Detailed information for compound 814719

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 464.598 | Formula: C22H28N2O5S2
  • H donors: 1 H acceptors: 4 LogP: 3.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c2CCN(Cc2sc1S(=O)(=O)Nc1ccc(cc1)C)C(=O)CCC(C)C
  • InChi: 1S/C22H28N2O5S2/c1-14(2)5-10-19(25)24-12-11-17-18(13-24)30-22(20(17)21(26)29-4)31(27,28)23-16-8-6-15(3)7-9-16/h6-9,14,23H,5,10-13H2,1-4H3
  • InChiKey: BRIWATKEUCVUES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.058 0.0653
Echinococcus multilocularis 0.0019 0.0184 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0536 0.0602
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0156 0.0156
Echinococcus multilocularis geminin 0.0178 0.5976 0.6833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0184 0.0076
Loa Loa (eye worm) hypothetical protein 0.0082 0.2464 0.2811
Loa Loa (eye worm) cysteine protease 0.0018 0.0156 0.0167
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.2464 0.6264
Brugia malayi Cytochrome P450 family protein 0.0065 0.1875 0.2136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.058 0.0653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Echinococcus multilocularis FTZ F1 alpha 0.003 0.058 0.0653
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.3467 0.7983
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1994 0.4887
Loa Loa (eye worm) CYP4Cod1 0.0065 0.1875 0.2136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.058 0.0653
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0071 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.1684 0.8874
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.058 0.0653
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0555 0.0624
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0156 0.0167
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Schistosoma mansoni nuclear receptor 0.0014 0.001 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0156 0.0167
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.2464 0.2811
Schistosoma mansoni lamin 0.0029 0.0555 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.3917 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.3467 0.3959
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.3467 0.3959
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.058 0.0653
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.1684 0.4064
Echinococcus granulosus ubiquitin specific protease 41 0.0122 0.3917 0.4475
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0122 0.3917 0.3917
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0122 0.3917 0.4475
Echinococcus multilocularis expressed protein 0.0082 0.2464 0.2811
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.3467 0.8803
Onchocerca volvulus 0.012 0.3841 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Brugia malayi MH2 domain containing protein 0.0128 0.4132 0.4722
Echinococcus granulosus geminin 0.0178 0.5976 0.6833
Leishmania major cathepsin L-like protease 0.0069 0.1994 0.4887
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1386 0.1576
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.3467 0.8803
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0029 0.0555 0.0624
Schistosoma mansoni follistatin 0.0082 0.2464 0.2464
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.3467 0.3467
Leishmania major cathepsin L-like protease 0.0069 0.1994 0.4887
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0156 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0122 0.3917 0.3917
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0184 0.0077
Schistosoma mansoni organic anion transporter 0.012 0.3841 0.3841
Onchocerca volvulus 0.0018 0.0156 0.038
Brugia malayi nuclear hormone receptor 0.003 0.058 0.0653
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.1875 0.457
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0178 0.5976 0.5976
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.3467 0.8803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Schistosoma mansoni agrin 0.0082 0.2464 0.2464
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Brugia malayi Cytochrome P450 family protein 0.0065 0.1875 0.2136
Brugia malayi secreted modular calcium-binding protein 1 0.0082 0.2464 0.2811
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0555 0.0624
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0071 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.058 0.0653
Schistosoma mansoni hypothetical protein 0.0178 0.5976 0.5976
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0082 0.2464 0.2811
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0156 0.0167
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.058 0.058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.3467 0.8803
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.3917 1
Echinococcus multilocularis cysteine protease 0.0018 0.0156 0.0167
Echinococcus multilocularis ubiquitin specific protease 41 0.0122 0.3917 0.4475
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.058 0.0653
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.2464 0.6264
Echinococcus granulosus FTZ F1 alpha 0.003 0.058 0.0653
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Onchocerca volvulus 0.0018 0.0156 0.038
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.3841 0.4388
Brugia malayi steroid hormone receptor 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.007
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0156 0.038
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.3467 0.3959
Brugia malayi prostaglandin transporter 0.012 0.3841 0.4388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.2464 0.6264
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.012 0.3841 0.4388
Brugia malayi MAP kinase sur-1 0.0109 0.3467 0.3959
Onchocerca volvulus 0.003 0.058 0.1487
Brugia malayi nuclear receptor RXR 0.0016 0.0071 0.007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0066 0.0064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0122 0.3917 0.4475
Leishmania major cathepsin L-like protease 0.0069 0.1994 0.4887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.058 0.0653
Brugia malayi hypothetical protein 0.0016 0.0071 0.007
Schistosoma mansoni coup transcription factor 0.003 0.058 0.058
