Detailed information for compound 74624

Basic information

Technical information
  • TDR Targets ID: 74624
  • Name: 2-butyl-5-chloro-3-[[5-[2-(2H-tetrazol-5-yl)p henyl]thiophen-2-yl]methyl]imidazole-4-carbal dehyde
  • MW: 426.922 | Formula: C20H19ClN6OS
  • H donors: 1 H acceptors: 5 LogP: 4.69 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1nc(c(n1Cc1ccc(s1)c1ccccc1c1n[nH]nn1)C=O)Cl
  • InChi: 1S/C20H19ClN6OS/c1-2-3-8-18-22-19(21)16(12-28)27(18)11-13-9-10-17(29-13)14-6-4-5-7-15(14)20-23-25-26-24-20/h4-7,9-10,12H,2-3,8,11H2,1H3,(H,23,24,25,26)
  • InChiKey: CLMNIXOLDGQORD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-butyl-5-chloro-3-[[5-[2-(2H-tetrazol-5-yl)phenyl]-2-thienyl]methyl]imidazole-4-carbaldehyde
  • 2-butyl-5-chloro-3-[[5-[2-(2H-tetrazol-5-yl)phenyl]-2-thienyl]methyl]-4-imidazolecarboxaldehyde
  • 2-butyl-5-chloro-3-[[5-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]thiophen-2-yl]methyl]imidazole-4-carbaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.002 0.0058 0.0067
Echinococcus granulosus leukotriene A 4 hydrolase 0.0239 0.2353 0.2702
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0306 0.306 0.3514
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0058 0.0067
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1308 0.5294
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0422 0.0485
Schistosoma mansoni lamin 0.0107 0.097 0.1261
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0542 0.4397
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1308 0.5294
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0049 0.0072
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0068 0.056 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1171 1
Echinococcus multilocularis nmda type glutamate receptor 0.0212 0.2066 0.2373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.026 0.0298
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0454 1
Loa Loa (eye worm) glutamate receptor 0.0693 0.7114 0.7114
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0654 0.4772
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0454 0.6719
Echinococcus multilocularis excitatory amino acid transporter 3 0.0246 0.2431 0.2791
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0059
Echinococcus multilocularis Excitatory amino acid transporter 0.0246 0.2431 0.2791
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0068 0.056 0.0643
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0262
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0239 0.2353 0.2353
Onchocerca volvulus 0.0515 0.5249 0.526
Plasmodium falciparum polyubiquitin binding protein, putative 0.0035 0.0214 0.2771
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0542 0.4413
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0144 0.1351 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0049 0.0039
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1171 0.1345
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0549 0.0714
Loa Loa (eye worm) doublecortin family protein 0.002 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0138 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.012
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0058 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.1123 0.1289
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0239 0.2353 0.3059
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0061 0.0066
Onchocerca volvulus 0.003 0.0155 0.0107
Echinococcus granulosus geminin 0.0174 0.1674 0.1922
Entamoeba histolytica hypothetical protein 0.0097 0.0861 0.7234
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0138 0.018
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0203 0.1456
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.0991 0.1288
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0075
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1132 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0068 0.056 0.0643
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0109 0.0991 0.1138
Echinococcus granulosus nmda type glutamate receptor 0.0097 0.0861 0.0988
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0138 0.0159
Echinococcus multilocularis nmda type glutamate receptor 0.0097 0.0861 0.0988
Brugia malayi Sulfatase family protein 0.0026 0.012 0.0138
Mycobacterium ulcerans epimerase 0.002 0.0058 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0049 0.0057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0203 0.0664
Echinococcus multilocularis RUN 0.002 0.0058 0.0067
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0049 0.0072
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1171 0.1171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0138 0.0138
Brugia malayi Metabotropic glutamate receptor precursor. 0.0693 0.7114 0.8166
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0274 0.211
Loa Loa (eye worm) hypothetical protein 0.0099 0.0888 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0138 0.0159
Schistosoma mansoni loxhd1 0.002 0.0058 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Plasmodium falciparum thioredoxin reductase 0.0055 0.0422 0.6187
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0155 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0248 0.0285
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0246 0.2431 1
Loa Loa (eye worm) hypothetical protein 0.0845 0.8709 0.8709
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0223 0.1638
Mycobacterium tuberculosis Probable sulfatase 0.0026 0.012 0.0314
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1161 0.4678
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0542 0.0623
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0442 0.0508
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0265 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0388 0.0388
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0223 0.0224
Loa Loa (eye worm) hypothetical protein 0.0122 0.1123 0.1123
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1132 0.13
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0035 0.0214 0.0215
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0197 0.1325
