TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 296.281 | Formula: C15H12N4O3
H donors: 2 H acceptors: 5 LogP: 1.09 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c(O)c2ccccc2n(c1=O)C)Nc1ncccn1
InChi: 1S/C15H12N4O3/c1-19-10-6-3-2-5-9(10)12(20)11(14(19)22)13(21)18-15-16-7-4-8-17-15/h2-8,20H,1H3,(H,16,17,18,21)
InChiKey: ZUFMARVSGCUMJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Saccharomyces cerevisiae	protein transporter TIM23	Starlite/ChEMBL	No references
Saccharomyces cerevisiae	protein transporter TIM10	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	Niemann-Pick disease, type C1	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	RAB9A, member RAS oncogene family	Starlite/ChEMBL	No references
Homo sapiens	NLR family, pyrin domain containing 3	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Photuris pennsylvanica	Luciferase	Starlite/ChEMBL	No references
Homo sapiens	synuclein, alpha (non A4 component of amyloid precursor)	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Mitochondrial import inner membrane translocase subunit Tim23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium knowlesi	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium knowlesi	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	niemann-pick C1 (NPC1)	Get druggable targets OG5_128206	All targets in OG5_128206
Babesia bovis	mitochondrial import inner membrane protein, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium yoelii	small zinc finger-like protein-related	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma japonicum	ko:K07003 Niemann Pick type C1, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Entamoeba histolytica	acyl-coA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium knowlesi	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	Get druggable targets OG5_128839	All targets in OG5_128839
Candida albicans	protein trans. across mito. Intermembrane space	Get druggable targets OG5_128839	All targets in OG5_128839
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Entamoeba histolytica	Niemann-Pick C1 protein, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	protein trans. across mito. Intermembrane space	Get druggable targets OG5_128839	All targets in OG5_128839
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	Mitochondrial import inner membrane translocase subunit Tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Echinococcus multilocularis	expressed protein	Get druggable targets OG5_128839	All targets in OG5_128839
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	Get druggable targets OG5_128839	All targets in OG5_128839
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Toxoplasma gondii	TIM10 family protein, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	import of proteins into mitochondrial matrix	Get druggable targets OG5_128152	All targets in OG5_128152
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	expressed protein	Get druggable targets OG5_128839	All targets in OG5_128839
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium yoelii	peroxisomal-coenzyme a synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Mycobacterium ulcerans	fatty-acid-CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Candida albicans	import of proteins into mitochondrial matrix	Get druggable targets OG5_128152	All targets in OG5_128152
Mycobacterium ulcerans	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Theileria parva	mitochondrial import inner membrane translocase subunit tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium vivax	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Plasmodium falciparum	acyl-CoA synthetase	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Neospora caninum	mitochondrial import inner membrane translocase subunit tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_126609	All targets in OG5_126609
Babesia bovis	mitochondrial transport complex Tim10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Candida albicans	potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home	Get druggable targets OG5_128206	All targets in OG5_128206
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Plasmodium berghei	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania major	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania mexicana	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Neospora caninum	Tim10/DDP family zinc finger containing protein, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Brugia malayi	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	Niemann-Pick C1 protein precursor	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Onchocerca volvulus		Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania braziliensis	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Leishmania infantum	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Entamoeba histolytica	acyl-CoA synthetase, putative	Get druggable targets OG5_126609	All targets in OG5_126609
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Plasmodium berghei	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Toxoplasma gondii	mitochondrial inner membrane translocase subunit TIM17, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	Get druggable targets OG5_128839	All targets in OG5_128839
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania donovani	4-coumarate:coa ligase-like protein	Get druggable targets OG5_126609	All targets in OG5_126609
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium berghei	mitochondrial import inner membrane translocase subunit TIM23, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Neospora caninum	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126609	All targets in OG5_126609
