Detailed information for compound 882842

Basic information

Technical information
  • TDR Targets ID: 882842
  • Name: 7-fluoro-2-(5-methyl-1,2-oxazol-3-yl)-1-(3-ni trophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dion e
  • MW: 421.335 | Formula: C21H12FN3O6
  • H donors: 0 H acceptors: 5 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)c(=O)c1c(o2)C(=O)N(C1c1cccc(c1)[N+](=O)[O-])c1noc(c1)C
  • InChi: 1S/C21H12FN3O6/c1-10-7-16(23-31-10)24-18(11-3-2-4-13(8-11)25(28)29)17-19(26)14-9-12(22)5-6-15(14)30-20(17)21(24)27/h2-9,18H,1H3
  • InChiKey: YCLQLQXESPUYGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-fluoro-2-(5-methylisoxazol-3-yl)-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 7-fluoro-2-(5-methyl-3-isoxazolyl)-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 7-fluoro-2-(5-methylisoxazol-3-yl)-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0183 0.0235
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0473 0.0548
Echinococcus granulosus dna polymerase eta 0.0062 0.1229 0.178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0015 0.0022
Onchocerca volvulus 0.0047 0.0867 1
Schistosoma mansoni smad 0.0016 0.0128 0.0186
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0779 0.8968
Echinococcus multilocularis smad 0.0016 0.0128 0.0172
Brugia malayi hypothetical protein 0.0014 0.0088 0.0166
Echinococcus multilocularis GPCR, family 2 0.0017 0.0165 0.0226
Onchocerca volvulus 0.0014 0.0088 0.0858
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0606 0.0866
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0473 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0026 0.0038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.2267 0.3294
Schistosoma mansoni glucose transport protein 0.0101 0.2164 0.3153
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0473 0.0676
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Mycobacterium ulcerans hypothetical protein 0.0012 0.0026 0.006
Schistosoma mansoni hypothetical protein 0.0047 0.0867 0.1263
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0606 0.09
Entamoeba histolytica hypothetical protein 0.0023 0.0289 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0114 0.0169
Schistosoma mansoni ran 0.0021 0.0239 0.0348
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0288 0.0419
Trichomonas vaginalis chromobox protein, putative 0.0077 0.1586 0.2075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0114 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0488 0.0711
Brugia malayi MH2 domain containing protein 0.0233 0.531 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0489 0.0489
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0606 0.0751
Schistosoma mansoni DNA polymerase eta 0.0062 0.1229 0.1791
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.531 0.7737
Schistosoma mansoni hypothetical protein 0.0038 0.0647 0.0943
Mycobacterium ulcerans sugar transporter 0.0014 0.0088 0.0238
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0049 0.0049
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0026 0.0038
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0049 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0945 0.1371
Loa Loa (eye worm) hypothetical protein 0.0062 0.1229 0.1791
Onchocerca volvulus 0.0014 0.0088 0.0858
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0183 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Schistosoma mansoni importin beta-1 0.0028 0.0415 0.0605
Loa Loa (eye worm) hypothetical protein 0.0028 0.0415 0.0605
Echinococcus multilocularis dna polymerase eta 0.0062 0.1229 0.178
Brugia malayi Protein cec-1. 0.0013 0.0049 0.0093
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.1586 0.2311
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2164 0.2855
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0183 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0498 0.0605
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0239 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0351 0.0485
Brugia malayi nuclear receptor NHR-88 0.0011 0.0015 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Schistosoma mansoni ap endonuclease 0.0018 0.0183 0.0267
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0288 1
Leishmania major hypothetical protein, conserved 0.0024 0.0331 0.0456
Onchocerca volvulus 0.0013 0.0049 0.0402
Giardia lamblia DINP protein human, muc B family 0.0037 0.0641 0.0793
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0593 0.0847
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0114 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0288 0.0419
Brugia malayi Sugar transporter family protein 0.0014 0.0088 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0498 0.0605
Giardia lamblia Fructose-bisphosphate aldolase 0.0323 0.7457 0.958
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0239 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0015 0.0008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0518 0.0754
Schistosoma mansoni protein kinase 0.0031 0.0488 0.0711
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0088 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0183 0.0181
Brugia malayi polk-prov protein 0.0012 0.0026 0.0048
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1063 0.2003
Trypanosoma brucei sugar transporter, putative 0.0014 0.0088 0.0131
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis solute carrier family 22 0.0014 0.0088 0.0114
Entamoeba histolytica protein kinase, putative 0.0031 0.0488 0.0567
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0015 0.0022
Onchocerca volvulus Alhambra homolog 0.0032 0.0518 0.5901
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.5229 0.7616
Echinococcus granulosus peregrin 0.0032 0.0518 0.0741
Entamoeba histolytica hypothetical protein 0.0013 0.0049 0.00000000032562
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0088 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0183 0.024
Brugia malayi Sugar transporter family protein 0.0101 0.2164 0.4076
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0088 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0518 0.0787
Giardia lamblia Sugar-proton symporter 0.0014 0.0088 0.0081
Brugia malayi Cam kinase protein 1 0.0031 0.0488 0.092
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.1229 0.2315
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0049 0.0058
Toxoplasma gondii exonuclease III APE 0.0018 0.0183 0.0279
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0351 0.0511
