Detailed information for compound 869700

Basic information

Technical information
  • TDR Targets ID: 869700
  • Name: N-(3-chlorophenyl)-2-ethyl-2,3-dihydro-1,4-be nzoxazine-4-carboxamide
  • MW: 316.782 | Formula: C17H17ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1Oc2ccccc2N(C1)C(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C17H17ClN2O2/c1-2-14-11-20(15-8-3-4-9-16(15)22-14)17(21)19-13-7-5-6-12(18)10-13/h3-10,14H,2,11H2,1H3,(H,19,21)
  • InChiKey: TTYCHSUUSRUIAD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi alpha-tubulin 0.0174 0.4135 0.7467
Echinococcus multilocularis muscleblind protein 1 0.0149 0.3513 0.3511
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0175 0.0172
Echinococcus multilocularis Tubulin beta 2C chain 0.023 0.5538 0.5537
Mycobacterium ulcerans cell division protein FtsZ 0.0054 0.1135 1
Schistosoma mansoni hypothetical protein 0.0169 0.4015 0.3994
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1027 0.1853
Echinococcus granulosus tubulin alpha 1C chain 0.0174 0.4135 0.4133
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1054 0.1051
Echinococcus multilocularis tubulin delta chain 0.0054 0.1135 0.1133
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Plasmodium vivax tubulin alpha chain, putative 0.0174 0.4135 0.7288
Loa Loa (eye worm) hypothetical protein 0.0174 0.4135 0.7467
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0972 0.1755
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Brugia malayi Protein kinase domain containing protein 0.0048 0.0972 0.1754
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0837 0.1511
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.1135 0.0635
Schistosoma mansoni tubulin subunit alpha 0.0174 0.4135 0.4116
Echinococcus granulosus Tubulin beta 2C chain 0.023 0.5538 0.5537
Schistosoma mansoni tubulin subunit epsilon 0.0125 0.29 0.2876
Trypanosoma brucei beta tubulin 0.023 0.5538 1
Giardia lamblia Gamma tubulin 0.0125 0.29 0.4117
Loa Loa (eye worm) tubulin beta chain 0.023 0.5538 1
Trypanosoma cruzi tubulin delta chain 0.0054 0.1135 0.1921
Echinococcus granulosus tubulin alpha 1C chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) tubulin beta-1 chain 0.023 0.5538 1
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Giardia lamblia Alpha-tubulin 0.0174 0.4135 0.6872
Trypanosoma brucei beta tubulin 0.0125 0.29 0.5159
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1054 0.1772
Leishmania major beta tubulin 0.023 0.5538 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0034 0.0061
Schistosoma mansoni alpha tubulin 0.0174 0.4135 0.4116
Schistosoma mansoni tyrosine kinase 0.0048 0.0972 0.0941
Schistosoma mansoni tubulin subunit beta 0.0054 0.1135 0.1105
Echinococcus multilocularis tubulin subunit TubB 0.0174 0.4135 0.4133
Leishmania major beta tubulin 0.023 0.5538 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0034 0.0061
Brugia malayi ecdysteroid receptor 0.001 0.0034 0.006
Echinococcus multilocularis insulin receptor 0.0048 0.0972 0.0969
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1858 0.1831
Brugia malayi Tubulin gamma chain 0.0125 0.29 0.5237
Brugia malayi Tubulin alpha chain 0.0174 0.4135 0.7467
Leishmania major delta tubulin, putative 0.0054 0.1135 0.1921
Trichomonas vaginalis tubulin epsilon chain, putative 0.023 0.5538 1
Echinococcus multilocularis tubulin epsilon chain 0.0125 0.29 0.2898
Leishmania major beta tubulin 0.023 0.5538 1
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0175 0.0316
Loa Loa (eye worm) tubulin alpha-3 chain 0.0104 0.237 0.428
Echinococcus granulosus epidermal growth factor receptor 0.008 0.1783 0.1781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1054 0.1772
Brugia malayi Furin-like cysteine rich region family protein 0.0149 0.3507 0.6333
Giardia lamblia Beta tubulin 0.023 0.5538 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0034 0.006
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0365 0.2645
Brugia malayi CHE-14 protein 0.0042 0.0837 0.151
Loa Loa (eye worm) alpha-tubulin 0.0174 0.4135 0.7467
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0054 0.1135 0.1489
Toxoplasma gondii beta tubulin 0.023 0.5538 1
Entamoeba histolytica tubulin family protein 0.023 0.5538 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0034 0.006
