Detailed information for compound 763613

Basic information

Technical information
  • TDR Targets ID: 763613
  • Name: (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido [1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)prop- 2-enamide
  • MW: 464.515 | Formula: C28H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 4.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)CC)nc2n(c1=O)cccc2)C(=O)NCCc1ccccc1
  • InChi: 1S/C28H24N4O3/c1-2-20-11-13-23(14-12-20)35-27-24(28(34)32-17-7-6-10-25(32)31-27)18-22(19-29)26(33)30-16-15-21-8-4-3-5-9-21/h3-14,17-18H,2,15-16H2,1H3,(H,30,33)/b22-18+
  • InChiKey: PTNLNGJJAIIAFC-RELWKKBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-phenylethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(2-phenylethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)acrylamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(2-phenylethyl)acrylamide
  • STOCK4S-33181

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0187
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0701 0.4157
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0072 0.0434 0.5783
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.013 0.152
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0518 0.3747 0.3732
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.079 0.4702
Brugia malayi nuclear hormone receptor 0.0028 0.0109 0.0354
Echinococcus granulosus lamin dm0 0.0049 0.0264 0.0769
Schistosoma mansoni sugar transporter 0.0045 0.0237 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0109 0.0354
Brugia malayi nuclear receptor RXR 0.0015 0.0012 0.0038
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0037 0.012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0043 0.0866
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Schistosoma mansoni endoplasmin 0.0031 0.013 0.0568
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Echinococcus multilocularis solute carrier family 22 0.0045 0.0237 0.0692
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0178 0.0955
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0178 0.0691
Entamoeba histolytica protein kinase, putative 0.0098 0.0631 1
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.013 0.1562
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0735 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0024 0.0084 0.1001
Echinococcus multilocularis geminin 0.0173 0.1188 0.3464
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0072 0.0434 0.0411
Leishmania major hypothetical protein, conserved 0.0037 0.0178 0.219
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0087 0.0548 0.1788
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0237 0.0692
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0037 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0109 0.0354
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus General substrate transporter 0.0276 0.1947 0.5679
Plasmodium falciparum calcium-dependent protein kinase 5 0.0098 0.0632 0.0609
Onchocerca volvulus 0.0045 0.0237 0.3134
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0364 0.1597
Schistosoma mansoni hypothetical protein 0.0038 0.0187 0.082
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Brugia malayi major facilitator superfamily protein 0.0045 0.0237 0.0774
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0109 0.0354
Brugia malayi RNA binding protein 0.0062 0.0364 0.1189
Echinococcus multilocularis solute carrier family 22 0.0045 0.0237 0.0692
Echinococcus granulosus solute carrier family 22 0.0045 0.0237 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0109 0.0354
Mycobacterium ulcerans lipase LipD 0.0037 0.0178 0.3787
Plasmodium falciparum mitogen-activated protein kinase 2 0.0518 0.3747 0.3732
Onchocerca volvulus 0.0045 0.0237 0.3134
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Schistosoma mansoni hypothetical protein 0.0065 0.0384 0.1684
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0024 0.0084 0.0381
Echinococcus granulosus expressed conserved protein 0.0087 0.0548 0.1598
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.3429 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0024 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0178 0.219
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0096 0.0617 0.1798
Brugia malayi ecdysteroid receptor 0.0028 0.0109 0.0354
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0109 0.0317
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0237 0.5239
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Loa Loa (eye worm) hypothetical protein 0.0018 0.0037 0.012
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0084 0.0276
Brugia malayi hypothetical protein 0.0015 0.0012 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0109 0.0354
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0077 0.0225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0024 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0198 0.0781
Trypanosoma cruzi hexose transporter, putative 0.01 0.0641 0.868
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0237 0.0774
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0037 0.0589
Schistosoma mansoni intermediate filament proteins 0.0049 0.0264 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0641 0.274
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0109 0.1434
Echinococcus granulosus lysyl tRNA synthetase 0.0072 0.0434 0.1265
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0024 0.0084 0.278
Trichomonas vaginalis sugar transporter, putative 0.01 0.0641 0.274
Schistosoma mansoni lamin 0.0049 0.0264 0.1156
