Detailed information for compound 83087

Basic information

Technical information
  • TDR Targets ID: 83087
  • Name: 2-(3-methyl-7-oxo-4-phenyl-[1,2]oxazolo[3,4-d ]pyridazin-6-yl)butanoic acid
  • MW: 313.308 | Formula: C16H15N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(n1nc(c2ccccc2)c2c(c1=O)noc2C)C(=O)O
  • InChi: 1S/C16H15N3O4/c1-3-11(16(21)22)19-15(20)14-12(9(2)23-18-14)13(17-19)10-7-5-4-6-8-10/h4-8,11H,3H2,1-2H3,(H,21,22)
  • InChiKey: JNSZXQGMBCMJKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-methyl-7-oxo-4-phenyl-isoxazolo[3,4-d]pyridazin-6-yl)butanoic acid
  • 2-(3-methyl-7-oxo-4-phenyl-6-isoxazolo[3,4-d]pyridazinyl)butanoic acid
  • 2-(7-keto-3-methyl-4-phenyl-isoxazolo[3,4-d]pyridazin-6-yl)butyric acid
  • 2-(3-methyl-7-oxo-4-phenyl-[1,2]oxazolo[4,3-d]pyridazin-6-yl)butanoic acid
  • 2-(3-methyl-7-oxo-4-phenyl-isoxazolo[4,3-d]pyridazin-6-yl)butanoic acid
  • 2-(3-methyl-7-oxo-4-phenyl-6-isoxazolo[4,3-d]pyridazinyl)butanoic acid
  • 2-(7-keto-3-methyl-4-phenyl-isoxazolo[4,3-d]pyridazin-6-yl)butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0412 0.0374
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0712 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0712 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0412 0.0374
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0412 0.0374
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0412 0.0531
Schistosoma mansoni neuropeptide receptor 0.002 0.0412 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0354 0.0448
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0678 0.294
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0412 0.0531
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0412 0.0531
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0429 0.0391
Schistosoma mansoni phosphoglucomutase 0.0022 0.0488 0.0639
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni hypothetical protein 0.0084 0.2917 0.4103
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0678 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1643 0.1609
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0678 0.294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0429 0.0391
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0101 0.0062
Echinococcus multilocularis lamin 0.0027 0.0683 0.0646
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0712 0.3188
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Brugia malayi RNA binding protein 0.0064 0.2139 0.2107
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0412 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1643 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0429 0.0391
Schistosoma mansoni lamin 0.0027 0.0683 0.0917
Onchocerca volvulus 0.0021 0.0429 0.0079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0412 0.0374
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0381 0.0342
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0182 0.0143
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0354 0.0448
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0488 0.0361
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0412 0.0374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0429 0.0391
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0412 0.0531
Leishmania major ribonuclease H1, putative 0.0022 0.0488 0.1544
Schistosoma mansoni hypothetical protein 0.0023 0.0511 0.0672
Schistosoma mansoni hypothetical protein 0.0188 0.7054 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0381 0.0342
Echinococcus multilocularis muscleblind protein 0.0166 0.6171 0.6156
Schistosoma mansoni phosphoglucomutase 0.0022 0.0488 0.0639
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1643 0.2285
Echinococcus granulosus allatostatin A receptor 0.002 0.0412 0.0374
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0412 0.0374
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1643 1
Brugia malayi hypothetical protein 0.0018 0.032 0.0281
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Brugia malayi RNase H family protein 0.0022 0.0488 0.045
Brugia malayi Serotonin receptor 0.002 0.0412 0.0374
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0412 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptide receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0683 0.0646
Schistosoma mansoni hypothetical protein 0.0127 0.4641 0.656
Schistosoma mansoni biogenic amine receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0563 0.1083
Brugia malayi Serotonin receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) RecQ helicase 0.002 0.0381 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Dopamine receptor protein 2 0.002 0.0412 0.0374
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0412 0.0374
Schistosoma mansoni hypothetical protein 0.002 0.0412 0.0531
Brugia malayi G-protein coupled receptor 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0412 0.0374
Brugia malayi Dopamine receptor 0.002 0.0412 0.0374
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0412 0.0374
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0595 0.0792
Echinococcus granulosus bloom syndrome protein 0.002 0.0381 0.0342
Echinococcus granulosus zinc finger protein 0.0022 0.0465 0.0427
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0412 0.0531
Echinococcus granulosus jun protein 0.0093 0.3296 0.3269
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0678 0.1521
Echinococcus multilocularis orexin receptor type 2 0.002 0.0412 0.0374
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0412 0.0531
Echinococcus multilocularis jun protein 0.0093 0.3296 0.3269
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1643 1
Schistosoma mansoni hypothetical protein 0.002 0.0412 0.0531
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0412 0.0374
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0412 0.0374
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0683 0.0646
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0412 0.0531
Echinococcus multilocularis ribonuclease H1 0.0022 0.0488 0.045
Schistosoma mansoni neuropeptide receptor 0.002 0.0412 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.1184 0.1149
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0429 0.0391
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0381 0.2318
Echinococcus granulosus g protein coupled receptor 0.002 0.0412 0.0374
Schistosoma mansoni amine GPCR 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi PHD-finger family protein 0.0028 0.0699 0.0662
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0354 0.0315
