Detailed information for compound 74953

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.527 | Formula: C14H18N6O2S3
  • H donors: 3 H acceptors: 3 LogP: 0.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=C(NS(=O)(=O)c1ccccc1)CCSCc1csc(n1)NC(=N)N
  • InChi: 1S/C14H18N6O2S3/c15-12(20-25(21,22)11-4-2-1-3-5-11)6-7-23-8-10-9-24-14(18-10)19-13(16)17/h1-5,9H,6-8H2,(H2,15,20)(H4,16,17,18,19)
  • InChiKey: VVCMIVOVMXKHHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0109 0.0991 0.1138
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0068 0.056 0.0643
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1132 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.0991 0.1288
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0203 0.1456
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0075
Echinococcus multilocularis nmda type glutamate receptor 0.0097 0.0861 0.0988
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0138 0.0159
Echinococcus granulosus nmda type glutamate receptor 0.0097 0.0861 0.0988
Plasmodium falciparum polyubiquitin binding protein, putative 0.0035 0.0214 0.2771
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0138 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0549 0.0714
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) doublecortin family protein 0.002 0.0058 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0049 0.0039
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1171 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0144 0.1351 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0542 0.4413
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0061 0.0066
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.1123 0.1289
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0058 0.0009
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0239 0.2353 0.3059
Entamoeba histolytica hypothetical protein 0.0097 0.0861 0.7234
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0138 0.018
Echinococcus granulosus geminin 0.0174 0.1674 0.1922
Onchocerca volvulus 0.003 0.0155 0.0107
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0654 0.4772
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0454 1
Loa Loa (eye worm) glutamate receptor 0.0693 0.7114 0.7114
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0059
Echinococcus multilocularis excitatory amino acid transporter 3 0.0246 0.2431 0.2791
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0454 0.6719
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0068 0.056 0.0643
Echinococcus multilocularis Excitatory amino acid transporter 0.0246 0.2431 0.2791
Onchocerca volvulus 0.0515 0.5249 0.526
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0239 0.2353 0.2353
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0262
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0058 0.0067
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0306 0.306 0.3514
Echinococcus granulosus leukotriene A 4 hydrolase 0.0239 0.2353 0.2702
Brugia malayi hypothetical protein 0.002 0.0058 0.0067
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0542 0.4397
Schistosoma mansoni lamin 0.0107 0.097 0.1261
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0422 0.0485
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1308 0.5294
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0068 0.056 0.0643
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0049 0.0072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1308 0.5294
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.026 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1171 1
Echinococcus multilocularis nmda type glutamate receptor 0.0212 0.2066 0.2373
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0197 0.1325
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0035 0.0214 0.0215
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1132 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Echinococcus multilocularis excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Echinococcus granulosus sodium:dicarboxylate symporter 0.0246 0.2431 0.2791
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1171 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1161 0.4678
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1801
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0542 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0265 0.1687
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0442 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.0122 0.1123 0.1123
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0223 0.0224
Loa Loa (eye worm) hypothetical protein 0.0052 0.0388 0.0388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.022 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Schistosoma mansoni loxhd1 0.002 0.0058 0.0075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0274 0.211
Loa Loa (eye worm) hypothetical protein 0.0099 0.0888 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0155 0.0155
Plasmodium falciparum thioredoxin reductase 0.0055 0.0422 0.6187
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0845 0.8709 0.8709
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0246 0.2431 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0248 0.0285
Mycobacterium tuberculosis Probable sulfatase 0.0026 0.012 0.0314
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0223 0.1638
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0049 0.0057
Mycobacterium ulcerans epimerase 0.002 0.0058 0.0099
Brugia malayi Sulfatase family protein 0.0026 0.012 0.0138
Echinococcus multilocularis RUN 0.002 0.0058 0.0067
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0203 0.0664
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0049 0.0072
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Brugia malayi Metabotropic glutamate receptor precursor. 0.0693 0.7114 0.8166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0138 0.0138
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1171 0.1171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0442 0.304
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0248 0.0323
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0246 0.2431 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0402 0.0402
Schistosoma mansoni hypothetical protein 0.0421 0.426 0.5537
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.1123 0.991
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0148 0.14 0.1819