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0012 0.0034
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0037 0.0212
Onchocerca volvulus 0.0045 0.0237 0.3134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0065 0.0384 0.112
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0095
Toxoplasma gondii lysine-tRNA ligase 0.0072 0.0434 0.0625
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0037 0.0013
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0237 0.303
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0178 0.0955
Mycobacterium ulcerans beta-lactamase 0.0037 0.0178 0.3787
Onchocerca volvulus 0.0037 0.0178 0.2343
Giardia lamblia Grp94/Hsp90 0.0024 0.0084 0.1001
Brugia malayi major facilitator superfamily protein 0.0045 0.0237 0.0774
Plasmodium falciparum endoplasmin, putative 0.0019 0.0042 0.0018
Entamoeba histolytica hypothetical protein 0.0065 0.0384 0.5843
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0096 0.0617 0.2702
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0364 0.1189
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0037 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.079 0.4702
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0072 0.0434 0.5783
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0096 0.0617 0.2011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Brugia malayi beta-lactamase family protein 0.0037 0.0178 0.0579
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0237 0.0692
Onchocerca volvulus 0.0049 0.0264 0.3481
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0037 0.012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0268 0.0875
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Brugia malayi lysyl-tRNA synthetase 0.0072 0.0434 0.1415
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0024 0.0084 0.0873
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0701 0.4157
Schistosoma mansoni hypothetical protein 0.0038 0.0187 0.082
Leishmania major lysyl-tRNA synthetase, putative 0.0072 0.0434 0.5783
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Plasmodium vivax CDK-related protein kinase 6, putative 0.1362 1 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Toxoplasma gondii ABC1 family protein 0.0037 0.0178 0.0237
Echinococcus granulosus intermediate filament protein 0.0049 0.0264 0.0769
Echinococcus multilocularis survival motor neuron protein 1 0.0427 0.3066 0.8941
Loa Loa (eye worm) RNA binding protein 0.0062 0.0364 0.1189
Trypanosoma cruzi heat shock protein 90, putative 0.0024 0.0084 0.0873
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0253 0.0229
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0037 0.0013
Echinococcus multilocularis protein dispatched 1 0.0045 0.0239 0.0698
Loa Loa (eye worm) endoplasmin 0.0031 0.013 0.0423
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Plasmodium vivax glutathione reductase, putative 0.0047 0.0253 0.0229
Toxoplasma gondii sugar transporter ST2 0.0045 0.0237 0.0327
Leishmania major protein kinase, putative 0.0098 0.0631 0.855
Trichomonas vaginalis heat shock protein, putative 0.0031 0.013 0.048
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.023
Onchocerca volvulus 0.0045 0.0237 0.3134
Echinococcus multilocularis expressed conserved protein 0.0087 0.0548 0.1598
Mycobacterium tuberculosis Conserved protein 0.0037 0.0178 0.0955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0268 0.1176
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0268 0.0782
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0042
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0096 0.0617 0.1798
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0178 0.0518
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0237 0.1322
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0109 0.0354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0109 0.0317
Loa Loa (eye worm) hypothetical protein 0.0048 0.0257 0.0839
Giardia lamblia Lysyl-tRNA synthetase 0.0072 0.0434 0.6916
Schistosoma mansoni glucose transport protein 0.0321 0.2282 1
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0042 0.0092
Mycobacterium ulcerans sugar transporter 0.0045 0.0237 0.5239
Brugia malayi Cam kinase protein 1 0.0098 0.0631 0.2059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0109 0.0317
Loa Loa (eye worm) nuclear hormone receptor 0.0098 0.0627 0.2045
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0037 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Brugia malayi hypothetical protein 0.0045 0.0237 0.0774
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0071
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Onchocerca volvulus 0.0045 0.0237 0.3134
Loa Loa (eye worm) sugar transporter 0.0321 0.2282 0.7442
Brugia malayi steroid hormone receptor 0.0028 0.0109 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0641 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.0956
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0178 0.0579
Loa Loa (eye worm) hypothetical protein 0.0072 0.0434 0.1415
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0237 0.0692
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0019
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Leishmania major glucose transporter, lmgt3 0.01 0.0641 0.868
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0109 0.0354
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0098 0.0631 0.2059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0109 0.0354
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0043 0.0125