Schistosoma mansoni hypothetical protein 0.0054 0.1725 0.2402
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0412 0.0374
Schistosoma mansoni adenoreceptor 0.002 0.0412 0.0531
Brugia malayi RNase H family protein 0.0022 0.0488 0.045
Loa Loa (eye worm) hypothetical protein 0.0078 0.2713 0.2684
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0429 0.0079
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0678 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2139 0.2992
Echinococcus multilocularis g protein coupled receptor 0.002 0.0412 0.0374
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0412 0.0374
Schistosoma mansoni hypothetical protein 0.0017 0.0277 0.0338
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0563 0.1083
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2139 0.2107
Brugia malayi hypothetical protein 0.0028 0.0712 0.0675
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0412 0.0374
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1643 0.1609
Schistosoma mansoni DNA helicase recq1 0.002 0.0381 0.0486
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0412 0.0374
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0412 0.0374
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0412 0.0374
Brugia malayi larval opioid receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni biogenic amine receptor 0.002 0.0412 0.0531
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.4853 0.4832
Schistosoma mansoni hypothetical protein 0.0188 0.7054 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0381 0.0342
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0381 0.2318
Trypanosoma brucei protein kinase, putative 0.0051 0.1643 0.5173
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0712 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi neuropeptide F receptor 0.002 0.0412 0.0374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0429 0.0391
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Schistosoma mansoni zinc finger protein 0.0017 0.0277 0.0338
Brugia malayi bZIP transcription factor family protein 0.0093 0.3296 0.3269
Echinococcus granulosus tar DNA binding protein 0.0064 0.2139 0.2107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0354 0.0448
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0412 0.0374
Schistosoma mansoni neuropeptide receptor 0.002 0.0412 0.0531
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0412 0.0374
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0354 0.0315
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0066
Brugia malayi G protein-coupled receptor 0.002 0.0412 0.0374
Brugia malayi MAP kinase sur-1 0.0051 0.1643 0.1609
Schistosoma mansoni myosin xvIII 0.002 0.0412 0.0531
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0412 0.0374
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0412 0.0374
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0381 0.0342
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2139 0.2992
Schistosoma mansoni survival motor neuron protein 0.0054 0.1725 0.2402
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1643 0.5173
Schistosoma mansoni thyroid hormone receptor 0.0148 0.5465 0.7736
Echinococcus multilocularis geminin 0.0188 0.7054 0.7042
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1643 1
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0381 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0488 0.2969
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni histamine h1 receptor 0.002 0.0412 0.0531
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0429 0.0391
Echinococcus granulosus neuropeptide receptor 0.002 0.0412 0.0374
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0027 0.0663 0.0626
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0412 0.0374
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0412 0.0374
Echinococcus multilocularis g protein coupled receptor 0.002 0.0412 0.0374
Echinococcus granulosus g protein coupled receptor 0.002 0.0412 0.0374
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0678 0.294
Trypanosoma brucei RNA helicase, putative 0.0084 0.2917 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0381 0.0486
Brugia malayi ORL1-like opioid receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1643 0.1609
Brugia malayi nuclear hormone receptor 0.0021 0.0429 0.0391
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0429 0.0391
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus multilocularis fmrfamide receptor 0.002 0.0412 0.0374
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0429 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0429 0.0391
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0488 0.1544
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0678 0.0641
Schistosoma mansoni jun-related protein 0.0076 0.2604 0.3656
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0125 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0381 0.0342
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0712 0.3188
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0712 0.165
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.4853 0.4832
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0563 0.1083
Schistosoma mansoni biogenic amine receptor 0.002 0.0412 0.0531
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0412 0.0374
Echinococcus granulosus ribonuclease H1 0.0022 0.0488 0.045
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni hypothetical protein 0.0027 0.0678 0.091
Schistosoma mansoni hypothetical protein 0.002 0.0412 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.1184 0.1149
Brugia malayi steroid hormone receptor 0.0021 0.0429 0.0391
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0101 0.0062
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0429 0.0391
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0412 0.0374
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0412 0.0531
Echinococcus granulosus geminin 0.0188 0.7054 0.7042
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0429 0.0391
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0412 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0412 0.0531
Brugia malayi GnHR receptor homolog 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0091 0.3195 0.3168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0429 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0712 0.4336
Echinococcus granulosus lamin 0.0027 0.0683 0.0646
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Brugia malayi neuropeptide F receptor 0.002 0.0412 0.0374
