Detailed information for compound 868112

Basic information

Technical information
  • TDR Targets ID: 868112
  • Name: 8-(4-tert-butylbenzoyl)-3-(4-methylphenyl)-1, 4,8-triazaspiro[4.5]dec-3-en-2-one
  • MW: 403.517 | Formula: C25H29N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C1=NC2(NC1=O)CCN(CC2)C(=O)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C25H29N3O2/c1-17-5-7-18(8-6-17)21-22(29)27-25(26-21)13-15-28(16-14-25)23(30)19-9-11-20(12-10-19)24(2,3)4/h5-12H,13-16H2,1-4H3,(H,27,29)
  • InChiKey: DZSYALZHVOZQDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[(4-tert-butylphenyl)-oxomethyl]-3-(4-methylphenyl)-1,4,8-triazaspiro[4.5]dec-3-en-2-one
  • 8-(4-tert-butylphenyl)carbonyl-3-(4-methylphenyl)-1,4,8-triazaspiro[4.5]dec-3-en-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0035 0.0106 0.0134
Leishmania major eukaryotic initiation factor 4a, putative 0.0754 0.7075 0.7072
Brugia malayi Cathepsin L-like precursor 0.0025 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0277 0.0268
Schistosoma mansoni alpha-glucosidase 0.0137 0.1097 0.1086
Mycobacterium tuberculosis Conserved protein 0.0072 0.0464 0.0071
Onchocerca volvulus 0.0038 0.0134 0.0122
Brugia malayi Integrin alpha pat-2 precursor 0.0313 0.2798 0.2798
Entamoeba histolytica hypothetical protein 0.0035 0.0106 0.0134
Trypanosoma cruzi oligopeptidase b 0.042 0.3835 0.3829
Brugia malayi amidase 0.0105 0.0781 0.0781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0754 0.7075 0.7072
Schistosoma mansoni hypothetical protein 0.0339 0.3047 0.3038
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0111 0.0838 0.0828
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0108 0.0137
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0478 0.0469
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0838 0.0829
Plasmodium falciparum eukaryotic initiation factor 4A 0.0754 0.7075 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0754 0.7075 0.7072
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0105 0.0781 0.0736
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0754 0.7075 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0108 0.006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0329 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0108 0.0098
Schistosoma mansoni integrin alpha-ps 0.014 0.1124 0.1114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0134 0.0175
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0754 0.7075 0.7061
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0108 0.0137
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0754 0.7075 0.7072
Toxoplasma gondii cathepsin CPL 0.0038 0.0134 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0464 0.064
Echinococcus granulosus integrin alpha 3 0.024 0.209 0.2081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0134 0.0173
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0108 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0464 0.064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0108 0.0108
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Entamoeba histolytica hypothetical protein 0.0035 0.0106 0.0134
Schistosoma mansoni bromodomain containing protein 0.0062 0.0362 0.0351
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0134 0.0124
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0111 0.0838 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Loa Loa (eye worm) integrin alpha pat-2 0.0482 0.444 0.4435
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0111 0.0838 0.0829
Echinococcus multilocularis survival motor neuron protein 1 0.0462 0.4243 0.4216
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0097 0.0709 0.0699
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0108 0.0098
Entamoeba histolytica prolyl oligopeptidase family protein 0.0111 0.0838 0.117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0185
Schistosoma mansoni hypothetical protein 0.0035 0.0106 0.0095
Onchocerca volvulus 0.0232 0.2015 0.2005
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0171 0.1418 0.141
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0134 0.0173
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0478 0.0432
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0754 0.7075 0.7061
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0105 0.0781 0.0736
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.042 0.3835 0.9287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) fibroinase 0.0038 0.0134 0.0124
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0478 0.066
Brugia malayi Bromodomain containing protein 0.0037 0.0126 0.0126
Plasmodium vivax peptide deformylase, putative 0.0447 0.4098 0.5787
Brugia malayi beta-lactamase family protein 0.0072 0.0464 0.0464
Entamoeba histolytica prolyl oligopeptidase family protein 0.0111 0.0838 0.117
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0478 0.0469
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0111 0.0838 0.0829
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0464 0.0464
Brugia malayi prolyl oligopeptidase family protein 0.0111 0.0838 0.0838
Echinococcus granulosus fatty acid amide hydrolase 1 0.0105 0.0781 0.077
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0111 0.0838 0.0828
Trypanosoma cruzi prolyl endopeptidase 0.1056 1 1
Echinococcus multilocularis integrin beta 2 0.0475 0.4367 0.4339
Leishmania major oligopeptidase b 0.042 0.3835 0.3829
Brugia malayi Bromodomain containing protein 0.0073 0.0473 0.0473
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0134 0.0134
Onchocerca volvulus 0.0038 0.0134 0.0122
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0108 0.0137
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0111 0.0838 0.0829
Brugia malayi beta-lactamase family protein 0.0072 0.0464 0.0464
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0289 0.0278
