TDR Targets

Basic information

Technical information

TDR Targets ID: 802258
Name: 1-ethyl-4-[2-(4-ethylpiperazin-1-yl)-2-oxoeth oxy]quinolin-2-one
MW: 343.42 | Formula: C19H25N3O3
H donors: 0 H acceptors: 2 LogP: 1.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)C(=O)COc1cc(=O)n(c2c1cccc2)CC
InChi: 1S/C19H25N3O3/c1-3-20-9-11-21(12-10-20)19(24)14-25-17-13-18(23)22(4-2)16-8-6-5-7-15(16)17/h5-8,13H,3-4,9-12,14H2,1-2H3
InChiKey: BCAIBNSARRAWJV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-ethyl-4-[2-(4-ethylpiperazin-1-yl)-2-oxo-ethoxy]quinolin-2-one
1-ethyl-4-[2-(4-ethyl-1-piperazinyl)-2-oxoethoxy]-2-quinolinone
1-ethyl-4-[2-(4-ethylpiperazin-1-yl)-2-keto-ethoxy]carbostyril
1-ethyl-4-[2-(4-ethylpiperazin-1-yl)-2-oxoethoxy]quinolin-2(1H)-one
MLS000089543
SMR000027891

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.0016	0.0055	0.0058
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0261	0.0261
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0144	0.151
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0157	0.0157
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0261	0.3374
Echinococcus granulosus	cathepsin l1	0.0016	0.0055	0.0128
Schistosoma mansoni	cpg binding protein	0.0034	0.0237	0.0548
Brugia malayi	hypothetical protein	0.0016	0.0053	0.0157
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0363	0.1067
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0178	0.2003
Brugia malayi	hypothetical protein	0.0286	0.2836	0.834
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0144	1
Leishmania major	cathepsin L-like protease	0.0016	0.0055	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Schistosoma mansoni	hypothetical protein	0.0354	0.3542	0.8204
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0003	0.0006
Onchocerca volvulus		0.0197	0.1919	1
Loa Loa (eye worm)	ctsf protein	0.0016	0.0055	0.0162
Brugia malayi	Glutamate receptor 2 precursor	0.0024	0.0139	0.0408
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0261	0.3412
Leishmania major	cathepsin L-like protease	0.0016	0.0055	0.0058
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0075	0.0667	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0178	0.0522
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0055	0.0162
Schistosoma mansoni	glutamate receptor NMDA	0.0024	0.0139	0.0321
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0186	0.0432
Echinococcus multilocularis	cysteine protease	0.0016	0.0055	0.0055
Schistosoma mansoni	gabp alpha	0.0075	0.0665	0.154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0028	0.0178	0.0657
Schistosoma mansoni	hypothetical protein	0.0033	0.0227	0.0527
Brugia malayi	hypothetical protein	0.0025	0.0144	0.0425
Echinococcus multilocularis	geminin	0.0354	0.3542	0.3542
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0029	0.0186	0.0432
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0547	0.1267
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0186	0.0432
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0023	0.0126	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0075	0.0667	1
Loa Loa (eye worm)	fibroinase	0.0016	0.0055	0.0162
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0055	0.0058
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0447	0.1036
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0227	0.0227
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.004	0.0299	0.088
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0502	0.7303
Onchocerca volvulus		0.0058	0.0489	0.2326
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0077	0.0179
Schistosoma mansoni	hypothetical protein	0.0033	0.0227	0.0527
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0527	0.7722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0075	0.0667	0.1961
Brugia malayi	intermediate filament protein	0.0054	0.0447	0.1315
Echinococcus granulosus	neutral alpha glucosidase AB	0.0075	0.0667	0.1545
Schistosoma mansoni	cpg binding protein	0.003	0.0198	0.0459
Echinococcus granulosus	lamin dm0	0.0054	0.0447	0.1036
Schistosoma mansoni	glutamate receptor AMPA	0.0024	0.0139	0.0321
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0261	0.5
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0261	0.3374
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0144	0.0425
Mycobacterium tuberculosis	Possible exported protein	0.0491	0.4963	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0447	0.1315
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2836	0.2836
Trichomonas vaginalis	alpha-glucosidase, putative	0.0075	0.0667	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0028	0.0178	0.2003
Echinococcus multilocularis	lamin dm0	0.0054	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0227
Loa Loa (eye worm)	fli-1 protein	0.0229	0.2248	0.6609
Chlamydia trachomatis	glutamine binding protein	0.0023	0.0126	0.5
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0075	0.0667	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0447	0.1315
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0029	0.0186	0.0186
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0178	0.205
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0055	0.0058
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0075	0.0665	0.1954
Loa Loa (eye worm)	glutamate receptor 1	0.0024	0.0139	0.0408
Schistosoma mansoni	hypothetical protein	0.0021	0.0109	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0447	0.1315
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0028	0.0178	0.2003
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0075	0.0667	0.1961
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Leishmania major	cathepsin L-like protease	0.0016	0.0055	0.0058
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0186	0.0186
Echinococcus granulosus	GA binding protein alpha chain	0.0075	0.0665	0.154
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0055	0.0128
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0186	0.0186
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0261	0.3412
