Detailed information for compound 784342

Basic information

Technical information
  • TDR Targets ID: 784342
  • Name: 2-(3-fluorophenyl)-6-methylchromen-4-one
  • MW: 254.256 | Formula: C16H11FO2
  • H donors: 0 H acceptors: 1 LogP: 3.65 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(=O)cc(o2)c1cccc(c1)F
  • InChi: 1S/C16H11FO2/c1-10-5-6-15-13(7-10)14(18)9-16(19-15)11-3-2-4-12(17)8-11/h2-9H,1H3
  • InChiKey: ACAYJZBNMJXVIL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-fluorophenyl)-6-methyl-chromen-4-one
  • 2-(3-fluorophenyl)-6-methyl-4-chromenone
  • 2-(3-fluorophenyl)-6-methyl-chromone
  • 2-(3-Fluoro-phenyl)-6-methyl-chromen-4-one
  • BAS 01121736
  • Oprea1_830092
  • AG-205/12755014
  • A2119/0088955
  • Oprea1_132312
  • ZINC00081662

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0085 0.007
Mycobacterium ulcerans polyketide synthase Pks9 0.0021 0.0232 0.037
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1899 0.5902
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0085 0.007
Brugia malayi glutathione reductase 0.0046 0.1182 0.3633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0033 0.0694 0.1054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1621 0.2545
Mycobacterium ulcerans thioesterase TesA 0.0026 0.043 0.0806
Leishmania major trypanothione reductase 0.0046 0.1182 0.3673
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0043 0.107 0.3363
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0033 0.0694 0.1385
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0063 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2004 0.3184
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.1436 0.2271
Mycobacterium ulcerans thioesterase 0.0026 0.043 0.0806
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3811 0.8168
Mycobacterium ulcerans polyketide synthase 0.0033 0.0694 0.1385
Echinococcus granulosus serotonin transporter 0.0053 0.1436 0.2247
Schistosoma mansoni hypothetical protein 0.0183 0.6249 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.013
Trypanosoma cruzi prolyl endopeptidase 0.01 0.3182 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.01 0.3182 1
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0521 0.1636
Plasmodium vivax glutathione reductase, putative 0.0046 0.1182 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0053 0.1436 0.4513
Brugia malayi RNA binding protein 0.0068 0.2004 0.6251
Loa Loa (eye worm) hypothetical protein 0.0049 0.1271 0.3995
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.2004 0.6299
Toxoplasma gondii type I fatty acid synthase, putative 0.0033 0.0694 0.205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0116 0.0364
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0063 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.081 0.1267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Trypanosoma brucei trypanothione reductase 0.0046 0.1182 0.3673
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0026 0.043 0.0452
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0932 0.1435
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.4614 1
Echinococcus granulosus dual specificity mitogen activated protein 0.0043 0.107 0.1657
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1899 0.4034
Brugia malayi jmjC domain containing protein 0.0036 0.081 0.2449
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1182 0.3716
Trichomonas vaginalis STE family protein kinase 0.0043 0.107 0.1013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0021 0.0232 0.037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Loa Loa (eye worm) fatty acid synthase 0.0031 0.0607 0.1908
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0085 0.0102
Mycobacterium ulcerans Type I modular polyketide synthase 0.0031 0.0622 0.1228
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0033 0.0694 0.1385
Loa Loa (eye worm) RNA binding protein 0.0068 0.2004 0.6299
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0085 0.007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1899 0.5942
Mycobacterium tuberculosis Probable peptidase 0.004 0.0946 0.194
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0063 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3811 0.8235
Echinococcus multilocularis zinc finger protein 0.0019 0.0176 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1126 0.1748
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0704 0.211
Echinococcus granulosus zinc finger protein 0.0019 0.0176 0.0216
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0043 0.107 0.3318
Loa Loa (eye worm) TAR-binding protein 0.0068 0.2004 0.6299
Loa Loa (eye worm) hypothetical protein 0.004 0.0938 0.2948
Mycobacterium tuberculosis Probable thioesterase TesA 0.0026 0.043 0.0806
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1275 0.3929
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.3375 0.7278
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.004 0.0946 0.163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Mycobacterium leprae Polyketide synthase Pks13 0.0046 0.1192 0.2191
Onchocerca volvulus 0.0054 0.1475 0.3588
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.2004 0.6251
Giardia lamblia PHD finger protein 15 0.0028 0.0521 0.046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.4614 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0031 0.0622 0.1228
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0214 0.0671
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0063 0.0071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0085 0.007
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.004 0.0946 0.194
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1899 0.2993
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2004 0.3184
Loa Loa (eye worm) hypothetical protein 0.0033 0.0704 0.2213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.1436 0.4441