Onchocerca volvulus 0.0029 0.0499 0.2548
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1303 0.1274
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Brugia malayi Cytochrome P450 family protein 0.0012 0.0088 0.0159
Entamoeba histolytica tubulin gamma chain 0.0125 0.29 0.49
Plasmodium vivax tubulin epsilon chain, putative 0.0125 0.29 0.49
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.2241 0.3626
Loa Loa (eye worm) tubulin alpha 2 0.0049 0.1016 0.1835
Echinococcus multilocularis tubulin alpha chain 0.0174 0.4135 0.4133
Leishmania major beta tubulin 0.023 0.5538 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0125 0.29 0.4389
Trichomonas vaginalis tubulin alpha chain, putative 0.023 0.5538 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0034 0.006
Brugia malayi MAP kinase sur-1 0.0051 0.1054 0.1903
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0499 0.09
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.0031
Echinococcus granulosus tubulin alpha 0.0125 0.29 0.2898
Echinococcus multilocularis tubulin alpha 1C chain 0.0174 0.4135 0.4133
Echinococcus multilocularis tubulin alpha chain 0.0174 0.4135 0.4133
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0142
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Loa Loa (eye worm) tubulin beta-2A chain 0.023 0.5538 1
Schistosoma mansoni hypothetical protein 0.0041 0.0799 0.0768
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.1546 0.1509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0034 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.006
Echinococcus granulosus tubulin delta chain 0.0054 0.1135 0.1133
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0365 0.2645
Schistosoma mansoni tyrosine kinase 0.0079 0.1762 0.1734
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Echinococcus granulosus tubulin epsilon chain 0.0125 0.29 0.2898
Loa Loa (eye worm) hypothetical protein 0.005 0.1027 0.1854
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0142
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Plasmodium vivax tubulin beta chain, putative 0.023 0.5538 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0034 0.006
Leishmania major gamma-tubulin 0.0125 0.29 0.5159
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0088 0.016
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0054 0.1135 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0125 0.29 0.4389
Schistosoma mansoni tubulin subunit delta 0.0054 0.1135 0.1105
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0054 0.1135 0.1489
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1027 0.1854
Trichomonas vaginalis tubulin, putative 0.0054 0.1135 0.0635
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1054 0.1051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1054 0.0463
Trypanosoma brucei tubulin delta chain 0.0054 0.1135 0.1921
Echinococcus granulosus Tubulin beta 2C chain 0.023 0.5538 0.5537
Trypanosoma brucei zeta tubulin 0.0054 0.1135 0.1921
Trypanosoma brucei epsilon tubulin 0.0125 0.29 0.5159
Schistosoma mansoni tubulin subunit gamma 0.0125 0.29 0.2876
Leishmania major beta tubulin 0.023 0.5538 1
Echinococcus granulosus alpha tubulin 0.0174 0.4135 0.4133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0034 0.0031
Brugia malayi steroid hormone receptor 0.001 0.0034 0.006
Schistosoma mansoni tubulin subunit alpha 0.0174 0.4135 0.4116
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1054 0.1772
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.0031
Schistosoma mansoni patched 1 0.0042 0.0837 0.0806
Echinococcus multilocularis tubulin subunit beta 0.023 0.5538 0.5537
Trypanosoma cruzi alpha tubulin, putative 0.0174 0.4135 0.7426
Loa Loa (eye worm) tubulin alpha chain 0.0174 0.4135 0.7467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0034 0.006
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0006
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0837 0.0834
Schistosoma mansoni cpg binding protein 0.003 0.054 0.0508
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Trypanosoma cruzi beta tubulin, putative 0.023 0.5538 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0175 0.0316
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0365 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0034 0.006
