Detailed information for compound 835160

Basic information

Technical information
  • TDR Targets ID: 835160
  • Name: ethyl 2-[6-[(4-fluorophenyl)sulfamoyl]-2-oxo- 1,3-benzoxazol-3-yl]acetate
  • MW: 394.374 | Formula: C17H15FN2O6S
  • H donors: 1 H acceptors: 4 LogP: 2.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cn1c(=O)oc2c1ccc(c2)S(=O)(=O)Nc1ccc(cc1)F
  • InChi: 1S/C17H15FN2O6S/c1-2-25-16(21)10-20-14-8-7-13(9-15(14)26-17(20)22)27(23,24)19-12-5-3-11(18)4-6-12/h3-9,19H,2,10H2,1H3
  • InChiKey: LLCRZWCMLURDBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[6-[(4-fluorophenyl)sulfamoyl]-2-oxo-1,3-benzoxazol-3-yl]acetic acid ethyl ester
  • 2-[6-[(4-fluorophenyl)sulfamoyl]-2-keto-1,3-benzoxazol-3-yl]acetic acid ethyl ester
  • ethyl 2-[6-[(4-fluorophenyl)sulfamoyl]-2-oxo-1,3-benzoxazol-3-yl]ethanoate
  • MLS000118243
  • SMR000095187

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Echinococcus multilocularis histone deacetylase 6 0.038 0.2308 0.2302
Onchocerca volvulus 0.0028 0.003 0.0107
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.003 0.0022
Schistosoma mansoni integrin beta subunit 0.0627 0.3911 0.3907
Echinococcus multilocularis orexin receptor type 2 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus multilocularis fmrfamide receptor 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0427 0.2615 0.7144
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0584
Echinococcus granulosus orexin receptor type 2 0.0028 0.003 0.0022
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0007 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0588 0.3657 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0101 0.0101
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0962 0.3486
Echinococcus granulosus cathepsin b 0.1567 1 1
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.003 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.1567 1 1
Schistosoma mansoni amine GPCR 0.0028 0.003 0.0022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.003 0.0022
Brugia malayi hypothetical protein 0.0032 0.0055 0.0055
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.003 0.0022
Brugia malayi histone deacetylase 11 0.0336 0.2027 0.2027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0344 0.0337
Loa Loa (eye worm) hypothetical protein 0.0095 0.0461 0.0461
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0101 0.0094
Onchocerca volvulus 0.0028 0.003 0.0107
Plasmodium vivax histone deacetylase 2, putative 0.0373 0.2268 0.8213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.0962 0.2616
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0171 0.0958 0.0958
Echinococcus granulosus histone deacetylase 6 0.038 0.2308 0.2302
Schistosoma mansoni amine GPCR 0.0028 0.003 0.0022
Brugia malayi Histone deacetylase family protein 0.0373 0.2268 0.2268
Onchocerca volvulus 0.0449 0.276 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0962 0.0955
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.003 0.0022
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Onchocerca volvulus Histone deacetylase 10 homolog 0.0163 0.0904 0.3276
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.003 0.0022
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0149 0.0817 0.2942
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Toxoplasma gondii histone deacetylase HDAC5 0.0163 0.0904 0.2457
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi cathepsin L-like precursor 0.0427 0.2615 0.2615
Onchocerca volvulus 0.0427 0.2615 0.9475
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.003 0.0022
Loa Loa (eye worm) RNA binding protein 0.0076 0.0344 0.0344
Echinococcus multilocularis integrin beta 2 0.0798 0.502 0.5017
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0168 0.0441
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0009 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.003 0.0022
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0071 0.0309 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0073 0.0073
Leishmania major hypothetical protein, conserved 0.0049 0.0168 0.046
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.003 0.0022
Echinococcus multilocularis cysteine protease 0.0449 0.276 0.2755
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0557 0.0557
Schistosoma mansoni hypothetical protein 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0063
Brugia malayi Serotonin receptor 0.0028 0.003 0.003
Mycobacterium leprae Probable lipase LipE 0.0035 0.0076 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0817 0.081
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Echinococcus granulosus histone deacetylase 8 0.0163 0.0904 0.0897
Giardia lamblia Cathepsin L-like protease 0.0149 0.0817 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0149 0.0817 0.2942
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Brugia malayi hypothetical protein 0.0171 0.0958 0.0958
Loa Loa (eye worm) histone deacetylase 1 0.0299 0.1785 0.1785
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi sulfakinin receptor protein 0.0028 0.003 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.0172 0.0962 0.0955
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0557 0.0557
Brugia malayi follicle stimulating hormone receptor 0.0028 0.003 0.003
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0055 0.0208 0.02
Toxoplasma gondii preprocathepsin c precursor, putative 0.0149 0.0817 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.003 0.0022