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1639 0.5151
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0102
Mycobacterium ulcerans polyketide synthase Pks13 0.0046 0.1192 0.248
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0059 0.1654 0.5135
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.009 0.2792 0.5997
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1899 0.4034
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0521 0.1636
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1182 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1621 0.2545
Loa Loa (eye worm) hypothetical protein 0.0052 0.1406 0.4418
Brugia malayi PHD-finger family protein 0.0028 0.0521 0.1526
Trypanosoma brucei prolyl endopeptidase 0.01 0.3182 1
Brugia malayi TAR-binding protein 0.0068 0.2004 0.6251
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.01 0.3182 0.5075
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0063 0.0133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0031 0.0622 0.0891
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1899 0.2993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0025 0.0397 0.0377
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0032
Echinococcus granulosus peregrin 0.0031 0.0606 0.091
Loa Loa (eye worm) hypothetical protein 0.01 0.3182 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1126 0.3455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1126 0.1748
Brugia malayi PHD-finger family protein 0.0024 0.0368 0.1039
Loa Loa (eye worm) glutathione reductase 0.0046 0.1182 0.3716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0266
Onchocerca volvulus 0.0053 0.1436 0.3439
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0018 0.0125 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1899 0.4034
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0046 0.1192 0.248
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2004 0.3184
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.01 0.3182 1
Echinococcus multilocularis geminin 0.0183 0.6249 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0025 0.0397 0.0733
Mycobacterium ulcerans Type I modular polyketide synthase 0.0031 0.0622 0.1228
Echinococcus multilocularis dual specificity mitogen activated protein 0.0043 0.107 0.1657
Trichomonas vaginalis STE family protein kinase 0.0043 0.107 0.1013
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0521 0.0772
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0063 0.0133
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.291 0.4622
Brugia malayi Thioredoxin reductase 0.0046 0.1182 0.3633
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0063 0.0035
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0298 0.0515
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0282 0.0388
Loa Loa (eye worm) hypothetical protein 0.0049 0.1275 0.4008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0765 0.1165
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0033 0.0694 0.1385
Trypanosoma cruzi oligopeptidase b 0.004 0.0946 0.2926
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0063 0.0133
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0063 0.0035
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0033 0.0694 0.1054
Trypanosoma brucei oligopeptidase b 0.004 0.0946 0.2926
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.004 0.0946 0.2926
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0043 0.107 0.3318
Schistosoma mansoni hypothetical protein 0.0033 0.0704 0.1096
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0031 0.0622 0.185
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0085 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0022 0.029 0.076
Onchocerca volvulus Fatty acid synthase homolog 0.0056 0.1547 0.3857
Treponema pallidum sodium- and chloride- dependent transporter 0.0053 0.1436 0.1381
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0282 0.0388
Echinococcus multilocularis serotonin transporter 0.0053 0.1436 0.2247
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2004 0.3184
Schistosoma mansoni hypothetical protein 0.0028 0.0521 0.0802
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.3375 0.7278
Schistosoma mansoni protein kinase 0.0043 0.107 0.1684
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3811 0.8235
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.004 0.0946 0.2926
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.004 0.0946 0.194
Mycobacterium tuberculosis Polyketide synthase Pks2 0.003 0.0587 0.115
Echinococcus multilocularis peregrin 0.0031 0.0606 0.091
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1182 0.3673
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0053 0.1436 0.2271
Trichomonas vaginalis STE family protein kinase 0.0043 0.107 0.1013
Schistosoma mansoni hypothetical protein 0.002 0.0214 0.0309
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.004 0.0946 0.2926
Schistosoma mansoni hypothetical protein 0.0183 0.6249 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1126 0.1774
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0765 0.1165
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0033 0.0694 0.1385
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0932 0.1435
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0063 0.0133
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0031 0.0622 0.1228
Onchocerca volvulus 0.0029 0.0547 0.0098
Brugia malayi Bromodomain containing protein 0.0031 0.0606 0.1798
Leishmania major oligopeptidase b 0.004 0.0946 0.2926
Trypanosoma brucei prolyl oligopeptidase, putative 0.004 0.0946 0.2926
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1899 0.3015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0521 0.0802
Loa Loa (eye worm) norepinephrine transporter 0.0053 0.1436 0.4513
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.291 0.4622