Schistosoma mansoni hypothetical protein 0.0041 0.0799 0.0768
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0034 0.0031
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0972 0.0969
Trichomonas vaginalis tubulin epsilon chain, putative 0.0054 0.1135 0.0635
Loa Loa (eye worm) beta-tubulin 0.023 0.5538 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0175 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0034 0.006
Echinococcus granulosus tubulin alpha chain 0.0174 0.4135 0.4133
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0142
Schistosoma mansoni hypothetical protein 0.0034 0.0632 0.0601
Trypanosoma brucei epsilon tubulin 0.0125 0.29 0.5159
Trypanosoma brucei beta tubulin 0.023 0.5538 1
Brugia malayi nuclear hormone receptor 0.001 0.0034 0.006
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0034 0.0061
Trypanosoma brucei alpha tubulin 0.0174 0.4135 0.7426
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Brugia malayi Tubulin alpha-2 chain 0.0174 0.4135 0.7467
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0972 0.0969
Trichomonas vaginalis tubulin beta chain, putative 0.023 0.5538 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0175 0.0172
Schistosoma mansoni cpg binding protein 0.0029 0.0499 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1054 0.0463
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0034 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0034 0.006
Echinococcus granulosus GPCR family 2 0.0016 0.0175 0.0172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.114 0.1499
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Loa Loa (eye worm) hypothetical protein 0.0104 0.237 0.428
Entamoeba histolytica tubulin alpha chain, putative 0.0174 0.4135 0.7288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.0031
Echinococcus granulosus beta tubulin 0.023 0.5538 0.5537
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.0031
Trypanosoma brucei zeta tubulin, putative 0.0054 0.1135 0.1921
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Brugia malayi Tubulin beta-1 chain 0.023 0.5538 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.1546 0.1509
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Echinococcus granulosus tubulin beta 1 chain 0.023 0.5538 0.5537
Trichomonas vaginalis tubulin epsilon chain, putative 0.0174 0.4135 0.7016
Echinococcus multilocularis Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Trichomonas vaginalis tubulin gamma chain, putative 0.023 0.5538 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0365 0.0508
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Plasmodium vivax tubulin alpha chain, putative 0.0174 0.4135 0.7288
Loa Loa (eye worm) hypothetical protein 0.0083 0.1858 0.3355
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0034 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0034 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.3296 0.3294
Echinococcus multilocularis protein dispatched 1 0.0048 0.0986 0.0983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Plasmodium vivax tubulin gamma chain, putative 0.0125 0.29 0.49
Brugia malayi Cell division protein ftsZ 0.0054 0.1135 0.205
Echinococcus granulosus tubulin gamma 1 chain 0.0125 0.29 0.2898
Plasmodium falciparum tubulin gamma chain 0.0125 0.29 0.49
Loa Loa (eye worm) hypothetical protein 0.0149 0.3513 0.6344
Echinococcus multilocularis tubulin alpha 1C chain 0.0174 0.4135 0.4133
Trypanosoma cruzi tubulin delta chain 0.0054 0.1135 0.1921
Schistosoma mansoni tyrosine kinase 0.0048 0.0972 0.0941
Echinococcus multilocularis tubulin alpha chain 0.0174 0.4135 0.4133
Echinococcus multilocularis geminin 0.0169 0.4015 0.4013
Brugia malayi beta-tubulin, identical 0.023 0.5538 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1027 0.1853
Trypanosoma cruzi tubulin gamma chain 0.0125 0.29 0.5159
Schistosoma mansoni cpg binding protein 0.003 0.054 0.0508
Echinococcus granulosus Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Echinococcus granulosus beta tubulin 0.023 0.5538 0.5537
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0034 0.0031
Echinococcus granulosus expressed conserved protein 0.0092 0.2092 0.2089
Loa Loa (eye worm) alpha-tubulin 0.0174 0.4135 0.7467
Echinococcus multilocularis tubulin alpha 3 chain 0.0174 0.4135 0.4133