Toxoplasma gondii cathepsin CPL 0.0449 0.276 0.7542
Plasmodium falciparum serine repeat antigen 7 0.0149 0.0817 0.2942
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0172 0.0962 0.2616
Onchocerca volvulus 0.0035 0.0076 0.0275
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Echinococcus multilocularis neuropeptide receptor 0.0028 0.003 0.0022
Toxoplasma gondii cathepsin CPC1 0.0149 0.0817 0.2218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Brugia malayi G-protein coupled receptor 0.0028 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0817 0.2218
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1567 1 1
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0817 0.081
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.003 0.0022
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.004 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0437 0.043
Echinococcus granulosus fmrfamide receptor 0.0028 0.003 0.0022
Trypanosoma brucei histone deacetylase, putative 0.0373 0.2268 0.6194
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0588 0.3657 0.3652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.004 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0324 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.003 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0427 0.2615 0.2609
Entamoeba histolytica cysteine proteinase 2 0.0172 0.0962 0.3486
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1567 1 1
Giardia lamblia Cathepsin L-like protease 0.0149 0.0817 0.2218
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0009 0.0002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0449 0.276 0.2755
Onchocerca volvulus 0.0028 0.003 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Echinococcus granulosus g protein coupled receptor 0.0028 0.003 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.003 0.0022
Schistosoma mansoni histamine h1 receptor 0.0028 0.003 0.0022
Echinococcus multilocularis chromobox protein 2 0.038 0.2311 0.2306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Toxoplasma gondii cathepsin CPC2 0.0149 0.0817 0.2218
Entamoeba histolytica cysteine proteinase 1, putative 0.0172 0.0962 0.3486
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0149 0.0817 0.081
Echinococcus granulosus hypothetical protein 0.0028 0.003 0.0022
Plasmodium falciparum serine repeat antigen 8 0.0149 0.0817 0.2942
Plasmodium falciparum histone deacetylase 2 0.0373 0.2268 0.8213
Echinococcus granulosus histone deacetylase 3 0.0299 0.1785 0.1779
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Echinococcus granulosus cysteine protease 0.0172 0.0962 0.0955
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.003 0.0022
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1567 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0437 0.043
Brugia malayi Dopamine receptor 0.0028 0.003 0.003
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.003 0.0022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Giardia lamblia Cathepsin B precursor 0.0149 0.0817 0.2218
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.003 0.0022
Echinococcus granulosus histone deacetylase 6 0.0373 0.2268 0.2262
Toxoplasma gondii ABC1 family protein 0.0035 0.0076 0.0187
Plasmodium falciparum histone deacetylase, putative 0.0373 0.2268 0.8213
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0076 0.0584
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0449 0.276 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0119 0.0119
Echinococcus granulosus serotonin receptor 0.0028 0.003 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Plasmodium falciparum cysteine proteinase falcipain 1 0.0172 0.0962 0.3468
Giardia lamblia Cathepsin B precursor 0.0149 0.0817 0.2218
Echinococcus granulosus cathepsin L cysteine protease 0.0172 0.0962 0.0955
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0817 0.0817
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Onchocerca volvulus 0.0049 0.0164 0.0595
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi AKH receptor 0.0028 0.003 0.003
Echinococcus granulosus cathepsin l cysteine peptidase 0.0449 0.276 0.2755
Echinococcus multilocularis histone deacetylase 8 0.0163 0.0904 0.0897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Echinococcus multilocularis histone deacetylase 7 0.0373 0.2268 0.2262
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0007 0.0007
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0192 0.0192
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0817 0.0817
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0588 0.3657 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0073 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0962 0.0955
Echinococcus granulosus tumor protein p63 0.0332 0.2003 0.1997
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Onchocerca volvulus 0.0449 0.276 1
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0275 0.1628 0.1622
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0073 0.0065
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0817 0.0817
Plasmodium vivax histone deacetylase, putative 0.0336 0.2027 0.7337
Plasmodium falciparum serine repeat antigen 6 0.0149 0.0817 0.2942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0962 0.3486
Schistosoma mansoni histone deacetylase 4 5 0.0373 0.2268 0.2262
Schistosoma mansoni adenoreceptor 0.0028 0.003 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.276 0.2755