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_126609	All targets in OG5_126609
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128152	All targets in OG5_128152
Theileria parva	mitochondrial import inner membrane translocase, putative	Get druggable targets OG5_128152	All targets in OG5_128152
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	Get druggable targets OG5_128839	All targets in OG5_128839
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	Get druggable targets OG5_128152	All targets in OG5_128152
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	515 aa	21.9 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferase	552 aa	467 aa	20.6 %
Mycobacterium leprae	Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferase	552 aa	474 aa	24.5 %
Mycobacterium leprae	Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferase	552 aa	458 aa	22.9 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferase	552 aa	491 aa	25.2 %
Mycobacterium tuberculosis	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)	Luciferase	552 aa	480 aa	21.7 %
Babesia bovis	long-chain acyl-CoA synthetase, putative	Luciferase	552 aa	446 aa	22.0 %
Mycobacterium leprae	FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	Luciferase	552 aa	533 aa	21.6 %
Mycobacterium tuberculosis	Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferase	552 aa	483 aa	23.6 %
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	Luciferase	552 aa	508 aa	22.0 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	546 aa	21.6 %
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	Luciferase	552 aa	544 aa	21.7 %
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	Luciferase	552 aa	505 aa	22.8 %
Cryptosporidium parvum	acetyl-coenzyme A synthetase	Luciferase	552 aa	570 aa	21.8 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	546 aa	21.6 %
Echinococcus multilocularis	long chain fatty acid transport protein 4	Luciferase	552 aa	470 aa	23.4 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 5	Luciferase	552 aa	486 aa	25.1 %
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	Luciferase	552 aa	503 aa	22.3 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferase	552 aa	530 aa	21.7 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferase	552 aa	472 aa	24.4 %
Toxoplasma gondii	type I fatty acid synthase, putative	Luciferase	552 aa	613 aa	20.9 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	588 aa	21.8 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferase	552 aa	483 aa	21.3 %
Candida albicans	similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase	Luciferase	552 aa	536 aa	23.1 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferase	552 aa	605 aa	23.3 %
Neospora caninum	acetyl-coenzyme a synthetase, putative	Luciferase	552 aa	514 aa	23.3 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	446 aa	22.4 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferase	552 aa	500 aa	23.2 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 1	Luciferase	552 aa	481 aa	23.7 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity.	Luciferase	552 aa	509 aa	22.0 %
Mycobacterium ulcerans	putative fatty-acid--CoA ligase	Luciferase	552 aa	485 aa	23.7 %
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	Luciferase	552 aa	493 aa	23.5 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferase	552 aa	480 aa	24.2 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferase	552 aa	550 aa	24.9 %
Mycobacterium tuberculosis	Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferase	552 aa	480 aa	21.7 %
Brugia malayi	AMP-binding enzyme family protein	Luciferase	552 aa	482 aa	24.5 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferase	552 aa	581 aa	21.3 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	530 aa	22.4 %
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	Luciferase	552 aa	531 aa	22.0 %
Onchocerca volvulus		Luciferase	552 aa	487 aa	24.4 %
Babesia bovis	fatty acyl-CoA synthetase family protein	Luciferase	552 aa	478 aa	24.1 %
Dictyostelium discoideum	fatty acyl-CoA synthetase	Luciferase	552 aa	473 aa	24.3 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	Luciferase	552 aa	541 aa	22.0 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferase	552 aa	514 aa	21.6 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferase	552 aa	518 aa	26.6 %
Brugia malayi	AMP-binding enzyme family protein	Luciferase	552 aa	492 aa	24.8 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferase	552 aa	525 aa	22.9 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	473 aa	22.4 %
Leishmania braziliensis	long-chain-fatty-acid-CoA ligase, putative	Luciferase	552 aa	476 aa	25.4 %
Giardia lamblia	Long chain fatty acid CoA ligase 5	Luciferase	552 aa	491 aa	21.8 %
Trichomonas vaginalis	antibiotic synthetase, putative	Luciferase	552 aa	580 aa	21.7 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	557 aa	21.4 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD11	Luciferase	552 aa	492 aa	25.2 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferase	552 aa	486 aa	25.9 %
Mycobacterium ulcerans	fatty-acid-CoA ligase FadD9	Luciferase	552 aa	473 aa	21.4 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferase	552 aa	501 aa	23.4 %
Cryptosporidium parvum	acyl-CoA synthetase	Luciferase	552 aa	460 aa	24.6 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	557 aa	21.4 %
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	Luciferase	552 aa	445 aa	20.9 %
Echinococcus granulosus	long chain fatty acid coenzyme A ligase 5	Luciferase	552 aa	481 aa	25.6 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase, FadD11	Luciferase	552 aa	492 aa	25.0 %
Neospora caninum	hypothetical protein	Luciferase	552 aa	529 aa	22.5 %