Entamoeba histolytica hypothetical protein 0.0023 0.0288 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.073 0.1051
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0473 0.0891
Brugia malayi hypothetical protein 0.0014 0.0088 0.0166
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0679 0.099
Brugia malayi Sugar transporter family protein 0.0014 0.0088 0.0166
Brugia malayi Muscleblind-like protein 0.0165 0.3688 0.6947
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0641 0.1207
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0489 0.0489
Echinococcus multilocularis snurportin 1 0.0298 0.6863 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0518 0.0741
Schistosoma mansoni chromobox protein 0.0013 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0114 0.0152
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0331 0.0331
Echinococcus multilocularis Chromo domain 0.0013 0.005 0.0058
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis chromobox protein 1 0.0077 0.1586 0.23
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3652 0.5556
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0331 0.0456
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0289 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0364 0.0541
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0015 0.0029
Loa Loa (eye worm) sugar transporter 0.0014 0.0088 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0049 0.0072
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.005 0.0058
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.005 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0026 0.0026
Leishmania major glucose transporter, lmgt1 0.0031 0.0498 0.0704
Echinococcus granulosus dna polymerase kappa 0.0037 0.0641 0.092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0029
Echinococcus granulosus smad 0.0016 0.0128 0.0172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0488 0.0698
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0606 0.1141
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0114 0.0152
Echinococcus multilocularis solute carrier family 22 0.0014 0.0088 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3652 0.3652
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0015 0.0008
Giardia lamblia DNA repair protein RAD52 0.0337 0.7783 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0498 0.0704
Loa Loa (eye worm) hypothetical protein 0.023 0.5229 0.762
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.2035 0.2567
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0029
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0606 0.0866
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0088 0.0052
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0641 0.092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0351 0.0485
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.531 0.7737
Schistosoma mansoni hypothetical protein 0.0013 0.005 0.0072
Echinococcus granulosus solute carrier family 22 0.0014 0.0088 0.0114
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0015 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0779 0.0984
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.024
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0114 0.0214
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0049 0.0049
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0641 0.1612
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0239 0.0364
Brugia malayi PHD-finger family protein 0.0032 0.0518 0.0975
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0641 0.092
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.6729 1
Schistosoma mansoni ap endonuclease 0.0018 0.0183 0.0267
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0443 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0029
Onchocerca volvulus 0.0014 0.0088 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Schistosoma mansoni sugar transporter 0.0014 0.0088 0.0129
Brugia malayi Heterochromatin protein 1 0.0077 0.1586 0.2987
Schistosoma mansoni hypothetical protein 0.0298 0.6863 1
Onchocerca volvulus 0.0014 0.0088 0.0858
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1156 0.1684
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0498 0.0704
Toxoplasma gondii sugar transporter ST2 0.0014 0.0088 0.0134
Onchocerca volvulus 0.0013 0.0049 0.0402
Schistosoma mansoni sugar transporter 0.0014 0.0088 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0518 0.0754
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0593 0.0593
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0489 0.0489
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0489 0.0744
Loa Loa (eye worm) sugar transporter 0.0101 0.2164 0.3153
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0351 0.0497
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0641 0.1612
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0498 0.074
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Trypanosoma brucei unspecified product 0.0026 0.0364 0.0541
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.005 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0415 0.0617
Schistosoma mansoni chromobox protein 0.0013 0.0049 0.0072
Echinococcus granulosus Smad4 0.0016 0.0128 0.0172
Trichomonas vaginalis ran, putative 0.0021 0.0239 0.0256
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0049 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0088 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0026 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0473 0.069
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0128 0.0172
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1063 0.2003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0606 0.0883
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0165 0.0226
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0088 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0013 0.005 0.005
Brugia malayi jmjC domain containing protein 0.0106 0.2267 0.427
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0288 0.0405
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.005 0.0072
Plasmodium falciparum protein kinase 7 0.0286 0.6573 0.6573
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0641 0.0952
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0331 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Leishmania major protein kinase, putative 0.0031 0.0488 0.069
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0488 0.0711