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0187
Loa Loa (eye worm) beta-lactamase 0.0035 0.0076 0.0076
Trypanosoma cruzi cruzipain precursor, putative 0.0449 0.276 0.2755
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0584
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Onchocerca volvulus Cathepsin L homolog 0.0449 0.276 1
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.0817 0.2218
Echinococcus granulosus glutamate receptor 1 0.0042 0.0119 0.0111
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trypanosoma cruzi histone deacetylase 1, putative 0.0299 0.1785 0.1779
Echinococcus multilocularis fmrfamide receptor 0.0028 0.003 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus granulosus histone deacetylase 6 0.0373 0.2268 0.2262
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0817 0.081
Onchocerca volvulus 0.0449 0.276 1
Schistosoma mansoni amine GPCR 0.0028 0.003 0.0022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.003 0.0022
Echinococcus granulosus glutamate receptor 4 0.0042 0.0119 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0187
Brugia malayi Glutamate receptor 1 precursor 0.0066 0.0279 0.0279
Giardia lamblia Cysteine protease 0.0149 0.0817 0.2218
Plasmodium vivax histone deacetylase 1, putative 0.0299 0.1785 0.6459
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Schistosoma mansoni histone deacetylase hda2 0.038 0.2308 0.2302
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.003 0.0022
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Echinococcus granulosus GPCR family 2 0.0035 0.0073 0.0065
Echinococcus granulosus neuropeptide receptor A26 0.0028 0.003 0.0022
Brugia malayi neuropeptide F receptor 0.0028 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Brugia malayi Glutamate receptor 2 precursor 0.0066 0.0279 0.0279
Schistosoma mansoni cathepsin B (C01 family) 0.0149 0.0817 0.081
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.003 0.0107
Schistosoma mansoni neuropeptide receptor 0.0028 0.003 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.003 0.0022
Giardia lamblia Cathepsin B precursor 0.0149 0.0817 0.2218
Giardia lamblia Cathepsin B precursor 0.0588 0.3657 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Loa Loa (eye worm) cysteine protease 0.0449 0.276 0.276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.003 0.0022
Schistosoma mansoni biogenic amine receptor 0.0028 0.003 0.0022
Brugia malayi putative neuropeptide receptor 0.0028 0.003 0.003
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0783 0.0783
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0007 0.5
Echinococcus granulosus cathepsin b 0.1567 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0324 0.2493
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.003 0.003
Brugia malayi RNA binding protein 0.0076 0.0344 0.0344
Brugia malayi Dopamine receptor protein 2 0.0028 0.003 0.003
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0007 0.0021
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.003 0.003
Loa Loa (eye worm) histone deacetylase 0.0373 0.2268 0.2268
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.004 0.0032
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0299 0.1785 0.4871
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.003 0.0022
Onchocerca volvulus 0.0028 0.003 0.0107
Echinococcus multilocularis g protein coupled receptor 0.0028 0.003 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Echinococcus multilocularis sex peptide receptor 0.0028 0.003 0.0022
Schistosoma mansoni opsin-like receptor 0.0028 0.003 0.0022
Echinococcus granulosus geminin 0.0667 0.4172 0.4168
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0065
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0817 0.2218
Brugia malayi Melatonin receptor type 1A 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) histone deacetylase 11 0.0336 0.2027 0.2027
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.003 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0962 0.3486
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.003 0.0022
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0817 0.2942
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.003 0.003
Onchocerca volvulus 0.0033 0.0063 0.0227
Loa Loa (eye worm) hypothetical protein 0.0163 0.0904 0.0904
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0817 0.2218
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0164 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0187
Trypanosoma cruzi cysteine protease, putative 0.0172 0.0962 0.0955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0817 0.2218
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.003 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.003 0.0022
Echinococcus granulosus somatostatin receptor 0.0028 0.003 0.0022
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0461 0.0454
Echinococcus granulosus allatostatin A receptor 0.0028 0.003 0.0022
Brugia malayi cathepsin L precursor 0.0149 0.0817 0.0817
Onchocerca volvulus Cathepsin L homolog 0.0149 0.0817 0.2961
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0149 0.0817 0.2942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Giardia lamblia Cysteine protease 0.0149 0.0817 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0028 0.003 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0076 0.0068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0153 0.0153
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0309 0.0302