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0037 0.096
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0043 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0109 0.0476
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0641 0.868
Brugia malayi beta-lactamase family protein 0.0037 0.0178 0.0579
Onchocerca volvulus 0.0045 0.0237 0.3134
Echinococcus multilocularis musashi 0.0049 0.0264 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Echinococcus multilocularis lysyl tRNA synthetase 0.0072 0.0434 0.1265
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.013 0.152
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0037 0.012
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0178 0.0955
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0434 0.1902
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0109 0.0476
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0237 0.303
Echinococcus multilocularis General substrate transporter 0.0276 0.1947 0.5679
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) intermediate filament protein 0.0049 0.0264 0.086
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0253 0.0825
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0109 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus survival motor neuron protein 1 0.0427 0.3066 0.8941
Brugia malayi TAR-binding protein 0.0062 0.0364 0.1189
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Mycobacterium tuberculosis Conserved protein 0.0037 0.0178 0.0955
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0237 0.0956
Brugia malayi hypothetical protein 0.0045 0.0237 0.0774
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0112 0.0735 0.1081
Echinococcus multilocularis Niemann Pick C1 protein 0.0132 0.0885 0.2579
Schistosoma mansoni hypothetical protein 0.0321 0.2282 1
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.3429 1
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Onchocerca volvulus Putative transporter 0.0045 0.0237 0.3134
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0024 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0109 0.1434
Brugia malayi Niemann-Pick C1 protein precursor 0.0093 0.059 0.1924
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0084 0.0276
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.086
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0098 0.0632 0.0925
Brugia malayi Steroid receptor seven-up type 2 0.0112 0.0736 0.2399
Loa Loa (eye worm) hypothetical protein 0.0427 0.3066 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Schistosoma mansoni sugar transporter 0.0045 0.0237 0.1041
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0735 1
Schistosoma mansoni glucose transporter 0.0045 0.0237 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0109 0.0354
Leishmania major glucose transporter, lmgt2 0.01 0.0641 0.868
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0109 0.0354
Plasmodium falciparum glutathione reductase 0.0047 0.0253 0.0229
Schistosoma mansoni patched 1 0.004 0.0198 0.0866
Brugia malayi beta-lactamase 0.0037 0.0178 0.0579
Schistosoma mansoni glucose transport protein 0.0321 0.2282 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0617 0.2011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.004 0.0198 0.0645
Trichomonas vaginalis glucose transporter, putative 0.01 0.0641 0.274
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0043 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0178 0.0778
Echinococcus granulosus Protein patched homolog 1 0.004 0.0198 0.0577
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0109 0.0476
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0096 0.0617 0.2702
Plasmodium vivax calcium-dependent protein kinase, putative 0.0098 0.0632 0.0609
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.013 0.152
Plasmodium falciparum calcium-dependent protein kinase 1 0.0098 0.0632 0.0609
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0098 0.0632 0.0925
Schistosoma mansoni hypothetical protein 0.0038 0.0187 0.082
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0109 0.0476
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0178 0.0955
Echinococcus multilocularis solute carrier family 22 0.0045 0.0237 0.0692
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0098 0.0631 0.2059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Trichomonas vaginalis esterase, putative 0.0037 0.0178 0.0691
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0024 0.0084 0.081
Echinococcus granulosus endoplasmin 0.0024 0.0084 0.0244
Echinococcus multilocularis protein patched 0.004 0.0198 0.0577
Echinococcus granulosus heat shock protein 90 0.0031 0.013 0.0378
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0178 0.3787
Brugia malayi Endoplasmin precursor 0.0031 0.013 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0109 0.0354
Onchocerca volvulus 0.0037 0.0178 0.2343
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0012 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0178 0.0154
Schistosoma mansoni sugar transporter 0.0045 0.0237 0.1041
Echinococcus multilocularis muscleblind protein 0.0129 0.0859 0.2505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0268 0.0782
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0109 0.0476
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0012 0.0038
Trypanosoma cruzi hexose transporter, putative 0.01 0.0641 0.868
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0109 0.0476
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0109 0.0317
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0109 0.0476
