Detailed information for compound 83152

Basic information

Technical information
  • TDR Targets ID: 83152
  • Name: 2-amino-6-(2-methoxyphenyl)sulfinylbenzonitri le
  • MW: 272.322 | Formula: C14H12N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1[S+](c1cccc(c1C#N)N)[O-]
  • InChi: 1S/C14H12N2O2S/c1-18-12-6-2-3-7-14(12)19(17)13-8-4-5-11(16)10(13)9-15/h2-8H,16H2,1H3
  • InChiKey: BMPCEVULSYDKKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-6-(2-methoxyphenyl)sulfinyl-benzonitrile
  • 2-azanyl-6-(2-methoxyphenyl)sulfinyl-benzenecarbonitrile
  • AIDS108452
  • 2-Amino-6-arylthiobenzonitrile deriv. 2a
  • 6-Amino-2-[(2-methoxyphenyl)sulfinyl]benzenecarbonitrile
  • AIDS-108452

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References
Human immunodeficiency virus 1 Reverse transcriptase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans hypothetical protein Reverse transcriptase   259 aa 223 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 245 aa 25.7 %
Candida albicans polyprotein of retrotransposon Tca8 Reverse transcriptase   259 aa 238 aa 26.5 %
Candida albicans ReverseTranscriptase similar to fruit fly Tom element Reverse transcriptase   259 aa 244 aa 27.9 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 208 aa 26.4 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 222 aa 22.5 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Trypanosoma congolense Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative Reverse transcriptase   259 aa 237 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 226 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0433 0.1008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0042 0.043
Brugia malayi major facilitator superfamily protein 0.0016 0.0013 0.0032
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0149 0.0278
Loa Loa (eye worm) beta-lactamase 0.0076 0.0433 0.1529
Echinococcus granulosus neuropeptide s receptor 0.0491 0.3298 0.3298
Echinococcus granulosus dna polymerase kappa 0.0084 0.0487 0.0487
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0387 0.5433
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.012 0.2379
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0052 0.0116
Chlamydia trachomatis endonuclease IV 0.0081 0.0465 0.0898
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0176
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.005 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Echinococcus multilocularis ribonuclease H1 0.0027 0.0089 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0102 0.0347
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0143 0.2886
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0089 0.1114
Brugia malayi RNase H family protein 0.0027 0.0089 0.0303
Echinococcus granulosus pyruvate kinase 0.0035 0.0149 0.0149
Giardia lamblia DINP protein human, muc B family 0.0063 0.0341 0.0787
Mycobacterium ulcerans epimerase 0.0021 0.0052 0.0081
Onchocerca volvulus 0.0032 0.0129 0.036
Plasmodium falciparum glutathione reductase 0.005 0.0251 0.5285
Brugia malayi Heterochromatin protein 1 0.0074 0.0414 0.1451
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0264
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.0478 0.2682
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0211 0.2882
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.012 0.2379
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.0037
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.3298 0.3298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0184
Trichomonas vaginalis esterase, putative 0.0076 0.0433 0.1008
Mycobacterium tuberculosis Conserved protein 0.0076 0.0433 0.1234
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0025 0.0274
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0414 0.1462
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0042 0.0137
Onchocerca volvulus 0.0076 0.0433 0.1304
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0052 0.0172
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0033 0.0131 0.0683
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0387 0.0387
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0251 0.3467
Schistosoma mansoni phosphoglucomutase 0.0027 0.0089 0.0077
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0025 0.0025
Trypanosoma brucei trypanothione reductase 0.005 0.0251 0.1375
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.012 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0042 0.0071
Echinococcus granulosus bloom syndrome protein 0.0021 0.005 0.005
Echinococcus multilocularis bloom syndrome protein 0.0021 0.005 0.005
Brugia malayi polk-prov protein 0.0045 0.0219 0.0763
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Schistosoma mansoni lamin 0.0028 0.0102 0.0089
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0149 0.0514
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0025 0.0278
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0013 0.0013
Toxoplasma gondii thioredoxin reductase 0.005 0.0251 0.5285
Echinococcus multilocularis geminin 0.0179 0.1142 0.1142
Giardia lamblia Pyruvate kinase 0.0018 0.003 0.0042
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0143 0.1893
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0075 0.0264
Leishmania major ribonuclease H1, putative 0.0027 0.0089 0.1114
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0149 0.3006
Leishmania major pyruvate kinase 0.0035 0.0149 0.1972
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0292 0.0822
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0702 0.2024
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0149 0.0422
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Mycobacterium ulcerans endonuclease IV 0.0081 0.0465 0.0924
Echinococcus multilocularis dna polymerase eta 0.0083 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0061 0.0325 0.1147