Echinococcus multilocularis excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus granulosus sodium:dicarboxylate symporter 0.0246 0.2431 0.2791
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1171 1
Brugia malayi SET domain containing protein 0.0016 0.0016 0.0018
Mycobacterium ulcerans arylsulfatase AtsD 0.0026 0.012 0.0573
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0265 0.2167
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.1972
Schistosoma mansoni alkaline phosphatase 0.0317 0.3174 0.4125
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0061 0.014
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0248 0.0323
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.026 0.0298
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0138 0.0159
Echinococcus granulosus RUN 0.002 0.0058 0.0067
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0138 0.0159
Echinococcus granulosus neutral amino acid transporter 0.0246 0.2431 0.2791
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0454 0.3635
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0144 0.1351 0.5475
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0442 0.0508
Brugia malayi 6-phosphofructokinase 0.0126 0.1171 0.1345
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0554
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0 0.00000000017198
Echinococcus granulosus glutamate NMDA receptor subunit 0.0104 0.094 0.1079
Brugia malayi Pre-SET motif family protein 0.0845 0.8711 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0248 0.0323
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0845 0.8711 0.8711
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0454 0.0522
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0448 0.0514
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0138 0.009
Echinococcus granulosus cpg binding protein 0.0031 0.0173 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0049 0.001
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0248 0.0285
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.0545 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0402 0.0402
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0246 0.2431 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0442 0.304
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0248 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.1123 0.991
Schistosoma mansoni hypothetical protein 0.0421 0.426 0.5537
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0248 0.0248
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0246 0.2431 0.2791
Loa Loa (eye worm) hypothetical protein 0.0515 0.5249 0.5249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0148 0.14 0.1819
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0138 0.018
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0623 0.5136
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Echinococcus granulosus Excitatory amino acid transporter 0.0246 0.2431 0.2791
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0107
Brugia malayi hypothetical protein 0.0371 0.3742 0.4295
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0138 0.0138
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Echinococcus granulosus phospholipase A 2 activating protein 0.0035 0.0214 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0265 0.2167
Brugia malayi Inositol-1 0.0036 0.0223 0.0256
Leishmania major DNA polymerase kappa, putative 0.0021 0.0061 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0596 0.6098 0.7
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0058 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0223 0.1363
Onchocerca volvulus 0.0107 0.097 0.0932
Toxoplasma gondii PUL domain-containing protein 0.0035 0.0214 0.1553
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0138 0.0159
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Brugia malayi hypothetical protein 0.0025 0.0107 0.0123
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Echinococcus multilocularis musashi 0.0107 0.097 0.1114
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0248 0.0285
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0454 0.3135
Onchocerca volvulus 0.0107 0.097 0.0932
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Echinococcus granulosus dna polymerase kappa 0.004 0.0265 0.0305
Loa Loa (eye worm) hypothetical protein 0.0204 0.1981 0.1981
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0067
Loa Loa (eye worm) glutamate receptor 0.0259 0.256 0.256
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0057
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0422 0.158
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0097 0.0861 0.0988
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0197 0.1399
Echinococcus granulosus tumor protein p63 0.0335 0.3362 0.386
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0203 0.3868
Schistosoma mansoni DNA helicase recq1 0.0039 0.026 0.0337
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0138 0.0159
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0058 0.0099
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0052
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0265 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Brugia malayi hypothetical protein 0.0036 0.022 0.0252
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0068 0.056 0.0643
Giardia lamblia Hypothetical protein 0.0026 0.012 0.1828
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0441 0.0506
Brugia malayi hypothetical protein 0.011 0.0998 0.1146
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0674 0.6914 0.7939
Onchocerca volvulus 0.0099 0.0888 0.0848
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0077 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Echinococcus granulosus excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.0298
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0248 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0138 0.0159
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0422 0.0485
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.027 0.2677 1
Trichomonas vaginalis set domain proteins, putative 0.0962 0.9935 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1268 0.1268