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Giardia lamblia Hexose transporter 0.0045 0.0237 0.3599
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0178 0.3787
Echinococcus multilocularis heat shock protein 0.0031 0.013 0.0378
Entamoeba histolytica hypothetical protein 0.0065 0.0384 0.5843
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0096 0.0617 0.9752
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0268 0.0875
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0096 0.0617 0.2011
Plasmodium vivax proline--tRNA ligase, putative 0.0112 0.0735 0.0712
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0364 0.1597
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0098 0.0632 0.0609
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0364 0.1597
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.013 0.152
Brugia malayi hypothetical protein 0.0015 0.0012 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus multilocularis endoplasmin 0.0024 0.0084 0.0244
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0178 0.0955
Brugia malayi CHE-14 protein 0.004 0.0198 0.0645
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Onchocerca volvulus 0.0028 0.0109 0.1434
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Brugia malayi intermediate filament protein 0.0049 0.0264 0.086
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0237 0.1041
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0037 0.0107
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0237 0.303
Leishmania major trypanothione reductase 0.0047 0.0253 0.3247
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Schistosoma mansoni endoplasmin 0.0031 0.013 0.0568
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0109 0.0317
Toxoplasma gondii exonuclease III APE 0.0019 0.0043 0.0033
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0037 0.0024
Echinococcus granulosus heat shock protein 90 0.0024 0.0084 0.0244
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0178 0.0691
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0306 0.3994
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0237 0.0956
Onchocerca volvulus 0.0045 0.0237 0.3134
Brugia malayi Muscleblind-like protein 0.0129 0.0859 0.2802
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0109 0.0317
Entamoeba histolytica hypothetical protein 0.0065 0.0384 0.5843
Onchocerca volvulus 0.0045 0.0237 0.3134
Plasmodium falciparum calcium-dependent protein kinase 3 0.0098 0.0632 0.0609
Brugia malayi hypothetical protein 0.0115 0.0758 0.2471
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.0354 0.2034
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0094 0.06 0.2631
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0043 0.0139
Schistosoma mansoni coup transcription factor 0.0028 0.0109 0.0476
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus Niemann Pick C1 protein 0.0132 0.0885 0.2579
Trypanosoma cruzi hexose transporter, putative 0.01 0.0641 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Plasmodium vivax hexose transporter 0.0321 0.2282 0.2263
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0096 0.0617 0.7742
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0043 0.052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.0264 0.086
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0043 0.0139
Schistosoma mansoni heat shock protein 0.0031 0.013 0.0568
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0037 0.0095
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0237 0.0774
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0631 0.2699
Brugia malayi Sugar transporter family protein 0.0045 0.0237 0.0774
Plasmodium vivax endoplasmin, putative 0.0031 0.013 0.0106
Schistosoma mansoni hypothetical protein 0.0173 0.1188 0.5207
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Onchocerca volvulus 0.0045 0.0237 0.3134
Schistosoma mansoni protein kinase 0.0098 0.0631 0.2767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0268 0.0782
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0641 0.868
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0019
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.004 0.0196 0.0639
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0109 0.0317
Onchocerca volvulus 0.0045 0.0237 0.3134
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0037 0.012
Echinococcus multilocularis Niemann Pick C1 protein 0.0093 0.059 0.172
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0037 0.0218
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0096 0.0314
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0098 0.0631 0.2059
Mycobacterium ulcerans hypothetical protein 0.0037 0.0178 0.3787
Loa Loa (eye worm) hypothetical protein 0.0096 0.0617 0.2011
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Onchocerca volvulus 0.0045 0.0237 0.3134
Onchocerca volvulus 0.0049 0.0264 0.3481
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0701 0.4157
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2282 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0024 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Brugia malayi Sugar transporter family protein 0.0045 0.0237 0.0774
Loa Loa (eye worm) hypothetical protein 0.0093 0.059 0.1924
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0109 0.0354
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0096 0.0314
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0155 0.3243
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0109 0.0354
Schistosoma mansoni hypothetical protein 0.0173 0.1188 0.5207
