Detailed information for compound 797186

Basic information

Technical information
  • TDR Targets ID: 797186
  • Name: N-[2-(dimethylamino)ethyl]-12-oxo-1,2,3,4-tet rahydro-12H-[1]benzothieno[2,3-d]pyrido[1,2-a ]pyrimidine-7-carboxamide
  • MW: 370.469 | Formula: C19H22N4O2S
  • H donors: 1 H acceptors: 2 LogP: 2.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1cccn2c1nc1sc3c(c1c2=O)CCCC3)C
  • InChi: 1S/C19H22N4O2S/c1-22(2)11-9-20-17(24)13-7-5-10-23-16(13)21-18-15(19(23)25)12-6-3-4-8-14(12)26-18/h5,7,10H,3-4,6,8-9,11H2,1-2H3,(H,20,24)
  • InChiKey: BZELMTVNEWHMCA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000309144
  • EU-0025936
  • MLS000730769

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.115 0.1725 0.1721
Brugia malayi follicle stimulating hormone receptor 0.0068 0.0089 0.1283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0016 0.0056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0071 0.0094 0.1151
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0035 0.0098
Echinococcus granulosus cpg binding protein 0.003 0.0033 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0024 0.6175
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.0089 0.0978
Onchocerca volvulus 0.0068 0.0089 0.0978
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.0089 0.1098
Entamoeba histolytica hypothetical protein 0.0036 0.0041 0.1872
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Onchocerca volvulus 0.0068 0.0089 0.0978
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0024 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0602 0.0897 0.3068
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni hypothetical protein 0.0068 0.0089 0.1098
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0034 0.95
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.0089 0.0306
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0024 0.6175
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Schistosoma mansoni myosin xvIII 0.0068 0.0089 0.1098
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0032 0.0034 0.0029
Toxoplasma gondii hypothetical protein 0.0079 0.0107 0.0463
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.0089 0.0306
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.0089 0.1098
Schistosoma mansoni hypothetical protein 0.0068 0.0089 0.1098
Echinococcus multilocularis allatostatin A receptor 0.0068 0.0089 0.0306
Brugia malayi sulfakinin receptor protein 0.0068 0.0089 0.1283
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0107 0.0149 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.0089 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0024 0.0338
Treponema pallidum licC protein (licC) 0.115 0.1725 1
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0032 0.0034 0.0093
Schistosoma mansoni amine GPCR 0.0068 0.0089 0.1098
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Echinococcus granulosus somatostatin receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0348
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0016 0.0011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.0089 0.0978
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.0089 0.0306
Onchocerca volvulus 0.0466 0.0692 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0016 0.3668
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0012 0.0042
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.0089 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0024 0.0587
Mycobacterium ulcerans hypothetical protein 0.115 0.1725 0.1721
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0016 0.0236
Echinococcus multilocularis neuropeptide receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis dynactin 5 p25 0.0032 0.0034 0.0118
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.002 0.0017 0.0151
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0069 0.027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.0089 0.1098
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi Serotonin receptor 0.0068 0.0089 0.1283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni amine GPCR 0.0068 0.0089 0.1098
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.002 0.0017 0.1022
Echinococcus granulosus smad 0.0017 0.0012 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Echinococcus multilocularis somatostatin receptor 0.0068 0.0089 0.0306
Schistosoma mansoni hypothetical protein 0.0524 0.0779 1
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0032 0.0034 0.1366
Echinococcus granulosus g-protein coupled receptor 0.0068 0.0089 0.0306
Onchocerca volvulus 0.0068 0.0089 0.0978
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni smad1 5 8 and 0.0017 0.0012 0.0102
Entamoeba histolytica hypothetical protein 0.0036 0.0041 0.1872
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0028 0.0029 0.761
Brugia malayi hypothetical protein 0.0032 0.0034 0.0487
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Schistosoma mansoni biogenic amine receptor 0.0068 0.0089 0.1098
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0012 0.0177
Brugia malayi hypothetical protein 0.0017 0.0012 0.0165
Brugia malayi GDP-mannose pyrophosphorylase B 0.0033 0.0036 0.0509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0033 0.0036 0.0123
Schistosoma mansoni neuropeptide receptor 0.0068 0.0089 0.1098
Onchocerca volvulus 0.0068 0.0089 0.0978
Onchocerca volvulus 0.0068 0.0089 0.0978
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.0089 0.1098