Loa Loa (eye worm) hypothetical protein 0.0515 0.5249 0.5249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0246 0.2431 0.2791
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0248 0.0248
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0454 0.0522
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0138 0.009
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0448 0.0514
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0049 0.001
Echinococcus granulosus cpg binding protein 0.0031 0.0173 0.0198
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.0545 0.0548
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0248 0.0285
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Brugia malayi 6-phosphofructokinase 0.0126 0.1171 0.1345
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0554
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0248 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0 0.00000000017198
Brugia malayi Pre-SET motif family protein 0.0845 0.8711 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0104 0.094 0.1079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0845 0.8711 0.8711
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0265 0.2167
Mycobacterium ulcerans arylsulfatase AtsD 0.0026 0.012 0.0573
Brugia malayi SET domain containing protein 0.0016 0.0016 0.0018
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0248 0.0323
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0061 0.014
Schistosoma mansoni alkaline phosphatase 0.0317 0.3174 0.4125
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.1972
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0138 0.0159
Echinococcus granulosus RUN 0.002 0.0058 0.0067
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0138 0.0159
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.026 0.0298
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0442 0.0508
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0454 0.3635
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0144 0.1351 0.5475
Echinococcus granulosus neutral amino acid transporter 0.0246 0.2431 0.2791
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0422 0.158
Loa Loa (eye worm) glutamate receptor 0.0259 0.256 0.256
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0057
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0067
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0197 0.1399
Echinococcus granulosus tumor protein p63 0.0335 0.3362 0.386
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0097 0.0861 0.0988
Schistosoma mansoni DNA helicase recq1 0.0039 0.026 0.0337
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0203 0.3868
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0058 0.0099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0138 0.0159
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Brugia malayi hypothetical protein 0.0025 0.0107 0.0123
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0138 0.0159
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0454 0.3135
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0248 0.0285
Echinococcus multilocularis musashi 0.0107 0.097 0.1114
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0422 0.0422
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Onchocerca volvulus 0.0107 0.097 0.0932
Loa Loa (eye worm) hypothetical protein 0.0204 0.1981 0.1981
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Echinococcus granulosus dna polymerase kappa 0.004 0.0265 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Leishmania major DNA polymerase kappa, putative 0.0021 0.0061 0.014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0138 0.0159
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0596 0.6098 0.7
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Toxoplasma gondii PUL domain-containing protein 0.0035 0.0214 0.1553
Onchocerca volvulus 0.0107 0.097 0.0932
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0223 0.1363
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0058 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0623 0.5136
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0138 0.018
Brugia malayi hypothetical protein 0.0371 0.3742 0.4295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0107
Echinococcus granulosus Excitatory amino acid transporter 0.0246 0.2431 0.2791
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0265 0.2167
Brugia malayi Inositol-1 0.0036 0.0223 0.0256
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Echinococcus granulosus phospholipase A 2 activating protein 0.0035 0.0214 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0586 0.5993 0.6882
Schistosoma mansoni serine-rich repeat protein 0.0158 0.1506 0.1957
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0248 0.0285
Echinococcus multilocularis receptor type guanylyl cyclase 0.0097 0.0861 0.0988
Entamoeba histolytica hypothetical protein 0.0023 0.0086 0.0335
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0056 0.0073
Echinococcus granulosus voltage dependent calcium channel subunit 0.0674 0.6914 0.7939
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2807 0.3649
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0136 0.1268 0.1268
Schistosoma mansoni hypothetical protein 0.0174 0.1674 0.2176
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0049 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0061 0.0397
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Brugia malayi steroid hormone receptor 0.0028 0.0138 0.0159
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4413
Leishmania major trypanothione reductase 0.0055 0.0422 0.3347
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0454 0.0457
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0077 0.0654 0.0654
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.0298
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0248 0.0323
Echinococcus granulosus excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Trichomonas vaginalis set domain proteins, putative 0.0962 0.9935 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0422 0.0485
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.027 0.2677 1
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0138 0.0159
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0138 0.0138
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0265 0.0267
Giardia lamblia Hypothetical protein 0.0026 0.012 0.1828
Brugia malayi hypothetical protein 0.0036 0.022 0.0252
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0068 0.056 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Onchocerca volvulus 0.0099 0.0888 0.0848