Plasmodium falciparum tubulin epsilon chain, putative 0.0125 0.29 0.49
Echinococcus granulosus Tubulin beta 2C chain 0.023 0.5538 0.5537
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Trypanosoma brucei alpha tubulin 0.0174 0.4135 0.7426
Echinococcus multilocularis hypothetical protein 0.0174 0.4135 0.4133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0034 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0034 0.006
Plasmodium falciparum tubulin delta chain, putative 0.0054 0.1135 0.1489
Leishmania major zeta tubulin, putative 0.0054 0.1135 0.1921
Trypanosoma brucei alpha tubulin, putative 0.0071 0.1546 0.2674
Trypanosoma brucei alpha tubulin 0.0174 0.4135 0.7426
Schistosoma mansoni hypothetical protein 0.0169 0.4015 0.3994
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.0034 0.0632 0.1142
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Trypanosoma cruzi zeta tubulin, putative 0.0054 0.1135 0.1921
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.2241 0.4046
Echinococcus granulosus Tubulin beta 2C chain 0.023 0.5538 0.5537
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.0174 0.4135 0.4133
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1054 0.1772
Schistosoma mansoni hypothetical protein 0.0409 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.0799 0.0768
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.1546 0.1509
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0034 0.0031
Loa Loa (eye worm) TK/EGFR protein kinase 0.0149 0.3507 0.6333
Trypanosoma cruzi epsilon tubulin, putative 0.0125 0.29 0.5159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0034 0.0061
Echinococcus multilocularis tubulin gamma 1 chain 0.0125 0.29 0.2898
Plasmodium vivax delta tubulin, putative 0.0054 0.1135 0.1489
Echinococcus multilocularis beta tubulin 0.023 0.5538 0.5537
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0088 0.016
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Trypanosoma cruzi epsilon tubulin, putative 0.0125 0.29 0.5159
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.2241 0.2238
Loa Loa (eye worm) hypothetical protein 0.0052 0.1074 0.194
Echinococcus multilocularis tubulin alpha 3 chain 0.0174 0.4135 0.4133
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Giardia lamblia Beta tubulin 0.023 0.5538 1
Toxoplasma gondii beta-1 tubulin, putative 0.023 0.5538 1
Leishmania major beta tubulin 0.023 0.5538 1
Leishmania major beta tubulin 0.023 0.5538 1
Entamoeba histolytica tubulin alpha-1 chain 0.0174 0.4135 0.7288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0175 0.0172
Echinococcus granulosus tubulin alpha chain 0.0174 0.4135 0.4133
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0632 0.1142
Echinococcus multilocularis epidermal growth factor receptor 0.0149 0.3507 0.3505
Echinococcus granulosus geminin 0.0169 0.4015 0.4013
Loa Loa (eye worm) hypothetical protein 0.0098 0.2241 0.4046
Echinococcus multilocularis expressed conserved protein 0.0092 0.2092 0.2089
Brugia malayi Tubulin beta chain 0.0054 0.1135 0.205
Loa Loa (eye worm) BEN-1 protein 0.023 0.5538 1
Leishmania major beta tubulin 0.023 0.5538 1
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Loa Loa (eye worm) tubulin gamma chain 0.0125 0.29 0.5237
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0054 0.1135 0.0635
Giardia lamblia Alpha-tubulin 0.0174 0.4135 0.6872
Trypanosoma brucei epsilon tubulin 0.0125 0.29 0.5159
Giardia lamblia Epsilon tubulin 0.0054 0.1135 0.0181
Plasmodium falciparum tubulin beta chain 0.023 0.5538 1
Loa Loa (eye worm) tubulin alpha 2 0.012 0.2781 0.5022
Echinococcus granulosus Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Leishmania major beta tubulin 0.023 0.5538 1
Echinococcus granulosus tubulin alpha chain 0.0174 0.4135 0.4133
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Echinococcus granulosus Tubulin beta 2C chain 0.023 0.5538 0.5537
Schistosoma mansoni hypothetical protein 0.0016 0.0175 0.0142
Echinococcus granulosus tubulin alpha chain 0.0174 0.4135 0.4133
Trichomonas vaginalis tubulin, putative 0.0071 0.1546 0.1509
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.1783 0.1781
Loa Loa (eye worm) tubulin alpha-2 chain 0.0174 0.4135 0.7467
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0034 0.0031
