Detailed information for compound 806668

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.56 | Formula: C23H28N4OS
  • H donors: 0 H acceptors: 2 LogP: 3.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nnc(n1CC1CCCO1)CN(Cc1ccc(cc1)c1ccccc1)C
  • InChi: 1S/C23H28N4OS/c1-26(15-18-10-12-20(13-11-18)19-7-4-3-5-8-19)17-22-24-25-23(29-2)27(22)16-21-9-6-14-28-21/h3-5,7-8,10-13,21H,6,9,14-17H2,1-2H3
  • InChiKey: XRAZFKREPUIVIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0147 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0147 0.0119
Echinococcus multilocularis sterol regulatory element binding protein 0.005 0.0158 0.0158
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0171 0.0171
Brugia malayi nuclear receptor NHR-67 0.0022 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0145 0.0549 0.1528
Brugia malayi Pre-SET motif family protein 0.0035 0.0098 0.0215
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0132 0.0253
Schistosoma mansoni ap endonuclease 0.0022 0.0042 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0091 0.0327 0.0327
Echinococcus granulosus Protein patched homolog 1 0.005 0.0158 0.0158
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0042 0.0441
Leishmania major DNA damage repair protein, putative 0.0028 0.0068 0.0931
Echinococcus multilocularis cpg binding protein 0.0036 0.01 0.01
Brugia malayi nuclear receptor NHR-88 0.0047 0.0147 0.0353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0171 0.0171
Schistosoma mansoni ceramide glucosyltransferase 0.0814 0.3318 0.3298
Onchocerca volvulus Huntingtin homolog 0.0145 0.0549 0.1545
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0147 0.0353
Echinococcus multilocularis musashi 0.0031 0.0081 0.0081
Schistosoma mansoni lamin 0.0031 0.0081 0.0052
Entamoeba histolytica deoxycytidyl transferase, putative 0.0091 0.0327 0.6794
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Echinococcus multilocularis geminin 0.058 0.2352 0.2352
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0044 0.0044
Schistosoma mansoni cpg binding protein 0.0036 0.01 0.0071
Loa Loa (eye worm) ceramide glucosyltransferase 0.0814 0.3318 0.9226
Echinococcus multilocularis expressed conserved protein 0.0109 0.0403 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0327 0.7057
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.005 0.0158 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0171 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0098 0.0069
Echinococcus granulosus ceramide glucosyltransferase 0.0814 0.3318 0.3318
Mycobacterium ulcerans DNA polymerase IV 0.0091 0.0327 1
Schistosoma mansoni ap endonuclease 0.0022 0.0042 0.0013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0056 0.0181 0.0181
Trichomonas vaginalis set domain proteins, putative 0.0276 0.1091 0.2954
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Echinococcus granulosus lamin 0.0031 0.0081 0.0081
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0132 0.3159
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0055 0.0095
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0068 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Loa Loa (eye worm) hypothetical protein 0.0479 0.1934 0.5379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0254 0.0226
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0056 0.0181 0.0181
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0037 0.0103 0.1771
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0042 0.0311
Schistosoma mansoni terminal deoxycytidyl transferase 0.0091 0.0327 0.0299
Loa Loa (eye worm) hypothetical protein 0.005 0.0158 0.0438
Brugia malayi nuclear hormone receptor 0.0022 0.0044 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0147 0.0316
Mycobacterium ulcerans DNA polymerase IV 0.0091 0.0327 1
Echinococcus multilocularis ceramide glucosyltransferase 0.0814 0.3318 0.3318
Loa Loa (eye worm) hypothetical protein 0.0061 0.0204 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0147 0.0409
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0044 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0068 0.0931
Schistosoma mansoni hypothetical protein 0.0056 0.0181 0.0153
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0048 0.015 0.0122
Schistosoma mansoni DNA polymerase eta 0.0121 0.0451 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0261 0.0233
Brugia malayi hypothetical protein 0.0022 0.0044 0.0064
Loa Loa (eye worm) DR-78 0.0022 0.0044 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0042 0.0311
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Schistosoma mansoni hypothetical protein 0.012 0.0448 0.042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Trypanosoma brucei unspecified product 0.0063 0.021 0.43
Echinococcus multilocularis Niemann Pick C1 protein 0.0166 0.0638 0.0638
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0147 0.0119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Brugia malayi hydrolase, alpha/beta fold family protein 0.0045 0.0136 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0068 0.0931
Brugia malayi TAR-binding protein 0.0075 0.0261 0.0671
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0028 0.0028
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0068 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Echinococcus multilocularis muscleblind protein 1 0.0162 0.0621 0.0621
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0327 0.7057
Schistosoma mansoni hypothetical protein 0.0056 0.0181 0.0153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0098 0.3574
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Schistosoma mansoni hypothetical protein 0.058 0.2352 0.233
Brugia malayi Muscleblind-like protein 0.0162 0.0621 0.168
Brugia malayi ecdysone receptor 0.0022 0.0044 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0147 0.0316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0171 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0068 0.0931
Entamoeba histolytica hypothetical protein 0.0123 0.0461 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0044 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0261 0.0233
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0147 0.0353
Mycobacterium tuberculosis Conserved hypothetical protein 0.0091 0.0327 1
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0147 0.0119
Echinococcus multilocularis dna polymerase eta 0.0121 0.0451 0.0451
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0044 0.0044