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi MH1 domain containing protein 0.0017 0.0012 0.0166
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0032 0.0034 0.1366
Mycobacterium tuberculosis Possible transferase 0.0032 0.0034 0.0029
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0028 0.0029 0.761
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.022 0.3175
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.002 0.0017 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Entamoeba histolytica hypothetical protein 0.002 0.0017 0.0022
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0107 0.0149 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0071 0.0094 0.032
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.0089 0.1098
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis fmrfamide receptor 0.0068 0.0089 0.0306
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.0089 0.1283
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.0089 0.1098
Mycobacterium ulcerans transferase 0.0032 0.0034 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0026 0.0868
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0033 0.0036 0.0408
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.0089 0.0306
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0028 0.0029 0.0402
Brugia malayi Cytochrome P450 family protein 0.0012 0.0005 0.0061
Leishmania major hypothetical protein, conserved 0.0032 0.0034 0.95
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0107 0.0149 0.214
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.0089 0.0306
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0024 0.6175
Echinococcus multilocularis fmrfamide receptor 0.0068 0.0089 0.0306
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.3668
Schistosoma mansoni smad 0.0017 0.0012 0.0102
Onchocerca volvulus 0.0071 0.0094 0.104
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0024 0.0019
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0028 0.0029 0.1041
Schistosoma mansoni adenoreceptor 0.0068 0.0089 0.1098
Schistosoma mansoni hypothetical protein 0.0068 0.0089 0.1098
Schistosoma mansoni cytochrome P450 0.0012 0.0005 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.0089 0.1292
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0005 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0034 0.95
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0028 0.0029 0.761
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.0089 0.1292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi Smad1 0.0017 0.0012 0.0166
Entamoeba histolytica serine acetyltransferase 1 0.0032 0.0034 0.1366
Brugia malayi Dopamine receptor 0.0068 0.0089 0.1283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus granulosus sex peptide receptor 0.0068 0.0089 0.0306
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0121
Giardia lamblia Rab geranylgeranyltransferase 0.0028 0.0029 0.0923
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0032 0.0034 0.1366
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0348
Echinococcus granulosus hypothetical protein 0.0068 0.0089 0.0306
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0089 0.0306
Onchocerca volvulus 0.0028 0.0029 0.0067
Giardia lamblia Translation initiation factor 0.0032 0.0034 0.1366
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.006 0.0862
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0089 0.0306
Schistosoma mansoni biogenic amine receptor 0.0068 0.0089 0.1098
Mycobacterium leprae conserved hypothetical protein 0.002 0.0017 0.0012
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.002 0.0017 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0089 0.1098
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0032 0.0034 1
Mycobacterium leprae POSSIBLE TRANSFERASE 0.0032 0.0034 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.0089 0.1283
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0028 0.0029 0.0313
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.0089 0.1098
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.115 0.1725 0.8768
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0033 0.0036 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.0089 0.1098
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.0089 0.1292
Trypanosoma cruzi serine acetyltransferase, putative 0.0032 0.0034 0.95
Brugia malayi hypothetical protein 0.0026 0.0026 0.0369
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0032 0.0034 0.1366
Echinococcus granulosus dynactin 5 p25 0.0032 0.0034 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0013 0.0008
Echinococcus granulosus allatostatin A receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0032 0.0034 0.0118
Leishmania major serine acetyltransferase 0.0032 0.0034 0.95
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.0089 0.0306
Schistosoma mansoni hypothetical protein 0.0032 0.0034 0.0388
Brugia malayi Serotonin receptor 0.0068 0.0089 0.1283
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0033 0.0036 0.1483
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.0089 0.0306
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0035 0.9815
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0032 0.0034 0.0497
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0035 0.1551
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.0364 0.5259
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.1352
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.0089 0.1098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0211