Schistosoma mansoni chromobox protein 0.0077 0.1586 0.2311
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0114 0.0169
Schistosoma mansoni hypothetical protein 0.0101 0.2164 0.3153
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Brugia malayi major facilitator superfamily protein 0.0014 0.0088 0.0166
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0606 0.0866
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0088 0.0094
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0026 0.0038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0015 0.0029
Toxoplasma gondii sugar transporter ST1 0.0014 0.0088 0.0134
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0114 0.0166
Leishmania major DNA polymerase eta, putative 0.0036 0.0614 0.0878
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0498 0.0605
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis muscleblind protein 1 0.0165 0.3688 0.5368
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0779 0.1135
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0351 0.0533
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0415 0.0632
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0114 0.0166
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.073 0.1051
Plasmodium vivax sugar transporter, putative 0.0014 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0096 0.2035 0.2567
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0857 0.109
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0498 0.0605
Brugia malayi Flap endonuclease-1 0.0025 0.0351 0.066
Schistosoma mansoni protein kinase 0.0031 0.0488 0.0711
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0158 0.3514 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0614 0.0878
Onchocerca volvulus 0.0014 0.0088 0.0858
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1336 0.1947
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0288 0.0288
Schistosoma mansoni glucose transport protein 0.0101 0.2164 0.3153
Plasmodium falciparum flap endonuclease 1 0.0025 0.0351 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.6729 1
Schistosoma mansoni flap endonuclease-1 0.0023 0.0293 0.0427
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0641 0.1812
Brugia malayi hypothetical protein 0.0016 0.0125 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0478 0.0579
Echinococcus granulosus survival motor neuron protein 1 0.023 0.5229 0.7616
Schistosoma mansoni Smad4 0.0016 0.0128 0.0186
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0415 0.0617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0114 0.0152
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0867 0.1632
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0088 0.0114
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Brugia malayi hypothetical protein 0.023 0.5229 0.9848
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1156 0.328
Echinococcus granulosus solute carrier family 22 0.0014 0.0088 0.0114
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0026 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0008
Echinococcus granulosus Chromo domain 0.0013 0.005 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0015 0.0022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0239 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1156 0.1684
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0029
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0088 0.0134
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0323 0.7457 0.9578
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0046 0.0067
Mycobacterium ulcerans hypothetical protein 0.0154 0.3425 0.9746
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0288 0.0428
Brugia malayi hypothetical protein 0.0014 0.0088 0.0166
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.005 0.0075
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0288 0.0542
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0015 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0008
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0049 0.0049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0498 0.0704
Brugia malayi steroid hormone receptor 0.0011 0.0015 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0606 0.0719
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0488 0.0711
Loa Loa (eye worm) hypothetical protein 0.0017 0.0165 0.024
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0351 0.0419
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0641 0.0765
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3052 0.4515
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0857 0.9887
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0351 0.0521
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0415 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0049 0.0049
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0473 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0128 0.0186
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0679 0.0977
Brugia malayi major facilitator superfamily protein 0.0014 0.0088 0.0166
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0606 0.0869
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2164 0.3292
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0088 0.0129
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.024
Leishmania major hypothetical protein, conserved 0.0014 0.0088 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0498 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0029
Brugia malayi RNA, U transporter 1 0.0079 0.1644 0.3096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0518 0.0787
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Loa Loa (eye worm) Smad1 0.0016 0.0128 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.024
Echinococcus multilocularis General substrate transporter 0.0087 0.1824 0.2648
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0337 0.7783 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3052 0.4515
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.3425 0.974
Brugia malayi isocitrate dehydrogenase 0.0015 0.0114 0.0214
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0593 0.0847
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0331 0.0492
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0489 0.0489
Echinococcus granulosus muscleblind protein 0.0165 0.3688 0.5368
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0606 0.0751
Trypanosoma cruzi hexose transporter 0.0031 0.0498 0.0704