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0674 0.6914 0.7939
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0441 0.0506
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Brugia malayi hypothetical protein 0.011 0.0998 0.1146
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0144 0.1351 0.4963
Brugia malayi Receptor family ligand binding region containing protein 0.0204 0.1981 0.2274
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0204 0.1981 0.1981
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis glutamate receptor 2 0.0133 0.124 0.1424
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0248 0.0285
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0138 0.018
Echinococcus multilocularis glutamate receptor 2 0.0104 0.094 0.1079
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0294 0.2929 0.3807
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0203 0.0205
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0486 0.7231
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0317 0.3174 0.3644
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0368 0.0368
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0422 0.3499
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0045 0.0052
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0138 0.018
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0138 0.018
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0049 0.0057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2428
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0203 0.2599
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0285
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0058 0.0067
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0203 0.1381
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0203 0.2599
Mycobacterium ulcerans sulfatase 0.0026 0.012 0.0573
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0214 0.1499
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0163 0.1283
Echinococcus multilocularis lamin dm0 0.0107 0.097 0.1114
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0049 0.001
Brugia malayi Glutamate receptor 2 precursor 0.0104 0.094 0.1079
Brugia malayi WD domain containing protein 0.0035 0.0214 0.0246
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0224
Brugia malayi Thioredoxin reductase 0.0055 0.0422 0.0484
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Onchocerca volvulus 0.0049 0.036 0.0314
Schistosoma mansoni cpg binding protein 0.0031 0.0173 0.0225
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0454 0.1556
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0026 0.012 0.0314
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0441 0.0506
Schistosoma mansoni polycystin 1-related 0.002 0.0058 0.0075
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0024 0.0093 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0052 0.0388 0.0446
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Toxoplasma gondii endonuclease IV APN 0.0077 0.0654 0.5604
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0104 0.094 0.1079
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0206 0.0207
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1171 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0045 0.0262
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0248 0.0285
Schistosoma mansoni lamin 0.0107 0.097 0.1261
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Echinococcus multilocularis tyrosine kinase 0.0097 0.0861 0.0988
Giardia lamblia DINP protein human, muc B family 0.0021 0.0061 0.0384
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0654 1
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0093 0.0093
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0203 0.147
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.077 0.0885
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Loa Loa (eye worm) glutamate receptor 1 0.0104 0.094 0.094
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.8597 0.9872
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Entamoeba histolytica cysteine protease, putative 0.0019 0.0049 0.001
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0542 0.0705
Schistosoma mansoni metabotropic glutamate receptor 0.0356 0.3576 0.4648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0138 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Treponema pallidum glutamate/aspartate transporter 0.0109 0.0991 0.3595
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0246 0.2431 0.2409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Onchocerca volvulus 0.0962 0.9935 1
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0203 0.1456
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2428
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0058 0.0211
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0138 0.018
Trichomonas vaginalis rotamase, putative 0.0034 0.0197 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0442 0.1665
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2807 0.3649
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.426 0.4891
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0248 0.0323
Schistosoma mansoni cpg binding protein 0.003 0.0155 0.0202
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0144 0.1351 0.4963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.0545 0.0625
Toxoplasma gondii cathepsin CPL 0.0019 0.0049 0.004
Onchocerca volvulus 0.0099 0.0888 0.0848
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0075
Plasmodium falciparum glutathione reductase 0.0055 0.0422 0.6187
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1171 0.1171
Toxoplasma gondii thioredoxin reductase 0.0055 0.0422 0.3467
Echinococcus granulosus nmda type glutamate receptor 0.0212 0.2066 0.2373
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0748 0.7693 1
Schistosoma mansoni metabotropic glutamate receptor 0.0586 0.5993 0.7791
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0138 0.0159
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0248 0.0248
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.1123 0.1289
Brugia malayi CXXC zinc finger family protein 0.003 0.0155 0.0178
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0109 0.0991 0.1138
Schistosoma mansoni glutamate receptor kainate 0.0104 0.094 0.1222
Echinococcus granulosus alkaline phosphatase 0.0317 0.3174 0.3644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Schistosoma mansoni protein kinase 0.0097 0.0861 0.1119
