Detailed information for compound 784659

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.449 | Formula: C20H20N2O4S
  • H donors: 2 H acceptors: 2 LogP: 3.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=C1C(=NC(=S)NC1c1c(ccc2c1cccc2)OC(=O)C)C)O
  • InChi: 1S/C20H20N2O4S/c1-4-25-19(24)16-11(2)21-20(27)22-18(16)17-14-8-6-5-7-13(14)9-10-15(17)26-12(3)23/h5-10,18,24H,4H2,1-3H3,(H,22,27)
  • InChiKey: LMRLJVCHVKXYFJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0038 0.0288 0.0968
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.097 0.2783
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0073 0.0183
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0283 0.035
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0293 0.3428 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Leishmania major hypothetical protein, conserved 0.0027 0.0156 0.525
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0054 0.0067
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0023 0.0023
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0293 0.3428 1
Brugia malayi beta-NAC-like protein 0.0036 0.0263 0.0878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0073 0.0183
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0038 0.0287 0.0963
Schistosoma mansoni hypothetical protein 0.0023 0.0102 0.0127
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0168 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1233
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0288 0.0288
Leishmania major trypanothione reductase 0.0037 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Brugia malayi hypothetical protein 0.0038 0.0287 0.0963
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0668 0.0828
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0073 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0017 0.003 0.0038
Entamoeba histolytica hypothetical protein 0.0038 0.0288 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.2434 0.88
Entamoeba histolytica hypothetical protein 0.0038 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2762 1
Brugia malayi hypothetical protein 0.0038 0.029 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0995 0.0995
Leishmania major protein kinase, putative 0.0016 0.0023 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.065 0.229
Treponema pallidum hypothetical protein 0.0293 0.3428 0.5
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0073 0.0183
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.017
Echinococcus multilocularis cpg binding protein 0.0063 0.0596 0.0596
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0069 0.0069
Trypanosoma cruzi ISWI complex protein 0.0017 0.003 0.0299
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.0145 0.1608 0.5787
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0073 0.0073
Brugia malayi steroid hormone receptor 0.002 0.0073 0.0183
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0038 0.029 0.0975
Onchocerca volvulus Protein cycle homolog 0.0038 0.029 0.0806
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0855 0.2445
Schistosoma mansoni single-minded 0.0016 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Schistosoma mansoni zinc finger protein 0.0025 0.0128 0.0159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0287 0.0963
Brugia malayi hypothetical protein 0.0017 0.0039 0.0057
Onchocerca volvulus 0.0057 0.0531 0.1701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0069 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0263 1
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0263 0.2054
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0073 0.0183
Schistosoma mansoni cpg binding protein 0.0063 0.0596 0.0739
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0102 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0263 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0288 0.0357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0073 0.0183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0287 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0073 0.0183
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0855 0.2445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0069 0.0086
Brugia malayi hypothetical protein 0.0054 0.0485 0.1687
Brugia malayi ecdysteroid receptor 0.002 0.0073 0.0183
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0073 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0156 0.525
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0156 0.0391
Plasmodium vivax glutathione reductase, putative 0.0037 0.0277 0.0745
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0263 0.9481
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0073 0.0183
Schistosoma mansoni hypothetical protein 0.0067 0.065 0.0806
Loa Loa (eye worm) hypothetical protein 0.0067 0.065 0.229
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.2434 0.88
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0855 0.2445
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0073 0.0091
Brugia malayi hypothetical protein 0.023 0.265 0.9589
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0073 0.0091
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.8069 0.8069
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0156 0.525
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0488 0.1699
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0038 0.029 0.0975
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0073 0.0091
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0283 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0073 0.0183
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0531 0.1853
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.097 0.2783
Loa Loa (eye worm) glutathione reductase 0.0037 0.0277 0.0926
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0073 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0073 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0156 0.1137
Toxoplasma gondii thioredoxin reductase 0.0037 0.0277 0.2166
Schistosoma mansoni thyroid hormone receptor 0.002 0.0073 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0073 0.0091
Schistosoma mansoni cpg binding protein 0.0057 0.0531 0.0658
Echinococcus multilocularis GPCR, family 2 0.0067 0.065 0.065
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0277 0.0926
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0277 0.0745
Brugia malayi hypothetical protein 0.0027 0.0156 0.0486
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0066 0.0157
Brugia malayi nuclear hormone receptor 0.002 0.0073 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0073 0.0091
Plasmodium falciparum thioredoxin reductase 0.0037 0.0277 0.0745
Echinococcus granulosus GPCR family 2 0.0067 0.065 0.0806
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0038 0.029 0.0359
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0073 0.0073
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0002
Onchocerca volvulus 0.0047 0.0401 0.1219
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0401 0.138
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Schistosoma mansoni hypothetical protein 0.0067 0.065 0.0806
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0263 0.9481
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0855 0.2445
Echinococcus granulosus survival motor neuron protein 1 0.023 0.265 0.3284
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0026 0.0026
Onchocerca volvulus Huntingtin homolog 0.0239 0.2762 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0073 0.0091
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0293 0.3428 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0073 0.0091
Echinococcus granulosus transcription factor btf3 0.0036 0.0263 0.0326
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0308 0.0308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.2434 0.88
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0073 0.0183
Echinococcus granulosus zinc finger protein 0.0025 0.0128 0.0159
Echinococcus multilocularis zinc finger protein 0.0025 0.0128 0.0128
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0855 0.2445
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0073 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0073 0.0183
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0073 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0073 0.0183