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.0089 0.0306
Toxoplasma gondii hypothetical protein 0.0032 0.0034 0.0093
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0032 0.0034 0.0029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0015
Echinococcus granulosus serotonin receptor 0.0068 0.0089 0.0306
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0035 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.006 0.0206
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0129
Echinococcus multilocularis sex peptide receptor 0.0068 0.0089 0.0306
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.3668
Leishmania major hypothetical protein, conserved 0.0032 0.0034 0.95
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.0089 0.1098
Echinococcus granulosus tm gpcr rhodopsin 0.1943 0.2923 1
Mycobacterium ulcerans hypothetical protein 0.0032 0.0034 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0016 0.3668
Leishmania major GDP-mannose pyrophosphorylase 0.0033 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0211
Echinococcus multilocularis serotonin receptor 0.0068 0.0089 0.0306
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0029 0.761
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.0089 0.0306
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Brugia malayi hypothetical protein 0.0032 0.0034 0.0487
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0032 0.0034 0.1366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0089 0.1098
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.0089 0.1292
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.0089 0.1098
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.0032 0.0034 0.0018
Brugia malayi hypothetical protein 0.0036 0.0041 0.0584
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0107 0.0149 0.0508
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0024 0.0019
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.002 0.0017 0.0151
Brugia malayi G-protein coupled receptor 0.0068 0.0089 0.1283
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0107 0.0149 0.2148
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0035 0.0501
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0035 0.9815
Onchocerca volvulus 0.0068 0.0089 0.0978
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0028 0.0029 0.0098
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0154 0.022 0.3175
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0034 0.95
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.0089 0.0306
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.0089 0.1292
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Plasmodium falciparum dynactin subunit 5, putative 0.0032 0.0034 0.1478
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0033 0.0036 0.1483
Brugia malayi putative neuropeptide receptor 0.0068 0.0089 0.1283
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0497
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0028 0.0029 0.761
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0029 0.761
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.0089 0.0306
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0071 0.0094 0.1343
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.0089 0.0306
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.0089 0.0306
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.0089 0.1292
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.9815
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0364
Schistosoma mansoni amine GPCR 0.0068 0.0089 0.1098
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0032 0.0034 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0107 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.0364 0.5259
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0034 0.95
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0602 0.0897 0.3068
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Brugia malayi RE15519p 0.0068 0.0089 0.1283
Brugia malayi Melatonin receptor type 1A 0.0068 0.0089 0.1283
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0107 0.0149 0.1862
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus granulosus geminin 0.0524 0.0779 0.2664
Echinococcus multilocularis cpg binding protein 0.003 0.0033 0.0111
Schistosoma mansoni hypothetical protein 0.0049 0.006 0.0722
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0032 0.0034 0.1478
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.006 0.0206
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0016 0.0056
Echinococcus multilocularis Smad4 0.0017 0.0012 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1943 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi Latrophilin receptor protein 2 0.0049 0.006 0.0862
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.006 0.0206
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0024 0.0587
Onchocerca volvulus 0.0029 0.003 0.009
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.0089 0.1098
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0032 0.0034 0.1366
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.0089 0.0306
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.0089 0.0306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0129
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0107 0.0149 1
Echinococcus granulosus Smad4 0.0017 0.0012 0.0042
Brugia malayi GnHR receptor homolog 0.0068 0.0089 0.1283
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0029 0.761
