TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.345 | Formula: C18H16N4O2
H donors: 3 H acceptors: 3 LogP: 2.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1n[nH]c(c1)C1CC1)N/N=C/c1c(O)ccc2c1cccc2
InChi: 1S/C18H16N4O2/c23-17-8-7-11-3-1-2-4-13(11)14(17)10-19-22-18(24)16-9-15(20-21-16)12-5-6-12/h1-4,7-10,12,23H,5-6H2,(H,20,21)(H,22,24)/b19-10+
InChiKey: JSSIRODPDPAPQM-VXLYETTFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ABC transporter, putative	0.0104	0.0858	1
Brugia malayi	ABC transporter transmembrane region family protein	0.0032	0.0162	0.0372
Plasmodium vivax	ABC transporter B family member 6, putative	0.0032	0.0162	0.0779
Brugia malayi	hypothetical protein	0.0025	0.0085	0.0196
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0032	0.0162	0.0235
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0038	0.0214	0.2037
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0032	0.0162	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0151	0.1257
Echinococcus granulosus	histone deacetylase 8	0.0038	0.0214	0.0166
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 3	0.0054	0.0373	0.0858
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0032	0.0162	0.0235
Trypanosoma brucei	multidrug resistance protein E	0.0032	0.0162	0.0235
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0054	0.0373	0.4007
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0121	0.1024	0.2353
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0085	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0856	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Schistosoma mansoni	multidrug resistance protein	0.0104	0.0858	0.188
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0032	0.0162	0.0262
Plasmodium vivax	multidrug resistance protein 2, putative	0.0032	0.0162	0.0779
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0031	0.0151	0.1257
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0085	0.0075
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0048	0.0311	0.3235
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Brugia malayi	MBOAT family protein	0.0021	0.0049	0.0113
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Trypanosoma brucei	histone deacetylase 2	0.0038	0.0214	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0847	0.1854
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0462	0.4352	1
Plasmodium vivax	histone deacetylase 1, putative	0.0038	0.0214	0.1306
Schistosoma mansoni	cathepsin D (A01 family)	0.0141	0.1219	0.2718
Loa Loa (eye worm)	histone deacetylase	0.0126	0.1073	0.2378
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0032	0.0162	0.5
Entamoeba histolytica	P-glycoprotein 6, putative	0.0032	0.0162	0.0118
Giardia lamblia	ABC transporter, putative	0.0032	0.0162	0.1751
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0104	0.0858	0.0813
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0125	0.106	0.1016
Trypanosoma cruzi	histone deacetylase 1, putative	0.0038	0.0214	0.0343
Leishmania major	histone deacetylase, putative	0.0038	0.0214	0.0343
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0048	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Schistosoma mansoni	histone deacetylase hda2	0.0038	0.0214	0.0383
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0125	0.106	0.235
Plasmodium falciparum	plasmepsin I	0.0048	0.0311	0.2287
Entamoeba histolytica	ABC transporter, putative	0.0032	0.0162	0.0118
Loa Loa (eye worm)	histone deacetylase 7A	0.0126	0.1073	0.2378
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0032	0.0162	0.0235
Echinococcus granulosus	multidrug resistance protein 1	0.0104	0.0858	0.0813
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0032	0.0162	0.0779
Leishmania major	ABC-thiol transporter	0.0032	0.0162	0.0235
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0104	0.0858	0.7904
Trypanosoma cruzi	histone deacetylase 1, putative	0.0038	0.0214	0.0343
Leishmania major	p-glycoprotein	0.0104	0.0858	0.1684
Echinococcus multilocularis	ATP binding cassette sub family B	0.0103	0.0847	0.0802
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0054	0.0373	0.2919
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.032	0.0735
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0032	0.0162	0.5
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0032	0.0162	0.5
Echinococcus multilocularis	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.104	1	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0373	0.0339
Brugia malayi	P-glycoprotein-like protein	0.0032	0.0162	0.0372
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0032	0.0162	0.0779
Brugia malayi	Histone deacetylase family protein	0.0126	0.1073	0.2464
Toxoplasma gondii	histone deacetylase HDAC3	0.0038	0.0214	0.161
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Echinococcus multilocularis	histone deacetylase 6	0.0126	0.1073	0.1028
Plasmodium vivax	histone deacetylase 2, putative	0.0126	0.1073	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0031	0.0151	0.0106