Brugia malayi Melatonin receptor type 1A 0.002 0.0412 0.0374
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0182 0.0143
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0412 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0125 0.0085
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.0073 0.2503 0.2473
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0354 0.0448
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0381 0.0342
Echinococcus multilocularis sex peptide receptor 0.002 0.0412 0.0374
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0429 0.0555
Brugia malayi RE15519p 0.002 0.0412 0.0374
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1643 0.1609
Brugia malayi Bromodomain containing protein 0.0042 0.1288 0.1253
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0429 0.0391
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0412 0.0374
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.0488 0.5
Trypanosoma brucei unspecified product 0.0024 0.0563 0.1083
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0488 0.0847
Entamoeba histolytica recQ family helicase, putative 0.002 0.0381 0.5613
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0429 0.0555
Brugia malayi MH2 domain containing protein 0.0132 0.4853 0.4832
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0429 0.0555
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.4641 0.462
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0381 0.0761
Brugia malayi G-protein coupled receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0412 0.0374
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Echinococcus granulosus somatostatin receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi sulfakinin receptor protein 0.002 0.0412 0.0374
Schistosoma mansoni opsin-like receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0429 0.0391
Schistosoma mansoni intermediate filament proteins 0.0027 0.0683 0.0917
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0166 0.6171 0.6156
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0013 0.0125 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0429 0.0391
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Echinococcus multilocularis survival motor neuron protein 1 0.0262 1 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0429 0.0391
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0381 0.0342
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0429 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0043 0.1291 0.1256
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1725 0.1692
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0412 0.0374
Brugia malayi putative neuropeptide receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0429 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0429 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0429 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0429 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0412 0.0374
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0354 0.0315
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0412 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Echinococcus multilocularis zinc finger protein 0.0022 0.0465 0.0427
Loa Loa (eye worm) hypothetical protein 0.0045 0.1395 0.1361
Echinococcus granulosus g protein coupled receptor 0.002 0.0412 0.0374
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0412 0.0374
Echinococcus multilocularis muscleblind protein 1 0.0166 0.6171 0.6156
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0488 0.1544
Echinococcus multilocularis fmrfamide receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0429 0.0391
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0511 0.0473
Schistosoma mansoni neuropeptide receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0429 0.0391
Echinococcus granulosus g-protein coupled receptor 0.002 0.0412 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2139 0.2992
Brugia malayi RNase H family protein 0.0022 0.0488 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0678 0.2358
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0047 0.1479 0.1445
Echinococcus multilocularis neuropeptide receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0166 0.6171 0.6156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.3296 0.3269
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0412 0.0374
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.2229 0.2198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0683 0.0646
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0678 0.1521
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1643 1
Onchocerca volvulus 0.0027 0.0683 0.1296
Echinococcus granulosus orexin receptor type 2 0.002 0.0412 0.0374
Brugia malayi ecdysteroid receptor 0.0021 0.0429 0.0391
Schistosoma mansoni opsin-like receptor 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0412 0.0531
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0429 0.0391
Onchocerca volvulus 0.0054 0.1725 0.6276
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0429 0.0391
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0412 0.0374
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2139 0.2107
Brugia malayi AKH receptor 0.002 0.0412 0.0374
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.5465 0.5447
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0429 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0429 0.0391
Echinococcus multilocularis bloom syndrome protein 0.002 0.0381 0.0342
Echinococcus multilocularis neuropeptide receptor 0.002 0.0412 0.0374
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.0488 0.5
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0381 0.0761
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0429 0.0555
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0412 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0429 0.0391
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0678 0.0641
Schistosoma mansoni lamin 0.0027 0.0683 0.0917
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0412 0.0531
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0412 0.0374
Onchocerca volvulus 0.0073 0.2503 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0412 0.0374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0429 0.0391
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0595 0.0558
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0412 0.0531
Brugia malayi Bromodomain containing protein 0.0083 0.2901 0.2873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0429 0.0391