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.0488 0.0605
Loa Loa (eye worm) hypothetical protein 0.0038 0.0287 0.0963
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Brugia malayi Thioredoxin reductase 0.0037 0.0277 0.0926
Schistosoma mansoni hypothetical protein 0.0038 0.0288 0.0357
Schistosoma mansoni nuclear hormone receptor 0.002 0.0073 0.0091
Brugia malayi CXXC zinc finger family protein 0.0057 0.0531 0.1853
Schistosoma mansoni hypothetical protein 0.0145 0.1608 0.1993
Loa Loa (eye worm) hypothetical protein 0.0077 0.0776 0.275
Loa Loa (eye worm) hypothetical protein 0.005 0.0439 0.1518
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0073 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0263 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0156 0.525
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0073 0.0073
Leishmania major protein kinase, putative 0.0016 0.0023 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0062 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0073 0.0183
Schistosoma mansoni transcription factor btf3 0.0036 0.0263 0.0326
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0168 0.0208
Echinococcus granulosus cpg binding protein 0.0063 0.0596 0.0739
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0277 0.0745
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0073 0.0183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0308 0.0382
Trypanosoma cruzi ISWI complex protein 0.0017 0.003 0.0299
Schistosoma mansoni survival motor neuron protein 0.0047 0.0401 0.0497
Onchocerca volvulus 0.0054 0.0485 0.1532
Brugia malayi PHD-finger family protein 0.0031 0.02 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0073 0.0183
Leishmania major basic transcription factor 3a, putative 0.0036 0.0263 0.9481
Onchocerca volvulus Huntingtin homolog 0.0239 0.2762 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0995 0.1233
Brugia malayi Bromodomain containing protein 0.0042 0.034 0.1157
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0263 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0073 0.0183
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0023 0.0002
Plasmodium falciparum glutathione reductase 0.0037 0.0277 0.0745
Brugia malayi Latrophilin receptor protein 2 0.0067 0.065 0.229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0995 0.3547
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0028
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0168 0.0208
Loa Loa (eye worm) hypothetical protein 0.0042 0.0341 0.1161
Loa Loa (eye worm) hypothetical protein 0.0054 0.0485 0.1687
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0288 0.0357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0073 0.0091
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0073 0.0073
Mycobacterium tuberculosis Probable reductase 0.0084 0.0855 0.2445
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0073 0.0091
Schistosoma mansoni hypothetical protein 0.0338 0.3975 0.4927
Brugia malayi nuclear receptor NHR-88 0.002 0.0073 0.0183
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0073 0.0091
Loa Loa (eye worm) hypothetical protein 0.0239 0.2762 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0054 0.0054
Schistosoma mansoni bromodomain containing protein 0.0073 0.0716 0.0888
Schistosoma mansoni cpg binding protein 0.0063 0.0596 0.0739
Loa Loa (eye worm) hypothetical protein 0.0038 0.0287 0.0963
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0263 0.0706
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0026 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0054 0.0067
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0995 0.3547
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0263 0.0878
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0338 0.3975 0.4927
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0073 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.065 0.065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.065 0.065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.065 0.0806
Trypanosoma brucei trypanothione reductase 0.0037 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.023 0.265 0.9589
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0156 0.0391
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0073 0.0091
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0073 0.0183
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0855 0.2445
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.065 0.229
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.265 0.265
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.097 0.2783
Echinococcus multilocularis transcription factor btf3 0.0036 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0073 0.0183
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.065 0.0806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1233
Schistosoma mansoni hypothetical protein 0.0067 0.065 0.0806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0073 0.0073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1322 0.1638
Echinococcus granulosus FTZ F1 alpha 0.002 0.0073 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0038 0.0288 1
Leishmania major hypothetical protein, conserved 0.0017 0.003 0.0299
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0069 0.0086
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0023 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0995 0.1233
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0038 0.029 0.0975
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0016 0.0023 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0073 0.0183
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0023 0.0028
Echinococcus multilocularis geminin 0.0338 0.3975 0.3975
Schistosoma mansoni hypothetical protein 0.0067 0.065 0.0806
Echinococcus granulosus microtubule associated protein 2 0.0671 0.8069 1
Trypanosoma brucei ISWI complex protein 0.0017 0.003 0.0299
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0293 0.3428 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0073 0.0183
Brugia malayi hypothetical protein 0.0239 0.2762 1
Entamoeba histolytica hypothetical protein 0.0038 0.0288 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0293 0.3428 0.5
Schistosoma mansoni zinc finger protein 0.0017 0.003 0.0038
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0043 0.0074
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0263 0.9481
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0073 0.0091
Schistosoma mansoni hypothetical protein 0.0047 0.0401 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0995 0.1233
Echinococcus granulosus geminin 0.0338 0.3975 0.4927
Brugia malayi Bromodomain containing protein 0.0085 0.0874 0.3107
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.097 0.2783
Loa Loa (eye worm) hypothetical protein 0.0212 0.2434 0.88
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0995 0.0995
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.8069 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1194 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0156 0.0391
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.0488 0.0488
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0023 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0373 0.1277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0156 0.0486
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0054 0.0067
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0073 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.1608 0.5787
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0023 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0073 0.0183
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0073 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0073 0.0183
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0023 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0043 0.0053
Schistosoma mansoni coup transcription factor 0.002 0.0073 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0183
Brugia malayi glutathione reductase 0.0037 0.0277 0.0926
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0023 0.0023
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0026 0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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