Trypanosoma brucei protein kinase, putative 0.0051 0.1054 0.1772
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Echinococcus multilocularis Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0034 0.0061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0175 0.0316
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.2241 0.2238
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.2279 0.2253
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0175 0.0172
Loa Loa (eye worm) tubulin beta chain 0.0054 0.1135 0.205
Treponema pallidum cell division protein FtsZ 0.0054 0.1135 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1054 0.1903
Loa Loa (eye worm) tubulin beta-4 chain 0.023 0.5538 1
Trypanosoma brucei tubulin gamma chain 0.0125 0.29 0.5159
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0365 0.0508
Leishmania major beta tubulin 0.023 0.5538 1
Brugia malayi Tubulin beta chain 0.0071 0.1546 0.2791
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1054 0.1772
Echinococcus multilocularis tubulin beta 1 chain 0.023 0.5538 0.5537
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0837 0.0834
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1054 0.1332
Echinococcus multilocularis beta tubulin 0.023 0.5538 0.5537
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0175 0.0316
Echinococcus granulosus insulin receptor 0.0048 0.0972 0.0969
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0034 0.0031
Schistosoma mansoni alpha tubulin 0.0174 0.4135 0.4116
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0174 0.4135 0.7016
Toxoplasma gondii beta-tubulin, putative 0.023 0.5538 1
Plasmodium falciparum alpha tubulin 1 0.0174 0.4135 0.7288
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0034 0.006
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0104 0.237 0.3263
Echinococcus granulosus cpg binding protein 0.003 0.054 0.0537
Echinococcus granulosus tubulin subunit TubB 0.0174 0.4135 0.4133
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0837 0.0834
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.006
Loa Loa (eye worm) tubulin alpha chain 0.0174 0.4135 0.7467
Leishmania major beta tubulin 0.023 0.5538 1
Trichomonas vaginalis tubulin, putative 0.0071 0.1546 0.1509
Leishmania major beta tubulin 0.023 0.5538 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0034 0.0031
Schistosoma mansoni tyrosine kinase 0.0149 0.3507 0.3485
Schistosoma mansoni tyrosine kinase 0.0079 0.1762 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.1135 0.0635
Echinococcus multilocularis Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0088 0.016
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1054 0.1051
Leishmania major beta tubulin 0.023 0.5538 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0125 0.29 0.4389
Echinococcus multilocularis Tubulin beta 2C chain 0.023 0.5538 0.5537
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0034 0.0031
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0125 0.29 0.49
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1858 0.3355
Echinococcus multilocularis cpg binding protein 0.003 0.054 0.0537
Trypanosoma brucei beta tubulin 0.023 0.5538 1
Schistosoma mansoni tyrosine kinase 0.0079 0.1762 0.1734
Onchocerca volvulus 0.0083 0.1858 1
Schistosoma mansoni tubulin subunit beta 0.023 0.5538 0.5523
Echinococcus multilocularis tubulin alpha 0.0125 0.29 0.2898
Leishmania major epsilon tubulin, putative 0.0125 0.29 0.5159
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0071 0.1546 0.1509
Loa Loa (eye worm) hypothetical protein 0.0042 0.0837 0.1511
Echinococcus granulosus muscleblind protein 0.0149 0.3513 0.3511
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0034 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1054 0.0463
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0034 0.006
Trichomonas vaginalis tubulin epsilon chain, putative 0.0174 0.4135 0.7016
Brugia malayi tubulin alpha-2 chain 0.0174 0.4135 0.7467
Echinococcus multilocularis Tubulin beta 2C chain 0.023 0.5538 0.5537
Brugia malayi Tubulin alpha-2 chain 0.0174 0.4135 0.7467
Mycobacterium tuberculosis Cell division protein FtsZ 0.0054 0.1135 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1054 0.1772
Echinococcus multilocularis protein patched 0.0042 0.0837 0.0834