Leishmania mexicana	long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative	Luciferase	552 aa	472 aa	21.6 %
Schistosoma mansoni	long-chain-fatty-acid--CoA ligase	Luciferase	552 aa	526 aa	22.2 %
Candida albicans	similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase	Luciferase	552 aa	525 aa	22.9 %
Cryptosporidium hominis	acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme)	Luciferase	552 aa	570 aa	21.6 %
Theileria parva	long-chain fatty acid CoA ligase, putative	Luciferase	552 aa	468 aa	20.5 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferase	552 aa	442 aa	21.7 %
Toxoplasma gondii	propionate-CoA ligase	Luciferase	552 aa	503 aa	21.7 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 1	Luciferase	552 aa	459 aa	25.5 %
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	Luciferase	552 aa	512 aa	22.7 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferase	552 aa	467 aa	20.8 %
Entamoeba histolytica	acyl-CoA synthetase, putative	Luciferase	552 aa	464 aa	23.3 %
Cryptosporidium parvum	putative long chain fatty acyl CoA synthetase having a signal peptide	Luciferase	552 aa	470 aa	24.5 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	529 aa	23.4 %
Trichomonas vaginalis	AMP dependent CoA ligase, putative	Luciferase	552 aa	523 aa	25.0 %
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase FadD15	Luciferase	552 aa	476 aa	24.6 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferase	552 aa	476 aa	24.8 %
Trichomonas vaginalis	long-chain-fatty-acid CoA ligase, putative	Luciferase	552 aa	510 aa	22.2 %
Onchocerca volvulus	Matrilysin homolog	Luciferase	552 aa	499 aa	22.0 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Dictyostelium discoideum	acetyl-CoA ligase	Luciferase	552 aa	546 aa	21.8 %
Onchocerca volvulus		Luciferase	552 aa	498 aa	23.5 %
Plasmodium vivax	long-chain fatty acid CoA ligase, putative	Luciferase	552 aa	453 aa	24.5 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferase	552 aa	496 aa	22.4 %
Entamoeba histolytica	acyl-CoA synthetase, putative	Luciferase	552 aa	510 aa	23.1 %
Theileria parva	acetyl-coenzyme A synthetase, putative	Luciferase	552 aa	580 aa	22.4 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferase	552 aa	516 aa	26.2 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferase	552 aa	554 aa	21.3 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	530 aa	22.4 %
Dictyostelium discoideum	hypothetical protein	Luciferase	552 aa	540 aa	22.8 %
Dictyostelium discoideum	AMP-dependent synthetase and ligase domain-containing protein	Luciferase	552 aa	537 aa	20.9 %
Plasmodium falciparum	ras-related protein Rab-5B	RAB9A, member RAS oncogene family	201 aa	165 aa	30.9 %
Onchocerca volvulus		Luciferase	552 aa	553 aa	24.8 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferase	552 aa	451 aa	22.4 %
Trichomonas vaginalis	AMP dependent ligase/synthetase, putative	Luciferase	552 aa	448 aa	23.0 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 5	Luciferase	552 aa	470 aa	25.1 %
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Luciferase	552 aa	481 aa	20.4 %
Mycobacterium ulcerans	acyl-CoA synthetase	Luciferase	552 aa	559 aa	21.6 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferase	552 aa	478 aa	22.6 %
Schistosoma japonicum	ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative	Luciferase	552 aa	461 aa	26.0 %
Babesia bovis	acetyl-CoA synthetase, putative	Luciferase	552 aa	545 aa	21.3 %
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Luciferase	552 aa	476 aa	24.8 %
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	Luciferase	552 aa	491 aa	23.2 %
Loa Loa (eye worm)	AMP-binding enzyme family protein	Luciferase	552 aa	531 aa	24.9 %
Echinococcus multilocularis	long chain fatty acid coenzyme A ligase 5	Luciferase	552 aa	486 aa	24.9 %
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	Luciferase	552 aa	445 aa	22.2 %
Cryptosporidium hominis	acyl-CoA synthetase	Luciferase	552 aa	460 aa	25.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0167	0.0658	0.4394
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0162	0.1878
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.0168	0.0163
Echinococcus multilocularis	protein patched	0.0051	0.0138	0.0195
Schistosoma mansoni	hypothetical protein	0.0198	0.0796	1
Schistosoma mansoni	hypothetical protein	0.0049	0.013	0.1469
Trypanosoma brucei	polo-like protein kinase	0.0115	0.0423	0.2816
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0157	0.1332
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0132	0.0853
Brugia malayi	hypothetical protein	0.0043	0.0104	0.0869
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0104	0.1139
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.225	1	1
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.0178	0.0288
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0138	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.1816
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0038	0.0033
Echinococcus multilocularis	neuropeptide s receptor	0.0558	0.2413	0.5555
Brugia malayi	CHE-14 protein	0.0051	0.0138	0.1166
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.005	0.0132	0.0853
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.225	1	1
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.225	1	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0104	0.1641
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.1198	0.5281	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0115	0.0423	0.2816
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0038	0.0287
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.0178	0.1164
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0132	0.0853
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0186	0.0742	0.1405