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0049 0.0039
Schistosoma mansoni hypothetical protein 0.0174 0.1674 0.2176
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4413
Brugia malayi steroid hormone receptor 0.0028 0.0138 0.0159
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.0397
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0454 0.0457
Leishmania major trypanothione reductase 0.0055 0.0422 0.3347
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Schistosoma mansoni serine-rich repeat protein 0.0158 0.1506 0.1957
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0586 0.5993 0.6882
Echinococcus multilocularis receptor type guanylyl cyclase 0.0097 0.0861 0.0988
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0248 0.0285
Echinococcus granulosus voltage dependent calcium channel subunit 0.0674 0.6914 0.7939
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0056 0.0073
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.0335
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2807 0.3649
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Brugia malayi Thioredoxin reductase 0.0055 0.0422 0.0484
Schistosoma mansoni cpg binding protein 0.0031 0.0173 0.0225
Onchocerca volvulus 0.0049 0.036 0.0314
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0441 0.0506
Schistosoma mansoni polycystin 1-related 0.002 0.0058 0.0075
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0026 0.012 0.0314
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0454 0.1556
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Toxoplasma gondii endonuclease IV APN 0.0077 0.0654 0.5604
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0052 0.0388 0.0446
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0024 0.0093 0.0094
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0058 0.0067
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0203 0.2599
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0214 0.1499
Mycobacterium ulcerans sulfatase 0.0026 0.012 0.0573
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0203 0.1381
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0203 0.2599
Echinococcus multilocularis lamin dm0 0.0107 0.097 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0163 0.1283
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0224
Brugia malayi WD domain containing protein 0.0035 0.0214 0.0246
Brugia malayi Glutamate receptor 2 precursor 0.0104 0.094 0.1079
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0049 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Loa Loa (eye worm) hypothetical protein 0.005 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0422 0.3499
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0138 0.018
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0138 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0045 0.0052
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0204 0.1981 0.1981
Brugia malayi Receptor family ligand binding region containing protein 0.0204 0.1981 0.2274
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0144 0.1351 0.4963
Echinococcus multilocularis glutamate receptor 2 0.0133 0.124 0.1424
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0138 0.018
Echinococcus multilocularis glutamate receptor 2 0.0104 0.094 0.1079
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0248 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0317 0.3174 0.3644
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0486 0.7231
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0203 0.0205
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0294 0.2929 0.3807
Schistosoma mansoni cpg binding protein 0.003 0.0155 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.426 0.4891
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0144 0.1351 0.4963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Toxoplasma gondii cathepsin CPL 0.0019 0.0049 0.004
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.0545 0.0625
Toxoplasma gondii thioredoxin reductase 0.0055 0.0422 0.3467
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1171 0.1171
Plasmodium falciparum glutathione reductase 0.0055 0.0422 0.6187
Onchocerca volvulus 0.0099 0.0888 0.0848
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0246 0.2431 0.2409
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Treponema pallidum glutamate/aspartate transporter 0.0109 0.0991 0.3595
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0058 0.0211
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2428
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0203 0.1456
Onchocerca volvulus 0.0962 0.9935 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0197 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0138 0.018
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2807 0.3649
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0442 0.1665
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.077 0.0885
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0093 0.0093
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0203 0.147
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.8597 0.9872
Loa Loa (eye worm) glutamate receptor 1 0.0104 0.094 0.094
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0138 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Schistosoma mansoni metabotropic glutamate receptor 0.0356 0.3576 0.4648
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0542 0.0705
Entamoeba histolytica cysteine protease, putative 0.0019 0.0049 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0206 0.0207
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0104 0.094 0.1079
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0045 0.0262
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0248 0.0285
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1171 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Schistosoma mansoni lamin 0.0107 0.097 0.1261
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0654 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0061 0.0384
Echinococcus multilocularis tyrosine kinase 0.0097 0.0861 0.0988