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0078 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0171 0.0171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0056 0.0181 0.0503
Schistosoma mansoni hydrolase 0.0045 0.0136 0.0108
Schistosoma mansoni lamin 0.0031 0.0081 0.0052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0081 0.0225
Brugia malayi Pre-SET motif family protein 0.0242 0.0953 0.2609
Schistosoma mansoni cpg binding protein 0.0036 0.01 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Schistosoma mansoni hypothetical protein 0.0048 0.015 0.0122
Echinococcus granulosus cpg binding protein 0.0036 0.01 0.01
Echinococcus granulosus dna polymerase eta 0.0121 0.0451 0.0451
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0042 0.19
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0147 0.0353
Giardia lamblia DINP protein human, muc B family 0.0091 0.0327 0.1985
Loa Loa (eye worm) hypothetical protein 0.012 0.0448 0.1245
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0132 0.2442
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0091 0.0327 0.0327
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0147 0.0147
Trypanosoma brucei DNA polymerase eta, putative 0.0121 0.0451 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Entamoeba histolytica hypothetical protein 0.0123 0.0461 1
Echinococcus multilocularis protein dispatched 1 0.0057 0.0187 0.0187
Trichomonas vaginalis DNA polymerase eta, putative 0.0091 0.0327 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0152
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0042 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0147 0.0147
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0147 0.0353
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0028 0.0079
Brugia malayi CXXC zinc finger family protein 0.0034 0.0092 0.0198
Schistosoma mansoni transcription factor LCR-F1 0.0123 0.0461 0.0434
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0044 0.0121
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0091 0.0327 0.0802
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0261 0.0233
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0044 0.0044
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0058 0.0192 0.8449
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0042 0.0042
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0132 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0132 0.2146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0171 0.0143
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0147 0.0147
Echinococcus multilocularis microtubule associated protein 2 0.2429 1 1
Leishmania major DNA polymerase eta, putative 0.0058 0.0192 0.3874
Echinococcus granulosus abhydrolase domain containing protein 0.0045 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0092 0.0255
Echinococcus multilocularis bile acid beta glucosidase 0.071 0.2889 0.2889
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0147 0.0353
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0132 0.2442
Schistosoma mansoni hypothetical protein 0.0123 0.0461 0.0434
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Echinococcus granulosus non lysosomal glucosylceramidase 0.071 0.2889 0.2889
Brugia malayi polk-prov protein 0.0028 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0175 0.0677 0.1883
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0147 0.0147
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0261 0.0725
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0147 0.0119
Echinococcus granulosus bile acid beta glucosidase 0.071 0.2889 0.2889
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0038
Schistosoma mansoni bile acid beta-glucosidase-related 0.071 0.2889 0.2868
Echinococcus multilocularis abhydrolase domain containing protein 0.0045 0.0136 0.0136
Schistosoma mansoni intermediate filament proteins 0.0031 0.0081 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0081 0.0225
Schistosoma mansoni zinc finger protein 0.0022 0.0044 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0327 0.7057
Echinococcus granulosus Niemann Pick C1 protein 0.0166 0.0638 0.0638
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0147 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0032
Echinococcus multilocularis protein patched 0.005 0.0158 0.0158
Brugia malayi Latrophilin receptor protein 2 0.0056 0.0181 0.0448
Loa Loa (eye worm) hypothetical protein 0.0056 0.0181 0.0503
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0147 0.0353
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Echinococcus multilocularis muscleblind protein 0.0162 0.0621 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0158 0.0326
Echinococcus granulosus lamin dm0 0.0031 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0609 0.2471 0.6836
Brugia malayi Inositol-1 0.0044 0.0132 0.031
Echinococcus granulosus Niemann Pick C1 protein 0.0116 0.0432 0.0432
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0068 0.0931
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0042 0.0116
Echinococcus multilocularis dna polymerase kappa 0.0091 0.0327 0.0327
Schistosoma mansoni inositol monophosphatase 0.0044 0.0132 0.0103
Brugia malayi nuclear receptor RXR 0.0025 0.0055 0.0095
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0068 0.0039
Brugia malayi steroid hormone receptor 0.0047 0.0147 0.0353
Schistosoma mansoni inositol monophosphatase 0.0044 0.0132 0.0103
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0028
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0132 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0055 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0056 0.0181 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0147 0.0147
Plasmodium vivax SET domain protein, putative 0.0035 0.0098 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0113 0.2827
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.021 0.43
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Onchocerca volvulus Huntingtin homolog 0.0145 0.0549 0.1545
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0028 0.0022
Entamoeba histolytica heat shock transcription factor, putative 0.0117 0.0435 0.9386
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0055 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0056 0.0181 0.0181
Entamoeba histolytica heat shock transcription factor, putative 0.0117 0.0435 0.9386
Brugia malayi tailless protein 0.0022 0.0044 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0147 0.0353