Echinococcus multilocularis solute carrier family 22 0.0016 0.0013 0.0013
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0464 0.3117 0.9049
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.0487 0.1137
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0702 0.1119
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0464 0.3117 0.6345
Schistosoma mansoni hypothetical protein 0.0179 0.1142 0.1131
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0089 0.0184
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0465 0.1631
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0184 0.0184
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0433 0.1234
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0042 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.019 0.0426
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0324 0.0312
Onchocerca volvulus 0.0028 0.0102 0.0277
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0702 0.1653
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0212 0.0478
Schistosoma mansoni phosphoglucomutase 0.0027 0.0089 0.0077
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0042 0.0042
Mycobacterium leprae Probable lipase LipE 0.0076 0.0433 0.1123
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0302 0.1994 0.582
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0042 0.0028
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0149 0.0285
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0172 0.1095 0.3179
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0433 0.1008
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0211 0.4394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0042 0.043
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0702 0.1653
Toxoplasma gondii exonuclease III APE 0.002 0.0042 0.0656
Brugia malayi hypothetical protein 0.0016 0.0013 0.0032
Onchocerca volvulus 0.0076 0.0433 0.1304
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.0672
Brugia malayi Thioredoxin reductase 0.005 0.0251 0.0877
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0508 0.3416 0.9932
Plasmodium vivax glutathione reductase, putative 0.005 0.0251 0.5285
Giardia lamblia DNA damage repair protein 0.0017 0.0025 0.003
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0433 0.9294
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0702 0.1917
Brugia malayi Pre-SET motif family protein 0.0423 0.283 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.012 0.0157
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0013 0.0032
Echinococcus granulosus pyruvate kinase 0.0035 0.0149 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.022 0.1196
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.012 0.0258
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0433 0.1234
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0433 0.0858
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0149 0.0399
Trypanosoma brucei ribonuclease H1 0.0027 0.0089 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Leishmania major DNA polymerase kappa, putative 0.0063 0.0341 0.4761
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0433 0.0433
Plasmodium falciparum pyruvate kinase 2 0.0018 0.003 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0341 0.1888
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0251 0.0889
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0042 0.0171
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0149 0.0326
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0433 0.1008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0324 0.0324
Echinococcus multilocularis pyruvate kinase 0.0028 0.0097 0.0097
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0149 0.0422
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0096 0.02
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.005 0.0819
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0073 0.1344
Brugia malayi Sugar transporter family protein 0.0016 0.0013 0.0032
Treponema pallidum fructose-bisphosphate aldolase 0.0618 0.4181 0.6871
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0107 0.0226
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Trypanosoma brucei unspecified product 0.0077 0.0438 0.2451
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.005 0.0819
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0042 0.0087
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.003 0.0383
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.005 0.005
Echinococcus multilocularis pyruvate kinase 0.0018 0.003 0.003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0387 0.5433
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0487 0.2729
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0089 0.0238
Schistosoma mansoni pyruvate kinase 0.0018 0.003 0.0017
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0052 0.0081
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.012 0.2379
Giardia lamblia Fructose-bisphosphate aldolase 0.0618 0.4181 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0702 0.1593
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0025 0.003
Mycobacterium tuberculosis Conserved protein 0.0076 0.0433 0.1234
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0071
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0784 0.216
Trichomonas vaginalis set domain proteins, putative 0.0481 0.3234 0.7729
Echinococcus granulosus Solute carrier family 22 5 0.1097 0.749 0.749
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0387 0.1367
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0149 0.0525
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0149 0.0326
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0324 0.1133
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0181 0.1157 0.3361