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0015 0.0022
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0288 0.0438
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0647 0.1219
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0026 0.0039
Schistosoma mansoni sugar transporter 0.0014 0.0088 0.0129
Onchocerca volvulus 0.0014 0.0088 0.0858
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0351 0.0389
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2164 0.3143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.1067 0.1555
Schistosoma mansoni glucose transporter 0.0014 0.0088 0.0129
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0015 0.0029
Brugia malayi CHD4 protein 0.0013 0.005 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0015 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0026 0.0039
Onchocerca volvulus 0.0014 0.0088 0.0858
Schistosoma mansoni glucose transport protein 0.0101 0.2164 0.3153
Schistosoma mansoni protein kinase 0.0031 0.0488 0.0711
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0114 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0641 0.0918
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.3052 0.4536
Entamoeba histolytica Ran family GTPase 0.0021 0.0239 0.0245
Brugia malayi SET domain containing protein 0.0013 0.0049 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0641 0.0952
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0606 0.0869
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0606 0.0869
Echinococcus granulosus flap endonuclease 1 0.0025 0.0351 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0478 0.0579
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0641 0.0934
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0183 0.0181
Echinococcus multilocularis Smad4 0.0016 0.0128 0.0172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0015 0.0022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0606 0.0869
Loa Loa (eye worm) helicase 0.0013 0.005 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0641 0.0918
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Brugia malayi Bromodomain containing protein 0.0032 0.0518 0.0975
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0008
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0026 0.0038
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0288 0.0391
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0165 0.0226
Brugia malayi Smad1 0.0016 0.0128 0.024
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Brugia malayi MH1 domain containing protein 0.0016 0.0128 0.024
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0015 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.1229 0.1796
Schistosoma mansoni hypothetical protein 0.0032 0.0518 0.0754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.1229 0.1827
Onchocerca volvulus 0.0014 0.0088 0.0858
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0606 0.0748
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0473 0.0806
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0026 0.0026
Brugia malayi ecdysteroid receptor 0.0011 0.0015 0.0029
Echinococcus granulosus chromobox protein 1 0.0077 0.1586 0.23
Leishmania major glucose transporter, lmgt3 0.0031 0.0498 0.0704
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0289 0.0323
Loa Loa (eye worm) hypothetical protein 0.0036 0.0606 0.0883
Echinococcus granulosus snurportin 1 0.0298 0.6863 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0049 0.0093
Trypanosoma brucei unspecified product 0.0026 0.0364 0.0541
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0088 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0488 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0498 0.0605
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0289 0.0323
Echinococcus multilocularis peregrin 0.0032 0.0518 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0364 0.0541
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0641 0.0952
Brugia malayi MH2 domain containing protein 0.0016 0.0128 0.024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.0641 0.1812
Brugia malayi MH1 domain containing protein 0.0016 0.0128 0.024
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0015 0.0008
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0288 0.0391
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0288 0.0405
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0049 0.0072
Entamoeba histolytica protein kinase, putative 0.0031 0.0488 0.0567
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0114 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.005 0.0093
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.073 0.1051
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0114 0.0114
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0473 0.0676
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0165 0.031
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0183 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0641 0.0918
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0593 0.0847
Toxoplasma gondii protein kinase, putative 0.0286 0.6573 1
Onchocerca volvulus 0.0014 0.0088 0.0858
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0641 0.0798
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0239 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0015 0.0022
Leishmania major glucose transporter, lmgt2 0.0031 0.0498 0.0704
Echinococcus multilocularis muscleblind protein 0.0165 0.3688 0.5368
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0288 0.0288
Onchocerca volvulus Putative transporter 0.0014 0.0088 0.0858
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0088 0.0166
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0165 0.0226
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0819 0.118
Onchocerca volvulus 0.0014 0.0088 0.0858
Loa Loa (eye worm) hypothetical protein 0.0165 0.3688 0.5375
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0015 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0029
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0288 0.0322
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0288 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0015 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.005 0.005
Echinococcus granulosus chromobox protein 2 0.0013 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Echinococcus granulosus chromobox protein 1 0.0077 0.1586 0.23
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0498 0.074