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0068 0.0931
Brugia malayi hypothetical protein 0.0025 0.0055 0.0095
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0044 0.0064
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0055 0.0152
Brugia malayi hypothetical protein 0.0022 0.0044 0.0064
Brugia malayi CHE-14 protein 0.005 0.0158 0.0383
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.0534 0.1485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0044 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0098 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0121 0.0451 0.1203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0261 0.0233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0147 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0171 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0147 0.0353
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0147 0.0147
Onchocerca volvulus 0.0034 0.0092 0.0146
Brugia malayi nuclear receptor NHR-88 0.0022 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0032
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0098 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.012 0.0448 0.1194
Brugia malayi Niemann-Pick C1 protein precursor 0.0116 0.0432 0.115
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0117 0.0435 0.121
Onchocerca volvulus 0.0047 0.0147 0.0316
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0044 0.0015
Brugia malayi intermediate filament protein 0.0031 0.0081 0.0168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0409
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0044 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0068 0.0931
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.0327 0.0856
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0042 0.1221
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0147 0.0119
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Echinococcus multilocularis Niemann Pick C1 protein 0.0116 0.0432 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0068 0.0931
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0118 0.0439 0.0412
Trypanosoma brucei unspecified product 0.0063 0.021 0.43
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0261 0.0261
Echinococcus granulosus muscleblind protein 0.0162 0.0621 0.0621
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0117 0.0435 0.1196
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0147 0.0353
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0068 0.3653
Schistosoma mansoni hypothetical protein 0.058 0.2352 0.233
Trypanosoma cruzi DNA polymerase eta, putative 0.0121 0.0451 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0152
Brugia malayi nuclear hormone receptor 0.0047 0.0147 0.0353
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0091 0.0327 0.0299
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0068 0.2031
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0044 0.0044
Onchocerca volvulus 0.0035 0.0098 0.0165
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0091 0.0327 0.0908
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0068 0.5681
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0044 0.0015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0091 0.0327 0.7057
Leishmania major DNA polymerase eta, putative 0.0121 0.0451 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.021 0.43
Mycobacterium ulcerans hypothetical protein 0.0028 0.0068 0.0919
Loa Loa (eye worm) hypothetical protein 0.0116 0.0432 0.1201
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0147 0.0147
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0042 0.0311
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0068 0.0931
Onchocerca volvulus 0.0276 0.1091 0.32
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0132 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0147 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Brugia malayi RNA binding protein 0.0075 0.0261 0.0671
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0147 0.0409
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0058
Loa Loa (eye worm) hypothetical protein 0.0162 0.0621 0.1728
Entamoeba histolytica hypothetical protein 0.0123 0.0461 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0147 0.0316
Schistosoma mansoni cpg binding protein 0.0034 0.0092 0.0063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0147 0.0147
Brugia malayi Ceramide glucosyltransferase 0.0814 0.3318 0.9222
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0147 0.0147
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0147 0.0353
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0042 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0147 0.0353
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0044 0.0121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0171 0.042
Loa Loa (eye worm) hypothetical protein 0.0162 0.0621 0.1728
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0132 0.2442
Schistosoma mansoni ceramide glucosyltransferase 0.0814 0.3318 0.3298
Echinococcus granulosus tar DNA binding protein 0.0075 0.0261 0.0261
Brugia malayi hypothetical protein 0.0025 0.0055 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0055 0.0095
Schistosoma mansoni hypothetical protein 0.0048 0.015 0.0122
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0261 0.0671
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0044 0.0044
Schistosoma mansoni nuclear receptor 0.0022 0.0044 0.0015
Echinococcus multilocularis lamin dm0 0.0031 0.0081 0.0081
Brugia malayi hypothetical protein 0.0123 0.0461 0.1232
Echinococcus granulosus dna polymerase kappa 0.0091 0.0327 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0147 0.0409
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0152
Schistosoma mansoni patched 1 0.005 0.0158 0.0129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0261 0.0725
Schistosoma mansoni nuclear receptor 0.0022 0.0044 0.0015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0044 0.0044
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0116 0.0432 0.9306
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0068 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Echinococcus granulosus expressed conserved protein 0.0109 0.0403 0.0403
Echinococcus granulosus sterol regulatory element binding protein 0.005 0.0158 0.0158
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0068 0.2031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0147 0.0353