Echinococcus granulosus GPCR family 2 0.0049 0.006 0.0206
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0032 0.0034 0.1366
Echinococcus multilocularis orexin receptor type 2 0.0068 0.0089 0.0306
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.0089 0.1098
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.0089 0.0306
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0155
Loa Loa (eye worm) hypothetical protein 0.0466 0.0692 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.0089 0.1098
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0028 0.0029 0.0923
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.0089 0.1292
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0035 0.0121
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0024 0.0019
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.0089 0.1283
Brugia malayi hypothetical protein 0.0032 0.0034 0.0487
Onchocerca volvulus 0.0068 0.0089 0.0978
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni dynactin subunit P25 0.0032 0.0034 0.0388
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus granulosus fmrfamide receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0211
Leishmania major hypothetical protein, conserved 0.0026 0.0026 0.6865
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0026 0.6865
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.0089 0.1292
Brugia malayi neuropeptide F receptor 0.0068 0.0089 0.1283
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.0089 0.0306
Brugia malayi MH1 domain containing protein 0.0017 0.0012 0.0166
Loa Loa (eye worm) nucleotidyl transferase 0.0033 0.0036 0.052
Onchocerca volvulus 0.0068 0.0089 0.0978
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0028 0.0029 0.0923
Giardia lamblia Rab geranylgeranyltransferase 0.0107 0.0149 1
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0017 0.3763
Schistosoma mansoni amine GPCR 0.0068 0.0089 0.1098
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.0089 0.1292
Toxoplasma gondii cytochrome p450 superfamily protein 0.1309 0.1965 1
Onchocerca volvulus 0.0068 0.0089 0.0978
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0033 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0034 0.95
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0033 0.0036 0.0408
Onchocerca volvulus 0.0068 0.0089 0.0978
Onchocerca volvulus 0.0068 0.0089 0.0978
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.0089 0.0306
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.0089 0.1283
Echinococcus granulosus g protein coupled receptor 0.0068 0.0089 0.0306
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0041 0.0141
Brugia malayi Cytochrome P450 family protein 0.0012 0.0005 0.0061
Plasmodium vivax dynactin subunit 5, putative 0.0032 0.0034 0.1478
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0016 0.0011
Mycobacterium ulcerans hypothetical protein 0.115 0.1725 0.1721
Echinococcus granulosus neuropeptide receptor 0.0068 0.0089 0.0306
Schistosoma mansoni hypothetical protein 0.0036 0.0041 0.0474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0089 0.1098
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0032 0.0034 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Echinococcus multilocularis L aminoadipate semialdehyde 0.0071 0.0094 0.032
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0032 0.0034 0.0093
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0364
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0024 0.0338
Onchocerca volvulus 0.0068 0.0089 0.0978
Loa Loa (eye worm) dynactin 5 0.0032 0.0034 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi larval opioid receptor 0.0068 0.0089 0.1283
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0035 0.0511
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1663 0.2501 0.8554
Loa Loa (eye worm) hypothetical protein 0.0049 0.006 0.0872
Entamoeba histolytica serine acetyltransferase 1 0.0032 0.0034 0.1366
Schistosoma mansoni biogenic amine receptor 0.0068 0.0089 0.1098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.022 0.3168
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0013 0.0008
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Entamoeba histolytica ankyrin, putative 0.0032 0.0034 0.1366
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0041 0.0141
Loa Loa (eye worm) Smad1 0.0017 0.0012 0.0177
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0028 0.0029 0.0098
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.0089 0.0306
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.9815
Brugia malayi MH2 domain containing protein 0.0017 0.0012 0.0166
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0033 0.0036 1
Brugia malayi Dopamine receptor protein 1 0.0068 0.0089 0.1283
Echinococcus multilocularis neuropeptide receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0033 0.0036 0.0101
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0024 0.0019
Schistosoma mansoni neuropeptide receptor 0.0068 0.0089 0.1098
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0107 0.0149 0.0508
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.0089 0.0306
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.0089 0.1098
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.0089 0.1098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Schistosoma mansoni histamine h1 receptor 0.0068 0.0089 0.1098
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0146 0.2101
Schistosoma mansoni neuropeptide receptor 0.0068 0.0089 0.1098