Schistosoma mansoni sugar transporter 0.0014 0.0088 0.0129
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0128 0.0172
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0489 0.0489
Echinococcus granulosus General substrate transporter 0.0087 0.1824 0.2648
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0239 0.045
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0088 0.0238
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0641 0.0798
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0647 0.0943
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0488 0.0726
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.2267 0.3294
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0088 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0518 0.0754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Onchocerca volvulus 0.0014 0.0088 0.0858
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0114 0.0132
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1749 0.2549
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0331 0.0331
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0008
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.005 0.0093
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0015 0.0008
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0221 0.0232
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0641 0.0934
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0088 0.0094
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Brugia malayi MH2 domain containing protein 0.0016 0.0128 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0049 0.0075
Leishmania major importin beta-1 subunit, putative 0.0023 0.0289 0.0393
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0331 0.0456
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0077 0.1586 0.2075
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0606 0.0751
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0473 0.069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1156 0.3116
Treponema pallidum fructose-bisphosphate aldolase 0.0323 0.7457 1
Brugia malayi nuclear hormone receptor 0.0011 0.0015 0.0029
Onchocerca volvulus 0.0014 0.0088 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Plasmodium vivax importin-beta 2, putative 0.0028 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0034 0.0556 0.081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0183 0.0253
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.073 0.1085
Loa Loa (eye worm) hypothetical protein 0.003 0.0473 0.069
Onchocerca volvulus 0.0014 0.0088 0.0858
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0183 0.0235
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0289 0.0393
Echinococcus multilocularis solute carrier family 22 0.0014 0.0088 0.0114
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0239 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0239 0.0319
Onchocerca volvulus 0.0034 0.0556 0.6354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0088 0.0052
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0498 0.0605
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0008
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0088 0.0094
Schistosoma mansoni chromobox protein 0.0077 0.1586 0.2311
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0114 0.0152
Echinococcus granulosus GPCR family 2 0.0017 0.0165 0.0226
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0606 0.0883
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0641 0.092
Trypanosoma brucei glucose transporter 2A 0.0031 0.0498 0.074
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0641 0.0952
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0443 0.0631
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1156 0.1672
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0088 0.0129
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0158 0.0198
Toxoplasma gondii sugar transporter ST3 0.0014 0.0088 0.0134
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0128 0.0172
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0088 0.0052
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0088 0.0238
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0207 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0158 0.3514 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0165 0.024
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0351 0.0351
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1156 0.1759
Brugia malayi jmjC domain containing protein 0.0039 0.0679 0.128
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0679 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0779 0.0984
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0128 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0183 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0186
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0351 0.0406
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0207 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1156 0.328
Brugia malayi hypothetical protein 0.0013 0.0049 0.0093
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0183 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Toxoplasma gondii hypothetical protein 0.0047 0.0874 0.133
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0641 0.0934
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0606 0.0869
Plasmodium falciparum importin beta, putative 0.0028 0.0415 0.0415
Schistosoma mansoni survival motor neuron protein 0.0047 0.0867 0.1263
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0158 0.3514 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0088 0.0094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0641 0.0918
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0679 0.099
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0518 0.0518
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Trypanosoma brucei glucose transporter 1E 0.0031 0.0498 0.074
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0679 0.0977
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0088 0.0129
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0114 0.0173
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0165 0.031
Brugia malayi Importin beta-1 subunit 0.0028 0.0415 0.0782
Giardia lamblia PHD finger protein 15 0.0032 0.0518 0.0634
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0489 0.0744
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0088 0.0114
Onchocerca volvulus 0.0013 0.0049 0.0402