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0437	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0261	0.0769
Trichomonas vaginalis	alpha-glucosidase, putative	0.0075	0.0667	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0075	0.0667	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0227	0.0527
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0471	0.682
Brugia malayi	Ets-domain containing protein	0.0075	0.0665	0.1954
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0261	0.3374
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0261	0.0261
Trichomonas vaginalis	alpha-glucosidase, putative	0.0075	0.0667	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0147	0.034
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0186	0.0432
Schistosoma mansoni	hypothetical protein	0.0354	0.3542	0.8204
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0157	0.0365
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Echinococcus multilocularis	zinc finger protein	0.0022	0.0115	0.0115
Leishmania major	cathepsin L-like protease	0.0062	0.0527	0.7722
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.007	0.0163
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.0546	0.0546
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0023	0.0126	0.5
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0489	0.1132
Brugia malayi	Bromodomain containing protein	0.008	0.071	0.2088
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0261	0.0606
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0077	0.0226
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0055	0.0128
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0178	0.2003
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0077	0.0179
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0055	0.0162
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0261	0.0606
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0667	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0261	0.0261
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0075	0.0667	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0147	0.034
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.0546	0.1265
Echinococcus granulosus	dnaJ subfamily B	0.0429	0.4317	1
Echinococcus multilocularis	glutamate receptor 2	0.0024	0.0139	0.0139
Onchocerca volvulus		0.0054	0.0447	0.2103
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0178	0.2003
Leishmania major	glycosyl hydrolase-like protein	0.0028	0.0178	0.205
Schistosoma mansoni	alpha-glucosidase	0.0293	0.2912	0.6744
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0187	0.055
Echinococcus granulosus	intermediate filament protein	0.0054	0.0447	0.1036
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0055	0.0055
Loa Loa (eye worm)	glutamate receptor 2	0.0024	0.0139	0.0408
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.0962	0.283
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Trypanosoma brucei	glucosidase, putative	0.0075	0.0667	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.039	0.5498
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0023	0.0126	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0178	0.2003
Leishmania major	alpha glucosidase II subunit, putative	0.0075	0.0667	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0198	0.0583
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0227	0.0227
Echinococcus granulosus	geminin	0.0354	0.3542	0.8204
Schistosoma mansoni	alpha glucosidase	0.0075	0.0667	0.1545
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0144	0.151
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0055	0.0055
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0024	0.0139	0.0321
Echinococcus multilocularis	nmda type glutamate receptor	0.0032	0.0219	0.0219
Schistosoma mansoni	bromodomain containing protein	0.0068	0.0584	0.1354
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.034	0.3401	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0527	0.7722
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0055	0.0128
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0527	0.7722
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0157	0.0463
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0144	1
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0447	0.1315
Trichomonas vaginalis	alpha-glucosidase, putative	0.0075	0.0667	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0646	0.1901
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0003	0.0003
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0055	0.0128
Schistosoma mansoni	zinc finger protein	0.0022	0.0115	0.0267
Echinococcus multilocularis	glutamate receptor 2	0.002	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0055	0.0162
Schistosoma mansoni	ets-related	0.0229	0.2248	0.5206
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0003	0.0008
Leishmania major	cathepsin L-like protease	0.0062	0.0527	0.7722
Schistosoma mansoni	alpha-glucosidase	0.0293	0.2912	0.6744
Echinococcus multilocularis	dnaJ subfamily B	0.0429	0.4317	0.4317
Onchocerca volvulus		0.0054	0.0447	0.2103
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0178	0.205
Echinococcus multilocularis	cpg binding protein	0.0034	0.0237	0.0237
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0147	0.0147
Leishmania major	cathepsin L-like protease	0.0062	0.0527	0.7722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.0962	0.283
Echinococcus multilocularis	cysteine protease	0.0016	0.0055	0.0055
Schistosoma mansoni	glutamate receptor NMDA	0.0029	0.0186	0.0432
Schistosoma mansoni	zinc finger protein	0.0016	0.0051	0.0119
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2836	0.657
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0261	0.0769
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0667	1
Brugia malayi	Fli-1 protein	0.0229	0.2248	0.6609
Schistosoma mansoni	ATP-binding cassette transporter	0.0024	0.0139	0.0321
Schistosoma mansoni	hypothetical protein	0.0033	0.0227	0.0527
