Detailed information for compound 822948

Basic information

Technical information
  • TDR Targets ID: 822948
  • Name: 3-[(3-bromophenyl)methyl]-1-(5-methyl-6-oxobe nzo[b][1,4]benzothiazepin-3-yl)urea
  • MW: 468.366 | Formula: C22H18BrN3O2S
  • H donors: 2 H acceptors: 2 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)N(C)C(=O)c1c(S2)cccc1)NCc1cccc(c1)Br
  • InChi: 1S/C22H18BrN3O2S/c1-26-18-12-16(25-22(28)24-13-14-5-4-6-15(23)11-14)9-10-20(18)29-19-8-3-2-7-17(19)21(26)27/h2-12H,13H2,1H3,(H2,24,25,28)
  • InChiKey: ZGWVQTYXKNNURX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3-bromophenyl)methyl]-1-(5-methyl-6-oxo-benzo[b][1,4]benzothiazepin-3-yl)urea
  • 3-[(3-bromophenyl)methyl]-1-(5-methyl-6-oxo-3-benzo[b][1,4]benzothiazepinyl)urea
  • 3-(3-bromobenzyl)-1-(6-keto-5-methyl-benzo[b][1,4]benzothiazepin-3-yl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1073 0.4368
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1073 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0594 0.535
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.055 0.0779
Echinococcus multilocularis General substrate transporter 0.0091 0.1787 0.739
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0594 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0243 0.5182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0444 0.0887
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0594 0.535
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0998 0.4047
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1073 0.1583
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0849
Brugia malayi follicle stimulating hormone receptor 0.0231 0.5006 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0594 0.535
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0594 0.535
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0243 0.0849
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0594 1
Toxoplasma gondii protein kinase, putative 0.0298 0.6557 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0445 0.0617
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7457
Schistosoma mansoni polycystin 1-related 0.002 0.0153 0.0468
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1073 1
Brugia malayi Cytochrome P450 family protein 0.0039 0.0594 0.1111
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0445 0.0404
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0243 0.1944
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0243 0.0308
Trypanosoma cruzi hexose transporter 0.0033 0.0454 0.7457
Plasmodium falciparum proline--tRNA ligase 0.0037 0.055 0.051
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0243 0.0849
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7457
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0454 0.1973
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0779
Schistosoma mansoni lipoxygenase 0.0117 0.2403 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Trypanosoma brucei glucose transporter 1E 0.0033 0.0454 0.7457
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0445 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0594 0.535
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0594 0.535
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.5006 1
Brugia malayi cytochrome P450 0.0039 0.0594 0.1111
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0429 0.9253
Echinococcus multilocularis RUN 0.002 0.0153 0.0468
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7457
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0998 0.4047
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0998 0.9265
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0445 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0445 0.0617
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0594 0.535
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0454 0.7457
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0445 0.0404
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0594 0.1187
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9198
Brugia malayi Doublecortin family protein 0.002 0.0153 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0444 0.1927
Leishmania major protein kinase, putative 0.0032 0.0444 0.3897
Leishmania major cytochrome p450-like protein 0.0039 0.0594 0.535
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0594 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0594 0.535
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0594 0.535
Echinococcus multilocularis 0.0039 0.0594 0.2337
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0429 0.6192
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0594 0.535
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0243 0.0201
Trypanosoma brucei glucose transporter 2A 0.0033 0.0454 0.7457
Loa Loa (eye worm) sugar transporter 0.0105 0.2128 0.425
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0153 0.0468
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1639
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0444 0.081
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0594 0.535
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0445 0.0617
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0594 0.535
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3622 0.5495
Brugia malayi hypothetical protein 0.002 0.0153 0.0222
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7457
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0243 0.3633
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0153 0.0111
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0444 0.1703
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0429 0.1855
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1639
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2128 0.8835
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0153 0.0468
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0594 0.535
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0444 0.0887
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0594 0.535
Schistosoma mansoni hypothetical protein 0.002 0.0153 0.0468
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0594 0.535
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0594 0.535
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0398 0.1508
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0594 0.535
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0153 0.0468
Brugia malayi Cytochrome P450 family protein 0.0115 0.2348 0.4645
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0153 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0444 0.1703
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.1944
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0243 0.0404
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.055 0.051
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0594 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2403 1
Schistosoma mansoni rab6-interacting 0.002 0.0153 0.0468
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0243 0.0849
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Schistosoma mansoni rab6-interacting 0.002 0.0153 0.0468
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0594 0.535
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0594 0.535
Brugia malayi Cytochrome P450 family protein 0.0039 0.0594 0.1111
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0594 0.535
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2128 1
Leishmania major cytochrome p450-like protein 0.0039 0.0594 0.535
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0594 0.535
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0594 0.535
Loa Loa (eye worm) doublecortin family protein 0.002 0.0153 0.0305
