Detailed information for compound 869104

Basic information

Technical information
  • TDR Targets ID: 869104
  • Name: 3-[(6-chloro-3-oxo-4H-1,4-benzoxazin-7-yl)sul fonyl]-N-[(4-fluorophenyl)methyl]propanamide
  • MW: 426.846 | Formula: C18H16ClFN2O5S
  • H donors: 2 H acceptors: 4 LogP: 1.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCS(=O)(=O)c1cc2OCC(=O)Nc2cc1Cl)NCc1ccc(cc1)F
  • InChi: 1S/C18H16ClFN2O5S/c19-13-7-14-15(27-10-18(24)22-14)8-16(13)28(25,26)6-5-17(23)21-9-11-1-3-12(20)4-2-11/h1-4,7-8H,5-6,9-10H2,(H,21,23)(H,22,24)
  • InChiKey: ASPSTFAAVVEURJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(6-chloro-3-keto-4H-1,4-benzoxazin-7-yl)sulfonyl]-N-(4-fluorobenzyl)propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.003 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.0011 0.0206 0.0307
Loa Loa (eye worm) ThiF family protein 0.0012 0.0238 0.0354
Schistosoma mansoni jumonji domain containing protein 0.0022 0.064 0.064
Giardia lamblia Sgs1 DNA helicase, putative 0.0007 0.0045 0.0141
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0588 0.0877
Echinococcus multilocularis bloom syndrome protein 0.0017 0.044 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0823 0.8517
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0588 0.7071
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0018 0.0482 0.0482
Onchocerca volvulus 0.0027 0.0823 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0823 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0217 0.1198
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0823 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0016 0.0409 0.061
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1639 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0022 0.0229
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0222 0.1228
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0588 0.2743
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0007 0.0045 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1958 0.1958
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0018 0.0482 0.0482
Trypanosoma brucei unspecified product 0.0021 0.0588 0.6089
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0823 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0409 0.061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0045 0.0249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0823 0.1226
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.6515 0.6515
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0022 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0022 0.0229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1958 0.2919
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0022 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0022 0.0229
Mycobacterium tuberculosis Conserved protein 0.0027 0.0823 0.0396
Mycobacterium ulcerans lipase LipD 0.0027 0.0823 1
Onchocerca volvulus 0.0027 0.0823 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0588 0.2743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0482 0.0719
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0016 0.0409 0.061
Leishmania major DNA polymerase eta, putative 0.003 0.0966 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0017 0.044 0.1862
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0823 0.4137
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0016 0.0417 0.0417
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.064 0.064
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0012 0.0238 0.1451
Trichomonas vaginalis esterase, putative 0.0027 0.0823 0.4137
Echinococcus granulosus dna polymerase kappa 0.0021 0.0588 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Trypanosoma brucei unspecified product 0.0014 0.0333 0.3452
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0588 0.0877
Brugia malayi Probable ATP-dependent helicase DHX35 0.0077 0.2803 0.4178
Plasmodium vivax ubiquitin activating enzyme, putative 0.0018 0.0482 0.2666
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0022 0.0229
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0007 0.0045 0.0045
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0588 0.0588
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1809 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0016 0.0409 0.061
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0012 0.0238 0.2462
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0022 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0823 0.0823
Giardia lamblia DINP protein human, muc B family 0.0021 0.0588 0.3501
Trichomonas vaginalis DNA helicase recq, putative 0.0017 0.044 0.1862
Echinococcus multilocularis dna polymerase eta 0.003 0.0966 0.0966
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0588 0.0588
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.04 0.414
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0823 0.1226
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0588 0.3052
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0823 0.4137
Brugia malayi jmjC domain containing protein 0.0022 0.064 0.0953
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0012 0.0238 0.0238
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0127 0.1311
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0588 0.7071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1958 0.1958
Schistosoma mansoni DNA helicase recq1 0.0007 0.0045 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1809 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1958 0.1958
Brugia malayi jmjC domain containing protein 0.0022 0.064 0.0953
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0022 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0966 1
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0823 0.0396
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0022 0.064 0.064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1958 0.2919
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0022 0.064 0.064
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0022 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0823 0.4137
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.001 0.0172 0.1782
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0045 0.0249
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0022 0.0229
Loa Loa (eye worm) hypothetical protein 0.0007 0.0045 0.0067
Echinococcus granulosus bloom syndrome protein 0.0017 0.044 0.044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Mycobacterium ulcerans beta-lactamase 0.0027 0.0823 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.04 0.2211