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) excitatory amino acid transporter 0.0246 0.2431 0.2431
Echinococcus multilocularis alkaline phosphatase 0.0317 0.3174 0.3644
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0246 0.2431 0.2791
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0262
Brugia malayi hypothetical protein 0.0097 0.0861 0.0988
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0105 0.095 0.095
Echinococcus granulosus bloom syndrome protein 0.0067 0.0545 0.0625
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1161 0.4678
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0442 0.3526
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0248 0.0285
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Trypanosoma cruzi extracellular receptor, putative 0.0097 0.0861 0.7242
Chlamydia trachomatis glutamine binding protein 0.0144 0.1351 0.5475
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.022 0.0285
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.1069 0.1228
Echinococcus granulosus alkaline phosphatase 0.0317 0.3174 0.3644
Schistosoma mansoni protein kinase 0.0097 0.0861 0.1119
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0109 0.0991 0.1138
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Brugia malayi Cache domain containing protein 0.0136 0.1268 0.1456
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0197 0.1577
Mycobacterium ulcerans arylsulfatase, AslA 0.0026 0.012 0.0573
Schistosoma mansoni ap endonuclease 0.0058 0.0454 0.0591
Schistosoma mansoni hypothetical protein 0.0165 0.1575 0.2047
Schistosoma mansoni alkaline phosphatase 0.0317 0.3174 0.4125
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1171 0.1171
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0052 0.0388 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0138 0.0159
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Schistosoma mansoni metabotropic glutamate receptor 0.0586 0.5993 0.7791
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0748 0.7693 1
Echinococcus granulosus nmda type glutamate receptor 0.0212 0.2066 0.2373
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0248 0.0248
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.1123 0.1289
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Brugia malayi CXXC zinc finger family protein 0.003 0.0155 0.0178
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0239 0.2353 0.2702
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Echinococcus multilocularis NMDA receptor 0.0068 0.056 0.0643
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0097 0.0861 0.0821
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0554
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Brugia malayi Cytochrome P450 family protein 0.0047 0.0339 0.0389
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0542 0.0623
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0254 0.2514 0.2887
Echinococcus granulosus receptor type guanylyl cyclase 0.0097 0.0861 0.0988
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Mycobacterium ulcerans hypothetical protein 0.002 0.0058 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0138 0.0159
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0248 0.0285
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0654 0.0751
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0317 0.3174 0.3644
Schistosoma mansoni hypothetical protein 0.0254 0.2514 0.3268
Onchocerca volvulus 0.0133 0.124 0.1204
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2626
Echinococcus granulosus Excitatory amino acid transporter 0.0246 0.2431 0.2791
Mycobacterium ulcerans arylsulfatase AtsB 0.0026 0.012 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni rotamase 0.0034 0.0206 0.0267
Echinococcus granulosus intestinal type alkaline phosphatase 0.0317 0.3174 0.3644
Schistosoma mansoni glutamate receptor NMDA 0.0201 0.1955 0.2542
Loa Loa (eye worm) hypothetical protein 0.0099 0.0888 0.0888
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1308 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0049 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0248 0.0285
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0454 0.0454
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0097 0.0861 0.0861
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0138 0.0159
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.026 0.0298
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0248 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Schistosoma mansoni tyrosine kinase 0.0097 0.0861 0.1119
Schistosoma mansoni DNA helicase recq5 0.0039 0.026 0.0337
Onchocerca volvulus 0.002 0.0058 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1132 0.1472
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.097 0.097
Echinococcus multilocularis Protein lozenge 0.0065 0.0523 0.0601
Echinococcus granulosus GPCR family 3 C terminal 0.0107 0.0965 0.1109
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0248 0.0285
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.01
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0223 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0068 0.056 0.0643
Brugia malayi glutathione reductase 0.0055 0.0422 0.0484
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0183 0.058
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0026 0.012 0.012
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Leishmania major extracellular receptor, putative 0.0097 0.0861 0.7242
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0479 0.3992
Loa Loa (eye worm) hypothetical protein 0.0107 0.097 0.097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0265 0.0267
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0138 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0163 0.1283
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0556 0.4536
Mycobacterium ulcerans hydrolase 0.0026 0.012 0.0573
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0248 0.0285
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1132 0.4558
Loa Loa (eye worm) hypothetical protein 0.0024 0.0093 0.0093
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0075
