Detailed information for compound 835607

Basic information

Technical information
  • TDR Targets ID: 835607
  • Name: dimethyl 4-(2,3,4-trimethoxyphenyl)-1,4-dihyd ropyridine-3,5-dicarboxylate
  • MW: 363.362 | Formula: C18H21NO7
  • H donors: 1 H acceptors: 2 LogP: 1.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=CNC=C(C1c1ccc(c(c1OC)OC)OC)C(=O)OC
  • InChi: 1S/C18H21NO7/c1-22-13-7-6-10(15(23-2)16(13)24-3)14-11(17(20)25-4)8-19-9-12(14)18(21)26-5/h6-9,14,19H,1-5H3
  • InChiKey: NFACOYJLYDDZAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,3,4-trimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(2,3,4-Trimethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl
  • 4-(2,3,4-Trimethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
  • BAS 02841772
  • A2362/0099770
  • EU-0040774
  • CBMicro_022017
  • BIM-0021837.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0021 0.0192 0.0892
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0546
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0035 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0062 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Onchocerca volvulus 0.0011 0.0062 0.0139
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0062 0.0139
Brugia malayi nuclear receptor NHR-88 0.0011 0.0062 0.0139
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0082 0.0943 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.797
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0062 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0159 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.8166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0062 0.005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0062 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0062 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0062 0.0139
Schistosoma mansoni coup transcription factor 0.0011 0.0062 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0159 0.1578
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.022 1
Trypanosoma brucei endonuclease G, putative 0.0082 0.0943 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0021 0.0192 0.0892
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0062 0.005
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0062 0.0139
Brugia malayi Smad1 0.0009 0.0035 0.0065
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0137 0.1619 0.4502
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0062 0.0247
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0159 0.0411
Brugia malayi MH2 domain containing protein 0.0009 0.0035 0.0065
Onchocerca volvulus 0.0137 0.1619 0.4502
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0062 0.0139
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.022 1
Brugia malayi hypothetical protein 0.0021 0.0192 0.0504
Echinococcus granulosus smad 0.0009 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0123 0.1448 0.4023
Echinococcus multilocularis geminin 0.017 0.2028 0.2018
Echinococcus multilocularis Endonuclease G 0.0082 0.0943 0.0932
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0021 0.0192 0.8641
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.797
Onchocerca volvulus Huntingtin homolog 0.0123 0.1448 0.4023
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0021 0.0192 0.0504
Onchocerca volvulus 0.0295 0.358 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0012 0.0546
Brugia malayi endonuclease G, mitochondrial precursor 0.0082 0.0943 0.2608
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.022 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0062 0.0139
Echinococcus multilocularis transferase 0.0021 0.0192 0.018
Brugia malayi MH2 domain containing protein 0.013 0.1534 0.4266
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0062 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0062 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0062 0.0139
Brugia malayi hypothetical protein 0.0021 0.0192 0.0504
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0295 0.358 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0012 0.0546
Schistosoma mansoni hypothetical protein 0.017 0.2028 0.5649
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0062 0.0139
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.022 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0062 0.0139
Schistosoma mansoni hypothetical protein 0.0295 0.358 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0062 0.0139
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0062 0.0139
Loa Loa (eye worm) hypothetical protein 0.0137 0.1619 0.4502
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0159 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0159 0.7217
Brugia malayi AEL166Cp 0.0021 0.0192 0.0504
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0546
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.797
Schistosoma mansoni smad1 5 8 and 0.0009 0.0035 0.0065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0159 0.0728
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0012 0.0546
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0062 0.0247
Echinococcus multilocularis Smad4 0.0009 0.0035 0.0023
Echinococcus multilocularis smad 0.0009 0.0035 0.0023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0035 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.2236
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.022 1
Brugia malayi MH1 domain containing protein 0.0009 0.0035 0.0065
Brugia malayi ecdysteroid receptor 0.0011 0.0062 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0159 0.0411
Brugia malayi hypothetical protein 0.0123 0.1448 0.4023
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0021 0.0192 0.0504
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0159 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0504
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0062 0.0139
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1534 0.4266
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0021 0.0192 0.0504
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0504
Schistosoma mansoni smad1 5 8 and 0.0009 0.0035 0.0065
Brugia malayi MH1 domain containing protein 0.0009 0.0035 0.0065
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0021 0.0192 0.0504
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0062 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.2236
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0082 0.0943 1
Onchocerca volvulus 0.0024 0.022 0.0583
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0082 0.0943 1
Onchocerca volvulus 0.0137 0.1619 0.4502
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0062 0.0139
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Leishmania major endonuclease G, putative 0.0082 0.0943 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0062 0.0139
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0035 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0583
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0062 0.0139
Echinococcus multilocularis ectonucleotide 0.0115 0.1352 0.1342
Echinococcus granulosus ectonucleotide 0.0115 0.1352 0.6649
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0137 0.1619 0.4502
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0137 0.1619 0.4502
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0012 0.0546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.022 1
Brugia malayi Thrombospondin type 1 domain containing protein 0.0295 0.358 1
Brugia malayi steroid hormone receptor 0.0011 0.0062 0.0139
Schistosoma mansoni smad1 5 8 and 0.0009 0.0035 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0062 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0062 0.0139
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0146 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0159 0.5