Giardia lamblia Pyruvate kinase 0.0035 0.0149 0.0326
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0464 0.3117 0.9121
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.019 0.0426
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0695 0.1899
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.005 0.0213
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0143 0.0244
Brugia malayi Flap endonuclease-1 0.0028 0.0096 0.0326
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0324 0.4517
Echinococcus granulosus solute carrier family 22 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus multilocularis pyruvate kinase 0.0018 0.003 0.003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0025 0.0025
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0025 0.0036
Brugia malayi hypothetical protein 0.0016 0.0013 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0487 0.688
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.005 0.0163
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0072
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0784 0.2265
Brugia malayi beta-lactamase family protein 0.0076 0.0433 0.1518
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0183
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.005 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.0438 0.2451
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0433 0.1234
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0025 0.0071
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0149 0.0513
Echinococcus granulosus chromobox protein 1 0.0074 0.0414 0.0414
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0169 0.1072 0.2165
Echinococcus granulosus geminin 0.0179 0.1142 0.1142
Schistosoma mansoni lamin 0.0028 0.0102 0.0089
Echinococcus multilocularis dna polymerase kappa 0.0084 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Trichomonas vaginalis rotamase, putative 0.0035 0.0149 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.005 0.0176
Echinococcus granulosus solute carrier family 22 0.0016 0.0013 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Mycobacterium tuberculosis Probable reductase 0.0114 0.0695 0.2006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0131 0.0683
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0725 0.4918 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0387 0.1356
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0414 0.0962
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0702 0.1593
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0149 0.0525
Plasmodium falciparum thioredoxin reductase 0.0017 0.0025 0.0274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0102 0.036
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0102 0.036
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0025 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0042 0.0061
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.005 0.005
Echinococcus multilocularis chromobox protein 1 0.0074 0.0414 0.0414
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0433 0.6097
Trypanosoma brucei ingi protein (ORF1) 0.0033 0.0131 0.0683
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0089 0.0106
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0089 0.1699
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0013 0.0013
Schistosoma mansoni ap endonuclease 0.002 0.0042 0.003
Plasmodium falciparum glutathione reductase 0.0017 0.0025 0.0274
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0387 0.2155
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.0487 0.1137
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0695 0.2006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0292 0.028
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0325 0.6901
Brugia malayi glutathione reductase 0.005 0.0251 0.0877
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.012 0.2379
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0414 0.0962
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.005 0.0089
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0511 0.3439 0.8221
Brugia malayi beta-lactamase 0.0076 0.0433 0.1518
Echinococcus multilocularis lamin 0.0028 0.0102 0.0102
Echinococcus granulosus pyruvate kinase 0.0018 0.003 0.003
Onchocerca volvulus 0.0076 0.0433 0.1304
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0702 0.1653
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0251 0.0251
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0025
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0025 0.0071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0292 0.0292
Echinococcus granulosus pyruvate kinase 0.0018 0.003 0.003
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.005 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0433 0.1529
Echinococcus granulosus solute carrier family 22 0.0016 0.0013 0.0013
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0149 0.0513
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0433 0.0421
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0025 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0702 0.3966
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0013 0.0032
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0359 0.239 0.4858
Brugia malayi chromobox protein homolog 3 0.0041 0.019 0.066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0408 0.0396
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0143 0.1893
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0149 0.0525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0487 0.688
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.018
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.012 0.2379
Leishmania major DNA damage repair protein, putative 0.0017 0.0025 0.0183
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0012