Echinococcus granulosus tar DNA binding protein 0.0068 0.2004 0.3162
Toxoplasma gondii thioredoxin reductase 0.0046 0.1182 0.361
Loa Loa (eye worm) serotonin transporter b 0.0053 0.1436 0.4513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0043 0.107 0.3275
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0063 0.0133
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0063 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.3375 0.7278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.004 0.0946 0.2926
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0412 0.0767
Mycobacterium tuberculosis Probable reductase 0.0105 0.3375 0.7278
Treponema pallidum fructose-bisphosphate aldolase 0.0284 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1182 0.1838
Loa Loa (eye worm) hypothetical protein 0.0037 0.0853 0.268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.01 0.3182 0.5075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0063 0.0133
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0547 0.1718
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0063 0.0133
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0521 0.1496
Brugia malayi jmjC domain containing protein 0.0093 0.291 0.9136
Loa Loa (eye worm) hypothetical protein 0.0041 0.1007 0.3164
Plasmodium falciparum phd finger protein, putative 0.0028 0.0521 0.4086
Schistosoma mansoni bromodomain containing protein 0.0062 0.175 0.2776
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1182 0.2458
Plasmodium falciparum thioredoxin reductase 0.0046 0.1182 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0547 0.1062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Loa Loa (eye worm) hypothetical protein 0.0069 0.2018 0.6343
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.081 0.2547
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1182 0.1838
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0521 0.4086
Giardia lamblia Kinase, STE STE20 0.0043 0.107 0.1013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1126 0.1774
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.3375 0.7278
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0521 0.1496
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0107 0.0335
Echinococcus granulosus prolyl endopeptidase 0.01 0.3182 0.5059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0085 0.0102
Brugia malayi prolyl oligopeptidase family protein 0.01 0.3182 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1899 0.3015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0063 0.0133
Loa Loa (eye worm) hypothetical protein 0.0053 0.1436 0.4513
Schistosoma mansoni zinc finger protein 0.0019 0.0176 0.0247
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0033 0.0694 0.1385
Echinococcus multilocularis tar DNA binding protein 0.0068 0.2004 0.3162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0282 0.0419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1126 0.1748
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2004 0.3184
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.003 0.0587 0.115
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.4614 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0547 0.1609
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0031 0.0622 0.0891
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0063 0.0133
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.081 0.1239
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 1 0.5
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0043 0.107 0.3318
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0063 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3811 0.8235
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0046 0.1192 0.248
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1275 0.3929
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.3375 0.7173
Schistosoma mansoni jumonji domain containing protein 0.0074 0.2203 0.3504
Echinococcus multilocularis prolyl endopeptidase 0.01 0.3182 0.5059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1126 0.1748
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0031 0.0622 0.1228
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0397 0.0733
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1126 0.354
Echinococcus granulosus geminin 0.0183 0.6249 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.3375 0.7278
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0521 0.0772
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0218 0.0528
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0031 0.0622 0.1228
Trypanosoma cruzi oligopeptidase b 0.004 0.0946 0.2926
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0063 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.1436 0.4513
Plasmodium falciparum glutathione reductase 0.0046 0.1182 1
Toxoplasma gondii prolyl endopeptidase 0.01 0.3182 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0063 0.0133
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0742 0.1128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.081 0.1267
Mycobacterium leprae Probable polyketide synthase Pks1 0.0033 0.0694 0.1054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1899 0.4034
Mycobacterium ulcerans polyketide synthase 0.0031 0.0622 0.1228
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0031 0.0622 0.1228
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0041 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1275 0.4008
Brugia malayi Bromodomain containing protein 0.0073 0.2172 0.6786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1126 0.1774
Loa Loa (eye worm) hypothetical protein 0.0053 0.1436 0.4513
Brugia malayi Bromodomain containing protein 0.0037 0.085 0.2575

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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