Mycobacterium ulcerans arylsulfatase, AslA 0.0026 0.012 0.0573
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0197 0.1577
Brugia malayi Cache domain containing protein 0.0136 0.1268 0.1456
Schistosoma mansoni ap endonuclease 0.0058 0.0454 0.0591
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0052 0.0388 0.0446
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1171 0.1171
Schistosoma mansoni alkaline phosphatase 0.0317 0.3174 0.4125
Schistosoma mansoni hypothetical protein 0.0165 0.1575 0.2047
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0248 0.0285
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0442 0.3526
Trypanosoma cruzi extracellular receptor, putative 0.0097 0.0861 0.7242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.1069 0.1228
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.022 0.0285
Chlamydia trachomatis glutamine binding protein 0.0144 0.1351 0.5475
Loa Loa (eye worm) excitatory amino acid transporter 0.0246 0.2431 0.2431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis alkaline phosphatase 0.0317 0.3174 0.3644
Loa Loa (eye worm) hypothetical protein 0.0105 0.095 0.095
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi hypothetical protein 0.0097 0.0861 0.0988
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0045 0.0045
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0262
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0246 0.2431 0.2791
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1161 0.4678
Echinococcus granulosus bloom syndrome protein 0.0067 0.0545 0.0625
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0049 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.01
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0223 0.0256
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0068 0.056 0.0643
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0026 0.012 0.012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0183 0.058
Brugia malayi glutathione reductase 0.0055 0.0422 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0248 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0138 0.0159
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.026 0.0298
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0097 0.0861 0.0861
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0454 0.0454
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0248 0.0285
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0248 0.0285
Echinococcus granulosus GPCR family 3 C terminal 0.0107 0.0965 0.1109
Schistosoma mansoni tyrosine kinase 0.0097 0.0861 0.1119
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1132 0.1472
Onchocerca volvulus 0.002 0.0058 0.0009
Echinococcus multilocularis Protein lozenge 0.0065 0.0523 0.0601
Schistosoma mansoni DNA helicase recq5 0.0039 0.026 0.0337
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.097 0.097
Onchocerca volvulus 0.0133 0.124 0.1204
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0318 0.2626
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0317 0.3174 0.3644
Schistosoma mansoni hypothetical protein 0.0254 0.2514 0.3268
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0248 0.0285
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0654 0.0751
Mycobacterium ulcerans hypothetical protein 0.002 0.0058 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus Excitatory amino acid transporter 0.0246 0.2431 0.2791
Mycobacterium ulcerans arylsulfatase AtsB 0.0026 0.012 0.0573
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1308 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0888 0.0888
Schistosoma mansoni glutamate receptor NMDA 0.0201 0.1955 0.2542
Schistosoma mansoni rotamase 0.0034 0.0206 0.0267
Echinococcus granulosus intestinal type alkaline phosphatase 0.0317 0.3174 0.3644
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0049 0.0049
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0097 0.0861 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Leishmania major cathepsin L-like protease 0.0074 0.0623 0.5136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus multilocularis NMDA receptor 0.0068 0.056 0.0643
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0239 0.2353 0.2702
Entamoeba histolytica hypothetical protein 0.0038 0.0248 0.178
Brugia malayi Cytochrome P450 family protein 0.0047 0.0339 0.0389
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0554
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0254 0.2514 0.2887
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0542 0.0623
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Echinococcus granulosus receptor type guanylyl cyclase 0.0097 0.0861 0.0988
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0448 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0138 0.0159
Schistosoma mansoni blooms syndrome DNA helicase 0.0047 0.0333 0.0433
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0542 0.0622
Loa Loa (eye worm) hypothetical protein 0.0047 0.0342 0.0342
Brugia malayi Doublecortin family protein 0.002 0.0058 0.0067
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0138 0.0159
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0339 0.0339
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0048 0.003
Echinococcus multilocularis glutamate receptor 2 0.0201 0.1955 0.2245
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.026 0.5238
Leishmania major hypothetical protein, conserved 0.0025 0.0107 0.0554
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.1972
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0454 0.0522
Brugia malayi hypothetical protein 0.002 0.0058 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Loa Loa (eye worm) ctsf protein 0.0019 0.0049 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0133 0.124 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0107 0.0965 0.0927
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi metabotropic glutamate receptor type 2 0.0356 0.3576 0.4105
Loa Loa (eye worm) fibroinase 0.0019 0.0049 0.0049
Echinococcus multilocularis cysteine protease 0.0019 0.0049 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1132 0.1472
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0138 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Mycobacterium tuberculosis Probable reductase 0.0125 0.1161 0.4678
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0206 0.0206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0138 0.0159
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1132 0.13