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1132 0.13
Echinococcus multilocularis tumor protein p63 0.0335 0.3362 0.386
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.026 0.3519
Toxoplasma gondii exonuclease III APE 0.0058 0.0454 0.3765
Brugia malayi polk-prov protein 0.003 0.0163 0.0187
Schistosoma mansoni cpg binding protein 0.0031 0.0173 0.0225
Echinococcus multilocularis dna polymerase kappa 0.004 0.0265 0.0305
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.077 0.1001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1308 0.5294
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0197 0.135
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.1123 0.1289
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0454 0.3617
Echinococcus granulosus intermediate filament protein 0.0107 0.097 0.1114
Loa Loa (eye worm) ctsf protein 0.0019 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0133 0.124 0.1612
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Brugia malayi hypothetical protein 0.002 0.0058 0.0067
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0454 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.1972
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0107 0.0965 0.0927
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0057
Loa Loa (eye worm) fibroinase 0.0019 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi metabotropic glutamate receptor type 2 0.0356 0.3576 0.4105
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0138 0.0159
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Mycobacterium tuberculosis Probable reductase 0.0125 0.1161 0.4678
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0138 0.018
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1132 0.1472
Brugia malayi Doublecortin family protein 0.002 0.0058 0.0067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0342 0.0342
Schistosoma mansoni blooms syndrome DNA helicase 0.0047 0.0333 0.0433
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0542 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0448 0.0448
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0048 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0339 0.0339
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0138 0.0159
Echinococcus multilocularis glutamate receptor 2 0.0201 0.1955 0.2245
Leishmania major hypothetical protein, conserved 0.0025 0.0107 0.0554
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.026 0.5238
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0198 0.1583
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1161 0.4678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Schistosoma mansoni lipoxygenase 0.002 0.0058 0.0075
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0248 0.0285
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0248 0.025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0052
Onchocerca volvulus 0.0028 0.0138 0.009
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0107 0.0579
Echinococcus multilocularis expressed protein 0.0748 0.7694 0.8835
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0454 0.3635
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0454 0.3635
Brugia malayi 6-phosphofructokinase 0.0126 0.1171 0.1345
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0203 0.0602
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.026 0.0298
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0223 0.1557
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0064
Echinococcus multilocularis cpg binding protein 0.0031 0.0173 0.0198
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0026 0.012 0.0314
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0442 0.0508
Trypanosoma brucei trypanothione reductase 0.0055 0.0422 0.3521
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0068 0.056 0.0643
Schistosoma mansoni glutamate receptor AMPA 0.0104 0.094 0.1222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Loa Loa (eye worm) RecQ helicase 0.0067 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0049 0.036 0.036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1161 0.4678
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Treponema pallidum glutamate transporter 0.0109 0.0991 0.3595
Echinococcus granulosus tyrosine kinase 0.0097 0.0861 0.0988
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0454 0.1716
Brugia malayi hypothetical protein 0.0026 0.012 0.0138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0138 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Echinococcus multilocularis bloom syndrome protein 0.0067 0.0545 0.0625
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0454 0.3802
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0317 0.3174 0.3644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Echinococcus granulosus metabotropic glutamate receptor 2 0.0586 0.5993 0.6882
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0138 0.0159
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0107 0.0965 0.0965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0138 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.029
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0203 0.147
Schistosoma mansoni hypothetical protein 0.0158 0.1506 0.1957
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0107 0.0965 0.1108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0138 0.0159
Echinococcus granulosus dnaJ subfamily B 0.0421 0.426 0.4891
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0056 0.0043
Entamoeba histolytica recQ family DNA helicase 0.002 0.0056 0.0072
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0107 0.0801
Onchocerca volvulus 0.0097 0.0861 0.0821
Chlamydia trachomatis endonuclease IV 0.0077 0.0654 0.2554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1171 0.4721
Brugia malayi PXA domain containing protein 0.0038 0.0248 0.0285
Echinococcus granulosus expressed protein 0.0034 0.0206 0.0236
Brugia malayi PXA domain containing protein 0.0038 0.0248 0.0285
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0246 0.2431 0.3159
Echinococcus granulosus neutral amino acid transporter A 0.0246 0.2431 0.2791