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Brugia malayi conserved hypotetical protein 0.0022 0.0044 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0171 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0089 0.0089
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0044 0.0015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0091 0.0327 1
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0132 0.0132
Brugia malayi nuclear receptor RXR 0.0022 0.0044 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0147 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0044 0.0015
Brugia malayi ecdysteroid receptor 0.0047 0.0147 0.0353
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0147 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Toxoplasma gondii exonuclease III APE 0.0022 0.0042 0.0679
Brugia malayi MH2 domain containing protein 0.0141 0.0534 0.1436
Entamoeba histolytica hypothetical protein 0.0123 0.0461 1
Brugia malayi hypothetical protein 0.0145 0.0549 0.1479
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0132 0.0253
Echinococcus granulosus intermediate filament protein 0.0031 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0147 0.0409
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0147 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0261 0.0233
Loa Loa (eye worm) hypothetical protein 0.0145 0.0549 0.1528
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0132 0.2442
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0044 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0123 0.0461 0.0461
Giardia lamblia Ceramide glucosyltransferase 0.0369 0.1477 1
Loa Loa (eye worm) RNA binding protein 0.0075 0.0261 0.0725
Schistosoma mansoni bile acid beta-glucosidase-related 0.071 0.2889 0.2868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0147 0.0409
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.0953 0.2651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0123 0.0461 0.0461
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0044 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.021 0.43
Echinococcus multilocularis non lysosomal glucosylceramidase 0.071 0.2889 0.2889
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0147 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0175 0.0677 0.1883
Leishmania major hypothetical protein, conserved 0.0045 0.0136 0.2549
Schistosoma mansoni hypothetical protein 0.0056 0.0181 0.0153
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0055 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0147 0.0119
Echinococcus granulosus geminin 0.058 0.2352 0.2352
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0147 0.0119
Echinococcus granulosus GPCR family 2 0.0056 0.0181 0.0181
Onchocerca volvulus 0.0031 0.0081 0.0113
Trypanosoma cruzi DNA polymerase eta, putative 0.0058 0.0192 0.3874
Entamoeba histolytica heat shock transcription factor, putative 0.0117 0.0435 0.9386
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0147 0.0119
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0121 0.0451 0.1254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0147 0.0409
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Plasmodium falciparum epoxide hydrolase 1 0.0045 0.0136 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0132 0.5327
Brugia malayi isocitrate dehydrogenase 0.0019 0.0028 0.0022
Leishmania major DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Schistosoma mansoni hypothetical protein 0.0056 0.0181 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Onchocerca volvulus 0.0031 0.0081 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0147 0.0353
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0113 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0081 0.0225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0147 0.0119
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0147 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0147 0.0353
Loa Loa (eye worm) hypothetical protein 0.0028 0.0068 0.0189
Schistosoma mansoni hypothetical protein 0.0048 0.015 0.0122
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0147 0.0147
Trypanosoma brucei unspecified product 0.0091 0.0327 0.7057
Onchocerca volvulus 0.0037 0.0103 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0327 0.7057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0147 0.0353
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0881 0.3596 1
Giardia lamblia DNA damage repair protein 0.0028 0.0068 0.0182
Schistosoma mansoni coup transcription factor 0.0047 0.0147 0.0119
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0814 0.3318 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0056 0.0181 0.0448
Schistosoma mansoni microtubule-associated protein tau 0.2429 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0042 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0147 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0534 0.1485
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Loa Loa (eye worm) hydrolase 0.0045 0.0136 0.0379
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0044 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0147 0.0147
Loa Loa (eye worm) inositol-1 0.0044 0.0132 0.0366
Echinococcus multilocularis lamin 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0152
Echinococcus multilocularis GPCR, family 2 0.0056 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Onchocerca volvulus Glucosylceramidase homolog 0.0578 0.2343 0.7022
Trichomonas vaginalis glucosylceramidase, putative 0.0609 0.2471 0.6836
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Trichomonas vaginalis glucosylceramidase, putative 0.0881 0.3596 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0044 0.0044
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0081 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0175 0.0677 0.1836
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0881 0.3596 1
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.2343 0.6474
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0175 0.0677 0.1836
Brugia malayi HSF-type DNA-binding domain containing protein 0.0117 0.0435 0.116
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0147 0.0409
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0042 0.0311
Leishmania major DNA polymerase kappa, putative 0.0028 0.0068 0.0931

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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