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0429 0.0391
Giardia lamblia Ribonuclease H 0.0022 0.0488 0.0847
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0412 0.0374
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2139 0.2107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0429 0.0555
Echinococcus granulosus hypothetical protein 0.002 0.0412 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0563 0.1083
Giardia lamblia Rrm3p helicase 0.0027 0.0678 0.2358
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus survival motor neuron protein 1 0.0262 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0429 0.0391
Echinococcus granulosus muscleblind protein 0.0166 0.6171 0.6156
Schistosoma mansoni amine GPCR 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.0019 0.0354 0.0315
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0429 0.0391
Echinococcus multilocularis g protein coupled receptor 0.002 0.0412 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0429 0.0391
Brugia malayi TAR-binding protein 0.0064 0.2139 0.2107
Schistosoma mansoni amine GPCR 0.002 0.0412 0.0531
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2139 0.2107
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0028 0.0712 0.0675
Schistosoma mansoni bromodomain containing protein 0.007 0.2386 0.3345
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0412 0.0374
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0412 0.0374
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0412 0.0374
Echinococcus granulosus fmrfamide receptor 0.002 0.0412 0.0374
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0429 0.0555
Brugia malayi Muscleblind-like protein 0.0166 0.6171 0.6156
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0381 0.0342
Schistosoma mansoni hypothetical protein 0.0013 0.0101 0.0088
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0412 0.0374
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0412 0.0374
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1643 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni amine GPCR 0.002 0.0412 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0678 0.294
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0429 0.0555
Echinococcus multilocularis serotonin receptor 0.002 0.0412 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0429 0.0391
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.3296 0.3269
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) RNA binding protein 0.0064 0.2139 0.2107
Brugia malayi intermediate filament protein 0.0027 0.0683 0.0646
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0412 0.0531
Echinococcus multilocularis serotonin receptor 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptide s receptor 0.002 0.0412 0.0374
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0429 0.0079
Echinococcus multilocularis somatostatin receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0412 0.0374
Echinococcus granulosus serotonin receptor 0.002 0.0412 0.0374
Echinococcus granulosus sex peptide receptor 0.002 0.0412 0.0374
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0429 0.0079
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1643 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0412 0.0374
Echinococcus multilocularis allatostatin A receptor 0.002 0.0412 0.0374
Echinococcus granulosus lamin dm0 0.0027 0.0683 0.0646
Schistosoma mansoni amine GPCR 0.002 0.0412 0.0531
Onchocerca volvulus 0.0027 0.0683 0.1296
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0683 0.0646
Schistosoma mansoni phosphoglucomutase 0.0022 0.0488 0.0639
Schistosoma mansoni zinc finger protein 0.0022 0.0465 0.0606
Echinococcus multilocularis lamin dm0 0.0027 0.0683 0.0646
Leishmania major hypothetical protein, conserved 0.0028 0.0712 0.3188
Echinococcus multilocularis musashi 0.0027 0.0683 0.0646
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0429 0.0391
Loa Loa (eye worm) hypothetical protein 0.0262 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0412 0.0374
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0354 0.0315
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0412 0.0374
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0595 0.0558
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.4641 0.462
Schistosoma mansoni opsin-like receptor 0.002 0.0412 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2139 0.2992
Schistosoma mansoni coup transcription factor 0.0021 0.0429 0.0555
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0412 0.0531
Echinococcus granulosus intermediate filament protein 0.0027 0.0683 0.0646
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Schistosoma mansoni hypothetical protein 0.002 0.0412 0.0531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Schistosoma mansoni thyroid hormone receptor 0.0148 0.5465 0.7736
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0412 0.0374
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Brugia malayi follicle stimulating hormone receptor 0.002 0.0412 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0412 0.0531
Brugia malayi Dopamine receptor protein 1 0.002 0.0412 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0412 0.0531
Schistosoma mansoni hypothetical protein 0.0076 0.2604 0.3656
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2139 0.2992
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0429 0.0391
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1643 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.2229 0.2198
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0412 0.0374
Trypanosoma brucei ribonuclease H1 0.0022 0.0488 0.0799
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0678 0.294
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0381 0.0394
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0381 0.0342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0429 0.0391
Brugia malayi hypothetical protein 0.002 0.0412 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0412 0.0374
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1643 0.1609
Brugia malayi hypothetical protein 0.002 0.0412 0.0374

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 75.015 uM In vitro inhibitory activity against Aldose reductase 2 obtained from calf lenses ChEMBL. 10354397
IC50 (binding) = 75.015 uM In vitro inhibitory activity against Aldose reductase 2 obtained from calf lenses ChEMBL. 10354397

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.