Giardia lamblia Cathepsin B precursor 0.0149 0.0817 0.2218
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0076 0.0584
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0168 0.0584
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0344 0.0337
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0149 0.0817 0.2942
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0208 0.02
Schistosoma mansoni hypothetical protein 0.0028 0.003 0.0022
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Trypanosoma cruzi major cysteine proteinase, putative 0.0149 0.0817 0.081
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0449 0.276 0.276
Onchocerca volvulus 0.0028 0.003 0.0107
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus granulosus cathepsin L 0.0149 0.0817 0.081
Brugia malayi Trypsin family protein 0.0095 0.0461 0.0461
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0172 0.0962 0.0955
Brugia malayi hypothetical protein 0.0049 0.0168 0.0168
Onchocerca volvulus 0.0028 0.003 0.0107
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.003 0.0022
Echinococcus granulosus cathepsin l1 0.0449 0.276 0.2755
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Entamoeba histolytica histone deacetylase, putative 0.0299 0.1785 0.6469
Brugia malayi ORL1-like opioid receptor 0.0028 0.003 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.003 0.0022
Schistosoma mansoni hypothetical protein 0.0028 0.003 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0437 0.043
Echinococcus multilocularis cathepsin L 0.0172 0.0962 0.0955
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0149 0.0817 0.2942
Echinococcus granulosus calpain A 0.0055 0.0208 0.02
Loa Loa (eye worm) hypothetical protein 0.0171 0.0958 0.0958
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.003 0.0022
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Schistosoma mansoni histone deacetylase 1 2 3 0.0163 0.0904 0.0897
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0076 0.0076
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.003 0.0022
Echinococcus granulosus cathepsin L cysteine proteinase 0.0449 0.276 0.2755
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0149 0.0817 0.2218
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0344 0.0337
Leishmania major histone deacetylase, putative 0.0373 0.2268 0.6202
Onchocerca volvulus 0.0028 0.003 0.0107
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.003 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0817 0.081
Mycobacterium ulcerans beta-lactamase 0.0035 0.0076 0.2342
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.003 0.0022
Schistosoma mansoni cathepsin S (C01 family) 0.0149 0.0817 0.081
Echinococcus granulosus tar DNA binding protein 0.0076 0.0344 0.0337
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0817 0.2942
Schistosoma mansoni amine GPCR 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trypanosoma brucei cysteine peptidase C (CPC) 0.0588 0.3657 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.0173 0.0972 0.0972
Plasmodium vivax vivapain-1 0.0172 0.0962 0.3468
Brugia malayi Cathepsin L-like cysteine proteinase 0.0427 0.2615 0.2615
Trypanosoma cruzi histone deacetylase, putative 0.0163 0.0904 0.0897
Echinococcus granulosus glutamate receptor 2 0.0071 0.0309 0.0302
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.276 0.2755
Brugia malayi Integrin beta pat-3 precursor 0.109 0.6912 0.6912
Onchocerca volvulus 0.0449 0.276 1
Schistosoma mansoni neuropeptide receptor 0.0028 0.003 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.003 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0817 0.0817
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0437 0.043
Brugia malayi cathepsin F-like cysteine proteinase 0.0149 0.0817 0.0817
Echinococcus multilocularis g protein coupled receptor 0.0028 0.003 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.003 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0028 0.003 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.003 0.0022
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0149 0.0817 0.2942
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0076 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0817 0.081
Echinococcus granulosus chromobox protein 2 0.038 0.2311 0.2306
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0076
Echinococcus multilocularis histone deacetylase 3 0.0299 0.1785 0.1779
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0101 0.0101
Schistosoma mansoni amine GPCR 0.0028 0.003 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0437 0.0437
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0817 0.081
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Trypanosoma cruzi histone deacetylase, putative 0.0163 0.0904 0.0897
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0333 0.0333
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0817 0.2961
Trypanosoma brucei histone deacetylase 3 0.0373 0.2268 0.6194
Trypanosoma brucei histone deacetylase 4 0.0373 0.2268 0.6194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0068
Trypanosoma cruzi histone deacetylase, putative 0.0373 0.2268 0.2262
Brugia malayi G protein-coupled receptor 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0427 0.2615 0.2615
Echinococcus granulosus cathepsin L 0.0172 0.0962 0.0955
Loa Loa (eye worm) hypothetical protein 0.0427 0.2615 0.2615
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0192 0.0185