Mycobacterium tuberculosis Conserved protein 0.0076 0.0433 0.1234
Loa Loa (eye worm) glutathione reductase 0.005 0.0251 0.0889
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0292 0.0604
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0387 0.0387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0465 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0219 0.119
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0075 0.0079
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0324 0.0636
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0325 0.0325
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0433 0.1234
Trypanosoma brucei RNA helicase, putative 0.0267 0.1749 1
Echinococcus multilocularis chromobox protein 1 0.0074 0.0414 0.0414
Brugia malayi RNase H family protein 0.0027 0.0089 0.0303
Leishmania major DNA polymerase eta, putative 0.0083 0.0478 0.6761
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0465 0.1328
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0089 0.0156
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0433 0.1234
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.005 0.0089
Echinococcus granulosus lamin 0.0028 0.0102 0.0102
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.018
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0143 0.1893
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0433 0.1008
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0169 0.1072 0.3112
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0433 0.1123
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0784 0.2265
Brugia malayi major facilitator superfamily protein 0.0016 0.0013 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0042 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Mycobacterium ulcerans beta-lactamase 0.0076 0.0433 0.0858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0433 0.1518
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0025 0.0025
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0013 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0025
Echinococcus granulosus pyruvate kinase 0.0018 0.003 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0025 0.0274
Loa Loa (eye worm) hypothetical protein 0.0045 0.0219 0.0775
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0702 0.2479
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.005 0.0163
Chlamydia trachomatis transglycolase/transpeptidase 0.0725 0.4918 1
Schistosoma mansoni ap endonuclease 0.002 0.0042 0.003
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0096 0.02
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0292 0.0292
Giardia lamblia Ribonuclease H 0.0027 0.0089 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0212 0.0478
Leishmania major hypothetical protein, conserved 0.0076 0.0433 0.6097
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0702 0.2479
Toxoplasma gondii endonuclease IV APN 0.0081 0.0465 1
Echinococcus multilocularis expressed protein 0.0035 0.0149 0.0149
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0487 0.0969
Trichomonas vaginalis rotamase, putative 0.0034 0.0143 0.0313
Loa Loa (eye worm) sugar transporter 0.0016 0.0013 0.0045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0292 0.1033
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0296 0.1045
Plasmodium falciparum pyruvate kinase 0.0035 0.0149 0.3006
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0433 0.0858
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Schistosoma mansoni chromobox protein 0.0074 0.0414 0.0401
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0433 0.1008
Brugia malayi beta-lactamase family protein 0.0076 0.0433 0.1518
Loa Loa (eye worm) RecQ helicase 0.0021 0.005 0.0176
Toxoplasma gondii ABC1 family protein 0.0076 0.0433 0.9294
Brugia malayi 6-phosphofructokinase 0.0115 0.0702 0.2469
Schistosoma mansoni rotamase 0.0035 0.0149 0.0136
Schistosoma mansoni DNA polymerase eta 0.0083 0.0478 0.0466
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0251 0.0702
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0387 0.5433
Echinococcus multilocularis musashi 0.0028 0.0102 0.0102
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0143 0.0751
Loa Loa (eye worm) hypothetical protein 0.0083 0.0478 0.169
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0702 1
Chlamydia trachomatis transglycolase/transpeptidase 0.0357 0.2377 0.4807
Brugia malayi 6-phosphofructokinase 0.0115 0.0702 0.2469
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0511 0.3439 1
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0149 0.0782
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0702 0.1653
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0702 0.1593
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0107 0.0226
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.4181 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.012 0.2379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.019 0.0551
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0695 0.2006
Entamoeba histolytica recQ family helicase, putative 0.0021 0.005 0.0018
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.003 0.0383
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0341 0.4761
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0433 0.1234
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0096 0.184
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0387 0.0833
Leishmania major DNA polymerase kappa, putative 0.0017 0.0025 0.0183
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.012 0.0194
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0433 0.0433
Brugia malayi Pre-SET motif family protein 0.0061 0.0325 0.1135
Brugia malayi hypothetical protein 0.0016 0.0013 0.0032
Schistosoma mansoni DNA helicase recq5 0.0021 0.005 0.0037
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.3298 0.3298