Echinococcus multilocularis tubulin alpha chain 0.0174 0.4135 0.4133
Trypanosoma brucei beta tubulin 0.023 0.5538 1
Plasmodium falciparum alpha tubulin 2 0.0174 0.4135 0.7288
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1858 0.1856
Echinococcus multilocularis muscleblind protein 0.0149 0.3513 0.3511
Trichomonas vaginalis tubulin, putative 0.023 0.5538 1
Schistosoma mansoni tyrosine kinase 0.008 0.1783 0.1755
Schistosoma mansoni hypothetical protein 0.0041 0.0799 0.0768
Echinococcus granulosus tubulin alpha 3 chain 0.0174 0.4135 0.4133
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1054 0.1772
Leishmania major beta tubulin 0.023 0.5538 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0034 0.006
Onchocerca volvulus 0.0071 0.1546 0.8288
Trypanosoma brucei alpha tubulin 0.0174 0.4135 0.7426
Echinococcus granulosus tubulin subunit beta 0.023 0.5538 0.5537
Toxoplasma gondii alpha tubulin TUBA1 0.0174 0.4135 0.7288
Leishmania major beta tubulin 0.023 0.5538 1
Schistosoma mansoni tyrosine kinase 0.008 0.1783 0.1755
Brugia malayi CXXC zinc finger family protein 0.0029 0.0499 0.09
Brugia malayi Muscleblind-like protein 0.0149 0.3513 0.6343
Schistosoma mansoni tubulin subunit alpha 0.0174 0.4135 0.4116
Mycobacterium leprae cell division protein FtsZ 0.0054 0.1135 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.023 0.5538 0.5537
Loa Loa (eye worm) alpha-tubulin isotype 2 0.012 0.2781 0.5022
Echinococcus granulosus tubulin alpha 3 chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) BEN-1 protein 0.023 0.5538 1
Echinococcus multilocularis Tubulin beta 2C chain 0.023 0.5538 0.5537
Schistosoma mansoni hypothetical protein 0.0052 0.1073 0.1043
Trichomonas vaginalis tubulin epsilon chain, putative 0.023 0.5538 1
Brugia malayi Tubulin alpha chain 0.0054 0.1135 0.205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0034 0.006
Leishmania major alpha tubulin 0.0174 0.4135 0.7426
Echinococcus multilocularis Tubulin beta 2C chain 0.023 0.5538 0.5537
Leishmania major beta tubulin 0.023 0.5538 1
Echinococcus multilocularis tubulin alpha chain 0.0174 0.4135 0.4133
Echinococcus granulosus FTZ F1 alpha 0.001 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.012 0.2781 0.5022
Schistosoma mansoni alpha tubulin 0.0174 0.4135 0.4116
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1054 0.1024
Schistosoma mansoni tubulin subunit alpha 0.0054 0.1135 0.1105
Brugia malayi tubulin alpha chain - mouse 0.0174 0.4135 0.7467
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0034 0.0031
Trichomonas vaginalis tubulin beta chain, putative 0.0174 0.4135 0.7016
Echinococcus multilocularis peroxisome assembly protein 26 0.0174 0.4135 0.4133
Giardia lamblia Delta tubulin 0.0054 0.1135 0.0181
Brugia malayi Cytochrome P450 family protein 0.0012 0.0088 0.0159
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1054 0.1051
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.012 0.2781 0.4136
Leishmania major beta tubulin 0.023 0.5538 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1858 0.1856
Entamoeba histolytica tubulin family protein 0.023 0.5538 1
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.1783 0.1781
Echinococcus multilocularis 0.0046 0.0934 0.0932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0034 0.0061
Echinococcus granulosus Tubulin alpha 1 chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) hypothetical protein 0.0149 0.3513 0.6344
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1054 0.0463
Trichomonas vaginalis tubulin beta chain, putative 0.0071 0.1546 0.1509
Echinococcus granulosus epidermal growth factor receptor 0.0149 0.3507 0.3505
Echinococcus granulosus tubulin beta 4A class IVa 0.023 0.5538 0.5537
Echinococcus granulosus tubulin alpha chain 0.0174 0.4135 0.4133
Loa Loa (eye worm) tubulin alpha 2 0.012 0.2781 0.5022
Toxoplasma gondii alpha-tubulin I, putative 0.0174 0.4135 0.7288
Leishmania major beta tubulin 0.023 0.5538 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0054 0.1135 0.0635
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.3296 0.3294
Trypanosoma cruzi zeta tubulin, putative 0.0054 0.1135 0.1921
Giardia lamblia Beta tubulin 0.023 0.5538 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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