Brugia malayi calpain family protein 1 0.0053 0.0192 0.0192
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.003 0.003
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0009 0.0002
Giardia lamblia Encystation-specific protease 0.0149 0.0817 0.2218
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0168 0.0161
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Plasmodium vivax histone deacetylase, putative 0.0373 0.2268 0.8213
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.003 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0344 0.0337
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0168 0.0584
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0817 0.2218
Toxoplasma gondii histone deacetylase HDAC3 0.0299 0.1785 0.4871
Loa Loa (eye worm) hypothetical protein 0.0075 0.0333 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0065
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0584
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.276 0.2755
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0149 0.0817 0.2942
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.003 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Echinococcus multilocularis neuropeptide s receptor 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi cathepsin Z-like cysteine proteinase 0.0149 0.0817 0.0817
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.003 0.0022
Onchocerca volvulus 0.0028 0.003 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.003 0.0022
Echinococcus multilocularis histone deacetylase 1 0.0299 0.1785 0.1779
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0168 0.0584
Schistosoma mansoni myosin xvIII 0.0028 0.003 0.0022
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0009 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0149 0.0817 0.2218
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0344 0.0344
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.003 0.0022
Brugia malayi Cathepsin L-like precursor 0.0427 0.2615 0.2615
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni histone deacetylase 4 5 0.0373 0.2268 0.2262
Loa Loa (eye worm) hypothetical protein 0.0042 0.0119 0.0119
Schistosoma mansoni biogenic amine receptor 0.0028 0.003 0.0022
Plasmodium falciparum serine repeat antigen 9 0.0149 0.0817 0.2942
Echinococcus multilocularis histone deacetylase 6 0.0373 0.2268 0.2262
Onchocerca volvulus 0.0149 0.0817 0.2961
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.003 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0076 0.0584
Schistosoma mansoni biogenic amine receptor 0.0028 0.003 0.0022
Echinococcus multilocularis glutamate receptor 2 0.0062 0.025 0.0243
Brugia malayi Papain family cysteine protease containing protein 0.0149 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trypanosoma cruzi histone deacetylase, putative 0.0373 0.2268 0.2262
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0076 0.0584
Brugia malayi G-protein coupled receptor 0.0028 0.003 0.003
Brugia malayi calpain family protein 1 0.0053 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0449 0.276 0.276
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0449 0.276 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi Histone deacetylase 1 0.0299 0.1785 0.1785
Loa Loa (eye worm) hypothetical protein 0.0109 0.0557 0.0557
Leishmania major hypothetical protein, conserved 0.0035 0.0076 0.0207
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0149 0.0817 0.0817
Giardia lamblia Histone deacetylase 0.0299 0.1785 0.4871
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0076 0.0584
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0076 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.003 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0449 0.276 0.276
Loa Loa (eye worm) hypothetical protein 0.0049 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.0817 0.081
Plasmodium vivax vivapain-3 0.0172 0.0962 0.3468
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0449 0.276 0.2755
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Brugia malayi fibroinase precursor 0.0149 0.0817 0.0817
Schistosoma mansoni hypothetical protein 0.0028 0.003 0.0022
Brugia malayi TAR-binding protein 0.0076 0.0344 0.0344
Echinococcus multilocularis cathepsin L cysteine protease 0.0449 0.276 0.2755
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.003 0.0022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.003 0.0022
Echinococcus multilocularis cathepsin L 0.0149 0.0817 0.081
Echinococcus granulosus tm gpcr rhodopsin 0.0538 0.3336 0.3331
Loa Loa (eye worm) hypothetical protein 0.0299 0.1785 0.1785
Giardia lamblia Cysteine protease 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.0053 0.0192 0.0192
Trypanosoma cruzi cysteine proteinase, putative 0.0172 0.0962 0.0955
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0073 0.0065
Brugia malayi histone deacetylase 1 (HD1) 0.0299 0.1785 0.1785
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.003 0.003
Onchocerca volvulus 0.0449 0.276 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.003 0.0022
Schistosoma mansoni histone deacetylase 0.0299 0.1785 0.1779
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus histone deacetylase 7 0.0373 0.2268 0.2262
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0065
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.004 0.0032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.003 0.0107