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0442	0.0912
Schistosoma mansoni	patched 1	0.0051	0.0138	0.1574
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0115	0.0423	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0353	0.149	1
Loa Loa (eye worm)	transport to inner mitochondrial membrane family member	0.0058	0.0168	0.1427
Brugia malayi	jmjC domain containing protein	0.0071	0.0228	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0003
Toxoplasma gondii	hypothetical protein	0.0057	0.0164	0.0036
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0165	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0276	0.1147	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0029	0.0038	0.0033
Schistosoma mansoni	hypothetical protein	0.0049	0.013	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0003
Schistosoma mansoni	hypothetical protein	0.0198	0.0796	1
Schistosoma mansoni	mitochondrial import inner membrane translocase subunit tim10	0.0058	0.0168	0.1955
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0228	0.1951
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0115	0.0423	0.9525
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0049	0.0129	0.1085
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0228	0.0406
Echinococcus granulosus	geminin	0.0198	0.0796	0.3143
Echinococcus multilocularis	geminin	0.0198	0.0796	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0062	0.019	0.1617
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0228	0.0731
Brugia malayi	MAP kinase sur-1	0.006	0.0178	0.1513
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0104	0.0207
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0228	0.2722
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0053	0.0418
Echinococcus granulosus	survival motor neuron protein 1	0.0276	0.1147	0.4631
Brugia malayi	hypothetical protein	0.0044	0.0108	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0129	0.1085
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0038	0.0033
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0055	0.0442
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0178	0.139
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0038	0.0287
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0162	0.1374
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0029	0.0038	0.0071
Entamoeba histolytica	hypothetical protein	0.0043	0.0104	0.1641
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0353	0.149	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0038	0.0287
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0431
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0228	0.2722
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0029	0.0038	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0442	0.383
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0049	0.0129	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0038	0.0287
Brugia malayi	hypothetical protein	0.0276	0.1147	1
Echinococcus multilocularis	expressed protein	0.0058	0.0168	0.0265
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0049	0.0129	0.1085
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.0442	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0132	0.0853
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0178	0.1164
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0104	0.1139
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0115	0.0423	0.0867
Toxoplasma gondii	TIM10 family protein, putative	0.0058	0.0168	0.004
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0038	0.0287
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.0671	0.2612
Schistosoma mansoni	hypothetical protein	0.0049	0.013	0.1469
Brugia malayi	hypothetical protein	0.0044	0.0108	0.0898
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.018	0.1181
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0423	0.2816
Leishmania major	mitochondrial DNA polymerase beta	0.0353	0.149	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.43	1
Trypanosoma brucei	protein kinase, putative	0.006	0.0178	0.1164
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0178	0.139
Schistosoma mansoni	lamin	0.0033	0.0055	0.0515
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.1816
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0178	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0003
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.225	1	1
Onchocerca volvulus		0.006	0.0177	0.3617
Giardia lamblia	Kinase, PLK	0.0115	0.0423	1
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0178	0.139
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0029	0.0038	0.0071
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0038	0.0221
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0178	0.1164
Plasmodium vivax	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0049	0.0129	0.0124
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0038	0.0221
Echinococcus multilocularis	tumor protein p63	0.0408	0.1739	0.3966
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0239
Brugia malayi	serine/threonine-protein kinase plk-2	0.0115	0.0423	0.3662
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.0228	0.0731
Loa Loa (eye worm)	hypothetical protein	0.006	0.0177	0.1508
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.0178	0.0519
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0115	0.0423	0.156
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0451	0.5575
Echinococcus granulosus	neuropeptide s receptor	0.0558	0.2413	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.015	0.1269
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0115	0.0423	0.3662
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.225	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0178	0.139