Brugia malayi hypothetical protein 0.0016 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.1024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1161 0.4678
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Brugia malayi Receptor family ligand binding region containing protein 0.0097 0.0861 0.0988
Echinococcus granulosus atrial natriuretic peptide receptor 0.0097 0.0861 0.0988
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0107 0.0574
Schistosoma mansoni glutamate receptor NMDA 0.0104 0.094 0.1222
Echinococcus granulosus excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Brugia malayi nuclear receptor NHR-88 0.0028 0.0138 0.0159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0442 0.304
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0138 0.0159
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0654 0.5655
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0249 0.0285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0138 0.0159
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1171 0.1523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.077 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1161 0.8825
Echinococcus granulosus neutral amino acid transporter A 0.0246 0.2431 0.2791
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.2807 0.3224
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0248 0.0248
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0214 0.1499
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0138 0.0159
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.0283 0.2204
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0454 0.0522
Echinococcus granulosus metabotropic glutamate receptor 5 0.0845 0.8709 1
Mycobacterium ulcerans arylsulfatase AtsD 0.0026 0.012 0.0573
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Schistosoma mansoni lozenge 0.0065 0.0523 0.068
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0197 0.135
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Trypanosoma brucei unspecified product 0.0034 0.0198 0.1583
Brugia malayi hypothetical protein 0.0099 0.0888 0.1019
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Echinococcus multilocularis phospholipase A 2 activating protein 0.0035 0.0214 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Brugia malayi Pre-SET motif family protein 0.0122 0.1123 0.1289
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0138 0.0159
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0138 0.0159
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0248 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Chlamydia trachomatis glutamate symporter 0.0246 0.2431 1
Echinococcus multilocularis lamin 0.0107 0.097 0.1114
Schistosoma mansoni hypothetical protein 0.0107 0.0965 0.1255
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1171 0.1523
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0026 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0039 0.026 0.026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.022 0.0252
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1132 0.9655
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.1024
Echinococcus granulosus excitatory amino acid transporter 3 0.0246 0.2431 0.2791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0183 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0248 0.0285
Mycobacterium tuberculosis Possible hydrolase 0.0026 0.012 0.0314
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0144 0.1351 0.5475
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) glutathione reductase 0.0055 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0049
Echinococcus granulosus lamin 0.0107 0.097 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0254 0.2514 0.2887
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0249 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.0545 0.0548
Brugia malayi ecdysteroid receptor 0.0028 0.0138 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0093 0.0122
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0654 0.2554
Brugia malayi follicle stimulating hormone receptor 0.0279 0.2776 0.3187
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0317 0.3174 0.3644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0888 0.1019
Schistosoma mansoni hypothetical protein 0.0068 0.056 0.0728
Mycobacterium ulcerans endonuclease IV 0.0077 0.0654 0.4665
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0138 0.018
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0317 0.3174 0.3644
Brugia malayi intermediate filament protein 0.0107 0.097 0.1114
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0845 0.8709 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0201 0.1955 0.2245
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.026 0.026
Leishmania major hypothetical protein, conserved 0.0035 0.0214 0.1499
Echinococcus granulosus cathepsin l1 0.0019 0.0049 0.0057
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0248 0.0285
Loa Loa (eye worm) inositol-1 0.0036 0.0223 0.0223
Echinococcus multilocularis expressed protein 0.0034 0.0206 0.0236
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0248 0.0285
Trichomonas vaginalis rotamase, putative 0.0034 0.0206 0.0207
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0442 0.0575
Schistosoma mansoni glutamate receptor AMPA 0.0104 0.094 0.1222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4413
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0204 0.1981 0.1981
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.005 0.0368 0.0368
Loa Loa (eye worm) intermediate filament protein 0.0107 0.097 0.097
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0201 0.1955 0.2245
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Loa Loa (eye worm) cysteine protease 0.0019 0.0049 0.0049
Schistosoma mansoni ap endonuclease 0.0058 0.0454 0.0591
Brugia malayi hypothetical protein 0.0038 0.0248 0.0285
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0248 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1171 0.428
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0248 0.0323
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0058 0.0067