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.003 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.003 0.0022
Giardia lamblia Hypothetical protein 0.0149 0.0817 0.2218
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.003 0.003
Schistosoma mansoni chromobox protein 0.038 0.2311 0.2306
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Brugia malayi histone deacetylase 3 (HD3) 0.0299 0.1785 0.1785
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.0667 0.4172 0.4168
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0299 0.1785 0.4871
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Loa Loa (eye worm) glutamate receptor 1 0.0066 0.0279 0.0279
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0279 0.0272
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0178 0.0171
Onchocerca volvulus 0.0028 0.003 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Brugia malayi cathepsin L-like cysteine proteinase 0.0149 0.0817 0.0817
Echinococcus granulosus neuropeptide receptor 0.0028 0.003 0.0022
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0035 0.0028
Loa Loa (eye worm) hypothetical protein 0.0217 0.1253 0.1253
Echinococcus multilocularis histone deacetylase 0.0373 0.2268 0.2262
Plasmodium vivax vivapain-2 0.0449 0.276 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Brugia malayi GnHR receptor homolog 0.0028 0.003 0.003
Echinococcus multilocularis GPCR, family 2 0.0035 0.0073 0.0065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0076 0.2342
Onchocerca volvulus 0.0028 0.003 0.0107
Toxoplasma gondii histone deacetylase HDAC4 0.0336 0.2027 0.5533
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Toxoplasma gondii cathepsin B 0.0588 0.3657 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0076 0.2342
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0172 0.0962 0.0955
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Schistosoma mansoni calpain-7 (C02 family) 0.0029 0.0035 0.0028
Plasmodium falciparum serine repeat antigen 4 0.0149 0.0817 0.2942
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0076 0.2342
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.0962 0.0962
Echinococcus multilocularis cathepsin b 0.1567 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0076 0.0068
Onchocerca volvulus 0.0035 0.0076 0.0275
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0427 0.2615 0.2609
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0149 0.0817 0.2218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0817 0.2218
Plasmodium vivax unspecified product 0.0149 0.0817 0.2942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Entamoeba histolytica cysteine proteinase, putative 0.0427 0.2615 0.9475
Brugia malayi larval opioid receptor 0.0028 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0068
Schistosoma mansoni hypothetical protein 0.0667 0.4172 0.4168
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0275 0.1628 0.1622
Echinococcus multilocularis histone deacetylase 6 0.0373 0.2268 0.2262
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0073 0.0073
Schistosoma mansoni histone deacetylase hda2 0.0163 0.0904 0.0897
Entamoeba histolytica cysteine proteinase, putative 0.0449 0.276 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Trypanosoma cruzi histone deacetylase, putative 0.0373 0.2268 0.2262
Entamoeba histolytica cysteine proteinase, putative 0.0449 0.276 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0324 0.0867
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Leishmania major histone deacetylase, putative 0.0299 0.1785 0.4882
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0149 0.0817 0.0817
Trypanosoma cruzi cysteine peptidase, putative 0.0449 0.276 0.2755
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0437 0.043
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0324 0.0317
Echinococcus multilocularis cathepsin b 0.1567 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0073 0.0065
Loa Loa (eye worm) integrin beta-2 0.109 0.6912 0.6912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Echinococcus granulosus g-protein coupled receptor 0.0028 0.003 0.0022
Leishmania major cysteine peptidase A (CPA) 0.0449 0.276 0.7547
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1299 1
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.003 0.0022
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Trichomonas vaginalis esterase, putative 0.0035 0.0076 0.0187
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0427 0.2615 0.2615
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus multilocularis calpain A 0.0055 0.0208 0.02
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0783 0.0783
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Brugia malayi Cathepsin L-like precursor 0.0449 0.276 0.276
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0009 0.0002
Echinococcus multilocularis somatostatin receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Onchocerca volvulus 0.0028 0.003 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Entamoeba histolytica cysteine protease, putative 0.0449 0.276 1
Plasmodium vivax unspecified product 0.0172 0.0962 0.3468
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Schistosoma mansoni opsin-like receptor 0.0028 0.003 0.0022
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.003 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Onchocerca volvulus 0.0028 0.003 0.0107
Giardia lamblia Cathepsin B precursor 0.0149 0.0817 0.2218