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0209 0.0198
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0447 0.4098 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.2059 0.2051
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1312 0.1302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0185
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0111 0.0838 0.0794
Echinococcus granulosus acylamino acid releasing enzyme 0.0111 0.0838 0.0828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0173 0.1438 0.1429
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1312 0.1304
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1056 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0111 0.0838 0.117
Toxoplasma gondii hypothetical protein 0.0447 0.4098 0.4093
Loa Loa (eye worm) prolyl oligopeptidase 0.0111 0.0838 0.0829
Trypanosoma cruzi oligopeptidase b 0.042 0.3835 0.3829
Brugia malayi hypothetical protein 0.0035 0.0106 0.0106
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0478 0.0469
Brugia malayi Pre-SET motif family protein 0.0029 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0111 0.0838 0.0829
Trypanosoma cruzi cruzipain precursor, putative 0.0084 0.0578 0.0569
Schistosoma mansoni amidase 0.0105 0.0781 0.077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0478 0.066
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0111 0.0838 0.0828
Loa Loa (eye worm) hypothetical protein 0.0462 0.4243 0.4238
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0111 0.0838 0.0794
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0754 0.7075 0.7072
Echinococcus granulosus cathepsin l1 0.0038 0.0134 0.0122
Brugia malayi hypothetical protein 0.0462 0.4243 0.4243
Brugia malayi Kelch motif family protein 0.0097 0.0709 0.0709
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1056 1 1
Onchocerca volvulus 0.0038 0.0134 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0048 0.0037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0478 0.066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0038 0.0026
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0108 0.0097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0678 0.0678
Trypanosoma brucei oligopeptidase b 0.042 0.3835 0.3829
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0111 0.0838 0.0828
Schistosoma mansoni survival motor neuron protein 0.0094 0.0678 0.0667
Toxoplasma gondii ABC1 family protein 0.0072 0.0464 0.0454
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0111 0.0838 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0838 0.117
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0478 0.066
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0111 0.0838 0.117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.014
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0754 0.7075 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0158
Leishmania major cathepsin L-like protease 0.0084 0.0578 0.0569
Echinococcus multilocularis cysteine protease 0.0038 0.0134 0.0086
Trypanosoma brucei prolyl endopeptidase 0.1056 1 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0945 0.8927 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0464 0.0452
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0134 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0002
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0464 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Echinococcus granulosus integrin beta 2 0.0475 0.4367 0.436
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0464 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0838 0.0829
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0108 0.0137
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0464 0.0071
Loa Loa (eye worm) cysteine protease 0.0038 0.0134 0.0124
Entamoeba histolytica prolyl oligopeptidase family protein 0.0111 0.0838 0.117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Plasmodium vivax vivapain-2 0.0038 0.0134 0.0175
Mycobacterium tuberculosis Conserved protein 0.0072 0.0464 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0117
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0104 0.0056
Brugia malayi eukaryotic initiation factor 4A 0.0754 0.7075 0.7075
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0134 0.0124
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0134 0.0175
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0185
Loa Loa (eye worm) hypothetical protein 0.0067 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0073 0.0473 0.0463
Brugia malayi Inositol-1 0.0074 0.0478 0.0478
Schistosoma mansoni alpha glucosidase 0.0035 0.0108 0.0097
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0478 0.0469
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0464 0.064
Leishmania major cathepsin L-like protease 0.0084 0.0578 0.0569
Mycobacterium tuberculosis Conserved protein 0.0072 0.0464 0.0071
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0134 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0106 0.0095
Loa Loa (eye worm) hypothetical protein 0.0038 0.0134 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.042 0.3835 0.9275
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0478 0.0467
Brugia malayi cathepsin L-like precursor 0.0025 0.0012 0.0012
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0111 0.0838 0.0829
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.042 0.3835 0.3829
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0754 0.7075 1
Plasmodium falciparum peptidase, putative 0.0111 0.0838 0.1172
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0134 0.0122
Schistosoma mansoni integrin alpha-ps 0.0073 0.0473 0.0462
Echinococcus multilocularis cysteine protease 0.0038 0.0134 0.0086
Onchocerca volvulus 0.0038 0.0134 0.0122