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Leishmania major glucose transporter, lmgt1 0.0033 0.0454 0.399
Echinococcus granulosus General substrate transporter 0.0091 0.1787 0.739
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0243 0.0961
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0594 0.535
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0594 0.535
Loa Loa (eye worm) cytochrome P450 0.0039 0.0594 0.1187
Brugia malayi Sugar transporter family protein 0.0105 0.2128 0.4201
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0998 0.9265
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0594 1
Plasmodium vivax hexose transporter 0.0105 0.2128 0.2094
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0153 0.0468
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0429 0.0779
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.9198
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0594 1
Schistosoma mansoni loxhd1 0.002 0.0153 0.0468
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0429 0.1639
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0594 0.535
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3622 0.3595
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0998 0.4047
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0594 0.535
Schistosoma mansoni hypothetical protein 0.0105 0.2128 0.8835
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0594 0.1187
Mycobacterium leprae putative cytochrome p450 0.0039 0.0594 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0454 0.7457
Loa Loa (eye worm) hypothetical protein 0.002 0.0153 0.0305
Onchocerca volvulus 0.002 0.0153 1
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0243 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0594 0.535
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0445 0.0404
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0594 0.1187
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0161 0.1152
Leishmania major glucose transporter, lmgt3 0.0033 0.0454 0.399
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2128 0.3201
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0444 0.0887
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0594 0.535
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0594 0.535
Loa Loa (eye worm) cytochrome P450 family protein 0.0115 0.2348 0.4691
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0594 0.535
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0594 0.535
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0113 0.1272
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0161 0.1152
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Schistosoma mansoni lipoxygenase 0.0082 0.159 0.6556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Brugia malayi Cam kinase protein 1 0.0032 0.0444 0.081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1073 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1073 0.4368
Schistosoma mansoni cytochrome P450 0.0039 0.0594 0.2337
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2403 1
Schistosoma mansoni glucose transport protein 0.0105 0.2128 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0594 0.0847
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0998 0.9265
Plasmodium falciparum protein kinase 7 0.0298 0.6557 0.6542
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3622 0.3595
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0998 0.1924
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0585
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0398 0.1508
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1073 0.4368
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0444 0.7284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0454 0.399
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0594 0.535
Loa Loa (eye worm) sugar transporter 0.0015 0.0042 0.0085
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0594 0.535
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0485
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Onchocerca volvulus 0.002 0.0153 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Entamoeba histolytica protein kinase, putative 0.0032 0.0444 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0445 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0594 0.535
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0594 0.535
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0594 0.535
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2128 0.8835
Brugia malayi hypothetical protein 0.002 0.0153 0.0222
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0857
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0594 1
Leishmania major glucose transporter, lmgt2 0.0033 0.0454 0.399
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0594 0.535
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0594 0.535
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.4921
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Leishmania major cytochrome p450-like protein 0.0039 0.0594 0.535
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0176 0.0641
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0454 0.1973
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0243 0.1886
Schistosoma mansoni protein kinase 0.0032 0.0444 0.1703
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0594 0.535
Echinococcus granulosus RUN 0.002 0.0153 0.0468
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.091 0.1818
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0429 0.1639
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0085
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Trypanosoma brucei glucose transporter, putative 0.0033 0.0454 0.7457
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0454 0.1973
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0594 0.2337
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0153 0.0468
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0857
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0444 0.1703
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0085
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0243 0.1944
Brugia malayi Cytochrome P450 family protein 0.0039 0.0594 0.1111
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0594 0.535
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0445 0.0404
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0998 0.9265
Plasmodium falciparum hexose transporter 0.0105 0.2128 0.2094
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1073 0.4368
Loa Loa (eye worm) hypothetical protein 0.002 0.0153 0.0305
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1073 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0594 0.535
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0429 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0445 0.0404
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0153 0.0111
Schistosoma mansoni hypothetical protein 0.0039 0.0594 0.2337
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0445 0.0404
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0594 0.535
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0594 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.055 0.9198
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0042 0.0085
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.055 0.4921
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1073 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0243 0.0201
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0042 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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