Plasmodium vivax	ABC transporter B family member 5, putative	0.0032	0.0162	0.0779
Schistosoma mansoni	histone deacetylase 4 5	0.0126	0.1073	0.2378
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0032	0.0162	0.0779
Plasmodium falciparum	plasmepsin VI	0.0048	0.0311	0.2287
Entamoeba histolytica	P-glycoprotein-2	0.0104	0.0858	0.0847
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0032	0.0162	0.0779
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Toxoplasma gondii	histone deacetylase HDAC2	0.0038	0.0214	0.161
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Schistosoma mansoni	multidrug resistance protein	0.0104	0.0858	0.188
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.0858	1
Echinococcus multilocularis	histone deacetylase 1	0.0038	0.0214	0.0166
Echinococcus multilocularis	multidrug resistance protein 1	0.0104	0.0858	0.0813
Toxoplasma gondii	histone deacetylase HDAC4	0.0038	0.0214	0.161
Brugia malayi	ABC transporter family protein	0.0104	0.0858	0.1972
Trichomonas vaginalis	hypothetical protein	0.0054	0.0373	0.4007
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0031	0.0151	0.0236
Loa Loa (eye worm)	histone deacetylase 11	0.0038	0.0214	0.0383
Brugia malayi	Histone deacetylase 1	0.0038	0.0214	0.0492
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0104	0.0858	0.0813
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0125	0.106	0.9881
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0104	0.0858	0.0813
Brugia malayi	histone deacetylase 1 (HD1)	0.0038	0.0214	0.0492
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0054	0.0373	0.0858
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0032	0.0162	0.0235
Trypanosoma cruzi	histone deacetylase, putative	0.0126	0.1073	0.2131
Brugia malayi	diacylglycerol acyltransferase	0.0125	0.106	0.2436
Trypanosoma brucei	ceramide phosphorylethanolamine synthase	0.0054	0.0373	0.0675
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0032	0.0162	0.5
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0858	0.188
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0704	0.1521
Brugia malayi	histone deacetylase 3 (HD3)	0.0038	0.0214	0.0492
Trichomonas vaginalis	taga, putative	0.0104	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0858	0.188
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0032	0.0162	0.5
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Trypanosoma brucei	inositol phosphorylceramide synthase	0.0054	0.0373	0.0675
Entamoeba histolytica	hypothetical protein	0.0032	0.0162	0.0118
Entamoeba histolytica	hypothetical membrane-spanning protein	0.0054	0.0373	0.0339
Plasmodium vivax	ABC transporter B family member 7, putative	0.0032	0.0162	0.0779
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0032	0.0162	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0048	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0085	0.0083
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0104	0.0858	0.188
Echinococcus multilocularis	multidrug resistance protein 1	0.0072	0.0552	0.0505
Loa Loa (eye worm)	multidrug resistance protein 3	0.0104	0.0858	0.188
Echinococcus multilocularis	histone deacetylase 8	0.0038	0.0214	0.0166
Brugia malayi	histone deacetylase 11	0.0038	0.0214	0.0492
Entamoeba histolytica	hypothetical protein	0.0054	0.0373	0.0339
Giardia lamblia	Histone deacetylase	0.0038	0.0214	1
Trypanosoma brucei	histone deacetylase 4	0.0126	0.1073	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0214	0.0383
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0104	0.0858	0.0813
Loa Loa (eye worm)	histone deacetylase 3	0.0038	0.0214	0.0383
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0032	0.0162	0.0372
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0032	0.0162	0.0779
Schistosoma mansoni	multidrug resistance protein	0.0104	0.0858	0.188
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0373	0.4007
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0032	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0311	0.0608
Leishmania major	p-glycoprotein e	0.0032	0.0162	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0104	0.0858	0.0813
Schistosoma mansoni	peptidylglycine monooxygenase	0.0245	0.2239	0.5089
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0054	0.0373	0.0858
Echinococcus granulosus	histone deacetylase 6	0.0126	0.1073	0.1028
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.0858	1
Brugia malayi	ABC transporter family protein	0.0032	0.0162	0.0372
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0032	0.0162	0.0118
Leishmania major	hypothetical protein, conserved	0.0025	0.0085	0.0075
Schistosoma mansoni	multidrug resistance protein	0.0032	0.0162	0.0262
Echinococcus granulosus	histone deacetylase 6	0.0126	0.1073	0.1028
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.0858	1
Trichomonas vaginalis	ABC transporter, putative	0.0104	0.0858	1