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0093 0.0093
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1132 0.4558
Mycobacterium ulcerans hydrolase 0.0026 0.012 0.0573
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0248 0.0285
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.026 0.3519
Echinococcus multilocularis tumor protein p63 0.0335 0.3362 0.386
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0454 0.3617
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.1123 0.1289
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0197 0.135
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1308 0.5294
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.077 0.1001
Echinococcus multilocularis dna polymerase kappa 0.004 0.0265 0.0305
Schistosoma mansoni cpg binding protein 0.0031 0.0173 0.0225
Toxoplasma gondii exonuclease III APE 0.0058 0.0454 0.3765
Brugia malayi polk-prov protein 0.003 0.0163 0.0187
Echinococcus granulosus intermediate filament protein 0.0107 0.097 0.1114
Leishmania major extracellular receptor, putative 0.0097 0.0861 0.7242
Loa Loa (eye worm) hypothetical protein 0.0107 0.097 0.097
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0265 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0479 0.3992
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0138 0.0138
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0556 0.4536
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0163 0.1283
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0138 0.0159
Echinococcus granulosus metabotropic glutamate receptor 2 0.0586 0.5993 0.6882
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Loa Loa (eye worm) RGC/RGC protein kinase 0.0097 0.0861 0.0861
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0138 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0138 0.0159
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0107 0.0965 0.1108
Schistosoma mansoni hypothetical protein 0.0158 0.1506 0.1957
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0203 0.147
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0033
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.029
Loa Loa (eye worm) hypothetical protein 0.0049 0.036 0.036
Loa Loa (eye worm) RecQ helicase 0.0067 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0454 0.1716
Echinococcus granulosus tyrosine kinase 0.0097 0.0861 0.0988
Treponema pallidum glutamate transporter 0.0109 0.0991 0.3595
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1161 0.4678
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Echinococcus multilocularis bloom syndrome protein 0.0067 0.0545 0.0625
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0138 0.0159
Brugia malayi hypothetical protein 0.0026 0.012 0.0138
Leishmania major cathepsin L-like protease 0.0019 0.0049 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0454 0.3802
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0317 0.3174 0.3644
Brugia malayi 6-phosphofructokinase 0.0126 0.1171 0.1345
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0454 0.3635
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0454 0.3635
Onchocerca volvulus 0.0028 0.0138 0.009
Echinococcus multilocularis expressed protein 0.0748 0.7694 0.8835
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0107 0.0579
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0052
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0248 0.025
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0203 0.0602
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.026 0.0298
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0223 0.1557
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0442 0.0508
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0068 0.056 0.0643
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0026 0.012 0.0314
Schistosoma mansoni glutamate receptor AMPA 0.0104 0.094 0.1222
Trypanosoma brucei trypanothione reductase 0.0055 0.0422 0.3521
Echinococcus multilocularis cpg binding protein 0.0031 0.0173 0.0198
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0198 0.1583
Schistosoma mansoni lipoxygenase 0.002 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1161 0.4678
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0049 0.0072
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0248 0.0285
Echinococcus granulosus neutral amino acid transporter A 0.0246 0.2431 0.2791
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1161 0.8825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.077 0.1001
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0214 0.1499
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1171 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.2807 0.3224
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0248 0.0248
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4559
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.0283 0.2204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0138 0.0159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0107 0.0574
Echinococcus granulosus atrial natriuretic peptide receptor 0.0097 0.0861 0.0988
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0654 0.5655
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0138 0.0159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0442 0.304
Echinococcus granulosus excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Brugia malayi nuclear receptor NHR-88 0.0028 0.0138 0.0159
Schistosoma mansoni glutamate receptor NMDA 0.0104 0.094 0.1222
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0249 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0049 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1171 0.1523
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0138 0.0159
Brugia malayi hypothetical protein 0.0016 0.0014 0.0017
Echinococcus granulosus neutral amino acid transporter A 0.0246 0.2431 0.2791
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.1024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1161 0.4678
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Brugia malayi Receptor family ligand binding region containing protein 0.0097 0.0861 0.0988
Entamoeba histolytica recQ family DNA helicase 0.002 0.0056 0.0072
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0056 0.0043
Echinococcus granulosus dnaJ subfamily B 0.0421 0.426 0.4891
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Onchocerca volvulus 0.0097 0.0861 0.0821
Chlamydia trachomatis endonuclease IV 0.0077 0.0654 0.2554