Onchocerca volvulus 0.0035 0.0076 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0149 0.0817 0.2218
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0007 0.0021
Trypanosoma cruzi histone deacetylase 1, putative 0.0299 0.1785 0.1779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0055 0.0208 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0068
Brugia malayi Histone deacetylase family protein 0.0373 0.2268 0.2268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0324 1
Loa Loa (eye worm) histone deacetylase 7A 0.0373 0.2268 0.2268
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0168 0.0441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Trypanosoma brucei histone deacetylase 2 0.0163 0.0904 0.2457
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.004 0.0032
Loa Loa (eye worm) fibroinase 0.0449 0.276 0.276
Onchocerca volvulus 0.0028 0.003 0.0107
Leishmania major cathepsin L-like protease 0.0449 0.276 0.7547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.0962 0.2616
Schistosoma mansoni opsin-like receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.003 0.003
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0324 0.0317
Loa Loa (eye worm) histone deacetylase 3 0.0299 0.1785 0.1785
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0071 0.0309 0.0302
Onchocerca volvulus 0.0028 0.003 0.0107
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0588 0.3657 0.3652
Echinococcus multilocularis geminin 0.0667 0.4172 0.4168
Schistosoma mansoni neuropeptide receptor 0.0028 0.003 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0449 0.276 0.2755
Loa Loa (eye worm) hypothetical protein 0.0211 0.1213 0.1213
Onchocerca volvulus 0.0449 0.276 1
Echinococcus granulosus histone deacetylase 1 0.0299 0.1785 0.1779
Loa Loa (eye worm) ctsf protein 0.0449 0.276 0.276
Echinococcus granulosus neuropeptide receptor 0.0028 0.003 0.0022
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0149 0.0817 0.2961
Echinococcus granulosus glutamate receptor 2 0.0062 0.025 0.0243
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0149 0.0817 0.2942
Loa Loa (eye worm) cathepsin B 0.0588 0.3657 0.3657
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0344 0.0337
Loa Loa (eye worm) hypothetical protein 0.0427 0.2615 0.2615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.0962 0.2616
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1567 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0076 0.0248
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0028 0.003 0.0022
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0149 0.0817 0.2218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.003 0.0022
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0007 0.0058
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0076 0.0584
Trypanosoma cruzi cysteine proteinase, putative 0.0172 0.0962 0.0955
Plasmodium falciparum serine repeat antigen 5 0.0149 0.0817 0.2942
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0149 0.0817 0.2942
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0119 0.0111
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0178 0.0171
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0149 0.0817 0.081
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.003 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0028 0.003 0.0022
Brugia malayi Dopamine receptor protein 1 0.0028 0.003 0.003
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0299 0.1785 0.4871
Plasmodium vivax vivapain-2 0.0449 0.276 1
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0009 0.0002
Onchocerca volvulus 0.0449 0.276 1
Onchocerca volvulus 0.0028 0.003 0.0107
Entamoeba histolytica cysteine protease, putative 0.0172 0.0962 0.3486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0208 0.02
Echinococcus granulosus g protein coupled receptor 0.0028 0.003 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0437 0.043
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0009 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0449 0.276 0.2755
Schistosoma mansoni hypothetical protein 0.0075 0.0333 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.003 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.003 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0028 0.003 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0538 0.3336 0.3331
Plasmodium falciparum serine repeat antigen 1 0.0149 0.0817 0.2942
Schistosoma mansoni cathepsin F (C01 family) 0.0449 0.276 0.2755
Echinococcus granulosus neuropeptide s receptor 0.0028 0.003 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.0962 0.3486
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0437 0.0437
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0168 0.0161
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Giardia lamblia Cathepsin B precursor 0.0588 0.3657 1
Onchocerca volvulus Cathepsin L homolog 0.0449 0.276 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.003 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0557 0.0557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0427 0.2615 0.7144
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.003 0.003
Leishmania major histone deacetylase, putative 0.0299 0.1785 0.4882
Leishmania major histone deacetylase, putative 0.0373 0.2268 0.6202
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0009 0.0002
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0007 0.0027
Giardia lamblia Cysteine protease 0.0149 0.0817 0.2218