Toxoplasma gondii	hypothetical protein	0.0054	0.0373	0.3167
Schistosoma mansoni	spingomyelin synthetase-related	0.0054	0.0373	0.0753
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0032	0.0162	0.0779
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Plasmodium falciparum	plasmepsin II	0.0048	0.0311	0.2287
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0162	0.0262
Entamoeba histolytica	P-glyco protein 6, putative	0.0104	0.0858	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0462	0.4352	1
Entamoeba histolytica	hypothetical protein	0.0054	0.0373	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0033	0.017	0.028
Loa Loa (eye worm)	ABC transporter	0.0032	0.0162	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0049	0.032	0.0629
Plasmodium falciparum	plasmepsin IV	0.0048	0.0311	0.2287
Schistosoma mansoni	histone deacetylase	0.0038	0.0214	0.0383
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0032	0.0162	0.0779
Brugia malayi	multidrug resistance related protein 1	0.0032	0.0162	0.0372
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0125	0.106	0.9876
Brugia malayi	MBOAT family protein	0.0021	0.0049	0.0113
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0104	0.0858	0.1684
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0048	0.0311	0.2557
Entamoeba histolytica	P-glycoprotein 5, putative	0.0031	0.0151	0.0106
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0032	0.0162	0.0779
Plasmodium vivax	plasmepsin IV, putative	0.0048	0.0311	0.2287
Plasmodium vivax	sphingomyelin synthase 1, putative	0.0054	0.0373	0.2919
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0462	0.4352	0.4324
Brugia malayi	MH2 domain containing protein	0.0116	0.0982	0.2257
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0032	0.0162	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0162	0.0262
Schistosoma mansoni	smdr1	0.0032	0.0162	0.0262
Toxoplasma gondii	histone deacetylase HDAC1	0.0126	0.1073	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Echinococcus multilocularis	histone deacetylase 7	0.0126	0.1073	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2239	0.5089
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Plasmodium falciparum	multidrug resistance protein 2	0.0032	0.0162	0.0779
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0032	0.0162	0.0235
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1
Trichomonas vaginalis	ABC transporter, putative	0.0104	0.0858	1
Trypanosoma brucei	p-glycoprotein	0.0032	0.0162	0.0235
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0032	0.0162	0.0779
Echinococcus multilocularis	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Echinococcus multilocularis	multidrug resistance protein 1	0.0104	0.0858	0.0813
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0462	0.4352	1
Schistosoma mansoni	multidrug resistance protein	0.0032	0.0162	0.0262
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.017	0.039
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0245	0.2239	0.5089
Brugia malayi	Sphingomyelin synthase-related 1	0.0054	0.0373	0.0858
Entamoeba histolytica	hypothetical protein, conserved	0.1	0.9603	1
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0462	0.4352	0.4324
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0032	0.0162	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0982	0.2168
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0513	0.4852	1
Brugia malayi	ABC transporter family protein	0.0032	0.0162	0.0372
Brugia malayi	MBOAT family protein	0.0021	0.0049	0.0113
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0032	0.0162	0.0235
Schistosoma mansoni	multidrug resistance protein	0.0032	0.0162	0.0262
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0085	0.035
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0054	0.0373	0.4007
Brugia malayi	Histone deacetylase family protein	0.0126	0.1073	0.2464
Leishmania major	histone deacetylase, putative	0.0126	0.1073	0.2131
Plasmodium falciparum	histone deacetylase 2	0.0126	0.1073	1
Brugia malayi	MBOAT family protein	0.0021	0.0049	0.0113
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0513	0.4852	1
Giardia lamblia	MRP-like ABC transporter	0.0032	0.0162	0.1751
Plasmodium falciparum	histone deacetylase, putative	0.0126	0.1073	1
Plasmodium vivax	histone deacetylase, putative	0.0126	0.1073	1
Leishmania major	phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0513	0.4852	1
Trypanosoma brucei	histone deacetylase, putative	0.0126	0.1073	0.2131
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0104	0.0858	0.5
Toxoplasma gondii	histone deacetylase HDAC5	0.0038	0.0214	0.161
Plasmodium vivax	ABC transporter B family member 4, putative	0.0032	0.0162	0.0779
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0031	0.0151	0.1257
Echinococcus multilocularis	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Leishmania major	histone deacetylase, putative	0.0126	0.1073	0.2131
Echinococcus multilocularis	histone deacetylase 3	0.0038	0.0214	0.0166