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0109 0.0354
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0178 0.219
Brugia malayi glutathione reductase 0.0047 0.0253 0.0825
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0024 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0065 0.0384 0.1684
Plasmodium falciparum protein kinase 7 0.0906 0.6624 0.6616
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0024 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0109 0.0317
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.013 0.1562
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0043 0.1411
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0037 0.0161
Toxoplasma gondii sugar transporter ST1 0.0045 0.0237 0.0327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0434 0.1902
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0237 0.303
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0301
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0109 0.0317
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0037 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.023
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0042 0.0092
Brugia malayi heat shock protein 90 0.0031 0.013 0.0423
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0037 0.0107
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0084 0.0276
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0098 0.0631 0.855
Leishmania major glucose transporter/membrane transporter D2, putative 0.01 0.0641 0.868
Brugia malayi Sugar transporter family protein 0.0321 0.2282 0.7442
Echinococcus multilocularis heat shock protein 90 0.0024 0.0084 0.0244
Onchocerca volvulus 0.0045 0.0237 0.3134
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0369 0.1536
Trichomonas vaginalis sugar transporter, putative 0.01 0.0641 0.274
Trypanosoma cruzi hexose transporter 0.01 0.0641 0.868
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0155 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0253 0.3247
Toxoplasma gondii facilitative glucose transporter GT1 0.0321 0.2282 0.3424
Loa Loa (eye worm) hypothetical protein 0.0098 0.0631 0.2059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0112 0.0736 0.2145
Trypanosoma brucei sugar transporter, putative 0.0045 0.0237 0.303
Brugia malayi nuclear receptor NHR-88 0.0028 0.0109 0.0354
Giardia lamblia Threonyl-tRNA synthetase 0.0018 0.0037 0.0212
Onchocerca volvulus 0.0045 0.0237 0.3134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.079 0.4702
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0037 0.0218
Echinococcus multilocularis heat shock protein 90 0.0031 0.013 0.0378
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0237 0.0956
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0024 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0631 0.2767
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0364 0.1597
Loa Loa (eye worm) sugar transporter 0.0045 0.0237 0.0774
Trichomonas vaginalis glucose transporter, putative 0.01 0.0641 0.274
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0024 0.0013
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0098 0.0632 0.0609
Echinococcus multilocularis sterol regulatory element binding protein 0.004 0.0198 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0178 0.2032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0109 0.0317
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0364 0.1597
Onchocerca volvulus 0.0037 0.0178 0.2343
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0178 0.0955
Plasmodium falciparum calcium-dependent protein kinase 4 0.0098 0.0632 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0109 0.0354
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0354 0.4326
Echinococcus granulosus lamin 0.0049 0.0264 0.0769
Plasmodium falciparum heat shock protein 90 0.0031 0.013 0.0106
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0024 0.0042
Toxoplasma gondii thioredoxin reductase 0.0047 0.0253 0.0351
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0012 0.0051
Echinococcus granulosus sterol regulatory element binding protein 0.004 0.0198 0.0577
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0112 0.0735 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0037 0.0377
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0354 0.2034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0024 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Brugia malayi hypothetical protein 0.0427 0.3066 1
Schistosoma mansoni protein kinase 0.0098 0.0631 0.2767
Plasmodium vivax heat shock protein 86, putative 0.0031 0.013 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0109 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0109 0.0354
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Loa Loa (eye worm) hypothetical protein 0.004 0.0198 0.0645
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0037 0.0202
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0043 0.0312
Echinococcus multilocularis calcium dependent protein kinase 0.0092 0.0586 0.171
Echinococcus granulosus tar DNA binding protein 0.0062 0.0364 0.1063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0178 0.0778
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Schistosoma mansoni heat shock protein 0.0031 0.013 0.0568
Onchocerca volvulus 0.0045 0.0237 0.3134
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0109 0.0317
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0518 0.3747 0.5643
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.0264 0.086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0301