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0578 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0185
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0754 0.7075 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0464 0.0454
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0134 0.0173
Onchocerca volvulus 0.0029 0.0048 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.4229 0.4489
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0464 0.064
Onchocerca volvulus 0.0072 0.0464 0.0452
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0111 0.0838 0.0829
Treponema pallidum ATP-dependent RNA helicase 0.0754 0.7075 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0134 0.0086
Entamoeba histolytica hypothetical protein 0.0035 0.0106 0.0134
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0108 0.0137
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0071 0.0456 0.0447
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0464 0.0417
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0464 0.0642
Loa Loa (eye worm) hypothetical protein 0.0246 0.2146 0.2138
Echinococcus multilocularis geminin 0.0339 0.3047 0.3013
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0111 0.0838 0.0828
Echinococcus granulosus prolyl endopeptidase 0.1056 1 1
Loa Loa (eye worm) ctsf protein 0.0038 0.0134 0.0124
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0464 0.0163
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0754 0.7075 0.7071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Loa Loa (eye worm) hypothetical protein 0.0105 0.0781 0.0772
Leishmania major eukaryotic initiation factor 4a, putative 0.0754 0.7075 0.7072
Onchocerca volvulus 0.0038 0.0134 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0108 0.0098
Leishmania major cathepsin L-like protease 0.0038 0.0134 0.0124
Leishmania major cathepsin L-like protease 0.0038 0.0134 0.0124
Brugia malayi Cathepsin L-like precursor 0.0025 0.0012 0.0012
Brugia malayi hypothetical protein 0.0097 0.0709 0.0709
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0012 0.0012
Plasmodium vivax SET domain protein, putative 0.0029 0.0048 0.0054
Chlamydia trachomatis peptide deformylase 0.0447 0.4098 0.5
Brugia malayi prolyl oligopeptidase family protein 0.0111 0.0838 0.0838
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0464 0.0071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0329 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.042 0.3835 0.4026
Plasmodium falciparum peptide deformylase 0.0447 0.4098 0.5787
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0111 0.0838 0.117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1742 0.1733
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Schistosoma mansoni hypothetical protein 0.0094 0.0678 0.0667
Trichomonas vaginalis esterase, putative 0.0072 0.0464 0.064
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Loa Loa (eye worm) prolyl oligopeptidase 0.0111 0.0838 0.0829
Loa Loa (eye worm) hypothetical protein 0.0069 0.0433 0.0423
Schistosoma mansoni fatty-acid amide hydrolase 0.0105 0.0781 0.077
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0754 0.7075 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0209 0.0198
Brugia malayi Pre-SET motif family protein 0.0204 0.1742 0.1742
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0134 0.0086
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0134 0.0122
Mycobacterium ulcerans peptide deformylase 0.0447 0.4098 1
Trypanosoma brucei Peptide deformylase 2 0.0171 0.1418 0.141
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0209 0.0162
Leishmania major cathepsin L-like protease 0.0084 0.0578 0.0569
Echinococcus granulosus integrin alpha ps 0.014 0.1124 0.1114
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Brugia malayi Integrin beta pat-3 precursor 0.0641 0.5977 0.5977
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0111 0.0838 0.0829
Leishmania major cathepsin L-like protease 0.0038 0.0134 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0578 0.0569
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.7467 0.7455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0209 0.0198
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0111 0.0838 0.0829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0454
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0578 0.0569
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0754 0.7075 0.7071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0754 0.7075 0.7071
Schistosoma mansoni integrin beta subunit 0.0378 0.3423 0.3415
Brugia malayi prolyl oligopeptidase family protein 0.0111 0.0838 0.0838
Mycobacterium leprae Probable lipase LipE 0.0072 0.0464 0.0163
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0464 0.0071
Trypanosoma brucei Polypeptide deformylase 1 0.0171 0.1418 0.141
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0108 0.0098
Loa Loa (eye worm) hypothetical protein 0.0111 0.0838 0.0829
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0464 0.0452
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.042 0.3835 0.3829
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0134 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0197 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Echinococcus granulosus Dipeptidyl peptidase 9 0.0111 0.0838 0.0828
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0111 0.0838 0.0828
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0478 0.0469
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0464 0.0071
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0134 0.0124
Leishmania major polypeptide deformylase-like protein, putative 0.0171 0.1418 0.141
Echinococcus multilocularis integrin alpha ps 0.014 0.1124 0.1081
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0134 0.0122
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2015 0.2836
