygenated condition ChEMBL. 8515418
IC50 (functional) > 500 uM Tested for 50% inhibition against EMT-6 murine mammary carcinoma cell under hypoxia condition ChEMBL. 8515418
IC90 (functional) > 500 uM Tested for 90% inhibition against EMT-6 murine mammary carcinoma cell under normal oxygenated condition ChEMBL. 8515418
IC90 (functional) > 500 uM Tested for 90% inhibition against EMT-6 murine mammary carcinoma cell under hypoxia condition ChEMBL. 8515418
IC90 (functional) > 500 uM Tested for 90% inhibition against EMT-6 murine mammary carcinoma cell under normal oxygenated condition ChEMBL. 8515418
IC90 (functional) > 500 uM Tested for 90% inhibition against EMT-6 murine mammary carcinoma cell under hypoxia condition ChEMBL. 8515418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.