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0107 0.0801
Echinococcus granulosus expressed protein 0.0034 0.0206 0.0236
Brugia malayi PXA domain containing protein 0.0038 0.0248 0.0285
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1171 0.4721
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0246 0.2431 0.3159
Brugia malayi PXA domain containing protein 0.0038 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0144 0.1351 0.5475
Echinococcus multilocularis neutral amino acid transporter A 0.0246 0.2431 0.2791
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0254 0.2514 0.2887
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus lamin 0.0107 0.097 0.1114
Loa Loa (eye worm) glutathione reductase 0.0055 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Brugia malayi ecdysteroid receptor 0.0028 0.0138 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.0545 0.0548
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0249 0.0285
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0093 0.0122
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0026 0.012 0.012
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1171 0.1523
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.022 0.0252
Loa Loa (eye worm) hypothetical protein 0.0039 0.026 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus granulosus excitatory amino acid transporter 3 0.0246 0.2431 0.2791
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.1024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1132 0.9655
Mycobacterium tuberculosis Possible hydrolase 0.0026 0.012 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0183 0.1004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0248 0.0285
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0248 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Brugia malayi Cathepsin L-like precursor 0.0019 0.0049 0.0057
Chlamydia trachomatis glutamate symporter 0.0246 0.2431 1
Schistosoma mansoni hypothetical protein 0.0107 0.0965 0.1255
Echinococcus multilocularis lamin 0.0107 0.097 0.1114
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0138 0.0159
Schistosoma mansoni lozenge 0.0065 0.0523 0.068
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Echinococcus granulosus metabotropic glutamate receptor 5 0.0845 0.8709 1
Mycobacterium ulcerans arylsulfatase AtsD 0.0026 0.012 0.0573
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0454 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0049 0.0064
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0201 0.1955 0.2245
Trypanosoma brucei unspecified product 0.0034 0.0198 0.1583
Brugia malayi hypothetical protein 0.0099 0.0888 0.1019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0197 0.135
Echinococcus multilocularis phospholipase A 2 activating protein 0.0035 0.0214 0.0246
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0138 0.0159
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0138 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Brugia malayi Pre-SET motif family protein 0.0122 0.1123 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0058 0.0067
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0248 0.0323
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1171 0.428
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0056 0.0104
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0223 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0138 0.009
Brugia malayi Excitatory amino acid transporter 0.0246 0.2431 0.279
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0454 0.3799
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.026 0.0298
Echinococcus granulosus expressed protein 0.0748 0.7694 0.8835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0368 0.0368
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0248 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0201 0.1955 0.2245
Loa Loa (eye worm) intermediate filament protein 0.0107 0.097 0.097
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0248 0.0285
Brugia malayi hypothetical protein 0.0038 0.0248 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Schistosoma mansoni ap endonuclease 0.0058 0.0454 0.0591
Loa Loa (eye worm) cysteine protease 0.0019 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0248
Leishmania major hypothetical protein, conserved 0.0035 0.0214 0.1499
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.026 0.026
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0201 0.1955 0.2245
Trichomonas vaginalis rotamase, putative 0.0034 0.0206 0.0207
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0248 0.0285
Loa Loa (eye worm) inositol-1 0.0036 0.0223 0.0223
Echinococcus multilocularis expressed protein 0.0034 0.0206 0.0236
Echinococcus granulosus cathepsin l1 0.0019 0.0049 0.0057
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0248 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0542 0.4413
Schistosoma mansoni glutamate receptor AMPA 0.0104 0.094 0.1222
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0442 0.0575
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0204 0.1981 0.1981
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0623 0.5263
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0317 0.3174 0.3644
Brugia malayi follicle stimulating hormone receptor 0.0279 0.2776 0.3187
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0654 0.2554
Schistosoma mansoni hypothetical protein 0.0068 0.056 0.0728
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0888 0.1019
Brugia malayi intermediate filament protein 0.0107 0.097 0.1114
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0845 0.8709 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0317 0.3174 0.3644
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0138 0.018
Mycobacterium ulcerans endonuclease IV 0.0077 0.0654 0.4665
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus multilocularis excitatory amino acid transporter 2 0.0246 0.2431 0.2791
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0248 0.0285
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0454 0.0457
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.1525
Brugia malayi nuclear hormone receptor 0.0028 0.0138 0.0159
Schistosoma mansoni hypothetical protein 0.0174 0.1674 0.2176
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0623 0.5136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0045 0.0262
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0542 0.0542
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0138 0.0138