Schistosoma mansoni	glutamate receptor kainate	0.0024	0.0139	0.0321
Schistosoma mansoni	cpg binding protein	0.0034	0.0237	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0325	0.0954
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0024	0.0139	0.0139
Echinococcus granulosus	cpg binding protein	0.0034	0.0237	0.0548
Schistosoma mansoni	glutamate receptor AMPA	0.0024	0.0139	0.0321
Brugia malayi	Glycosyl hydrolases family 31 protein	0.034	0.3401	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0227	0.0669
Echinococcus multilocularis	lysosomal alpha glucosidase	0.034	0.3401	0.3401
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0622	0.1829
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2836	0.834
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0261	0.3374
Schistosoma mansoni	lamin	0.0054	0.0447	0.1036
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0261	0.3412
Brugia malayi	PHD-finger family protein	0.0028	0.0172	0.0507
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0489	0.1437
Schistosoma mansoni	glutamate receptor kainate	0.0024	0.0139	0.0321
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0227	0.0527
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0028	0.0178	0.205
Echinococcus granulosus	GPCR family 2	0.0033	0.0227	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0227	0.0669
Echinococcus granulosus	lysosomal alpha glucosidase	0.034	0.3401	0.7878
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0186	0.0186
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0075	0.0667	1
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0023	0.0126	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0227	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0147	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0552	0.1623
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1376	0.4046
Echinococcus granulosus	lamin	0.0054	0.0447	0.1036
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0622	0.1829
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0187	0.055
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.0962	0.283
Brugia malayi	CXXC zinc finger family protein	0.003	0.0198	0.0583
Echinococcus granulosus	nmda type glutamate receptor	0.0032	0.0219	0.0507
Schistosoma mansoni	hypothetical protein	0.0058	0.0489	0.1132
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0527	0.7722
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0055	0.0162
Echinococcus multilocularis	musashi	0.0054	0.0447	0.0447
Brugia malayi	Bromodomain containing protein	0.004	0.0298	0.0877
Schistosoma mansoni	lamin	0.0054	0.0447	0.1036
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.007	0.0163
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1376	0.4046
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.007	0.007
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0144	0.151
Schistosoma mansoni	hypothetical protein	0.0429	0.4317	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0178	0.2003
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0028	0.0178	0.0522
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0144	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Echinococcus granulosus	glutamate receptor 2	0.002	0.0093	0.0216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0075	0.0667	0.0667
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0075	0.0667	1
Echinococcus multilocularis	GA binding protein alpha chain	0.0075	0.0665	0.0665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0178	0.2003
Echinococcus granulosus	zinc finger protein	0.0022	0.0115	0.0267
Echinococcus multilocularis	lysosomal alpha glucosidase	0.034	0.3401	0.3401
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0261	0.0606
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0227	0.0669
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0055	0.0055
Loa Loa (eye worm)	cysteine protease	0.0016	0.0055	0.0162
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0186	0.0432
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0109	0.032
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.007	0.0163
Onchocerca volvulus		0.003	0.0198	0.0768
Schistosoma mansoni	glutamate receptor kainate	0.0024	0.0139	0.0321
Schistosoma mansoni	hypothetical protein	0.0016	0.0051	0.0119
Leishmania major	hypothetical protein, conserved	0.0025	0.0144	0.151
Brugia malayi	Glutamate receptor 1 precursor	0.0024	0.0139	0.0408
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0261	0.0606
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0077	0.0077
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0075	0.0667	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0527	0.7722
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0032	0.0219	0.0219
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0227	0.0227
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0261	0.0606
Schistosoma mansoni	hypothetical protein	0.0071	0.0622	0.1441
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0273	0.0632
Schistosoma mansoni	hypothetical protein	0.0033	0.0227	0.0527
Brugia malayi	Ets-domain containing protein	0.0075	0.0665	0.1954
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0077	0.0179
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0962	0.283
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0178	0.2003
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0055	0.0162
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0273	0.0273
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0144	0.1461
Brugia malayi	MH2 domain containing protein	0.0144	0.1376	0.4046
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0261	0.3412
Echinococcus multilocularis	lamin	0.0054	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0147	0.0433
Leishmania major	cathepsin L-like protease	0.0016	0.0055	0.0058

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	10.3225 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1597376
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 802258