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.042 0.3835 0.3829
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0111 0.0838 0.117
Leishmania major cathepsin L-like protease 0.0038 0.0134 0.0124
Plasmodium vivax vivapain-2 0.0038 0.0134 0.0175
Toxoplasma gondii prolyl endopeptidase 0.1056 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0289 0.0242
Loa Loa (eye worm) hypothetical protein 0.0097 0.0709 0.0699
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0108 0.0098
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0134 0.0175
Onchocerca volvulus 0.0072 0.0464 0.0452
Mycobacterium tuberculosis Probable peptidase 0.042 0.3835 0.4026
Schistosoma mansoni integrin alpha 0.0313 0.2798 0.2789
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0108 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0237 0.2059 0.2059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0002
Leishmania major hypothetical protein, conserved 0.0072 0.0464 0.0454
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0048 0.0038
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0754 0.7075 0.7071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0108 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0048 0.0037
Echinococcus multilocularis integrin alpha ps 0.0067 0.0416 0.037
Entamoeba histolytica cysteine protease, putative 0.0038 0.0134 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0046 0.0209 0.02
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0108 0.0137
Schistosoma mansoni hypothetical protein 0.0339 0.3047 0.3038
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0464 0.0454
Schistosoma mansoni hypothetical protein 0.0067 0.0416 0.0405
Onchocerca volvulus Prolyl endopeptidase homolog 0.1056 1 1
Leishmania major cathepsin L-like protease 0.0038 0.0134 0.0124
Plasmodium vivax RNA helicase-1, putative 0.0754 0.7075 1
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0134 0.0173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0134 0.0086
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.042 0.3835 0.3829
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1312 0.1312
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0464 0.0454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0111 0.0838 0.0829
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0838 0.1172
Brugia malayi beta-lactamase 0.0072 0.0464 0.0464
Loa Loa (eye worm) inositol-1 0.0074 0.0478 0.0469
Brugia malayi prolyl oligopeptidase family protein 0.0111 0.0838 0.0838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.1056 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0106 0.0095
Onchocerca volvulus 0.0094 0.0678 0.0667
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0447 0.4098 0.4335
Echinococcus multilocularis integrin alpha ps 0.014 0.1124 0.1081
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1312 0.127
Onchocerca volvulus 0.0038 0.0134 0.0122
Loa Loa (eye worm) hypothetical protein 0.0754 0.7075 0.7072
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0447 0.4098 1
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0464 0.0071
Echinococcus multilocularis acylamino acid releasing enzyme 0.0111 0.0838 0.0794
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0464 0.0071
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0754 0.7075 0.7827
Trypanosoma cruzi Peptide deformylase 2, putative 0.0171 0.1418 0.141
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0464 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0134 0.0086
Schistosoma mansoni lipoxygenase 0.0054 0.0289 0.0278
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0171 0.1418 0.141
Echinococcus granulosus eukaryotic initiation factor 4A 0.0754 0.7075 0.7071
Trypanosoma brucei glucosidase, putative 0.0035 0.0108 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0464 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Schistosoma mansoni inositol monophosphatase 0.0074 0.0478 0.0467
Trypanosoma brucei prolyl oligopeptidase, putative 0.042 0.3835 0.3829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Echinococcus granulosus integrin alpha ps 0.0067 0.0416 0.0405
Loa Loa (eye worm) integrin beta-2 0.0641 0.5977 0.5973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0134 0.0122
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0134 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0108 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0134 0.0173
Echinococcus granulosus geminin 0.0339 0.3047 0.3038
Echinococcus granulosus fatty acid amide hydrolase 1 0.0105 0.0781 0.077
Loa Loa (eye worm) beta-lactamase 0.0072 0.0464 0.0454
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1312 0.127
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0108 0.0137
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0478 0.004
Onchocerca volvulus 0.0072 0.0464 0.0452
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0002
Schistosoma mansoni alpha-glucosidase 0.0137 0.1097 0.1086
Echinococcus granulosus survival motor neuron protein 1 0.0462 0.4243 0.4237
Brugia malayi Cathepsin L-like precursor 0.0038 0.0134 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0197 0.0187
Trypanosoma cruzi Peptide deformylase 2, putative 0.0171 0.1418 0.141
Brugia malayi hypothetical protein 0.0025 0.001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0106 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0578 0.0569
Echinococcus multilocularis integrin alpha 3 0.024 0.209 0.2051
Onchocerca volvulus 0.0038 0.0134 0.0122
Echinococcus multilocularis prolyl endopeptidase 0.1056 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0104 0.0093
Onchocerca volvulus 0.0092 0.066 0.0649
Schistosoma mansoni inositol monophosphatase 0.0074 0.0478 0.0467

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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