Echinococcus granulosus lamin dm0 0.0107 0.097 0.1114
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0138 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0049 0.005
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.077 0.0885
Giardia lamblia Hypothetical protein 0.0026 0.012 0.1828
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0248 0.025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0212 0.2066 0.2373
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0206 0.0236
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0454 0.1716
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0067
Echinococcus granulosus voltage dependent calcium channel subunit 0.0306 0.306 0.3514
Plasmodium vivax vivapain-2 0.0019 0.0049 0.0041
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0248 0.0285
Echinococcus granulosus glutamate receptor subunit protein glur 0.0068 0.056 0.0643
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1171 0.8623
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1171 0.1179
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0197 0.135
Schistosoma mansoni intermediate filament proteins 0.0107 0.097 0.1261
Echinococcus granulosus glutamate receptor 2 0.0133 0.124 0.1424
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0318 0.032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0138 0.0159
Brugia malayi Glutamate receptor 1 precursor 0.0104 0.094 0.1079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1132 0.8325
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0279 0.2776 0.2776
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0203 0.1456
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0138 0.018
Schistosoma mansoni ATP-binding cassette transporter 0.0104 0.094 0.1222
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0265 0.1956
Schistosoma mansoni coup transcription factor 0.0028 0.0138 0.018
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0067
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Brugia malayi phosphofructokinase 0.0126 0.1171 0.1345
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.029
Echinococcus multilocularis geminin 0.0174 0.1674 0.1922
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0056 0.01
Onchocerca volvulus Poor gastrulation protein homolog 0.0107 0.0965 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0138 0.0159
Brugia malayi Guanylyl cyclase protein 23 0.0097 0.0861 0.0988
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0024 0.0093 0.0681
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1171 0.8907
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0138 0.0159
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0097 0.0861 0.0988
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0049 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0203 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Echinococcus granulosus glutamate receptor 2 0.0201 0.1955 0.2245
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Echinococcus multilocularis GPCR, family 3, C terminal 0.0107 0.0965 0.1109
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0248 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0138 0.0138
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0318 0.2406
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.036 0.0468
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0026 0.012 0.0071
Loa Loa (eye worm) runx1 0.0065 0.0523 0.0523
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0138 0.0159
Chlamydia trachomatis neutral amino acid transporter 0.0109 0.0991 0.3966
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0109 0.0991 0.1288
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0265 0.2167
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0422 0.3347
Plasmodium vivax glutathione reductase, putative 0.0055 0.0422 0.3499
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0248 0.0248
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0515 0.5249 0.5249
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.1581
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.1123 0.1459
Plasmodium vivax vivapain-2 0.0019 0.0049 0.0041
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0203 0.0664
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0223 0.0746
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0248 0.0285
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0248 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0248 0.0323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0138 0.018
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0265 0.1687
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0058 0.0054
Onchocerca volvulus 0.002 0.0058 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0058
Schistosoma mansoni tyrosine kinase 0.0097 0.0861 0.1119
Echinococcus multilocularis Excitatory amino acid transporter 0.0246 0.2431 0.2791
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1171 0.1345
Brugia malayi hypothetical protein 0.0038 0.0248 0.0285
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0248 0.0285
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.097 0.1114
Schistosoma mansoni lipoxygenase 0.0057 0.0441 0.0573
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0248 0.0285
Plasmodium vivax SET domain protein, putative 0.0122 0.1123 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0045 0.0045
Brugia malayi hypothetical protein 0.0515 0.5249 0.6026
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0067
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0201 0.1955 0.2245
Onchocerca volvulus 0.0097 0.0861 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0138 0.0159
Loa Loa (eye worm) hypothetical protein 0.0097 0.0861 0.0861
Loa Loa (eye worm) glutamate receptor 2 0.0104 0.094 0.094
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0457 0.3657

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.0000007 M Histamine H2 receptor antagonist activity (chronotropic response to histamine) in guinea pig right atrium ChEMBL. 2888895
ED50 (functional) = 0.0000007 M Histamine H2 receptor antagonist activity (chronotropic response to histamine) in guinea pig right atrium ChEMBL. 2888895
ED50 (functional) = 0.0568 mg kg-1 Reduction in gastric acid secretion under histamine[160 ug/(kg h)] stimulation in anesthetized dogs after intravenous administration ChEMBL. 2888895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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