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0138	0.1166
Echinococcus multilocularis	survival motor neuron protein 1	0.0276	0.1147	0.2572
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.0178	0.1513
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0442	0.383
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0177	0.2074
Echinococcus granulosus	expressed protein	0.0058	0.0168	0.0477
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0038	0.0033
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0157	0.0239
Onchocerca volvulus		0.0056	0.0162	0.3219
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0138	0.1166
Echinococcus multilocularis	protein dispatched 1	0.0058	0.017	0.0271
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0138	0.0351
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0157	0.1816
Plasmodium falciparum	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.0168	0.0163
Onchocerca volvulus		0.0033	0.0055	0.0458
Mycobacterium ulcerans	hypothetical protein	0.0029	0.0038	0.0033
Brugia malayi	intermediate filament protein	0.0033	0.0055	0.0442
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.0178	0.0288
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0055	0.0442
Echinococcus multilocularis	expressed conserved protein	0.0112	0.041	0.0836
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0029	0.0038	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0423	0.5224
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0029	0.0038	0.0033
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0104	0.0115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0157	0.0431
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.0165	0.0941
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0353	0.149	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0038	0.0287
Toxoplasma gondii	mitochondrial import inner membrane translocase subunit TIM10, putative	0.0058	0.0168	0.004
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Echinococcus granulosus	tumor protein p63	0.0408	0.1739	0.714
Schistosoma mansoni	hypothetical protein	0.0049	0.013	0.1469
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0442	0.1642
Echinococcus granulosus	expressed conserved protein	0.0112	0.041	0.1504
Schistosoma mansoni	hypothetical protein	0.0049	0.0129	0.1455
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	0.2413	0.5555
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0167	0.0658	0.4394
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.225	1	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.0671	0.1451
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.0178	0.1164
Onchocerca volvulus		0.0033	0.0055	0.0458
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0055	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0005	0.0003
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.0178	0.1164
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.0178	0.0519
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.225	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0157	0.1332
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0038	0.0221
Schistosoma mansoni	kinase	0.0059	0.0172	0.2004
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.0178	0.005
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0005	0.001
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0138	0.0351
Entamoeba histolytica	hypothetical protein	0.0043	0.0104	0.1641
Brugia malayi	jmjC domain containing protein	0.0071	0.0228	0.1951
Entamoeba histolytica	hypothetical protein	0.0043	0.0104	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0055	0.0442
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0055	0.0442
Mycobacterium ulcerans	hypothetical protein	0.0186	0.0742	0.0738
Schistosoma mansoni	lamin	0.0033	0.0055	0.0515
Brugia malayi	Cytochrome P450 family protein	0.0054	0.015	0.1269
Brugia malayi	Mitochondrial import inner membrane translocase subunit Tim17 family protein	0.0049	0.0129	0.1085
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.0178	0.1164
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.0178	0.1164
Schistosoma mansoni	hypothetical protein	0.0056	0.0162	0.1878
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0167	0.0658	0.4394
Echinococcus granulosus	neuropeptide receptor A26	0.0558	0.2413	1
Echinococcus multilocularis	mitochondrial import inner membrane translocase subunit TIM23, putative	0.0049	0.0129	0.0173
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.0423	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.0423	0.2816
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.0228	0.2722
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.0228	0.0406
Brugia malayi	Mitochondrial import inner membrane translocase subunit TIM10	0.0058	0.0168	0.1427

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3.18 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2825, AID2832]	ChEMBL.	No reference
IC50 (functional)	= 4.78 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463212, AID463216, AID493002]	ChEMBL.	No reference
IC50 (functional)	= 8.49 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463212, AID463216, AID504657, AID504672]	ChEMBL.	No reference
IC50 (functional)	= 13.6 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2825, AID2832]	ChEMBL.	No reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.636 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	1.7783 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.9953 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	8.4368 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.2 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1529733
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 820163