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0127 0.1311
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0022 0.0229
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0007 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Mycobacterium tuberculosis Conserved protein 0.0027 0.0823 0.0396
Leishmania major DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0007 0.0045 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.003 0.0966 0.144
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.6709 1
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0823 0.4548
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0823 0.4137
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1809 1
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0966 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.064 0.064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.6709 0.6709
Loa Loa (eye worm) hypothetical protein 0.0027 0.0823 0.1226
Schistosoma mansoni DNA polymerase eta 0.003 0.0966 0.0966
Leishmania major ubiquitin-activating enzyme-like protein 0.0012 0.0238 0.2462
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0823 0.0396
Schistosoma mansoni blooms syndrome DNA helicase 0.0013 0.0298 0.0298
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0015 0.0358 0.2185
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0588 0.6089
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0022 0.0229
Leishmania major DNA polymerase kappa, putative 0.0006 0.0022 0.0229
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0823 0.0396
Loa Loa (eye worm) acetyltransferase 0.0175 0.6709 1
Toxoplasma gondii ThiF family protein 0.0012 0.0238 0.1314
Schistosoma mansoni microtubule-associated protein tau 0.0258 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.017 0.6509 1
Brugia malayi ThiF family protein 0.0012 0.0238 0.0354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1958 0.1958
Loa Loa (eye worm) DEAH box polypeptide 35 0.0077 0.2803 0.4178
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0588 0.6089
Brugia malayi ThiF family protein 0.0018 0.0482 0.0719
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0022 0.0135
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0007 0.0045 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.064 0.0953
Schistosoma mansoni DNA helicase recq5 0.0007 0.0045 0.0045
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1809 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0012 0.0238 0.2462
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0012 0.0238 0.0238
Brugia malayi beta-lactamase family protein 0.0027 0.0823 0.1226
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0045 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Schistosoma mansoni hypothetical protein 0.0011 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0033
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0022 0.0122
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0018 0.0482 0.2943
Loa Loa (eye worm) beta-lactamase 0.0027 0.0823 0.1226
Mycobacterium leprae Probable lipase LipE 0.0027 0.0823 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1958 0.1958
Trypanosoma brucei unspecified product 0.0014 0.0333 0.3452
Echinococcus granulosus lysine specific demethylase 5A 0.0022 0.064 0.064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1958 0.1958
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0012 0.0238 0.1314
Loa Loa (eye worm) hypothetical protein 0.0077 0.2803 0.4178
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1639 1
Leishmania major DNA damage repair protein, putative 0.0006 0.0022 0.0229
Toxoplasma gondii hypothetical protein 0.0018 0.0482 0.2666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1958 0.1958
Leishmania major DNA polymerase eta, putative 0.0016 0.04 0.414
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0012 0.0238 0.0238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0823 0.0823
Toxoplasma gondii ABC1 family protein 0.0027 0.0823 0.4548
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0823 0.0396
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1809 0.1809
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0823 0.0396
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0052 0.1812 0.27
Brugia malayi Bloom's syndrome protein homolog 0.0017 0.044 0.0656
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1809 1
Mycobacterium tuberculosis Conserved protein 0.0027 0.0823 0.0396
Brugia malayi beta-lactamase 0.0027 0.0823 0.1226
Echinococcus multilocularis microtubule associated protein 2 0.0258 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0333 0.3452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0823 0.0823
Loa Loa (eye worm) RecQ helicase 0.0017 0.044 0.0656
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0127 0.1311
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0333 0.3452
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.6709 0.6709
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0588 0.6089
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0018 0.0482 0.0482
Mycobacterium ulcerans hypothetical protein 0.0027 0.0823 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0022 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0823 0.8517
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0823 0.0396
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0823 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0588 0.0588
Brugia malayi polk-prov protein 0.0006 0.0022 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0333 0.3452
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0588 0.0588
Brugia malayi beta-lactamase family protein 0.0027 0.0823 0.1226
Onchocerca volvulus 0.0027 0.0823 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0966 0.144
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0588 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Leishmania major hypothetical protein, conserved 0.0027 0.0823 0.8517
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1639 1
Brugia malayi latrophilin 2 splice variant baaae 0.0011 0.0206 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0588 0.6089
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0022 0.0022
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0007 0.0045 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0823 0.8517
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0588 0.6089
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0823 0.4137

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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