Schistosoma mansoni nuclear hormone receptor 0.0014 0.001 0.001
Echinococcus multilocularis musashi 0.0029 0.0555 0.0624
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.058 0.0653
Echinococcus granulosus follistatin 0.0082 0.2464 0.2811
Echinococcus granulosus organic anion transporting polypeptide 30B 0.012 0.3841 0.4388
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0122 0.3917 1
Onchocerca volvulus 0.0018 0.0156 0.038
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0082 0.2464 0.6264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.058 0.0653
Echinococcus multilocularis lamin dm0 0.0029 0.0555 0.0624
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.1684 0.1918
Echinococcus multilocularis cysteine protease 0.0018 0.0156 0.0167
Onchocerca volvulus 0.0082 0.2464 0.6406
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.058 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.058 0.0653
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.058 0.0653
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.1684 0.1918
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0156 0.0167
Loa Loa (eye worm) cytochrome P450 0.0019 0.0184 0.02
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.058 0.058
Onchocerca volvulus 0.0018 0.0156 0.038
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.1684 0.4064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0122 0.3917 0.4475
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Schistosoma mansoni ap endonuclease 0.006 0.1684 0.1684
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1994 0.4887
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0082 0.2464 0.2811
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.058 0.0653
Trichomonas vaginalis ap endonuclease, putative 0.006 0.1684 0.4064
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0156 0.0156
Trypanosoma brucei RNA helicase, putative 0.0289 1 1
Onchocerca volvulus Putative organic anion transporter 0.012 0.3841 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0122 0.3917 0.4475
Toxoplasma gondii protease inhibitor PI2 0.0082 0.2464 0.6264
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.1461 0.3469
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.058 0.058
Brugia malayi cytochrome P450 0.0019 0.0184 0.0199
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0255 0.874 1
Loa Loa (eye worm) agrin synaptic family protein 0.0082 0.2464 0.2811
Loa Loa (eye worm) sodium-independent organic anion transporter 0.012 0.3841 0.4388
Brugia malayi Cathepsin L-like precursor 0.0018 0.0156 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.058 0.0653
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0184 0.0076
Onchocerca volvulus 0.012 0.3841 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.1684 1
Schistosoma mansoni nuclear receptor 0.0014 0.001 0.001
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.1994 0.4887
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.007
Schistosoma mansoni ap endonuclease 0.006 0.1684 0.1684
Onchocerca volvulus 0.0052 0.1386 0.3591
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.1778 0.4312
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0184 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Onchocerca volvulus 0.012 0.3841 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.1875 0.2136
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.1994 0.4887
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0184 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.058 0.0653
Onchocerca volvulus Putative organic anion transporter 0.012 0.3841 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.058 0.0653
Schistosoma mansoni thyroid hormone receptor 0.003 0.058 0.058
Leishmania major cytochrome p450-like protein 0.0019 0.0184 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Onchocerca volvulus 0.012 0.3841 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.058 0.0653
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.058 0.1487
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0184 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.3467 0.8803
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.058 0.0653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.001 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0071 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.1684 0.1917
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0156 0.0167
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.3841 0.4388
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.058 0.058
Brugia malayi nuclear receptor NHR-88 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0071 0.007
Echinococcus multilocularis follistatin 0.0082 0.2464 0.2811
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.058 0.058
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0122 0.3917 1
Schistosoma mansoni hypothetical protein 0.0019 0.0184 0.0184
Onchocerca volvulus 0.0018 0.0156 0.038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.058 0.0653
Schistosoma mansoni organic anion transporter 0.012 0.3841 0.3841
Brugia malayi Cytochrome P450 family protein 0.0019 0.0184 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.058 0.058
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.4132 0.4722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.007
Schistosoma mansoni hypothetical protein 0.0052 0.1386 0.1386
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.058 0.0653
Onchocerca volvulus 0.0029 0.0555 0.1423
Echinococcus granulosus intermediate filament protein 0.0029 0.0555 0.0624
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0066 0.0064
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Trypanosoma cruzi cytochrome P450, putative 0.0065 0.1875 0.457
Loa Loa (eye worm) ctsf protein 0.0018 0.0156 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0156 0.0167
Leishmania major cytochrome p450-like protein 0.0019 0.0184 0.0076
Trypanosoma brucei cytochrome P450, putative 0.0065 0.1875 0.1722
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.2464 0.2811
Echinococcus granulosus agrin 0.0082 0.2464 0.2811
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.001 0.001
Schistosoma mansoni survival motor neuron protein 0.0052 0.1386 0.1386
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.058 0.0653