Plasmodium vivax	sphingomyelin synthase 2, putative	0.0054	0.0373	0.2919
Echinococcus granulosus	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0104	0.0858	1
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0054	0.0373	0.0326
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0032	0.0162	0.1393
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0104	0.0858	0.0813
Loa Loa (eye worm)	ABC transporter	0.0032	0.0162	0.0262
Brugia malayi	ABC transporter	0.0032	0.0162	0.0372
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0032	0.0162	0.5
Brugia malayi	multidrug resistance protein 3	0.0104	0.0858	0.1972
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0054	0.0373	0.0858
Trichomonas vaginalis	ABC transporter, putative	0.0104	0.0858	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0032	0.0162	0.0113
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0032	0.0162	0.0235
Schistosoma mansoni	histone deacetylase	0.0038	0.0214	0.0383
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0032	0.0162	0.0235
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0032	0.0162	0.0118
Echinococcus multilocularis		0.0032	0.0162	0.0113
Schistosoma mansoni	histone deacetylase 1 2 3	0.0038	0.0214	0.0383
Trypanosoma cruzi	histone deacetylase, putative	0.0038	0.0214	0.0343
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0311	0.0608
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0032	0.0162	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0151	0.0236
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0104	0.0858	0.0813
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0982	0.2168
Onchocerca volvulus		0.0104	0.0858	1
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0125	0.106	0.1016
Brugia malayi	hypothetical protein	0.0032	0.0162	0.0372
Giardia lamblia	Multidrug resistance-associated protein 1	0.0032	0.0162	0.1751
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0513	0.4852	1
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Schistosoma mansoni	hypothetical protein	0.0033	0.017	0.028
Echinococcus granulosus	multidrug resistance protein 1	0.0072	0.0552	0.0505
Brugia malayi	ABC transporter family protein	0.0032	0.0162	0.0372
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0124	0.106	0.2435
Leishmania major	pentamidine resistance protein 1	0.0032	0.0162	0.0235
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0104	0.0858	0.7904
Echinococcus granulosus	histone deacetylase	0.0126	0.1073	0.1028
Schistosoma mansoni	histone deacetylase 4 5	0.0126	0.1073	0.2378
Echinococcus granulosus	multidrug resistance protein 1	0.0072	0.0552	0.0505
Echinococcus multilocularis	histone deacetylase 6	0.0126	0.1073	0.1028
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Entamoeba histolytica	P-glycoprotein-2, putative	0.0104	0.0858	0.0847
Trypanosoma cruzi	histone deacetylase, putative	0.0126	0.1073	0.2131
Entamoeba histolytica	hypothetical protein	0.0054	0.0373	0.0339
Plasmodium falciparum	histone deacetylase 1	0.0038	0.0214	0.1306
Brugia malayi	ABC transporter transmembrane region family protein	0.0032	0.0162	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0373	0.0753
Echinococcus granulosus	histone deacetylase 6	0.0126	0.1073	0.1028
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0104	0.0858	0.0813
Toxoplasma gondii	aspartyl protease ASP1	0.0048	0.0311	0.2557
Echinococcus granulosus	multidrug resistance associated protein 7	0.0032	0.0162	0.0113
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0054	0.0373	0.0326
Trypanosoma cruzi	histone deacetylase, putative	0.0126	0.1073	0.2131
Entamoeba histolytica	P-glycoprotein 6, putative	0.0032	0.0162	0.0118
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0104	0.0858	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Echinococcus multilocularis	histone deacetylase	0.0126	0.1073	0.1028
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0032	0.0162	0.0235
Entamoeba histolytica	histone deacetylase, putative	0.0038	0.0214	0.0172
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0032	0.0162	0.5
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0032	0.0162	0.1101
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0245	0.2239	0.5144
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0103	0.0847	0.0802
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0085	0.0075
Brugia malayi	ABC transporter transmembrane region family protein	0.0031	0.0151	0.0347
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0048	0.0311	0.0608
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0054	0.0373	0.0858
Schistosoma mansoni	multidrug resistance protein	0.0032	0.0162	0.0262
Entamoeba histolytica	P-glycoprotein 5, putative	0.0104	0.0858	0.0847
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Loa Loa (eye worm)	ABC transporter	0.0032	0.0162	0.0262
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0031	0.0151	0.1257