Echinococcus granulosus neuropeptide s receptor 0.0068 0.0089 0.0306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.0089 0.0306
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Schistosoma mansoni Smad4 0.0017 0.0012 0.0102
Schistosoma mansoni opsin-like receptor 0.0068 0.0089 0.1098
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0035 0.0121
Trypanosoma cruzi hypothetical protein 0.0032 0.0034 0.95
Brugia malayi neuropeptide F receptor 0.0068 0.0089 0.1283
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0028 0.0029 0.1041
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0107 0.0149 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.115 0.1725 0.1721
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0024 0.0019
Schistosoma mansoni opsin-like receptor 0.0068 0.0089 0.1098
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Onchocerca volvulus 0.0068 0.0089 0.0978
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.6624 1 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0024 0.0019
Echinococcus multilocularis 0.0012 0.0005 0.0017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.0089 0.1283
Brugia malayi Nucleotidyl transferase family protein 0.0033 0.0036 0.0509
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.6624 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0013 0.0008
Onchocerca volvulus 0.0068 0.0089 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0034 0.1366
Echinococcus granulosus neuropeptide receptor 0.0068 0.0089 0.0306
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0035 0.0401
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0026 0.0868
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0033 0.0036 0.052
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni smad1 5 8 and 0.0017 0.0012 0.0102
Echinococcus multilocularis geminin 0.0524 0.0779 0.2664
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.022 0.3168
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0026 0.6865
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0033 0.0036 0.0408
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0089 0.0306
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0032 0.0034 0.0118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0026 0.0051
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.0089 0.0306
Leishmania major phosphopantetheinyl transferase-like protein 0.002 0.0017 0.3763
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0035 0.1551
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.0089 0.0306
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.0089 0.0306
Schistosoma mansoni hypothetical protein 0.0049 0.006 0.0722
Echinococcus granulosus g protein coupled receptor 0.0068 0.0089 0.0306
Treponema pallidum 4'-phosphopantetheinyl transferase 0.002 0.0017 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.0089 0.1292
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0028 0.0029 0.761
Onchocerca volvulus 0.0068 0.0089 0.0978
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Schistosoma mansoni cpg binding protein 0.0029 0.003 0.0332
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0028 0.0029 0.0413
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.006 0.0872
Brugia malayi hypothetical protein 0.0466 0.0692 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.006 0.0206
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0033 0.0036 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.0089 0.0306
Mycobacterium tuberculosis Conserved hypothetical protein 0.115 0.1725 0.1721
Schistosoma mansoni hypothetical protein 0.0068 0.0089 0.1098
Plasmodium falciparum liver specific protein 2, putative 0.0032 0.0034 0.1478
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi hypothetical protein 0.0068 0.0089 0.1283
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.0089 0.0306
Schistosoma mansoni smad1 5 8 and 0.0017 0.0012 0.0102
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0107 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0121
Brugia malayi Cytochrome P450 family protein 0.0012 0.0005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0211
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0034 0.0029
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0033 0.0036 0.1593
Brugia malayi MH2 domain containing protein 0.0017 0.0012 0.0166
Schistosoma mansoni opsin-like receptor 0.0068 0.0089 0.1098
Mycobacterium leprae PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) 0.0032 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0034 0.95
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.002 0.0017 0.0002
Brugia malayi Cytochrome P450 family protein 0.0012 0.0005 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0348
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0035 0.9815
Loa Loa (eye worm) hypothetical protein 0.0107 0.0149 0.2148
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0034 0.95
Entamoeba histolytica hypothetical protein 0.0036 0.0041 0.1872
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0033 0.0036 0.1483
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0012 0.0102
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0155
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0033 0.0036 0.0031
Trypanosoma cruzi serine acetyltransferase, putative 0.0032 0.0034 0.95
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.0089 0.0306
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.0089 0.1098
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0034 0.1478