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0223 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0138 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0104
Brugia malayi Excitatory amino acid transporter 0.0246 0.2431 0.279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus granulosus expressed protein 0.0748 0.7694 0.8835
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.0298
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0454 0.3799
Echinococcus multilocularis geminin 0.0174 0.1674 0.1922
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.029
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Brugia malayi phosphofructokinase 0.0126 0.1171 0.1345
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0138 0.0159
Onchocerca volvulus Poor gastrulation protein homolog 0.0107 0.0965 0.0927
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0097 0.0861 0.0988
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1171 0.8907
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0138 0.0159
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0024 0.0093 0.0681
Brugia malayi Guanylyl cyclase protein 23 0.0097 0.0861 0.0988
Schistosoma mansoni intermediate filament proteins 0.0107 0.097 0.1261
Echinococcus granulosus glutamate receptor 2 0.0133 0.124 0.1424
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0318 0.032
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0197 0.135
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0279 0.2776 0.2776
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Brugia malayi Glutamate receptor 1 precursor 0.0104 0.094 0.1079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0138 0.0159
Schistosoma mansoni ATP-binding cassette transporter 0.0104 0.094 0.1222
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0203 0.1456
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0138 0.018
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0067
Schistosoma mansoni coup transcription factor 0.0028 0.0138 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Giardia lamblia Hypothetical protein 0.0026 0.012 0.1828
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.077 0.0885
Echinococcus granulosus voltage dependent calcium channel subunit 0.0306 0.306 0.3514
Plasmodium vivax vivapain-2 0.0019 0.0049 0.0041
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0067
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0454 0.1716
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0206 0.0236
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0212 0.2066 0.2373
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0248 0.0285
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1171 0.8623
Echinococcus granulosus glutamate receptor subunit protein glur 0.0068 0.056 0.0643
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0248 0.0285
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0454 0.0457
Brugia malayi nuclear hormone receptor 0.0028 0.0138 0.0159
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0045 0.0262
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Schistosoma mansoni hypothetical protein 0.0174 0.1674 0.2176
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0138 0.0159
Echinococcus granulosus lamin dm0 0.0107 0.097 0.1114
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0138 0.0138
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0542 0.0542
Schistosoma mansoni tyrosine kinase 0.0097 0.0861 0.1119
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1171 0.1345
Echinococcus multilocularis Excitatory amino acid transporter 0.0246 0.2431 0.2791
Brugia malayi hypothetical protein 0.0038 0.0248 0.0285
Plasmodium vivax SET domain protein, putative 0.0122 0.1123 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0045 0.0045
Brugia malayi hypothetical protein 0.0515 0.5249 0.6026
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0248 0.0285
Schistosoma mansoni lipoxygenase 0.0057 0.0441 0.0573
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.097 0.1114
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) glutamate receptor 2 0.0104 0.094 0.094
Onchocerca volvulus 0.0097 0.0861 0.0821
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0457 0.3657
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0067
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0203 0.0664
Plasmodium vivax vivapain-2 0.0019 0.0049 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0223 0.0746
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0058 0.0054
Onchocerca volvulus 0.002 0.0058 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0138 0.018
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0265 0.1687
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0248 0.0285
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0138 0.0159
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0026 0.012 0.0071
Loa Loa (eye worm) runx1 0.0065 0.0523 0.0523
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.0991 0.1288
Chlamydia trachomatis neutral amino acid transporter 0.0109 0.0991 0.3966
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Loa Loa (eye worm) hypothetical protein 0.0515 0.5249 0.5249
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0049 0.0057
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0248 0.0248
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0422 0.3347
Plasmodium vivax glutathione reductase, putative 0.0055 0.0422 0.3499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0138 0.0138
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0248 0.0285
Echinococcus multilocularis GPCR, family 3, C terminal 0.0107 0.0965 0.1109
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Echinococcus granulosus glutamate receptor 2 0.0201 0.1955 0.2245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0318 0.2406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.036 0.0468

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 330 nM In vitro antagonist activity was determined by the ability to antagonize the contractile response to angiotensin II in the isolated rabbit aortic strips ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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