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.0187
Trichomonas vaginalis histone deacetylase, putative 0.0299 0.1785 0.4871
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.0164
Giardia lamblia Cathepsin L precursor 0.0149 0.0817 0.2218
Plasmodium falciparum serine repeat antigen 3 0.0149 0.0817 0.2942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus multilocularis serotonin receptor 0.0028 0.003 0.0022
Onchocerca volvulus 0.0086 0.0407 0.1474
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0344 0.0337
Trypanosoma brucei histone deacetylase 1 0.0299 0.1785 0.4871
Onchocerca volvulus 0.0028 0.003 0.0107
Echinococcus granulosus cathepsin l1 0.0427 0.2615 0.2609
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0449 0.276 0.276
Entamoeba histolytica hypothetical protein 0.0149 0.0817 0.2961
Loa Loa (eye worm) hypothetical protein 0.0035 0.0073 0.0073
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0009 0.0002
Schistosoma mansoni histone deacetylase 0.0299 0.1785 0.1779
Brugia malayi beta-lactamase 0.0035 0.0076 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.003 0.0022
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0149 0.0817 0.2942
Entamoeba histolytica cysteine protease, putative 0.0149 0.0817 0.2961
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0073 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0076 0.0187
Brugia malayi neuropeptide F receptor 0.0028 0.003 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0172 0.0962 0.0962
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0461 0.0454
Echinococcus multilocularis cysteine protease 0.0449 0.276 0.2755
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.003 0.0022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0149 0.0817 0.081
Echinococcus granulosus sex peptide receptor 0.0028 0.003 0.0022
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1567 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0149 0.0817 0.2218
Onchocerca volvulus 0.0028 0.003 0.0107
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.003 0.003
Mycobacterium ulcerans lipase LipD 0.0035 0.0076 0.2342
Loa Loa (eye worm) hypothetical protein 0.0095 0.0461 0.0461
Brugia malayi MH2 domain containing protein 0.0144 0.0783 0.0783
Giardia lamblia Hypothetical protein 0.0149 0.0817 0.2218
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0149 0.0817 0.0817
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0324 0.0317
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.003 0.0022
Echinococcus granulosus histone deacetylase 0.0373 0.2268 0.2262
Plasmodium vivax serine-repeat antigen (SERA) 0.0149 0.0817 0.2942
Brugia malayi Kelch motif family protein 0.0171 0.0958 0.0958
Giardia lamblia Cathepsin B precursor 0.0588 0.3657 1
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Onchocerca volvulus 0.0095 0.0461 0.1671
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0149 0.0817 0.2942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.276 0.7542
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.003 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0449 0.276 0.7542
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0437 0.043
Toxoplasma gondii histone deacetylase HDAC2 0.0299 0.1785 0.4871
Brugia malayi hypothetical protein 0.0028 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0035 0.0073 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.003 0.0022
Toxoplasma gondii histone deacetylase HDAC1 0.0373 0.2268 0.6194
Echinococcus multilocularis serotonin receptor 0.0028 0.003 0.0022
Plasmodium falciparum serine repeat antigen 2 0.0149 0.0817 0.2942
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.003 0.0022
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.003 0.0022
Echinococcus granulosus g protein coupled receptor 0.0028 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Plasmodium falciparum histone deacetylase 1 0.0299 0.1785 0.6459
Loa Loa (eye worm) hypothetical protein 0.0042 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0149 0.0817 0.2218
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.003 0.003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0449 0.276 1
Echinococcus granulosus integrin beta 2 0.0798 0.502 0.5017
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0149 0.0817 0.2942
Brugia malayi RE15519p 0.0028 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.276 0.7542
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.003 0.003
Onchocerca volvulus Cathepsin F homolog 0.0449 0.276 1
Schistosoma mansoni cathepsin C 0.0149 0.0817 0.081
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.004 0.0032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0344 0.0344
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0076
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0324 0.0886
Brugia malayi Serotonin receptor 0.0028 0.003 0.003
Echinococcus multilocularis tumor protein p63 0.0332 0.2003 0.1997

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 29.9 um PUBCHEM_BIOASSAY: Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3). (Class of assay: confirmatory) [Related pubchem assays: 1424, 1448 ] ChEMBL. No reference
EC50 (functional) > 29.9 uM PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel N1 (TRPN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1424, AID1448] ChEMBL. No reference
Potency (functional) 0.631 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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