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0178 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0109 0.0354
Plasmodium falciparum thioredoxin reductase 0.0047 0.0253 0.0229
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0112 0.0736 0.2145
Loa Loa (eye worm) hypothetical protein 0.0078 0.0483 0.1575
Echinococcus granulosus solute carrier family 22 0.0045 0.0237 0.0692
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0237 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0109 0.0354
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0237 0.0774
Onchocerca volvulus 0.0045 0.0237 0.3134
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0072 0.0434 0.1826
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0024 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0178 0.0691
Loa Loa (eye worm) glutathione reductase 0.0047 0.0253 0.0825
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0237 0.303
Giardia lamblia Sugar-proton symporter 0.0045 0.0237 0.3599
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0109 0.0476
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.079 1
Schistosoma mansoni hypothetical protein 0.0087 0.0548 0.2402
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0098 0.0632 0.0609
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0037 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.3429 1
Echinococcus granulosus muscleblind protein 0.0129 0.0859 0.2505
Echinococcus granulosus heat shock protein 0.0031 0.013 0.0378
Echinococcus multilocularis solute carrier family 22 0.0045 0.0237 0.0692
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0237 1
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0037 0.0218
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0109 0.0317
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0043 0.0131
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0024 0.0042
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0253 0.0738
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0042
Loa Loa (eye worm) heat shock protein 90 0.0031 0.013 0.0423
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0098 0.0632 0.0925
Treponema pallidum heat shock protein 90 0.0024 0.0084 0.4532
Plasmodium falciparum proline--tRNA ligase 0.0112 0.0735 0.0712
Plasmodium falciparum hexose transporter 0.0321 0.2282 0.2263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0178 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0037 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Leishmania major glucose transporter, lmgt1 0.01 0.0641 0.868
Trichomonas vaginalis sugar transporter, putative 0.01 0.0641 0.274
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0109 0.0476
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0037 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0701 0.8842
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Mycobacterium ulcerans heat shock protein 90 0.0024 0.0084 0.1509
Trypanosoma brucei glucose transporter 2A 0.01 0.0641 0.868
Toxoplasma gondii sugar transporter ST3 0.0045 0.0237 0.0327
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0321 0.2282 0.6654
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0178 0.0691
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0237 0.0327
Giardia lamblia Prolyl-tRNA synthetase 0.0096 0.0617 1
Schistosoma mansoni lamin 0.0049 0.0264 0.1156
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0109 0.1434
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Plasmodium vivax sugar transporter, putative 0.0045 0.0237 0.0214
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0096 0.0617 0.2634
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0037 0.0589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0024 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0043 0.0301
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0024 0.0042
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0112 0.0735 1
Entamoeba histolytica protein kinase, putative 0.0098 0.0631 1
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0364 0.1063
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0237 0.0774
Toxoplasma gondii protein kinase, putative 0.0906 0.6624 1
Echinococcus granulosus neuropeptide s receptor 0.0476 0.3429 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0859 0.2802
Onchocerca volvulus Huntingtin homolog 0.0115 0.0758 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0859 0.2802
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.013 0.152
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0065 0.0384 0.112
Echinococcus granulosus geminin 0.0173 0.1188 0.3464
Trypanosoma brucei glucose transporter, putative 0.01 0.0641 0.868
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0109 0.0354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0268 0.0782
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0109 0.0476
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0093 0.059 0.93
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0253 0.1416
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0012 0.0051
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0701 0.4157
Loa Loa (eye worm) beta-lactamase 0.0037 0.0178 0.0579
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0354
Mycobacterium leprae Probable lipase LipE 0.0037 0.0178 0.2032
Mycobacterium tuberculosis Conserved protein 0.0037 0.0178 0.0955
Echinococcus granulosus calcium dependent protein kinase 0.0092 0.0586 0.171
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0109 0.0317
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0579