Onchocerca volvulus 0.0018 0.0156 0.038
Mycobacterium leprae putative cytochrome p450 0.0019 0.0184 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0156 0.0167
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.1875 0.2136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.058 0.0653
Loa Loa (eye worm) hypothetical protein 0.0047 0.1192 0.1354
Trypanosoma cruzi MFS transporter, putative 0.012 0.3841 0.9798
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.1994 0.1844
Schistosoma mansoni zinc finger protein 0.0014 0.001 0.001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.3467 0.8803
Brugia malayi Steroid receptor seven-up type 2 0.003 0.058 0.0653
Brugia malayi hypothetical protein 0.0016 0.0071 0.007
Schistosoma mansoni lamin 0.0029 0.0555 0.0555
Brugia malayi ecdysteroid receptor 0.003 0.058 0.0653
Trichomonas vaginalis ap endonuclease, putative 0.006 0.1684 0.4064
Brugia malayi Cytochrome P450 family protein 0.0019 0.0184 0.0199
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.2464 0.2811
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.3467 0.3959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.058 0.0653
Brugia malayi intermediate filament protein 0.0029 0.0555 0.0624
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0555 0.0624
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.3467 0.8803
Schistosoma mansoni nuclear hormone receptor 0.003 0.058 0.058
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.058 0.1487
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.3917 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.058 0.0653
Loa Loa (eye worm) fibroinase 0.0018 0.0156 0.0167
Toxoplasma gondii transporter, major facilitator family protein 0.012 0.3841 1
Leishmania major cytochrome p450-like protein 0.0065 0.1875 0.457
Onchocerca volvulus 0.012 0.3841 1
Trypanosoma brucei protein kinase, putative 0.0109 0.3467 0.3344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.058 0.0653
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0122 0.3917 0.4475
Echinococcus granulosus lamin dm0 0.0029 0.0555 0.0624
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.3467 0.8984
Loa Loa (eye worm) hypothetical protein 0.0082 0.2464 0.2811
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0156 0.0167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.058 0.058
Echinococcus granulosus lamin 0.0029 0.0555 0.0624
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0184 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.007
Brugia malayi SPARC precursor 0.0082 0.2464 0.2811
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0184 0.0076
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.3467 0.3344
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0122 0.3917 1
Brugia malayi sodium-independent organic anion transporter family protein 0.012 0.3841 0.4388
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.1684 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.058 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.058 0.0653
Brugia malayi hypothetical protein 0.012 0.3841 0.4388
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0156 0.038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.058 0.0653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.1684 0.1528
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0071 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.058 0.058
Echinococcus granulosus cathepsin l1 0.0018 0.0156 0.0167
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0156 0.038
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.1684 0.5
Brugia malayi hypothetical protein 0.0255 0.874 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.001 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.3467 0.8803
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.3467 0.8803
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.058 0.058
Schistosoma mansoni intermediate filament proteins 0.0029 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.012 0.3841 0.4388
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.874 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.058 0.0653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.1684 0.4064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.058 0.0653
Schistosoma mansoni cytochrome P450 0.0019 0.0184 0.0184
Onchocerca volvulus 0.0018 0.0156 0.038
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.1684 0.1918
Echinococcus granulosus Solute carrier organic anion transporter family 0.012 0.3841 0.4388
Onchocerca volvulus Bile acid receptor homolog 0.003 0.058 0.1487
Toxoplasma gondii exonuclease III APE 0.006 0.1684 0.4148
Loa Loa (eye worm) hypothetical protein 0.0082 0.2464 0.2811
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.3467 0.3959
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.3467 0.8803
Echinococcus multilocularis Solute carrier organic anion transporter family 0.012 0.3841 0.4388
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.3917 0.3802
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.058 0.0653
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0122 0.3917 0.4475
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.1684 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0065 0.1875 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0082 0.2464 0.2811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.058 0.0653
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.1684 0.5
Schistosoma mansoni thyroid hormone receptor 0.003 0.058 0.058
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.3917 1
Echinococcus multilocularis lamin 0.0029 0.0555 0.0624
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.4132 0.4722
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.1684 0.4064
Onchocerca volvulus Putative organic anion transporter 0.012 0.3841 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.058 0.0653
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.874 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.058 0.0653
Brugia malayi hypothetical protein 0.012 0.3841 0.4388
Onchocerca volvulus 0.0029 0.0555 0.1423
Echinococcus multilocularis agrin 0.0082 0.2464 0.2811

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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