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.0089 0.1292
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0079 0.0107 0.6823
Toxoplasma gondii hypothetical protein 0.0028 0.0029 0.0063
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0012 0.0042
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0035 0.0098
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.0089 0.0306
Mycobacterium ulcerans serine acetyltransferase CysE 0.0032 0.0034 0.0029
Brugia malayi CXXC zinc finger family protein 0.0029 0.003 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.0089 0.1283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Echinococcus multilocularis GPCR, family 2 0.0049 0.006 0.0206
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0005 0.0017
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0033 0.0036 0.0123
Echinococcus multilocularis serotonin receptor 0.0068 0.0089 0.0306
Brugia malayi Dopamine receptor protein 2 0.0068 0.0089 0.1283
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0012 0.0042
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0033 0.0036 0.0031
Leishmania major hypothetical protein, conserved 0.0032 0.0034 0.95
Loa Loa (eye worm) cytochrome P450 0.0012 0.0005 0.0072
Loa Loa (eye worm) nuclear factor I 0.0009 0.0001 0.0011
Schistosoma mansoni hypothetical protein 0.0049 0.006 0.0722
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0035 0.0121
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0015
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0028 0.0029 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0379
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0028 0.0029 0.761
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0032 0.0034 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0024 0.0587
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0079 0.0963
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0032 0.0034 0.0487
Trypanosoma brucei nucleotidyl transferase, putative 0.0033 0.0036 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.003 0.0435
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0012 0.0177
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0497
Schistosoma mansoni amine GPCR 0.0068 0.0089 0.1098
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0012 0.0042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.0089 0.0306
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0005 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0089 0.0306
Brugia malayi G-protein coupled receptor 0.0068 0.0089 0.1283
Schistosoma mansoni hypothetical protein 0.0049 0.006 0.0722
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0015 0.001
Schistosoma mansoni hypothetical protein 0.0524 0.0779 1
Onchocerca volvulus 0.0068 0.0089 0.0978
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.0089 0.0306
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0015 0.001
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0033 0.0036 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0041 0.0474
Brugia malayi cytochrome P450 0.0012 0.0005 0.0061
Brugia malayi AKH receptor 0.0068 0.0089 0.1283
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0028 0.0029 0.0098
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.002 0.0017 0.0012
Onchocerca volvulus 0.0068 0.0089 0.0978
Brugia malayi ORL1-like opioid receptor 0.0068 0.0089 0.1283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0016 0.0226
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0033 0.0036 0.0123
Entamoeba histolytica acetyltransferase, putative 0.0032 0.0034 0.1366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0089 0.1098
Brugia malayi MH2 domain containing protein 0.0249 0.0364 0.5254
Loa Loa (eye worm) hypothetical protein 0.0105 0.0146 0.2109
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.0089 0.1283
Echinococcus multilocularis smad 0.0017 0.0012 0.0042
Schistosoma mansoni neuropeptide receptor 0.0068 0.0089 0.1098
Entamoeba histolytica serine acetyltransferase, putative 0.0032 0.0034 0.1366
Brugia malayi hypothetical protein 0.0032 0.0034 0.0487
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.6624 1 1
Brugia malayi zgc:92842 0.0032 0.0034 0.0487
Echinococcus granulosus g protein coupled receptor 0.0068 0.0089 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.0089 0.0306
Entamoeba histolytica hypothetical protein 0.0036 0.0041 0.1872
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.0089 0.1283
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0024 0.0019
Schistosoma mansoni hypothetical protein 0.0105 0.0146 0.1827
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.002 0.0017 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0026 0.0868
Echinococcus granulosus orexin receptor type 2 0.0068 0.0089 0.0306
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0028 0.0029 0.761
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0005 0.0072
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0033 0.0036 0.1593
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.0089 0.0306
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0026 0.6865
Loa Loa (eye worm) hypothetical protein 0.0068 0.0089 0.1292
Brugia malayi G protein-coupled receptor 0.0068 0.0089 0.1283
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0024 0.0338
Brugia malayi isocitrate dehydrogenase 0.0032 0.0035 0.0501

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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