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0109 0.0476
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.013 0.0164
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.013 0.152
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0701 0.4157
Brugia malayi hypothetical protein 0.0065 0.0384 0.1253
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.0861
Entamoeba histolytica hypothetical protein 0.0072 0.0434 0.6679
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0109 0.0476
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Schistosoma mansoni protein kinase 0.0098 0.0631 0.2767
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0178 0.219
Trypanosoma cruzi heat shock protein 90, putative 0.0018 0.0037 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0178 0.0691
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.013 0.178
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0095
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0237 0.5239
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0178 0.0518
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0237 0.0774
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0043 0.0301
Trypanosoma brucei trypanothione reductase 0.0047 0.0253 0.3247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0268 0.1176
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0037 0.0218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0251
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0109 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.0956
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0077 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0268 0.1176
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0109 0.0354
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0364 0.1189
Loa Loa (eye worm) hypothetical protein 0.0099 0.0639 0.2083
Leishmania major hypothetical protein, conserved 0.0045 0.0237 0.303
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0112 0.0735 1
Brugia malayi hypothetical protein 0.0045 0.0237 0.0774
Echinococcus granulosus Niemann Pick C1 protein 0.0093 0.059 0.172
Loa Loa (eye worm) hypothetical protein 0.0045 0.0237 0.0774
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0434 1
Trypanosoma cruzi heat shock protein 85, putative 0.0024 0.0084 0.0873
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0012 0.0034
Onchocerca volvulus 0.0087 0.0548 0.7235
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Trypanosoma brucei glucose transporter 1E 0.01 0.0641 0.868
Schistosoma mansoni glucose transport protein 0.0321 0.2282 1
Echinococcus granulosus solute carrier family 22 0.0045 0.0237 0.0692
Schistosoma mansoni hypothetical protein 0.0038 0.0187 0.082
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.013 0.152
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0364 0.1189
Plasmodium falciparum calcium-dependent protein kinase 2 0.0098 0.0632 0.0609
Mycobacterium tuberculosis Probable reductase 0.0108 0.0701 0.4157
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0237 0.0214
Brugia malayi Thioredoxin reductase 0.0047 0.0253 0.0825
Echinococcus multilocularis muscleblind protein 1 0.0129 0.0859 0.2505
Entamoeba histolytica hypothetical protein 0.0065 0.0384 0.5843
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0253 0.0738
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0024 0.0084 0.0244
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1657 1
Onchocerca volvulus 0.0045 0.0237 0.3134
Toxoplasma gondii heat shock protein HSP90 0.0031 0.013 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0109 0.0354
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0098 0.0631 0.1841
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0237 0.5239
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.0631 0.1841
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0109 0.0354
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0109 0.0317
Leishmania major heat shock protein 83-1 0.0031 0.013 0.152
Plasmodium vivax lysine--tRNA ligase, putative 0.0072 0.0434 0.0411
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0037 0.0307
Loa Loa (eye worm) hypothetical protein 0.0115 0.0758 0.2471
Echinococcus granulosus solute carrier family 22 0.0045 0.0237 0.0692
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0012 0.0038
Chlamydia trachomatis lysine--tRNA ligase 0.0072 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0758 0.2471
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0155 0.3193
Echinococcus multilocularis lamin dm0 0.0049 0.0264 0.0769
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0024 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0024 0.0071
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0237 0.1322
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.013 0.152
Schistosoma mansoni sugar transporter 0.0045 0.0237 0.1041
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0037 0.012
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0321 0.2282 0.6654
Onchocerca volvulus Huntingtin homolog 0.0115 0.0758 1
Trypanosoma brucei heat shock protein, putative 0.0031 0.013 0.152
Schistosoma mansoni survival motor neuron protein 0.0087 0.0548 0.2402
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0072 0.0434 0.5366
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0237 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0641 0.868
Echinococcus multilocularis lamin 0.0049 0.0264 0.0769

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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