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0072	0.0552	0.6218
Plasmodium vivax	aspartyl proteinase, putative	0.0048	0.0311	0.2287
Plasmodium vivax	multidrug resistance protein 1, putative	0.0104	0.0858	0.7828
Entamoeba histolytica	multidrug resistance protein, putative	0.0032	0.0162	0.0118
Schistosoma mansoni	histone deacetylase hda2	0.0126	0.1073	0.2378
Brugia malayi	Hhat protein	0.0021	0.0049	0.0113
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0104	0.0858	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0104	0.0858	0.0813
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0032	0.0162	0.0235
Toxoplasma gondii	ABC transporter, putative	0.0032	0.0162	0.1101
Entamoeba histolytica	hypothetical protein	0.0054	0.0373	0.0339
Echinococcus granulosus	multidrug resistance protein 1	0.0104	0.0858	0.0813
Echinococcus multilocularis	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0032	0.0162	0.1101
Echinococcus granulosus	histone deacetylase 7	0.0126	0.1073	0.1028
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0032	0.0162	0.0235
Trypanosoma brucei	histone deacetylase 3	0.0126	0.1073	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0214	0.0383
Trichomonas vaginalis	abcb9, putative	0.0104	0.0858	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0704	0.1521
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0032	0.0162	0.0113
Entamoeba histolytica	P-glycoprotein-5	0.0104	0.0858	0.0847
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0125	0.106	0.9876
Echinococcus granulosus	histone deacetylase 1	0.0038	0.0214	0.0166
Echinococcus granulosus	ATP binding cassette sub family B	0.0032	0.0162	0.0113
Loa Loa (eye worm)	histone deacetylase 1	0.0038	0.0214	0.0383
Schistosoma mansoni	cathepsin D (A01 family)	0.0141	0.1219	0.2718
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0513	0.4852	1
Brugia malayi	MBOAT family protein	0.0021	0.0049	0.0113
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0038	0.0214	0.2037
Echinococcus granulosus	histone deacetylase 3	0.0038	0.0214	0.0166
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0038	0.0214	0.2037
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0125	0.106	0.235
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.032	0.0735
Treponema pallidum	alginate O-acetylation protein (algI)	0.0021	0.0049	0.5
Plasmodium vivax	histone deacetylase, putative	0.0038	0.0214	0.1306
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.0858	1
Schistosoma mansoni	multidrug resistance protein	0.0032	0.0162	0.0262
Plasmodium falciparum	multidrug resistance protein 1	0.0104	0.0858	0.7828
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0054	0.0373	0.4007
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0054	0.0373	0.2919
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0125	0.106	0.9881
Trichomonas vaginalis	histone deacetylase, putative	0.0038	0.0214	0.2037
Schistosoma mansoni	smdr2	0.0104	0.0858	0.188
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0151	0.0236
Entamoeba histolytica	P-glycoprotein-2	0.0104	0.0858	0.0847
Echinococcus multilocularis	histone deacetylase 6	0.0126	0.1073	0.1028
Brugia malayi	ABC transporter	0.0031	0.0151	0.0347
Trypanosoma cruzi	histone deacetylase, putative	0.0038	0.0214	0.0343
Trichomonas vaginalis	abcb9, putative	0.0104	0.0858	1
Toxoplasma gondii	ABC transporter family protein	0.0032	0.0162	0.1101
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0032	0.0162	0.0235
Echinococcus granulosus	ATP binding cassette sub family B	0.0031	0.0151	0.0102
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0104	0.0858	1
Entamoeba histolytica	P-glycoprotein-1	0.0104	0.0858	0.0847
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0032	0.0162	0.0235
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0054	0.0373	0.4007
Schistosoma mansoni	multidrug resistance protein	0.0031	0.0151	0.0236
Plasmodium falciparum	sphingomyelin synthase 2, putative	0.0054	0.0373	0.2919
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0038	0.0214	0.2037
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.032	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0162	0.0262
Trypanosoma brucei	histone deacetylase 1	0.0038	0.0214	0.0343
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0032	0.0162	0.0118
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0032	0.0162	0.0235
Trichomonas vaginalis	abcb9, putative	0.0104	0.0858	1
Echinococcus granulosus	multidrug resistance protein 1	0.0104	0.0858	0.0813
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0104	0.0858	1
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0032	0.0162	0.5
Giardia lamblia	Multidrug resistance-associated protein 1	0.0032	0.0162	0.1751
Plasmodium vivax	ABC transporter B family member 3, putative	0.0032	0.0162	0.0779
Leishmania major	histone deacetylase, putative	0.0038	0.0214	0.0343
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0104	0.0858	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 870835