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0219 0.119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0098 0.0347
Schistosoma mansoni hypothetical protein 0.0179 0.1142 0.1131
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0025 0.003
Schistosoma mansoni flap endonuclease-1 0.0025 0.0077 0.0065
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0433 0.1234
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0013 0.0032
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0508 0.3416 0.6956
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0702 0.0702
Chlamydia trachomatis pyruvate kinase 0.0035 0.0149 0.0252
Schistosoma mansoni pyruvate kinase 0.0035 0.0149 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0183
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0341 0.0964
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0149 0.0422
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0025 0.003
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.005 0.0089
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.001 0.0024
Onchocerca volvulus 0.0028 0.0102 0.0277
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.012 0.2379
Leishmania major pyruvate kinase 0.0035 0.0149 0.1972
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0511 0.3439 0.7003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0042 0.0656
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0702 0.1408
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0508 0.3416 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0025 0.0076
Treponema pallidum hypothetical protein 0.0169 0.1072 0.1731
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0096 0.1207
Loa Loa (eye worm) hypothetical protein 0.0028 0.0102 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0149 0.3006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.0454
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0478 0.168
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0096 0.0096
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0169 0.1072 0.3011
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0052 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Onchocerca volvulus 0.0481 0.3234 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.005 0.0819
Mycobacterium ulcerans hypothetical protein 0.0021 0.0052 0.0081
Echinococcus multilocularis solute carrier family 22 0.0016 0.0013 0.0013
Treponema pallidum penicillin-binding protein (pbp-1) 0.0725 0.4918 0.8091
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0072
Treponema pallidum penicillin-binding protein (pbp-3) 0.0892 0.6073 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0324 0.0636
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0042 0.0656
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0465 1
Echinococcus granulosus ribonuclease H1 0.0027 0.0089 0.0089
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0702 0.069
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0025 0.0274
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0096 0.0339
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0089 0.1114
Trypanosoma brucei ingi protein (ORF1) 0.0033 0.0131 0.0683
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0302 0.1994 0.5732
Echinococcus multilocularis solute carrier family 22 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.3276 0.9588
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.005 0.0089
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0325 0.0312
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0025 0.0013
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0465 0.1218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0695 0.2006
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0695 0.2006
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0096 0.184
Trypanosoma brucei unspecified product 0.0039 0.0172 0.0919
Echinococcus multilocularis pyruvate kinase 0.0035 0.0149 0.0149
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.012 0.0194
Echinococcus granulosus intermediate filament protein 0.0028 0.0102 0.0102
Brugia malayi RNase H family protein 0.0027 0.0089 0.0303
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0013 0.0013
Echinococcus granulosus lamin dm0 0.0028 0.0102 0.0102
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0149 0.0526
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0324 0.0914
Mycobacterium ulcerans hypothetical protein 0.0017 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0387 0.0375
Echinococcus granulosus solute carrier family 22 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0013 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0025 0.0274
Brugia malayi intermediate filament protein 0.0028 0.0102 0.0347
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.012 0.0258
Trypanosoma brucei unspecified product 0.0033 0.0131 0.0683
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0149 0.1972
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0487 0.2729
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0478 0.6761
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0302 0.1994 0.4049
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.022 0.1196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.4181 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0042 0.043
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0025 0.0278
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0071
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0212 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0487 0.2729
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0292 0.1022
Mycobacterium ulcerans hypothetical protein 0.0076 0.0433 0.0858
Echinococcus multilocularis lamin dm0 0.0028 0.0102 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0325 0.0312