Toxoplasma gondii exonuclease III APE 0.0019 0.0159 0.1578
Echinococcus granulosus geminin 0.017 0.2028 1
Schistosoma mansoni smad 0.0009 0.0035 0.0065
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0062 0.0139
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.022 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0583
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0583
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0159 0.7057
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0583
Schistosoma mansoni Smad4 0.0009 0.0035 0.0065
Echinococcus granulosus Smad4 0.0009 0.0035 0.0115
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0146 0.6617
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0062 0.005
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0082 0.0943 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0062 0.0139
Schistosoma mansoni hypothetical protein 0.0021 0.0192 0.0504
Brugia malayi MH2 domain containing protein 0.0009 0.0035 0.0065
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Schistosoma mansoni hypothetical protein 0.017 0.2028 0.5649
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0021 0.0192 0.018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0062 0.0139
Schistosoma mansoni endonuclease related 0.0082 0.0943 0.2608
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0062 0.0139
Trypanosoma brucei endonuclease G, putative 0.0082 0.0943 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.022 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0035 0.0023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0062 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0062 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0062 0.0139
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0021 0.0192 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0035 0.0065
Onchocerca volvulus Huntingtin homolog 0.0123 0.1448 0.4023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.6071
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0021 0.0192 0.018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0374
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0374
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Mycobacterium ulcerans hypothetical protein 0.0024 0.022 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0115 0.1352 0.1342
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0021 0.0192 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.6071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0021 0.0192 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0062 0.0139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0062 0.005
Loa Loa (eye worm) hypothetical protein 0.0123 0.1448 0.4023
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0021 0.0192 0.0504
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0012 0.0546
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0062 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0504
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0146 0.7431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.2236
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.022 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0159 0.1578
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0012 0.0546
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0062 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 1
Trypanosoma cruzi endonuclease G, putative 0.0082 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0374
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0021 0.0192 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0062 0.0139
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0062 0.0247
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0062 0.005
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0411
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.1608
Schistosoma mansoni hypothetical protein 0.0021 0.0192 0.0504
Trypanosoma brucei endonuclease G, putative 0.0082 0.0943 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.797
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0021 0.0192 0.0504
Loa Loa (eye worm) hypothetical protein 0.0137 0.1619 0.4502
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0411
Schistosoma mansoni hypothetical protein 0.0021 0.0192 0.0504
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1534 0.4266
Leishmania major ethanolamine phosphotransferase, putative 0.0021 0.0192 0.1932
Loa Loa (eye worm) hypothetical protein 0.0011 0.0062 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.022 1
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0062 0.0139
Brugia malayi nuclear hormone receptor 0.0011 0.0062 0.0139
Loa Loa (eye worm) hypothetical protein 0.0137 0.1619 0.4502
Echinococcus granulosus transferase 0.0021 0.0192 0.0892
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0546
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0021 0.0192 0.1932
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0062 0.005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0035 0.0065
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0146 0.91
Mycobacterium ulcerans hypothetical protein 0.0021 0.0192 0.8641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0062 0.0247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0062 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.6071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0062 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0062 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0062 0.0139
Echinococcus granulosus Endonuclease G 0.0082 0.0943 0.4617
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0012 0.0546
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0583
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0504
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0137 0.1619 0.4502
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0159 0.1578
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0062 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0159 0.7057
Loa Loa (eye worm) Smad1 0.0009 0.0035 0.0065
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0021 0.0192 0.018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0062 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0062 0.0139
Trypanosoma cruzi endonuclease G, putative 0.0082 0.0943 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0062 0.0139
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0021 0.0192 0.8641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0374
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0137 0.1619 0.797
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.022 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0062 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.6071
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0115 0.1352 0.6649
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0146 0.6421
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0021 0.0192 0.018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0159 0.0147
Schistosoma mansoni hypothetical protein 0.0021 0.0192 0.0504
Mycobacterium leprae hypothetical protein 0.0021 0.0192 0.8641
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0062 0.005
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0021 0.0192 0.0504
Loa Loa (eye worm) hypothetical protein 0.0115 0.1352 0.3756
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0035 0.0115
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0062 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0062 0.0139
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0137 0.1619 0.4502
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0159 0.1578

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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