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0026 0.0037
Echinococcus granulosus solute carrier family 22 0.0014 0.0088 0.0114
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0498 0.0704
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0518 0.0741
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Echinococcus granulosus solute carrier family 22 0.0014 0.0088 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0488 0.0698
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.005 0.0058
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0473 0.069
Leishmania major GTP-binding protein, putative 0.0021 0.0239 0.0319
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0593 0.0903
Echinococcus multilocularis solute carrier family 22 0.0014 0.0088 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0029
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0489 0.0489
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0128 0.0186
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0088 0.0088
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0183 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0819 0.118
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0593 0.0882
Schistosoma mansoni ran 0.0021 0.0239 0.0348
Giardia lamblia Hexose transporter 0.0014 0.0088 0.0081
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0165 0.0226
Leishmania major DNA polymerase eta, putative 0.0062 0.1229 0.1796
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0288 0.0338
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0183 0.0235
Echinococcus granulosus Chromobox protein 3 0.0013 0.0049 0.0058
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0088 0.0131
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0614 0.0935
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0489 0.0489
Plasmodium falciparum phd finger protein, putative 0.0032 0.0518 0.0518
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0288 0.0807
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1156 0.328
Echinococcus multilocularis chromobox protein 1 0.0077 0.1586 0.23
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.0129
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0049 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0026 0.0038
Loa Loa (eye worm) hypothetical protein 0.0055 0.1063 0.155
Onchocerca volvulus 0.0014 0.0088 0.0858
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0498 0.074
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1156 0.1672
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0489 0.0489
Echinococcus multilocularis chromobox protein 2 0.0013 0.0049 0.0058
Schistosoma mansoni hypothetical protein 0.0017 0.0165 0.024
Leishmania major DNA polymerase kappa, putative 0.0037 0.0641 0.0918
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.005 0.0072
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0239 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0331 0.0331
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0239 0.0239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1063 0.155
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0088 0.0052
Brugia malayi chromobox protein homolog 3 0.0043 0.0779 0.1467
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0015 0.0022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0015 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.6863 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0488 0.092
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.6729 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0183 0.0272
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0183 1
Onchocerca volvulus 0.0014 0.0088 0.0858
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0239 0.0334
Plasmodium vivax hexose transporter 0.0101 0.2164 0.2164
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1156 0.1686
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0183 0.0509
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0323 0.7457 0.9578
Trypanosoma brucei unspecified product 0.0037 0.0641 0.0952
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0857 0.109
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0473 0.0891
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0022
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0088 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0641 0.0918
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0183 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Schistosoma mansoni coup transcription factor 0.0011 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0337 0.0492
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2164 0.3143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0114 0.0132
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0128 0.0172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0331 0.0483
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0593 0.0847
Plasmodium falciparum hexose transporter 0.0101 0.2164 0.2164
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3652 0.3652
Echinococcus granulosus importin subunit beta 1 0.0028 0.0415 0.0591
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.6729 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0364 0.0541
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0114 0.0075
Brugia malayi hypothetical protein 0.0024 0.0331 0.0624
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0088 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0114 0.0152
Loa Loa (eye worm) hypothetical protein 0.0165 0.3688 0.5375
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0288 0.0807
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0029
Trypanosoma brucei glucose transporter, putative 0.0031 0.0498 0.074
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0489 0.0489
Onchocerca volvulus 0.0014 0.0088 0.0858
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0489 0.0744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0072
Schistosoma mansoni smad1 5 8 and 0.0016 0.0128 0.0186
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0606 0.0869
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0288 0.0246
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0088 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0323 0.7457 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0183 0.0277
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0488 0.0711

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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