Schistosoma mansoni pyruvate kinase 0.0035 0.0149 0.0136
Brugia malayi Sugar transporter family protein 0.0016 0.0013 0.0032
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.005 0.005
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.005 0.0537
Echinococcus multilocularis microtubule associated protein 2 0.1459 1 1
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0181 0.1157 0.3261
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0096 0.0479
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0025 0.0278
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.005 0.0537
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0702 0.2479
Trypanosoma brucei unspecified product 0.0039 0.0172 0.0919
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.022 0.1196
Mycobacterium ulcerans lipase LipD 0.0076 0.0433 0.0858
Schistosoma mansoni intermediate filament proteins 0.0028 0.0102 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0487 0.688
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.283 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.012 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0045
Echinococcus granulosus dna polymerase eta 0.0083 0.0478 0.0478
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0025 0.0025
Schistosoma mansoni chromobox protein 0.0074 0.0414 0.0401
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0149 0.1972
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0359 0.239 0.6984
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0324 0.0324
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0292 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0149 0.0525
Brugia malayi phosphofructokinase 0.0115 0.0702 0.2469
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0042 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.4181 1
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0702 0.0702
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0695 0.2006
Echinococcus granulosus expressed protein 0.0035 0.0149 0.0149
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0433 0.2418
Leishmania major trypanothione reductase 0.005 0.0251 0.3467
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0325 0.0325
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0784 0.2265
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0359 0.239 0.6902
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0702 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0433 0.6097
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0025 0.018
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0487 0.0969
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0076 0.0433 0.1529
Echinococcus multilocularis pyruvate kinase 0.0018 0.003 0.003
Plasmodium falciparum flap endonuclease 1 0.0028 0.0096 0.184
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0149 0.0782
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.3298 0.3298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0325 0.0312
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0723 0.4906 1
Brugia malayi Sugar transporter family protein 0.0016 0.0013 0.0032
Leishmania major DNA polymerase eta, putative 0.0044 0.0211 0.2882
Plasmodium falciparum thioredoxin reductase 0.005 0.0251 0.5285
Echinococcus granulosus transcription factor Dp 1 0.004 0.0184 0.0184
Onchocerca volvulus 0.0073 0.0408 0.1227
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0025 0.018
Loa Loa (eye worm) hypothetical protein 0.0081 0.0465 0.1642
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0042 0.0071
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0013 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0325 0.0325
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0096 0.0129
Plasmodium vivax SET domain protein, putative 0.0061 0.0325 0.6901
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0096 0.1207
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0433 0.0421
Echinococcus multilocularis pyruvate kinase 0.0035 0.0149 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0487 0.688
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0149 0.0327
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0251 0.5285
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0025 0.0072
Treponema pallidum penicillin-binding protein (pbp-2) 0.0511 0.3439 0.5646
Echinococcus granulosus flap endonuclease 1 0.0028 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0267 0.1749 0.1739
Loa Loa (eye worm) sugar transporter 0.0016 0.0013 0.0045
Echinococcus multilocularis solute carrier family 22 0.0016 0.0013 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.1459 1 1
Schistosoma mansoni phosphoglucomutase 0.0027 0.0089 0.0077
Echinococcus granulosus chromobox protein 1 0.0074 0.0414 0.0414
Schistosoma mansoni DNA helicase recq1 0.0021 0.005 0.0037
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0702 0.069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.018

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -4.92 Inhibitory concentration against Reverse transcriptase ChEMBL. 15916427
IC50 (binding) = 1.921 Inhibition of HIV1 reverse transcriptase ChEMBL. 19054595
IC50 (binding) = 4.92 Inhibition of HIV-1 reverse transcriptase ChEMBL. No reference
IC50 (functional) = 4.8 uM Antiviral activity against HIV-1 infected human MT-4 cells. ChEMBL. 11384233
IC50 (binding) = 12 uM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 11384233
IC50 (binding) = 12 uM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 11384233
IC50 (functional) > 200 uM Cell culture cytotoxicity against MT-4 cells. ChEMBL. 11384233
IC50 (functional) > 200 uM Cell culture cytotoxicity against MT-4 cells. ChEMBL. 11384233
Log IC50 (binding) = 4.92 Inhibitory concentration against Reverse transcriptase ChEMBL. 15916427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.